Advances in burn wound management: innovative strategies for healing and infection control.

IF 1.4 4区 医学 Q3 DERMATOLOGY
Alosh Greeny, Rekha R Shenoy
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引用次数: 0

Abstract

Burn wounds are insults to the skin that can be caused by various sources, including thermal, electrical, or chemical sources, and even natural sources such as the sun. A burn wound is conventionally categorized into 3 distinct zones: (1) coagulation, (2) ischemia/stasis, and (3) hyperemia. In addition to the potential for physiological scarring, burn wounds can lead to microbial infections, such as pneumonia and methicillin-resistant Staphylococcus aureus, that are difficult to treat using conventional antimicrobial therapy. Patients whose burn wounds trigger a systemic inflammatory response experience further deterioration of their medical condition. Moreover, an increase in the incidence of antibiotic resistance poses a major challenge in the treatment of wounds. Researchers are shifting their focus to newer techniques, such as acellular fish skin, hydrogels, negative pressure wound therapy, nanotherapeutics, and stem cell therapy to counter the disadvantages associated with conventional therapy. This review provides an overview of burn wound causes, classifications, and treatments, and it discusses the healing phases of wounds, possible types of infections, the complexities associated with existing conventional treatments, and the advanced techniques currently used in burn wound management that have proven to reduce hospital stays and make treatment more cost-effective.

烧伤创面管理的进展:治疗和感染控制的创新策略。
烧伤是对皮肤的伤害,可以由各种来源引起,包括热、电或化学来源,甚至是太阳等自然来源。烧伤创面通常分为3个不同的区域:(1)凝血区,(2)缺血/停滞区,(3)充血区。除了潜在的生理性瘢痕外,烧伤创面还可能导致微生物感染,如肺炎和耐甲氧西林金黄色葡萄球菌,这些都是难以用常规抗菌药物治疗的。烧伤创面引发全身炎症反应的患者,其医疗状况会进一步恶化。此外,抗生素耐药性发生率的增加对伤口治疗构成了重大挑战。研究人员正在将他们的注意力转移到新的技术上,如无细胞鱼皮、水凝胶、负压伤口疗法、纳米疗法和干细胞疗法,以克服传统疗法的缺点。本文综述了烧伤创面的原因、分类和治疗方法,并讨论了伤口的愈合阶段、可能的感染类型、与现有常规治疗相关的复杂性,以及目前在烧伤创面管理中使用的先进技术,这些技术已被证明可以减少住院时间并使治疗更具成本效益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
11.80%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.
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