Wounds : a compendium of clinical research and practice最新文献_第4页

Treatment of refractory leg ulcer in a patient with lupus undergoing combination therapies. 联合治疗狼疮患者难治性腿部溃疡1例。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2026-02-01 DOI: 10.25270/wnds/25025

Chi Young Bang, Seung Ho Lee, Kun Yong Sung

{"title":"Treatment of refractory leg ulcer in a patient with lupus undergoing combination therapies.","authors":"Chi Young Bang, Seung Ho Lee, Kun Yong Sung","doi":"10.25270/wnds/25025","DOIUrl":"10.25270/wnds/25025","url":null,"abstract":"Background: Systemic lupus erythematosus can present with refractory chronic leg ulcers, often linked to antiphospholipid syndrome or vasculopathy. Standard immunosuppressive therapy may be unsuccessful in such cases, necessitating alternative approaches such as anticoagulation and advanced wound care.Case report: This report presents the case of a 46-year-old male with systemic lupus erythematosus who developed a persistent leg ulcer on the right lateral ankle that was unresponsive to immunosuppressive treatment of more than 6 months' duration. A short-term multimodal therapeutic approach incorporating anticoagulation, negative pressure wound therapy, and cultured epidermal homograft successfully induced robust granulation and marked epithelialization with 1 week of hospitalization, a much shorter period than the previously reported 2 months needed for full resolution with anticoagulation alone. Although in the present case complete epithelial closure was not achieved during the brief inpatient period, the wound showed near-total epithelialization with continued outpatient care, indicating rapid and stable wound recovery.Conclusion: This case demonstrates that adjunctive use of negative pressure wound therapy and cultured epidermal homograft appears to shorten the healing process compared with anticoagulation therapy alone.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 2","pages":"16-19"},"PeriodicalIF":1.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting of social demographics in diabetic foot ulcer randomized controlled trials: a scoping review. 糖尿病足溃疡随机对照试验的社会人口学报告：范围综述。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2026-01-01 DOI: 10.25270/wnds/25020

Dominick J Casciato, Kevin Ruiz, Nigel Morris, Joshua Calhoun

{"title":"Reporting of social demographics in diabetic foot ulcer randomized controlled trials: a scoping review.","authors":"Dominick J Casciato, Kevin Ruiz, Nigel Morris, Joshua Calhoun","doi":"10.25270/wnds/25020","DOIUrl":"10.25270/wnds/25020","url":null,"abstract":"Background: Diabetic foot ulcerations (DFUs) remain a major public health issue, disproportionately affecting diverse populations. The extent to which race, ethnicity, and social demographics are reported in randomized controlled trials (RCTs) on graft treatments for DFU remains unclear.Objective: To assess the reporting frequency of these patient characteristics and social determinants of health in order to provide insight into providing more representative, evidence-based care.Methods: Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, a scoping review of PubMed was conducted for RCTs on graft treatment for DFU published in the years 2014 to 2024. Studies were screened for the reporting and analysis of demographics, including age, sex, race, ethnicity, and social determinants of health.Results: Among 63 studies, 100% reported age, 98% reported sex, and 67% reported weight or body mass index. Race and ethnicity were reported in 46% and 27% of studies, respectively. Insurance and socioeconomic class were noted in 2% and 3% of studies, respectively, with no income data reported. Bivariate or multivariate analyses of these variables in relation to outcomes were performed for age (10%), sex (13%), race (11%), and ethnicity (8%).Conclusion: Reporting of race, ethnicity, and social determinants of health in RCTs on grafting for DFU is limited. Given the effect of these factors on outcomes, future studies should prioritize them to improve research representation and patient care.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 1","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The positive side of the local coverage determination changes. 本地覆盖确定的积极方面发生了变化。

IF 1.1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2026-01-01 DOI: 10.25270/wnds/0126-01

John C Lantis

引用次数: 0

Plantar-to-plantar punch skin grafts for a wound caused by crush injury. 足底与足底之间的皮肤移植治疗挤压伤。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2026-01-01 DOI: 10.25270/wnds/25053

Francisco Javier Ramírez-Fernández, Isidro Velázquez-Jacobo, Adriana Lozano-Platonoff, Monica Navarrete-Martínez, José Contreras-Ruiz

{"title":"Plantar-to-plantar punch skin grafts for a wound caused by crush injury.","authors":"Francisco Javier Ramírez-Fernández, Isidro Velázquez-Jacobo, Adriana Lozano-Platonoff, Monica Navarrete-Martínez, José Contreras-Ruiz","doi":"10.25270/wnds/25053","DOIUrl":"10.25270/wnds/25053","url":null,"abstract":"Background: Skin grafting of the sole of the foot poses a special challenge because it is subjected to friction and shear. Various kinds of grafts have been used throughout history for this purpose based on the features of the donor site and graft thickness. Given these unique characteristics, as well as the need to withstand pressure bearing and friction, the best grafts should be obtained from identical skin.Case report: A patient with a crush wound of the plantar and dorsal region of the left foot underwent combined treatment with plantar-to-plantar punch grafting and split-thickness skin grafting of the dorsal region to obtain full closure with appropriate region-specific skin. One week later, 85% of the grafts had taken and the donor site was healing. The patient refused a second grafting procedure and decided to wait for the initial grafts to continue growing. After 3 months, complete healing of both the dorsal and the plantar aspects of the foot was achieved.Conclusion: Skin obtained from other sites lacks, and will not develop, the same phenotype as plantar skin, which may result in complications such as hair growth, re-ulceration, hyperkeratosis, marginal scarring, pain, hyperpigmentation, or recurrent breakdown of a preexisting graft. This case demonstrates success with grafting skin of the same glabrous phenotype.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 1","pages":"7-11"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a multilayer antimicrobial foam dressing indicated for use on surgical incisions. 多层抗菌泡沫敷料用于外科切口的评价。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-12-01 DOI: 10.25270/wnds/25033

Stephanie Constable, Jacquelyn Bergo, Sarah Tuttle, Jennifer Jane Gale

{"title":"Evaluation of a multilayer antimicrobial foam dressing indicated for use on surgical incisions.","authors":"Stephanie Constable, Jacquelyn Bergo, Sarah Tuttle, Jennifer Jane Gale","doi":"10.25270/wnds/25033","DOIUrl":"10.25270/wnds/25033","url":null,"abstract":"Background: Many orthopedic procedures are performed every year in the United States on a population deemed low risk for surgical site infections (SSIs). To avoid wound complications, an appropriate dressing must be used that includes features such as conformability and antimicrobial properties.Objective: To evaluate use of a multilayer antimicrobial surgical incision dressing in patients at low risk of SSI.Methods: Data were collected from 8 hospitals in the United States. All patients involved were at low risk of infection following the surgical procedure, and the dressings were used prophylactically. Data were collected using a standardized questionnaire; respondents completed 1 survey per patient about product application, performance of dressing, and continued use.Results: Out of the 54 responses, 83% of surgeries (n = 45) were orthopedic procedures. The dressing was well received, with 91% of clinicians stating that the ease of application met, exceeded, or greatly exceeded their expectations. Seventy percent of respondents stated that the dressing's ability to conform to body contours exceeded or greatly exceeded their expectations, and 96% of clinicians stated they would like to continue using the dressing.Conclusion: The dressing demonstrates excellent conformability and other required features of a postoperative dressing in a patient population at low risk of SSI.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 12","pages":"451-455"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A season of reflection and progress in wound management. 这是伤口管理反思和进步的季节。

IF 1.1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-12-01 DOI: 10.25270/wnds/1225-01

John C Lantis

引用次数: 0

Nonhealing wound debridement using a finger-mounted debridement tool. 使用手指安装的清创工具对未愈合的伤口进行清创。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-11-01 DOI: 10.25270/wnds/25016

Elvis Castillo-Garcia

{"title":"Nonhealing wound debridement using a finger-mounted debridement tool.","authors":"Elvis Castillo-Garcia","doi":"10.25270/wnds/25016","DOIUrl":"10.25270/wnds/25016","url":null,"abstract":"Background: Chronic wound management consisting of debridement of nonhealing wounds can reduce bacterial bioburden and remove devitalized tissue. However, traditional debridement tools such as curettes, scissors, forceps, and scalpels can result in patient discomfort, particularly in difficult to access areas of tunneling and undermining.Objective: To evaluate the efficacy of a novel finger-mounted debridement tool in the treatment of nonhealing wounds.Materials and methods: The finger-mounted debridement tool was assessed in 11 patients. Patients and clinicians were asked to rate their experience following debridement with the device.Results: The debridement time was 43 ± 14 seconds for an average wound area of 9.06 ± 9.04 cm² prior to debridement. Clinicians rated ease of use and wound accessibility as 5, the highest rating. No bleeding or minimal amounts of bleeding was observed in 92% of wounds post-debridement. In a survey, 67% of patients reported no pain and 33% reported a pain level of 2 to 6 out of 10 possible. Compared with traditional debridement tools, the finger-mounted debridement tool alone was preferred by 56% of patients and the finger-mounted debridement tool with traditional debridement tools was preferred by 33%. Of the patients who responded to the survey, 67% reported being less anxious, 78% perceived faster procedure time, and 89% perceived easier wound access. Providers reported that the device was easy to use and the wounds were more accessible than with traditional tools.Conclusion: The finger-mounted debridement tool proved to be an effective wound debridement tool that required less time, improved wound accessibility in challenging and uneven areas, and was easier to use than traditional debridement tools.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 11","pages":"438-444"},"PeriodicalIF":1.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in cadaveric skin graft survival in organ transplant recipients on immunosuppressive regimens: a case report. 免疫抑制方案对器官移植受者尸体皮肤移植存活的挑战：1例报告。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-11-01 DOI: 10.25270/wnds/25048

Steven Tohmasi, Carolyn Tsung, Ariana Naaseh, Jennifer Yu, John P Kirby, Lindsay M Kranker

{"title":"Challenges in cadaveric skin graft survival in organ transplant recipients on immunosuppressive regimens: a case report.","authors":"Steven Tohmasi, Carolyn Tsung, Ariana Naaseh, Jennifer Yu, John P Kirby, Lindsay M Kranker","doi":"10.25270/wnds/25048","DOIUrl":"10.25270/wnds/25048","url":null,"abstract":"Background: Complex wound management in solid organ transplant recipients presents several challenges due to impaired tissue healing resulting from chronic immunosuppressive therapy. Although some studies suggest prolonged cadaveric skin graft survival in appropriately selected immunosuppressed patients, the long-term efficacy of this approach remains unclear.Case report: Two solid organ transplant recipients experienced delayed failure of cadaveric skin grafts, highlighting the potential role of alternative wound management strategies over traditional autologous split-thickness skin grafting. A 59-year-old male with end-stage renal and liver disease who underwent a liver-kidney transplant 3 months prior presented with a hematoma and overlying skin necrosis to his lower extremity. After serial debridements, a 25 cm × 9 cm cadaveric skin graft was applied along with negative pressure wound therapy; despite initial adherence, the allograft subsequently failed by 4 weeks post-procedure. A 62-year-old male with a history of diabetes-related renal disease and liver-kidney transplant 6 years prior presented with a necrotizing soft tissue infection to his lower extremity. After serial debridements, a 28 cm × 12 cm cadaveric graft was applied. The allograft initially adhered, but it gradually disintegrated by 8 weeks post-procedure. During close clinical follow-up, both patients declined subsequent split-thickness skin grafting in favor of continued local wound care.Conclusion: These cases underscore the unpredictable long-term efficacy of cadaveric skin grafting in chronically immunosuppressed patients, emphasizing the need for extended follow-up and improved wound healing strategies in this patient population.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 11","pages":"426-430"},"PeriodicalIF":1.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-reported outcomes favor below-knee over above-knee amputation in patients with nontraumatic lower extremity wounds. 患者报告的结果倾向于对非创伤性下肢创伤患者进行膝下截肢而不是膝上截肢。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-11-01 DOI: 10.25270/wnds/25060

Ryan P Lin, Danny S Chamaa, Sami Ferdousian, Rachel N Rohrich, Isabel A Snee, Richard C Youn, Karen K Evans, Christopher E Attinger

{"title":"Patient-reported outcomes favor below-knee over above-knee amputation in patients with nontraumatic lower extremity wounds.","authors":"Ryan P Lin, Danny S Chamaa, Sami Ferdousian, Rachel N Rohrich, Isabel A Snee, Richard C Youn, Karen K Evans, Christopher E Attinger","doi":"10.25270/wnds/25060","DOIUrl":"10.25270/wnds/25060","url":null,"abstract":"Background: Below-knee amputation and above-knee amputation are often last-resort treatment options for chronic lower extremity wounds.Objective: To compare, for the first time, patient-reported outcome measures in patients who underwent below-knee amputation or above-knee amputation for nontraumatic chronic lower extremity wounds.Methods: Patient-reported outcome measures, including the 20-item Self-Reporting Questionnaire, the Patient-Reported Outcomes Measurement Information System Pain Intensity 3-item scale, the Connor-Davidson Resilience Scale, and the Lower Extremity Functional Scale, were collected for patients who underwent above-knee amputation or below-knee amputation and who presented to a tertiary wound center between June 2022 and October 2024. Mental well-being, pain intensity, resilience, and function were measured at 1 month, 3 months, 6 months, 1 year, 2 years, and 5 years postoperative.Results: Of 96 patients, 22 underwent above-knee amputation and 74 underwent below-knee amputation. Significant differences were observed between patients who underwent above-knee amputation versus below-knee amputation in mean overall function, psychological distress, and pain intensity.Conclusion: Patients who underwent above-knee amputation had higher pain intensity, more psychological distress, and lower function compared with patients who underwent below-knee amputation.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 11","pages":"431-437"},"PeriodicalIF":1.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation in wounds of individuals with diabetes: a nonrandomized pilot study. 糖尿病患者伤口的光生物调节：一项非随机试点研究。

IF 1 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2025-11-01 DOI: 10.25270/wnds/25012

Beatriz Barbieri Bortolozo, Amanda Ramiro Gomes da Silva, Thais Paulino Prado, Bianca Campos Oliveira, Joseane Morari, Flávia Cristina Zanchetta, Eliana Pereira Araújo, Beatriz Guitton Renaud Baptista de Oliveira, Bruna Maiara Ferreira Barreto Pires, Priscila Peruzzo Apolinario, Maria Helena Melo Lima

{"title":"Photobiomodulation in wounds of individuals with diabetes: a nonrandomized pilot study.","authors":"Beatriz Barbieri Bortolozo, Amanda Ramiro Gomes da Silva, Thais Paulino Prado, Bianca Campos Oliveira, Joseane Morari, Flávia Cristina Zanchetta, Eliana Pereira Araújo, Beatriz Guitton Renaud Baptista de Oliveira, Bruna Maiara Ferreira Barreto Pires, Priscila Peruzzo Apolinario, Maria Helena Melo Lima","doi":"10.25270/wnds/25012","DOIUrl":"10.25270/wnds/25012","url":null,"abstract":"Background: Photobiomodulation has shown promising results in accelerating wound healing and modulating inflammation.Objective: To evaluate the feasibility of photobiomodulation therapy in treating lower limb wounds in people with diabetes.Materials and methods: This was a 12-week prospective, pilot, multicenter, nonrandomized clinical trial. The 25 participants were divided into the intervention group, in which a laser was applied once a week and hydrogel was applied daily, and the control group, in which hydrogel was applied daily. Participants older than 18 years with a diagnosis of diabetes mellitus and with lower limb wounds smaller than 100 cm² were included. Participants with lupus, pyoderma gangrenosum, and Stevens-Johnson syndrome were excluded. Comparisons between the groups were performed using the Mann-Whitney U test, and comparisons between different time points were performed using the Friedman test. The Fisher exact test was used to assess associations between groups and qualitative variables.Results: No statistically significant difference in wound area was observed when comparing the 4 time points evaluated between groups. However, there was a significant difference when comparing the 4 time points in the intervention group. No significant difference between groups was observed in the expression of the cytokines investigated.Conclusion: Application of photobiomodulation at an intensity of 2 J/cm² once a week did not produce measurable changes in cytokine gene expression. However, significant reduction in wound area and improvement in tissue repair were observed in patients treated with photobiomodulation.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 11","pages":"417-425"},"PeriodicalIF":1.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0