Effect of social determinants of health on clinical trials conducted for diabetic foot ulcer and venous leg ulcer at a safety net hospital.

IF 1.4 4区 医学 Q3 DERMATOLOGY
Nolan Patrick Joyce, Aniket Vazirani, Connor Roddy, Marina A Malikova
{"title":"Effect of social determinants of health on clinical trials conducted for diabetic foot ulcer and venous leg ulcer at a safety net hospital.","authors":"Nolan Patrick Joyce, Aniket Vazirani, Connor Roddy, Marina A Malikova","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Failure to adhere to study protocol is among the most common observations during inspections conducted by competent authorities for clinical trials.</p><p><strong>Objective: </strong>To evaluate patterns of protocol deviations, and to analyze how social determinants of health (SDoH) correlate with the rate of protocol deviations as indicators of study protocol noncompliance.</p><p><strong>Materials and methods: </strong>Data obtained at a single clinical site from 19 clinical trials with a total of 186 subjects enrolled were analyzed retrospectively, and correlations between SDoH (eg, race/ethnicity, gender [eg, male/female], socioeconomic status, distance traveled, etc) and study protocol noncompliance (ie, rate of deviations) were examined. The Kruskal-Wallis test was performed to compare SDoH variables with rate of deviations per subjects enrolled. Associations between SDoH and deviations were examined using the Spearman correlation test.</p><p><strong>Results: </strong>A retrospective analysis showed that the majority of deviations were attributed to study visits that had not been performed in a timely manner or were missed, and study procedures that either were not performed or were completed late. The tests demonstrated no statistical significance between age, gender, and race and rates of dropout from the study (P = .1857, P = .3836, and P = .2150, respectively). Increased body mass index was associated with higher dropout rates (P = .0340), which can be an indicator of higher disease burden and an obstacle to trial participation.</p><p><strong>Conclusion: </strong>Further studies are warranted to investigate how quality in wound care clinical trials can be improved with identification of patients who need more resources based on their SDoH to efficiently mitigate risks, increase access to trials for disadvantaged populations, and improve study protocol compliance.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"158-165"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wounds : a compendium of clinical research and practice","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Failure to adhere to study protocol is among the most common observations during inspections conducted by competent authorities for clinical trials.

Objective: To evaluate patterns of protocol deviations, and to analyze how social determinants of health (SDoH) correlate with the rate of protocol deviations as indicators of study protocol noncompliance.

Materials and methods: Data obtained at a single clinical site from 19 clinical trials with a total of 186 subjects enrolled were analyzed retrospectively, and correlations between SDoH (eg, race/ethnicity, gender [eg, male/female], socioeconomic status, distance traveled, etc) and study protocol noncompliance (ie, rate of deviations) were examined. The Kruskal-Wallis test was performed to compare SDoH variables with rate of deviations per subjects enrolled. Associations between SDoH and deviations were examined using the Spearman correlation test.

Results: A retrospective analysis showed that the majority of deviations were attributed to study visits that had not been performed in a timely manner or were missed, and study procedures that either were not performed or were completed late. The tests demonstrated no statistical significance between age, gender, and race and rates of dropout from the study (P = .1857, P = .3836, and P = .2150, respectively). Increased body mass index was associated with higher dropout rates (P = .0340), which can be an indicator of higher disease burden and an obstacle to trial participation.

Conclusion: Further studies are warranted to investigate how quality in wound care clinical trials can be improved with identification of patients who need more resources based on their SDoH to efficiently mitigate risks, increase access to trials for disadvantaged populations, and improve study protocol compliance.

健康的社会决定因素对在一家安全网医院进行的糖尿病足溃疡和静脉腿溃疡临床试验的影响。
背景:不遵守研究方案是主管部门对临床试验进行检查时最常见的观察结果之一。目的:评估方案偏离的模式,并分析健康的社会决定因素(SDoH)如何与方案偏离率相关,作为研究方案不遵守的指标。材料和方法:回顾性分析单个临床站点19项临床试验共186名入组受试者的数据,并检查SDoH(如种族/民族、性别[如男/女]、社会经济地位、旅行距离等)与研究方案不遵守(即偏差率)之间的相关性。采用Kruskal-Wallis检验比较SDoH变量与入组受试者的偏差率。使用Spearman相关检验检验SDoH与偏差之间的关系。结果:回顾性分析显示,大多数偏差是由于研究访问没有及时进行或错过,以及研究程序没有执行或完成晚。检验显示,年龄、性别、种族和研究中途退出率之间无统计学意义(P = .1857、P = .3836和P = .2150)。体重指数增加与较高的辍学率相关(P = 0.0340),这可能是较高疾病负担的一个指标,也是参与试验的一个障碍。结论:伤口护理临床试验的质量如何通过根据患者的SDoH识别需要更多资源的患者来提高,从而有效降低风险,增加弱势群体的试验可及性,并提高研究方案的依从性,值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.50
自引率
11.80%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信