Alcyjara Rêgo Costa, Tatiane Avelar Ribeiro, Diego Marques C Silva, José Ribamar da Silva Júnior, Tiago Barbalho Lima, Rui M Gil da Costa, Ana I Faustino-Rocha, Paula A Oliveira, Ana Lúcia Abreu-Silva
{"title":"Effects of Canthoplasty in Preventing Secondary Ocular Surface Lesions in Brachycephalic Dogs.","authors":"Alcyjara Rêgo Costa, Tatiane Avelar Ribeiro, Diego Marques C Silva, José Ribamar da Silva Júnior, Tiago Barbalho Lima, Rui M Gil da Costa, Ana I Faustino-Rocha, Paula A Oliveira, Ana Lúcia Abreu-Silva","doi":"10.3390/vetsci12090889","DOIUrl":"10.3390/vetsci12090889","url":null,"abstract":"<p><p>When detected early, canthoplasty controls the clinical signs and complications associated with accentuated eye exposure. The aim of this study was to evaluate the reduction in the palpebral fissure to prevent ophthalmic lesions secondary to brachycephalic dog syndrome. A total of 64 eyes of brachycephalic dogs were studied, divided into the control group (22 eyes submitted to traditional clinical treatment) and the treated group (42 eyes submitted to canthoplasty). Tear production, tear film break-up time (TFBUT), tear crystallization time (TCT), and the occurrence of corneal ulcers were assessed prior to treatment (T0), seven days after therapy or surgery (T7), and after 30 days (T30), and reassessments were performed every three months, until month 18. It was observed that the treated animals (treated group) showed an improvement in tear production compared to the control animals (control group). In addition, the treated animals showed a significant increase in TFBUT (T9M), which was higher than the control group. The TCT evaluation scores of the treated group decreased compared to the control group (T12M), and the occurrence of corneal ulcers was significantly higher in the control group in the medium term. We concluded that early canthoplasty in brachycephalic dogs prevented the occurrence of secondary lesions, increased tear production and quality, and reduced the occurrence of ulcers, particularly in the medium term.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed El-Sayed, Mohamed Marzok, Huda A Alqahtani, Amin Tahoun, Adel I Almubarak, Rasha Yassin Elkhidr, Zakriya Al Mohamed, Elshymaa A Abdelnaby, Hussein Babiker, Hanan M Alharbi, Khairiah M Alwutayd, Ahmed Ateya
{"title":"Genomic Variants, Transcriptomic Profile, Ultrasonographic Findings, and Antioxidant and Immunological Biomarkers Linked to Pregnancy Toxemia Susceptibility in Goats.","authors":"Ahmed El-Sayed, Mohamed Marzok, Huda A Alqahtani, Amin Tahoun, Adel I Almubarak, Rasha Yassin Elkhidr, Zakriya Al Mohamed, Elshymaa A Abdelnaby, Hussein Babiker, Hanan M Alharbi, Khairiah M Alwutayd, Ahmed Ateya","doi":"10.3390/vetsci12090891","DOIUrl":"10.3390/vetsci12090891","url":null,"abstract":"<p><p>Pregnancy toxemia (PT) represents a significant metabolic disorder affecting small ruminants that causes substantial economic losses due to reduced productivity, reproductive failure, and high mortality. This study investigated the clinical, ultrasonographic, hematobiochemical, oxidative stress, and immunological profiles, as well as the gene expression and nucleotide sequence variations, associated with PT susceptibility in Shami goats. Fifty late-pregnant does (33 healthy and 17 PT-affected) were examined. Clinical evaluation, complete blood count, biochemical analysis, cytokine profiling, antioxidant assays, hepatic ultrasonography, quantitative real-time PCR of immune (IL6, IL8), antioxidant (SOD3, HMOX1), and lipogenic (ACACA, FASN) genes, and PCR-DNA sequencing were performed. PT does exhibit significant hypoglycemia, hyperketonemia, elevated liver and kidney function biomarkers, dyslipidemia, oxidative stress (↑ MDA, ↓ GSH, GPx, SOD, CAT), increased pro-inflammatory cytokines (IL1α, IL1β, IL6, TNFα), and reduced IL10. Gene expression analysis revealed upregulation of IL6 and IL8 and downregulation of SOD3, HMOX1, ACACA, and FASN in PT does. Sequencing identified multiple synonymous and non-synonymous SNPs significantly associated with PT. Ultrasonography indicated hepatic fatty infiltration. Discriminant analysis using SNPs achieved 100% classification accuracy between healthy and PT does. These findings suggested that combined clinical, biochemical, oxidative, immunological, and genetic markers could enhance early PT diagnosis and may provide a basis for future studies aimed at selective breeding for improved resistance.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of Custom-Designed 3D-Printed Drill Guides in the Treatment of Lateral Humeral Condylar Fractures in a French Bulldog Bone Model.","authors":"Jirawat Srikusalanukul, Nattapon Chantarapanich, Chaiyakorn Thitiyanaporn","doi":"10.3390/vetsci12090888","DOIUrl":"10.3390/vetsci12090888","url":null,"abstract":"<p><p>The French Bulldog is a breed predisposed to lateral humeral intercondylar fractures. A transcondylar lag screw combined with an epicondylar pin is most commonly used for their repair. However, improper screw and pin placement is common. This study used a 3D-printed plastic bone model, designed from a 5-year-old 19.5 kg French Bulldog's humerus. Then, a 3D-printed drill guide was designed specifically for a lateral humeral condylar fracture. The bone models were divided into two groups: the first group included the use of the 3D-printed drill guide during the screw and pin placement, and the second group did not. After implantation, we compared the angle deviation of the transcondylar screw and the epicondylar pin, as well as the exit point translation of the transcondylar screw. The results showed differences between the two groups. The first group exhibited a lower angle deviation than the second group. Additionally, the exit point translation of the transcondylar screw was reduced in the drill guide group. The use of a custom-designed 3D-printed drill guide significantly improved the accuracy of the transcondylar screw and epicondylar pin placement. This advancement could reduce the incidence of postoperative complications.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhihua Wang, Zhengxi Liu, Hao Sun, Chunyan Bai, Te Pi, Huihai Ma, Zhongli Zhao, Shouqing Yan
{"title":"Detection of the Candidate Genes of Economically Important Traits in Dorper Sheep Through Whole-Genome Resequencing.","authors":"Zhihua Wang, Zhengxi Liu, Hao Sun, Chunyan Bai, Te Pi, Huihai Ma, Zhongli Zhao, Shouqing Yan","doi":"10.3390/vetsci12090887","DOIUrl":"10.3390/vetsci12090887","url":null,"abstract":"<p><p>Dorper sheep (DOR) are a commercially important mutton breed renowned for their high growth rate, favorable carcass composition, environmental adaptability, and natural wool shedding. In China, they are widely utilized as terminal sires to enhance growth and carcass yield in local breeds. To elucidate the genetic basis of these traits, we sequenced the genomes of 20 DOR and integrated the data with whole-genome sequences from 73 individuals representing four Chinese indigenous breeds. Analyses of genetic diversity, inbreeding coefficients, and population structure revealed reduced genomic diversity, elevated inbreeding levels, and clear genetic separation for DOR from other indigenous breeds. Selective sweep scans using <i>F</i><sub>ST</sub>, <i>pi</i>, and XP-EHH identified candidate genes involved in five major trait categories: growth performance and development (<i>COL2A1</i>, <i>DAB2IP</i>, <i>EPYC</i>, <i>TSPAN18</i>, <i>WNT1</i>, <i>CTPS1</i>, <i>FBXW7</i>, <i>INSR</i>, <i>S100A6</i>, <i>SOCS2</i>), energy metabolism (<i>ACSS3</i>, <i>ADGRE3</i>, <i>CPT2</i>, <i>GCGR</i>, <i>PRKAA1</i>), fat deposition and adipocyte differentiation (<i>EHBP1</i>, <i>FOXP1</i>, <i>KLF12</i>, <i>PDGFD</i>, <i>RALGAPA2</i>), immune response (<i>CXCR6</i>, <i>IL17RB</i>, <i>NFKBIZ</i>, <i>TMEM154</i>), and wool traits (<i>CERS4</i>, <i>MITF</i>). These results will provide novel insights into the genomic architecture of economically important traits in DOR and support their genetic improvement through informed crossbreeding with Chinese local breeds.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunyi Chen, Shimei Luo, Nijing Lei, Zhenghao Ye, Xianping Ma, Shaoyu Yang, Huaijie Jia, Guangyu Qi, Guanghua Wang, Huashan Yi
{"title":"Genomic Characteristics of a Novel Recombinant Bluetongue Virus Serotype 1 in Yunnan, China.","authors":"Yunyi Chen, Shimei Luo, Nijing Lei, Zhenghao Ye, Xianping Ma, Shaoyu Yang, Huaijie Jia, Guangyu Qi, Guanghua Wang, Huashan Yi","doi":"10.3390/vetsci12090886","DOIUrl":"10.3390/vetsci12090886","url":null,"abstract":"<p><p>Bluetongue virus belongs to the Reoviridae family, which causes morbidity in ruminants. Herein, we report the full-length genome sequence of a recombinant BTV strain of serotype 1 (YNDH/103/2013) isolated from sentinel cattle in Yunnan Province, China, in 2013. To identify and understand the characteristics of YNDH/103/2013, we screened closely related viruses using Simplot 3.5.1 software and conducted verification via phylogenetic analysis using MEGA 11.0.13 software. Phylogenetic analysis and segment examination showed that the YNDH/103/2013 strain likely originated from multiple recombination events involving prevalent strains such as Y863, NRT37/ABT/HSR, and YTS-4 in China and India. The genome of BTV-1/YNDH/103/2013 derives from at least three reassortments with these strains, showing recombination breakpoints mainly in segments 4, 6, 8, and 9. This study improves our understanding of the origin and spread of BTV-1 in China.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuliano Ravasio, Martina Amari, Chiara Locatelli, Francesco Ferrari, Andrea Jacchetti, Valerio Bronzo, Federica Alessandra Brioschi
{"title":"Dexmedetomidine or Butorphanol for Co-Induction of General Anaesthesia with Propofol in Unpremedicated Healthy Dogs: Clinical and Echocardiographic Assessment.","authors":"Giuliano Ravasio, Martina Amari, Chiara Locatelli, Francesco Ferrari, Andrea Jacchetti, Valerio Bronzo, Federica Alessandra Brioschi","doi":"10.3390/vetsci12090885","DOIUrl":"10.3390/vetsci12090885","url":null,"abstract":"<p><p>High induction doses of propofol (PPF) may cause adverse effects. Co-induction protocols can reduce doses and enhance the beneficial profile of each drug. This study compared the induction quality, clinical, and echocardiographic effects of two rapid co-inductions in healthy, unpremedicated dogs. Baseline cardiorespiratory and echocardiographic variables were recorded. Dogs randomly received rapid intravenous PPF (2.2 mg/kg) with either dexmedetomidine (3 µg/kg) (PROPODEX; <i>n</i> = 12) or butorphanol (0.4 mg/kg) (PROPOBUT; <i>n</i> = 12). Induction quality, additional PPF dose, intubation time, cardiorespiratory parameters (2, 5, 10, 15, 20 min), and recovery quality were recorded. A second echocardiography was performed 5 min after induction. Induction quality was significantly higher in PROPODEX, with significantly lower additional PPF requirements and shorter intubation time. In PROPODEX, heart rate significantly decreased from baseline and was significantly lower than PROPOBUT, while arterial blood pressures significantly increased in PROPODEX and decreased in PROPOBUT from baseline. PROPOBUT significantly reduced left ventricular (LV) diastolic volumes and increased E/A ratio, while PROPODEX significantly increased LV systolic diameter and volumes, and significantly decreased fractional shortening. Recovery was significantly faster and better in PROPODEX. PROPOBUT preserved cardiac function but caused hypotension. PROPODEX provided superior induction and recovery quality, and cardiorespiratory stability, with only mild systolic function depression.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mojtaba Daneshi, Pawel P Borowicz, Virginia Montgomery, Yssi L Entzie, Jessica G Syring, Layla E King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P Reynolds, Alison K Ward, Carl R Dahlen, Matthew S Crouse, Joel S Caton
{"title":"Effects of Maternal Nutrition and One-Carbon Metabolite Supplementation on Fetal Jejunal Morphology and Hexose Transporter Expression in Beef Cattle.","authors":"Mojtaba Daneshi, Pawel P Borowicz, Virginia Montgomery, Yssi L Entzie, Jessica G Syring, Layla E King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P Reynolds, Alison K Ward, Carl R Dahlen, Matthew S Crouse, Joel S Caton","doi":"10.3390/vetsci12090884","DOIUrl":"10.3390/vetsci12090884","url":null,"abstract":"<p><p>The small intestine, particularly the jejunum, is a key site for nutrient absorption and metabolic activity in mature and growing ruminants [...].</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolation and Characterization of Vancomycin-Resistant <i>Enterococcus faecium</i> from Cattle: Antimicrobial Resistance, Virulence Genes, and Pathogenicity.","authors":"Mengyuan Cao, Fang Cao, Chenyu Wang, Xueqi Yan, Feng Dong, Shilei Zhang, Shaymaa Abousaad, Lin Yang, Ayman M Abouzeid, Yongjie Wang, Yayin Qi","doi":"10.3390/vetsci12090880","DOIUrl":"10.3390/vetsci12090880","url":null,"abstract":"<p><p>This study aimed to investigate the antimicrobial resistance, virulence gene profile, and pathogenicity of <i>Enterococcus faecium</i> isolated from a large-scale cattle farm in Xinjiang, China, to provide a scientific basis for the prevention and control of <i>E. faecium</i> infections in the region. Nineteen rectal swabs were aseptically collected from diarrheic calves for bacterial isolation. Isolates were identified through morphological observation, biochemical characterization, and PCR amplification. Homology analysis was conducted using 16S rRNA gene sequencing. Antimicrobial susceptibility was evaluated by the disk diffusion method, and key virulence genes were detected using PCR. Pathogenicity was assessed through intraperitoneal inoculation of mice, followed by histopathological examination. Three isolates were identified as <i>E. faecium</i>, consistent with morphological and molecular results. Biochemical tests indicated that the strains could metabolize sucrose, maltose, lactose, melibiose, and raffinose, but not sorbitol. Phylogenetic analysis revealed that isolates SCQ3 and SCQ4 shared 99.3% homology with <i>E. faecium</i> strain MF678878.1, while SCQ11 showed 91% similarity to strain JP2. Antimicrobial susceptibility testing indicated that SCQ11 was resistant to vancomycin. PCR analysis identified the presence of multiple virulence genes, including <i>psaA</i>, <i>hyp</i>, <i>asal</i>, <i>sprE</i>, <i>nuc</i>, <i>cbh</i>, <i>srtA</i>, <i>hyl</i>, <i>scm</i>, and <i>agg</i>. In vivo pathogenicity testing demonstrated that the vancomycin-resistant strain exhibited strong virulence in mice, with gross lesions observed in the liver, spleen, and intestines. Histopathological examination confirmed varying degrees of tissue damage, particularly in the liver and spleen. All three <i>E. faecium</i> isolates exhibited multidrug resistance, with one strain showing vancomycin resistance and harboring a high number of virulent genes. This strain demonstrated significant pathogenicity in vivo. These findings highlight the potential public health threat posed by multidrug-resistant <i>E. faecium</i> in livestock and provide essential data for regional prevention and control strategies.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Franklin Riet-Correa, Rodrigo Ferreira Krüger, Jose Augusto Bastos Afonso, João Alberto Negrão
{"title":"Trypanosomosis by <i>Trypanosoma</i> (<i>Megatrypanum</i>) <i>vivax</i> in Ruminants in Brazil: Epidemiology, Clinical Signs, Pathology, Diagnosis, and Control.","authors":"Franklin Riet-Correa, Rodrigo Ferreira Krüger, Jose Augusto Bastos Afonso, João Alberto Negrão","doi":"10.3390/vetsci12090882","DOIUrl":"10.3390/vetsci12090882","url":null,"abstract":"<p><p>In Brazil, <i>Trypanosoma vivax</i> was identified between 1970 and 1984 in buffalo, cattle, and sheep in northern Brazil. In the 1990s, the disease was diagnosed in the Pantanal of Mato Grosso. Currently, the disease is considered in enzootic stability in both regions. From 2006 to 2018, outbreaks of the disease associated with the presence of horseflies (Tabanidae) and stable flies (<i>Stomoxys calcitrans</i>) or transmitted by needle and syringe reuse were diagnosed in sheep, goats, and cattle during the rainy season in the semiarid region of Northeast Brazil, a region considered to have enzootic instability. Since 2013, numerous outbreaks have been diagnosed associated with oxytocin inoculation to induce milk letdown in dairy cows. Most outbreaks occur in cattle transported from areas of enzootic instability to areas of stability, or vice versa. Serological, parasitological, and molecular techniques have identified <i>T. vivax</i> in asymptomatic animals in all Brazilian regions. For disease prophylaxis, it is important not to reuse syringes and needles when administering medication and to avoid transporting animals during periods of insect abundance. It is also necessary to avoid the use of oxytocin or adopt safe injection practices, using disposable or disinfected needles and syringes only for cows with ineffective milk ejection.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasamin Vali, Aquilino Villamonte Chevalier, Henri van Bree, Bart J G Broeckx, Ingrid Gielen
{"title":"Cross-Modality Diagnostic Agreement in Canine Medial Coronoid Disease in a Screening Population: Radiographs vs. CT in 424 Elbow Joints.","authors":"Yasamin Vali, Aquilino Villamonte Chevalier, Henri van Bree, Bart J G Broeckx, Ingrid Gielen","doi":"10.3390/vetsci12090883","DOIUrl":"10.3390/vetsci12090883","url":null,"abstract":"<p><p>Diagnostic imaging is a crucial non-invasive tool for evaluating canine elbow joints, particularly for screening and treatment planning of medial coronoid disease (MCD). Radiography remains the most accessible and widely used screening modality, but its diagnostic accuracy varies significantly. Sensitivity values reported in previous studies vary depending on factors such as study population, imaging technique, and interpretation criteria. This study compared four measures (sensitivity, specificity, positive and negative predictive value) of radiography with a more advanced imaging method, computed tomography (CT), which provides more detailed images of bones. The results showed that radiography correctly identified 65% of the cases (17/26), while missing some of the affected joints. Furthermore, 7% of the healthy joints (29/398) were misdiagnosed as diseased, leading to a specificity of 93% (369/398). For a disease prevalence of 6% (26/424), the positive and negative predictive value of radiography were 37% (17/46) and 98% (369/378), respectively. Overall, when CT is available, it is the preferred technique for screening. In cases where it is not available, it is important to have an idea of the sensitivity and specificity, but also of the positive and negative predictive value, especially at low prevalences. These results help veterinarians make better decisions when screening for elbow problems in dogs.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}