Veterinary Sciences最新文献

{"title":"Intraoperative Analgesic Requirements in Dogs Receiving Retromammillary or Erector Spinae Plane Blocks for Thoracolumbar or Lumbar Hemilaminectomy: A Single-Center Retrospective Cohort Study.","authors":"Mariana Cavalcanti-McKenzie, Raiane A Moura, Enzo Vettorato, Marta Romano, Ludovica Chiavaccini, Chiara De Gennaro, Elizabeth A Maxwell, Pablo E Otero, Diego A Portela","doi":"10.3390/vetsci13090995","DOIUrl":"10.3390/vetsci13090995","url":null,"abstract":"<p><p>Thoracolumbar and lumbar hemilaminectomy in dogs requires effective perioperative analgesia. The erector spinae plane (ESP) and retromammillary (RM) blocks are ultrasound-guided regional anesthesia techniques targeting the dorsal branches of spinal nerves, but comparative clinical data are lacking. This retrospective cohort study compared perioperative analgesic requirements and complication rates between ESP (n = 62) and RM (n = 207) blocks in client-owned dogs undergoing hemilaminectomy. The primary outcome was intraoperative opioid rescue analgesia; secondary outcomes included rescue analgesia using any analgesic agent, perioperative opioid consumption (expressed as morphine equivalents, mg kg^-1), pain scores, time to voluntary food intake, and complications. Multivariable logistic regression, with covariates selected using a directed acyclic graph, assessed independent predictors of intraoperative opioid rescue administration. Dogs receiving ESP blocks were more likely to require intraoperative opioid rescue than those receiving RM blocks (59.7% versus 38.7%; adjusted odds ratio (OR) 3.4, 95% confidence interval (CI) 1.7-6.6; <i>p</i> < 0.001). Rescue analgesia using any analgesic agent was also more frequent in the ESP group (64.5% versus 43.0%; <i>p</i> = 0.004). Postoperative pain scores, time to first voluntary food intake, and complications were similar between groups. The RM block was associated with reduced intraoperative rescue analgesia compared to the ESP block, though both techniques provided effective postoperative analgesia within multimodal protocols. Prospective randomized trials are warranted to confirm these findings.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of β-Lactamase and Carbapenemase-Producing <i>Escherichia coli</i> at the Animal-Food Interface in the Middle East and North Africa.","authors":"Hamid Reza Sodagari, Ihab Habib","doi":"10.3390/vetsci13090994","DOIUrl":"10.3390/vetsci13090994","url":null,"abstract":"<p><p>Antimicrobial resistance is a major global health challenge, and food-producing animals and foods of animal origin may contribute to the dissemination of resistant bacteria through the food chain. This review aimed to summarize recent evidence on extended-spectrum β-lactamase- and carbapenemase-producing <i>Escherichia coli</i> in food animals and animal-derived foods across Middle East and North Africa countries. A structured literature search was conducted to identify peer-reviewed studies published between 2016 and 2025. Data regarding country, sample type, prevalence, and resistance genes were extracted and analyzed descriptively. Twenty-eight studies from nine MENA countries revealed the presence of resistant <i>E. coli</i> in poultry, cattle, sheep, swine, camels, seafood, and other animal-derived products. Poultry showed a higher reported prevalence of extended-spectrum β-lactamase-producing <i>E. coli</i>, while carbapenem-resistant isolates were less frequently reported but were detected in several countries. The <i>bla</i>_CTX-M family was the predominant extended-spectrum β-lactamase determinant, whereas <i>bla</i>_NDM, <i>bla</i>_OXA-48-like, and <i>bla</i>_KPC were among the commonly identified carbapenemase genes. These findings demonstrate that food animals and animal-derived foods may represent important reservoirs of clinically relevant resistance genes in the Middle East and North Africa region. Strengthening One Health surveillance, antimicrobial stewardship, and regional collaboration is essential to limit the spread of resistant bacteria.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Monitoring Paradox: Frontal Electroencephalography Reveals Profound Cortical Depression Despite Cardiovascular Stability in Dogs Undergoing Tibial Plateau Leveling Osteotomy with Isoflurane Anesthesia and Multimodal Analgesic Protocols.","authors":"Jeff C Ko, Alejandro Vargas Araya, Carla Murillo, Hsin-Yi Weng, Ann B Weil, Tomohito Inoue","doi":"10.3390/vetsci13090990","DOIUrl":"10.3390/vetsci13090990","url":null,"abstract":"<p><p>Conventional monitoring relies on autonomic reflexes but fails to directly measure cortical hypnosis, creating a critical information gap regarding true brain state. The objective of this article was to evaluate the cardiorespiratory and cortical responses using frontal EEG and parasympathetic tone activity (PTA) in dogs under isoflurane anesthesia and distinct analgesic protocols. Twenty-one adult dogs (<i>n</i> = 7 per group) undergoing tibial plateau leveling osteotomies were assessed at 12 procedural time points using heart rate, blood pressure, Patient State Index (PSI), suppression ratio (SR), and PTA. Treatments included isoflurane maintenance with either intravenous fentanyl, epidural morphine, or regional local blocks. Despite clinically acceptable cardiorespiratory indices, significant treatment-by-time interactions occurred for PSI (p=0.003) and SR (p=0.050). The fentanyl group experienced the deepest cortical suppression and highest Double-Low state incidence compared to epidural morphine (p=0.024). Rapid emergence from these suppressed states yielded dysphoric recoveries in 9 of 21 dogs. In conclusion, evaluating cardiorespiratory and cortical responses demonstrates that standard autonomic monitoring can mask severe intraoperative cortical depression; integrating EEG and PTA offers a valuable approach to optimizing neurophysiological stability.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Triladyl^® and Andromed^® Extenders Combined with Pre-Freezing Cooling Methods for Ram Semen Cryopreservation.","authors":"Abdallah M Shahat, Montana Williams, Taeja Brisby, Joshua Woodard, Niki C Whitley, Mahipal Singh, Brou Kouakou, Adel R Moawad","doi":"10.3390/vetsci13090991","DOIUrl":"10.3390/vetsci13090991","url":null,"abstract":"<p><p>Cryopreservation can adversely affect the quality of ram spermatozoa, reducing their suitability for artificial insemination. Therefore, optimizing cryopreservation protocols, including extender composition and cooling procedures, is important for improving post-thaw sperm quality. Our aim was to assess the effects of two commercially available extenders (Triladyl^® and Andromed^®) and two cooling methods before freezing (cooling in 15 mL conical tube versus cooling in straws) on the quality of cryopreserved ram semen. Semen samples collected from five mature Katahdin rams once/week for four weeks were pooled and diluted in either Andromed^® or Triladyl^® to a final concentration of 800 × 10⁶ spermatozoa/mL. Samples were allocated into four treatment groups in a 2 × 2 factorial design: Triladyl^® package-then-cool (T1), Triladyl^® cool-then-package (T2), Andromed^® package-then-cool (A1), and Andromed^® cool-then-package (A2). In the cool-then-package method, semen was cooled in 15 mL conical tubes before being loaded into 0.25 mL French straws, whereas in the package-then-cool method, semen was first loaded into the straws and then cooled. All groups were kept at 4 °C for 3 h before freezing. Samples were subsequently frozen in a programmable freezer (MiniDigitcool, IMV^®), stored in liquid nitrogen, and thawed later for analysis. Following thawing, sperm motility (using CASA), viability and abnormalities (using trypan-blue stain), membrane integrity (by hypos-osmotic swelling (HOS) test), acrosome status (by Hoechst 33342/FITC-PNA), mitochondrial activity (using Hoechst 33342/Rhodamin 123), and lipid peroxidation (using BODIPY 581/591 C11) were evaluated. Total motility, acrosome status, mitochondrial activity, and lipid peroxidation showed extender effects (<i>p</i> < 0.05). However, progressive motility, and membrane integrity showed cooling effects (<i>p</i> < 0.05). Moreover, among the four treatment groups, the percentages of motile sperm, live sperm, sperm with intact acrosomes, and sperm with active mitochondria were the highest (<i>p</i> < 0.05) in the Triladyl^® cool-then-package (T2; 31.1 ± 2.1, 26.7 ± 2.3, 66.3 ± 1.9, 76.2 ± 1.1, and 78.0 ± 1.2, respectively) group. Meanwhile, the percentages of abnormal and lipid peroxidation-positive sperm were the lowest (<i>p</i> < 0.05) in the same group (18.0 ± 0.7 and 12.3 ± 1.0, respectively). In conclusion, cryopreservation of ram semen using the Triladyl^® extender in combination with the cool-then-package method resulted in superior post-thaw sperm quality than other extender and cooling procedures.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoxyl Sulfate, Cardiac Biomarkers, and Left Ventricular Wall Thickening in Cats with Chronic Kidney Disease.","authors":"Murat Akbaba, Idil Bastan, Filiz Bakar-Ates, Osman Safa Terzi","doi":"10.3390/vetsci13090989","DOIUrl":"10.3390/vetsci13090989","url":null,"abstract":"<p><p>Factors associated with left ventricular wall thickening (LVWT) in cats with chronic kidney disease (CKD) remain unclear. This prospective observational study compared renal variables, systolic blood pressure (SBP), echocardiographic measurements, cardiac biomarkers, and uremic toxins in 31 cats: 12 with CKD without LVWT, 8 with CKD and LVWT, and 11 healthy controls. LVWT was defined as IVSd and/or LVPWd ≥ 6 mm in at least two of three examinations. IRIS stage distribution did not differ between the CKD groups (<i>p</i> = 1.000). Urea, creatinine, and phosphorus concentrations were higher in both CKD groups than in controls but were similar between CKD groups. SBP, NT-proBNP, and cardiac troponin I concentrations were highest in the CKD-LVWT group (<i>p</i> < 0.001). Plasma indoxyl sulfate concentrations were significantly higher in the CKD-LVWT group than in both other groups, whereas serum p-cresyl sulfate concentrations did not differ between CKD groups. However, SBP was markedly higher in the CKD-LVWT group and represents a major potential confounder. However, because SBP was also higher in the CKD-LVWT group and reliable multivariable adjustment could not be performed, the independent contribution of indoxyl sulfate could not be determined. The observed association may have been influenced by systemic hypertension, CKD stage, antihypertensive treatment and adherence, and other potential confounders and should not be interpreted as independent or causal.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Age Category and eCG Dose on Reproductive Performance in Ile-de-France Ewe Lambs and Adult Ewes Under Seasonal-Transition Field Conditions.","authors":"Muhammed Furkan Ciftci, Fatma Satilmis","doi":"10.3390/vetsci13090992","DOIUrl":"10.3390/vetsci13090992","url":null,"abstract":"<p><p>This field study evaluated the effects of 400 and 500 IU equine chorionic gonadotropin (eCG) on oestrus response, fertility, and lambing performance in Ile-de-France ewe lambs and adult ewes under seasonal-transition field conditions. A total of 914 animals were assigned to four groups according to age category and eCG dose: ewe lambs receiving 400 IU (EL400, <i>n</i> = 173) or 500 IU eCG (EL500, <i>n</i> = 169), and adult ewes receiving 400 IU (AE400, <i>n</i> = 301) or 500 IU eCG (AE500, <i>n</i> = 271), following a 7-day intravaginal progesterone-based synchronization protocol. Oestrus rate did not differ among groups (<i>p</i> = 0.861), indicating that both doses were similarly effective in inducing behavioural oestrus, whereas the interval to oestrus onset showed significant main effects of both age category (<i>p</i> < 0.001) and eCG dose (<i>p</i> < 0.001), with no significant age × dose interaction (<i>p</i> = 0.559). Using a 2 × 2 factorial analysis, significant main effects of age category were observed for outcomes including pregnancy rate following oestrus, overall pregnancy rate, and fecundity (<i>p</i> = 0.001, <i>p</i> = 0.009, and <i>p</i> = 0.004, respectively), with higher values in adult ewes than in ewe lambs regardless of eCG dose. In contrast, 500 IU eCG was associated with a greater overall litter size and multiple birth rate than 400 IU eCG (<i>p</i> = 0.039 and <i>p</i> = 0.033, respectively). The age × dose interactions for litter size and multiple birth rate were not statistically significant (<i>p</i> = 0.058 and <i>p</i> = 0.071, respectively). The age × dose interaction for lambing rate was also not statistically significant (<i>p</i> = 0.064). These results indicate that age category and eCG dose were associated with different aspects of reproductive performance. Under the specific seasonal-transition field conditions of this single-breed, single-farm study, selecting the eCG dose according to the reproductive objective may represent a practical management consideration.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caprine Kobuvirus VP1 Protein Activates the Mitochondrial Apoptotic Pathway via Interaction with BAD.","authors":"Kehamo Abi, Zhizhong Jing, Cheng Tang, Yao Wang, Kegu Ji'e, Yang Su, Falong Yang","doi":"10.3390/vetsci13090993","DOIUrl":"10.3390/vetsci13090993","url":null,"abstract":"<p><p>Caprine kobuvirus (CKoV) is a member of the <i>Picornaviridae</i> family that causes enteritis in goats and poses a significant health threat, yet its molecular pathogenesis remains largely unknown. Here, we show that experimental infection of goats with CKoV induces apoptosis in the spleen, lungs, and intestine tissues. In vitro, CKoV infection of HEK293T cells triggers apoptosis, with the viral structural protein VP1 identified as sufficient to induce apoptosis. VP1 activates the mitochondrial (intrinsic) apoptotic pathway, as evidenced by increased reactive oxygen species (ROS) production, activation of caspase-9 and caspase-3, elevated Bax/Bcl-2 ratio, cytochrome c release, and Bax translocation to mitochondria. Notably, VP1 associates with the pro-apoptotic protein BAD (BCL2-associated agonist of cell death) and co-localizes with it in mitochondria. Overexpression of BAD enhances VP1-induced apoptosis, whereas BAD knockdown by siRNA suppresses it, demonstrating that BAD plays a contributory role in VP1-induced apoptosis. These findings uncover a novel VP1-BAD mitochondrial apoptosis axis in CKoV pathogenesis and suggest that VP1 may merit further investigation as a potential molecular target for antiviral intervention against CKoV-associated enteritis in goats.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Classification of Tropical Cattle Feeding Systems Reveals Consistent Associations with Dairy Lipid Quality, Enteric Methane Emissions, and Preclinical Metabolic Outcomes: A Multi-Study Narrative Synthesis.","authors":"Mario Cuchillo-Hilario, Margarita Díaz-Martínez, Gustavo Flores-Coello, Claudia Delgadillo-Puga, José Nahed-Toral","doi":"10.3390/vetsci13090988","DOIUrl":"10.3390/vetsci13090988","url":null,"abstract":"<p><p>Administrative labels such as \"organic\" or \"pasture-fed\" animal food products inadequately capture the biological complexity of dairy production systems and consequently fail to differentiate potentially meaningful associations with nutritional quality, environmental impact and consumers' health. We developed a functional classification framework based on three measurable traits: (1) botanical diversity, (2) concentrate dependence, and (3) input intensity, and applied it to six observational and/or experimental studies from tropical Mexico (n = 109 farms across Yucatán, Chiapas, and Colima federal states). Animal production systems were categorized as: (a) biodiverse grazing (silvopastoral, organic, or traditional grazing; >15 plant species or 8-14 species with concentrate < 25% dry matter intake and no synthetic inputs) or (b) conventional (monoculture/indoor systems; <5 plant species or 6-10 species with concentrate >40% with a use of agrochemicals). Biodiverse grazing systems produced lower daily milk yields (6.1 vs. 7.7 L d^-1; <i>p</i> < 0.0001) but yielded milk with more favorable cardiovascular lipid indices: atherogenic index (AI: 1.6-2.2 vs. 1.9-2.5), thrombogenic index (TI: 2.3-2.7 vs. 2.3-3.1), and health promotion index (HPI: 0.46-0.67 vs. 0.40-0.54). Artisan cheese from biodiverse systems contained substantially higher concentrations of tocopherols (127 vs. 77 mg 100 g^-1 DM) and monoterpenes (460-475 vs. 111-126 ng kg^-1). An intensive silvopastoral system reduced enteric methane emissions by 18.2% (376 vs. 460 g d^-1; <i>p</i> < 0.05) and by 21.3% per unit dry matter intake (24.0 vs. 30.5 g kg^-1 DMI; <i>p</i> < 0.0001). Forage nutritional quality (crude protein, neutral detergent fiber, acid detergent fiber) varied by species and season, with these parameters influencing estimated methane emissions. In a C57BL/6 murine model of high-fat diet-induced obesity, milk from biodiverse silvopastoral systems attenuated body weight gain (30.5 vs. 36.8 g; <i>p</i> < 0.05), preserved glucose tolerance (AUC: 32,616 vs. 45,248), nearly eliminated hepatic macrovesicular steatosis, and promoted smaller adipocyte size (1863 vs. 3880 µm²; <i>p</i> < 0.05) compared with conventional milk. These findings suggest that functional ecological traits provide a useful framework for evaluating dairy systems, with biodiverse grazing offering a potential convergence of environmental sustainability and preclinical health benefits. Nevertheless, external validation across diverse tropical regions and direct human intervention trials remain necessary to establish generalizability, and the associations identified should be considered hypothesis-generating rather than confirmatory.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: El-Sayed et al. Genomic Variants, Transcriptomic Profile, Ultrasonographic Findings, and Antioxidant and Immunological Biomarkers Linked to Pregnancy Toxemia Susceptibility in Goats. <i>Vet. Sci.</i> 2025, <i>12</i>, 891.","authors":"Ahmed El-Sayed, Mohamed Marzok, Huda A Alqahtani, Amin Tahoun, Adel I Almubarak, Rasha Yassin Elkhidr, Zakriya Al Mohamed, Elshymaa A Abdelnaby, Hussein Babiker, Hanan M Alharbi, Khairiah M Alwutayd, Ahmed Ateya","doi":"10.3390/vetsci13090986","DOIUrl":"10.3390/vetsci13090986","url":null,"abstract":"<p><p>In the original publication [...].</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p53 in Canine Mammary Tumors: From Molecular Pathogenesis to Biomarker Applications and Comparative Oncology.","authors":"Ziqiao Wang, Yi Qin, Yongping Zeng, Shan Liao, Xiaoqi Tao, Xiao Liu","doi":"10.3390/vetsci13090984","DOIUrl":"10.3390/vetsci13090984","url":null,"abstract":"<p><p>Canine mammary tumors (CMTs) are common neoplasms in female dogs and serve as an important naturally occurring model for studying human breast cancer. The p53 protein plays an important role in CMT biology, with alterations in the p53 pathway implicated in tumor development, progression, and tumor microenvironment regulation. However, reported frequencies of <i>TP53</i> mutations and p53 expression vary among CMT studies, and their associations with malignancy are not uniform. Thus, p53 has potential as a biomarker for CMT, although its clinical applicability requires standardized assessment and further validation. Studies examining p53 in combination with other molecular markers, p53-miRNA interactions, and the role of p53 in chemoresistance further highlight its potential diagnostic, prognostic, and therapeutic relevance. This review synthesizes current evidence on <i>TP53</i>/p53 alterations, biological functions, and biomarker applications in CMT, with particular emphasis on evidence heterogeneity, methodological limitations, and species-specific differences relevant to comparative oncology.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"13 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}