意大利北部兽医教学医院犬尿路病原菌患病率及耐药性趋势:10年回顾性研究(2014-2023)

IF 2.3 2区 农林科学 Q2 VETERINARY SCIENCES
Filippo Tagliasacchi, Jari Zambarbieri, Guido Grilli, Valerio Bronzo, Emanuele Giacobbe Zampollo, Angelica Stranieri, Sara Pansecchi, Piera Anna Martino, Paola Scarpa
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引用次数: 0

摘要

尿路感染(uti)是抗菌药物在犬兽医实践中的主要驱动力。国际伴侣动物传染病学会(ISCAID)指南建议,经验性抗菌治疗应以当地病原体流行率和耐药模式的最新数据为指导。本回顾性研究分析了2014年至2023年意大利北部一家兽医教学医院通过膀胱穿刺术获得的201例阳性尿液培养物。目的是评估2019年ISCAID指南发布前后尿路病原体分布和抗菌药物耐药性趋势。大肠杆菌为优势分离菌(47.5%),随时间稳定流行。阿莫西林耐药率较高(62.4%),甲氧苄啶-磺胺甲恶唑耐药率较低(33.6%)。重要的是,阿莫西林-克拉维酸耐药率从52.6%下降到25.6% (p = 0.0002)。这些发现表明,单独使用阿莫西林可能不是局部经验治疗的最佳选择,而阿莫西林-克拉维酸和甲氧苄氨嘧啶-磺胺甲恶唑仍然是合适的一线药物。持续的地方监测对于支持循证抗菌药物管理至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and Antimicrobial Resistance Trends of Canine Uropathogens in a Veterinary Teaching Hospital in Northern Italy: A 10-Year Retrospective Study (2014-2023).

Urinary tract infections (UTIs) are a major driver of antimicrobial use in canine veterinary practice. The International Society for Companion Animal Infectious Diseases (ISCAID) guidelines recommend that empirical antimicrobial therapy be guided by locally updated data on pathogen prevalence and resistance patterns. This retrospective study analyzed 201 positive urine cultures obtained via cystocentesis from dogs at a veterinary teaching hospital in northern Italy between 2014 and 2023. The aim was to assess uropathogen distribution and antimicrobial resistance trends before and after the 2019 ISCAID guideline release. Escherichia coli was the predominant isolate (47.5%) showing stable prevalence over time. High resistance rates were observed for amoxicillin (62.4%), whereas resistance to trimethoprim-sulfamethoxazole was lower (33.6%). Importantly, resistance to amoxicillin-clavulanate declined significantly from 52.6% to 25.6% (p = 0.0002). These findings suggest amoxicillin alone may be suboptimal for empirical therapy locally, while amoxicillin-clavulanate and trimethoprim-sulfamethoxazole remain suitable first-line agents. Ongoing local surveillance is essential to support evidence-based antimicrobial stewardship.

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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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