Veterinary Surgery最新文献

{"title":"Efficacy of virtual surgical planning and a three-dimensional-printed, patient-specific reduction system to facilitate alignment of diaphyseal tibial fractures stabilized by minimally invasive plate osteosynthesis in dogs: A prospective clinical study.","authors":"Logan M Scheuermann, Daniel D Lewis, Matthew D Johnson, Adam H Biedrzycki, Stanley E Kim","doi":"10.1111/vsu.14118","DOIUrl":"10.1111/vsu.14118","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of a three-dimensional (3D)-printed, patient-specific reduction system for aligning diaphyseal tibial fractures stabilized using minimally invasive plate osteosynthesis (MIPO).</p><p><strong>Study design: </strong>Prospective clinical trial.</p><p><strong>Sample population: </strong>Fifteen client owned dogs.</p><p><strong>Methods: </strong>Virtual 3D models of both pelvic limbs were created. Pin guides were designed to conform to the proximal and distal tibia. A reduction bridge was designed to align the pin guides based on the guides' spatial location. Guides were 3D printed, sterilized, and applied, in conjunction with transient application of a circular fixator, to facilitate indirect fracture realignment before plate application. Alignment of the stabilized tibiae was assessed using postoperative computed tomography scans.</p><p><strong>Results: </strong>Mean duration required for virtual planning was 2.5 h and a mean of 50.7 h elapsed between presentation and surgery. Guide placement was accurate with minor median discrepancies in translation and frontal, sagittal, and axial plane positioning of 2.9 mm, 3.6°, 2.7°, and 6.8°, respectively. Application of the reduction system restored mean tibial length and frontal, sagittal, and axial alignment within 1.7 mm, 1.9°, 1.7°, and 4.5°, respectively, of the contralateral tibia.</p><p><strong>Conclusion: </strong>Design and fabrication of a 3D-printed, patient-specific fracture reduction system is feasible in a relevant clinical timeline. Intraoperative pin-guide placement was reasonably accurate with minor discrepancies compared to the virtual plan. Custom 3D-printed reduction system application facilitated near-anatomic or acceptable fracture reduction in all dogs.</p><p><strong>Clinical significance: </strong>Virtual planning and fabrication of a 3D-printing patient-specific fracture reduction system is practical and facilitated acceptable, if not near-anatomic, fracture alignment during MIPO.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1039-1051"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter study investigating long-term survival after synovial lavage of contaminated and septic synovial structures in horses presented to 10 UK referral hospitals.","authors":"Therese C de Souza, John Burford, Evita Busschers, Sarah Freeman, Joanna M Suthers","doi":"10.1111/vsu.14107","DOIUrl":"10.1111/vsu.14107","url":null,"abstract":"<p><strong>Objective: </strong>To report the long-term survival of adult horses that were subjected to synovial lavage for treatment of contaminated and septic synovial structures.</p><p><strong>Study design: </strong>Multicenter, prospective observational trial.</p><p><strong>Animals: </strong>Horses (n = 240) presented for synovial sepsis at 10 UK referral centers.</p><p><strong>Methods: </strong>Data for horses presented for treatment of synovial sepsis were collected over a 15 month recruitment period. Owners were contacted a minimum of 365 days after surgery using a structured client interview to assess long term survival. Descriptive statistics, and univariable and Cox proportional hazards models for postoperative survival time were developed.</p><p><strong>Results: </strong>Survival to discharge was 228/240 (95%) and overall long-term survival was 89.4% (185/207). Unknown cause of injury (p = .017), increasing duration of surgery (p = .003), increasing weight (p = .008), forelimb injuries (p = .027), and type of synovial structure (p = .008) were found to be associated with death using Cox proportional hazards models.</p><p><strong>Conclusion: </strong>This study provides information on risk factors associated with survival and death after treatment for synovial sepsis at referral hospitals in the UK. Survival to discharge and long-term survival was excellent. Heavier horses, injuries affecting the forelimbs, tendon sheaths and bursae were associated with poorer long term outcomes. Longer duration of surgery was also found to be associated with a worse prognosis.</p><p><strong>Clinical significance: </strong>These findings help to provide prognostic information for owners and veterinarians treating horses with synovial sepsis.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1083-1092"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Athletic prognosis following arthroscopic removal of osteochondral fragments of the proximal dorsal sagittal ridge of the fetlock in Thoroughbreds intended for flat racing.","authors":"Mackenzie L Luick, Natalie A Khouzam, Marcos Pérez-Nogués","doi":"10.1111/vsu.14129","DOIUrl":"10.1111/vsu.14129","url":null,"abstract":"<p><strong>Objective: </strong>To establish racing prognosis in Thoroughbred yearlings with proximal sagittal ridge osteochondral lesions and compare them to dorsoproximal and palmar/plantar first phalanx osteochondral lesions.</p><p><strong>Animals: </strong>A total of 47 horses had proximal sagittal ridge lesions, 34 had palmar/plantar first phalanx lesions, and 115 had dorsoproximal first phalanx lesions.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>Medical records of Thoroughbred yearling racing prospects treated arthroscopically for fetlock osteochondral lesions were reviewed. Data were collected from a public database, including the ability to train and race, earnings, starts, wins, and placed races. Racing prognosis was analyzed and compared between three lesion locations.</p><p><strong>Results: </strong>Of the proximal sagittal ridge group, 76.6% raced, 65.71% of the palmar/plantar first phalanx group, and 74.58% of the dorsoproximal first phalanx group. Career length was similar for all lesions. A lower number of \"starts\" in the group \"five years old and older\" was found for the dorsoproximal first phalanx group compared to the cohort with proximal sagittal ridge lesions. Mares had more \"earnings\" at two years old but fewer \"starts\" at \"five years old\" compared to colts and geldings. Forelimb lesions were predictive for fewer total career starts.</p><p><strong>Conclusion: </strong>Proximal sagittal ridge lesions had similar prognoses to dorsoproximal and palmar/plantar first phalanx lesions. In older horses, there was an increase in the number of starts for the proximal sagittal ridge group compared to the dorsoproximal first phalanx group. Mares and forelimb lesions were associated with decreased racing starts.</p><p><strong>Clinical significance: </strong>These findings aid in prognostication for Thoroughbreds with osteochondral lesions removed arthroscopically in the fetlock joint.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"980-987"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of arthroscopy on post-procedure intra-articular elbow injections: A cadaveric study.","authors":"Emalee M Blumhagen, Daniel I Spector, Anthony J Fischetti","doi":"10.1111/vsu.14122","DOIUrl":"10.1111/vsu.14122","url":null,"abstract":"<p><strong>Objective: </strong>To determine the influence of arthroscopy and injection volume on post-procedure intra-articular (IA) injection extravasation.</p><p><strong>Study design: </strong>Ex vivo prospective study.</p><p><strong>Sample population: </strong>A total of 40 paired canine cadaver forelimbs.</p><p><strong>Methods: </strong>After radiographs and computed tomography (CT) scans with three-dimensional (3D) digital bone model reconstructions, elbows were randomly assigned to the arthroscopy or control group and randomly assigned to receive an IA injection of 2 or 4 mL of contrast. Elbow arthroscopy was performed on assigned specimens, followed by IA injections of contrast in all elbows, and imaging was repeated. 3D digital model volumes were compared. Images were interpreted and scored for extravasation by a radiologist unaware of treatment and volume assignments.</p><p><strong>Results: </strong>Based on CT images and regardless of treatment group, IA injections of 4 mL resulted in a mean extravasation score of 2.25 (SD 0.97) versus 1.55 (SD 1.05) (p = .02) for 2 mL IA injections. The change in 3D model volumes after IA injections was a mean of 13.2 cm³ (SD 5.85) after 4 mL injections, compared to 6.97 cm³ (SD 6.28) (p = .003) after 2 mL injections. On radiographic evaluation, but not CT, the mean extravasation scores were 2.45 (SD 1.15) for the arthroscopy group and 1.25 (SD 0.79) for the control group (p < .001).</p><p><strong>Conclusion: </strong>A larger volume of IA injection resulted in higher CT extravasation scores and larger 3D volumes regardless of arthroscopic treatment.</p><p><strong>Clinical significance: </strong>IA injections performed immediately after arthroscopy resulted in 50% or less extravasation, especially with a smaller IA injection volume.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"988-998"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bupivacaine liposome injectable solution and fentanyl for postoperative analgesia in dogs undergoing limb amputation.","authors":"Snighdha Paul, Alena Strelchik, Jack O'Day, Alonso G P Guedes, Wanda J Gordon-Evans","doi":"10.1111/vsu.14080","DOIUrl":"10.1111/vsu.14080","url":null,"abstract":"<p><strong>Objective: </strong>The objectives of the study were to compare the clinical efficacy and adverse effects of two analgesic protocols consisting of bupivacaine liposome injectable solution (BLIS) and 0.5% bupivacaine and fentanyl for postsurgical analgesia in dogs undergoing limb amputation.</p><p><strong>Study design: </strong>Randomized, double-blind, prospective, controlled, intent-to-treat, clinical noninferiority trial.</p><p><strong>Animals: </strong>Forty client-owned dogs.</p><p><strong>Methods: </strong>Dogs undergoing amputation were randomly assigned to either the BLIS or control group. Postoperative pain, sedation, nausea, and amount eaten were assessed using appropriate scales at 6, 12, 18, and 24 h by trained individuals blinded to the treatment protocol. Rescue analgesia was provided for Glasgow composite measure pain scale (short form) (CMPS-SF) scores of 5 or above. Clients were requested to pain score their dogs at home using a visual analogue scale (VAS) for 48 h following discharge.</p><p><strong>Results: </strong>Forty dogs completed this study (20 control dogs and 20 BLIS dogs). The BLIS and control groups were equivalent for sedation, nausea, amount eaten, and pain, at all time periods except at 6 h (p < .01), when the BLIS group pain score was lower.</p><p><strong>Conclusion: </strong>The BLIS provided equivalent analgesia with fewer adverse effects than fentanyl constant rate infusion (CRI) following limb amputation. Rescue analgesia was provided to five dogs in the BLIS group and four in the control group, and there was no statistical difference. Nausea scores did not differ statistically.</p><p><strong>Clinical significance: </strong>As BLIS provides equivalent analgesia, this may allow for decreased reliance on opioids in the immediate postoperative period.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1102-1110"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel transcoronal surgical technique for the treatment of cystic lesions of the distal phalanx: A cadaveric study.","authors":"Sjoerd K Frietman, Rick van Proosdij, Astrid B M Rijkenhuizen, Elisabeth van Veggel","doi":"10.1111/vsu.14105","DOIUrl":"10.1111/vsu.14105","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of a novel transcoronal approach for the treatment of axial type 3 cysts of the palmar/plantar aspect of the distal phalanx (P3).</p><p><strong>Study design: </strong>Ex vivo, experimental study.</p><p><strong>Sample population: </strong>Ten cadaveric specimens, four forelimbs and six hindlimbs.</p><p><strong>Methods: </strong>All cadaveric specimens underwent radiographically guided drilling, followed by cortical screw placement. The cartilage was macroscopically assessed after disarticulation of the distal interphalangeal joint. The entry point and trajectory were evaluated with computed tomography. Results were categorized as: axial, near-axial and abaxial. The minimal distance from the outer margin of the drill hole and the proximal border of the subchondral bone plate was measured using frontal computed tomographic slices.</p><p><strong>Results: </strong>Eight of the 10 screws were in an axial to near-axial position and nine followed the desired axial to near-axial trajectory. One screw was inserted axially but continued in an abaxial trajectory. Iatrogenic damage to the joint cartilage, flexor cortex and solar canal of P3 was not observed. All cortical screws were placed close to the proximal subchondral bone-plate of P3.</p><p><strong>Conclusion: </strong>The desired axial/near-axial drilling and screw placement, under radiographic guidance, was achieved in nine out of 10 specimens.</p><p><strong>Clinical significance: </strong>This novel technique seems promising for the treatment of inaccessible P3 cysts. Additional studies are required to investigate its feasibility in clinical cases, and the long-term outcome following transcystic screw placement of type 3 P3 cysts.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1062-1072"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of near-infrared fluorescence angiography with indocyanine green to evaluate direct cutaneous arteries used for canine axial pattern flaps.","authors":"Sophie N Eiger, Judit Bertran, Penny S Reynolds, Penny Regier, J Brad Case, Kathleen Ham, Michael Mison, W Alexander Fox-Alvarez","doi":"10.1111/vsu.14121","DOIUrl":"10.1111/vsu.14121","url":null,"abstract":"<p><strong>Objective: </strong>To describe the use of near-infrared angiography (NIRFA) to identify the vascularization of three canine axial pattern flaps (APFs) omocervical (OMO), thoracodorsal (THO), and caudal superficial epigastric (CSE); to establish a vascular fluorescence pattern (VFP) grading system; and to evaluate the effect of NIRFA on surgeon flap dimension planning compared to traditional landmark palpation (LP) and visualization assessments.</p><p><strong>Study design: </strong>Experimental study.</p><p><strong>Animals: </strong>A total of 15 healthy, client-owned dogs.</p><p><strong>Methods: </strong>Dogs were sedated and flap sites were clipped. LP-based margins were drawn and preinjection images were recorded. Indocyanine green (ICG) was administered and VFP images were recorded. VFP scores were determined by five surgeons. Margin alterations were performed based on NIRFA-ICG images. Altered measurements were compared between LP and NIRFA-ICG images.</p><p><strong>Results: </strong>Vascularization of the CSE flap was most visible with NIRFA with VFP scores 4/4 for 13/15 dogs. Intersurgeon agreement for VFP grades was poorest for THO (ICC = 0.35) and intermediate for OMO (ICC = 0.49) flaps. Surgeons were more likely to adjust dimensions for CSE flaps relative to OMO (OR 17.3, 95% CI: 6.2, 47.8) or THO (25.5; 8.6, 75.7).</p><p><strong>Conclusion: </strong>Using a grading system, we demonstrated that the CSE flap was most visible. Surgeons were more likely to adjust the LP-CSE flap margins based on fluorescence patterns and were more likely to rely on LP when visualization scores were low.</p><p><strong>Clinical significance: </strong>NIRFA has possible applications identifying some direct cutaneous arteries of APFs and their associated angiosomes in real-time. Further investigation is indicated to study NIRFA's potential to improve patient specific APF planning.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1073-1082"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of a hybrid negative pressure system for wound therapy.","authors":"Jack S Davey, Wye Li Chong, Jake Fountain, Jane Heller, Rui Sul, Kieri Jermyn, Jacob Michelsen, Louisa Ho Eckart","doi":"10.1111/vsu.14101","DOIUrl":"10.1111/vsu.14101","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to assess whether negative pressure could be maintained accurately and repeatably with a wall-suction-based hybrid negative pressure wound therapy (h-NPWT) system by comparing it with a commercial negative pressure wound therapy (NPWT) device.</p><p><strong>Study design: </strong>In vitro experimental study.</p><p><strong>Methods: </strong>A commercial NPWT device (control) and three h-NPWT devices, with 0, 3, and 6 meters of additional tubing using the hospital-wall suction (groups 1, 2, and 3 respectively), were applied sequentially to a commercial NPWT dressing on a silicone skin substrate and set to run at a continuous pressure of -125 mmHg. The pressure within the wound space was monitored at 10 second intervals for 24 h. The process was repeated five times for each group.</p><p><strong>Results: </strong>The commercial NPWT device produced an average pressure variance of 3.02 mmHg, and the h-NPWT produced average variances of 4.38, 4.24 and 4.20 mmHg for groups 1, 2 and 3, respectively. All groups produced an average pressure within 0.15 mmHg of -125 mmHg over the 24-hour period, and the h-NPWT systems produced the smallest range with all values remaining within a ±5% variation from -125 mmHg.</p><p><strong>Conclusion: </strong>The h-NPWT system achieved negative pressures that were comparable to those of a commercial control NPWT device. The addition of tubing between the skin substrate and the canister did not affect the pressure applied at the wound site.</p><p><strong>Clinical significance: </strong>The h-NPWT device tested in this study can be considered as an alternative for negative wound therapy when a commercial device cannot be used.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1093-1101"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation, diagnosis, and outcomes of cats undergoing surgical treatment of ectopic ureters.","authors":"Gabriela L Cortez, Christopher B Thomson, Valery F Scharf, Allyson Berent, Nicole J Buote, Brittney A Carson, Margaret Cassandra, Philipp D Mayhew, Ameet Singh","doi":"10.1111/vsu.14103","DOIUrl":"10.1111/vsu.14103","url":null,"abstract":"<p><strong>Objective: </strong>To describe the signalment, treatment, complications, and outcomes of cats treated surgically for ectopic ureters.</p><p><strong>Study design: </strong>Retrospective, multi-institutional study.</p><p><strong>Animals: </strong>Twelve client-owned cats.</p><p><strong>Methods: </strong>Medical records of cats diagnosed with unilateral or bilateral ectopic ureters were reviewed and analyzed. Data reported included signalment, clinical signs, diagnostics, open celiotomy, or cystoscopic surgical interventions, and outcomes.</p><p><strong>Results: </strong>Seven of the 12 cats in the study population were female or female spayed and the median age at time of presentation was 4 years, with an interquartile range (IQR) of 6 months-14 years. Presurgical diagnostic imaging diagnosed ectopic ureters by abdominal ultrasound (8/10), contrast enhanced computed tomography (3/3), fluoroscopic urography (3/4), or cystoscopy (6/7). Eight of 12 cats had extramural ectopic ureters and six cats were affected bilaterally. Eight affected cats underwent ureteroneocystostomy, one cat underwent neoureterostomy, two cats underwent cystoscopic laser ablation, and one cat underwent nephroureterostomy. Immediate postoperative complications occurred in three cats; one cat required additional surgical intervention. Short-term complications occurred in three cats, and long-term complications in two cats. All cats that underwent surgical or cystoscopic intervention had improvement of their urinary incontinence scores, with complete resolution in 11 cats.</p><p><strong>Conclusion: </strong>Surgical correction of ectopic ureters in cats is associated with good long-term outcomes. Ectopic ureters in cats are commonly extramural and bilateral. Postoperative outcomes were acceptable and there were few postoperative complications, with varying forms of surgical correction.</p><p><strong>Clinical significance: </strong>Ectopic ureters in cats are rare but urinary incontinence can be corrected or improved successfully with surgery.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1019-1028"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pharmacokinetics of metoclopramide administered via subcutaneous bolus and intravenous constant rate infusion to adult horses.","authors":"Amy M Brandon, Jarred M Williams, Jen L Davis, Emily G Martin, Ava M Capper, Naomi E Crabtree","doi":"10.1111/vsu.14128","DOIUrl":"10.1111/vsu.14128","url":null,"abstract":"<p><strong>Objective: </strong>To determine the pharmacokinetics (PK) of metoclopramide administered via intravenous continuous rate infusion (IV CRI) and subcutaneous (SC) bolus and evaluate for gastrointestinal motility and adverse side effects.</p><p><strong>Study design: </strong>Experimental study; randomized, crossover design.</p><p><strong>Animals: </strong>Six healthy adult horses.</p><p><strong>Methods: </strong>Each horse received metoclopramide via IV CRI (0.04 mg/kg/h for 24 h) and SC bolus (0.08 mg/kg once), with ≥1 week washout period between. Plasma was analyzed by UPLC-MS/MS. Compartmental modeling was used to determine PK parameters for each treatment; nonparametric superposition was used to simulate multiple SC bolus regimens. Gastrointestinal motility and evidence of adverse effects were monitored.</p><p><strong>Results: </strong>T_max (h) for SC bolus was 0.583 ± 0.204 versus 17.3 ± 6.41 for IV CRI, while C_max (ng/mL) was 27.7 ± 6.38 versus 43.6 ± 9.97, respectively. AUC (h × ng/mL) was calculated as 902 ± 189 for 24 h IV CRI versus 244 ± 37.4 simulated for 0.08 mg/kg SC bolus every 8 h. Simulations revealed similar exposure between groups with administration of 0.96 mg/kg/day SC bolus, divided into three, four, or six doses. SC bolus bioavailability was estimated as 110 ± 11.5%. No clear trends in motility alteration were identified. No adverse effects were noted.</p><p><strong>Conclusion: </strong>Repeated SC boluses of metoclopramide at 0.08 mg/kg would result in lower total drug exposure and T_max than IV CRI administration but would be highly bioavailable.</p><p><strong>Clinical significance: </strong>Higher and/or more frequent SC bolus doses are needed to achieve a similar AUC to IV CRI. No adverse effects were noted; however, evaluation of alternative dosing strategies is warranted.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1111-1122"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}