Veterinary Surgery最新文献

{"title":"Investigation of the \"R\" tumor margin classification and prognostic factors in apocrine gland anal sac adenocarcinoma of dogs.","authors":"Casey L Gordon, Maurine Thomson, Arnon Gal, Kathleen O'Connell, Elizabeth Morgan, Katherine Elizabeth Steele","doi":"10.1111/vsu.70044","DOIUrl":"10.1111/vsu.70044","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to investigate the relative frequency of R0 margin classification following excision of canine apocrine gland anal sac adenocarcinoma (AGASACA). Secondary aims were to establish if R0/R1 margins, or other dog or tumor characteristics, were prognostic.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Sample population: </strong>Seventy-four dogs that underwent AGASACA excision.</p><p><strong>Methods: </strong>Each tumor margin was classified as R0 or R1 from the histopathology report. Additional data relating to primary tumor characteristics, preoperative assessment, local recurrence, metastases and survival were collated from the medical record.</p><p><strong>Results: </strong>The rate of R0 margin classification following AGASACA excision was 75.7%. An R1 margin classification was associated with increased risk of local recurrence (OR 23, p < .0001). Overall median survival time following surgery was 25 months (95% CI 21-33). Survival time was reduced in dogs with preoperative hypercalcemia (7.5 months, p = .012), presence of metastatic disease (17 months, p = .005) and lymphovascular invasion on histopathology (21 months, p = .021). Mitotic count (p = .0069) and absence of adjunct therapy (p = .0247) also reduced survival time.</p><p><strong>Conclusion: </strong>The R margin classification was clinically useful in predicting local recurrence. Preoperative hypercalcemia, lymphovascular invasion on histopathology, presence of metastatic disease, mitotic count, and absence of adjunct therapy all negatively affected survival.</p><p><strong>Clinical impact: </strong>Achieving complete margins was feasible in most dogs undergoing AGASACA excision and reduced the risk of local recurrence. The R margin classification scheme was clinically useful when reporting histopathology of canine AGASACAs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"744-751"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral biportal endoscopy (UBE) spine surgery for thoracolumbar intervertebral disc diseases in dogs: An ex vivo cadaveric and in vivo preclinical study.","authors":"Sanghyun Nam, Youngjin Jeon, Jueun Kim, Jaemin Jeong, Seongmok Jeong, Youngwon Lee, Haebeom Lee","doi":"10.1111/vsu.14324","DOIUrl":"10.1111/vsu.14324","url":null,"abstract":"<p><strong>Objective: </strong>To determine optimal portal position for thoracolumbar unilateral biportal endoscopy (UBE) spine surgery in dogs.</p><p><strong>Study design: </strong>Experimental ex vivo cadaveric and in vivo preclinical study.</p><p><strong>Animals: </strong>Seven cadavers and three healthy purpose-bred Beagles.</p><p><strong>Methods: </strong>In the ex vivo phase, thoracolumbar mini-hemilaminectomy was performed at T13-L1, L1-L2, and L2-L3 in seven cadavers using two UBE portal positions. The distance (X) from the spinous process to the mammillary process was measured fluoroscopically. Group A portals were placed from X to 2X; Group B portals from 2X to 3X. Visualization and instrument accessibility were compared. Based on cadaveric results, mini-hemilaminectomy was performed in three live dogs using the superior (Group B) portal position. Intraoperative epidural pressure was measured. Postoperative magnetic resonance image (MRI) on day 0, 14, and 28 evaluated muscle recovery, fluid extravasation, and spinal/dural compression.</p><p><strong>Results: </strong>Mini-hemilaminectomy was successfully performed with both portal positions. Surgical time and number of fluoroscopic scans did not differ between groups. Scope insertion angles were steeper in Group B (p < .001), which also showed higher visualization and accessibility scores (p < .001). Group B portals were used in the in vivo study. Epidural pressure remained stable, and MRI revealed transient postoperative muscle edema that resolved by day 28.</p><p><strong>Conclusion: </strong>UBE was feasible in cadavers and safe in live dog models. Group B portal positioning provided better visualization and accessibility.</p><p><strong>Clinical significance: </strong>UBE presents a potential minimally invasive approach for thoracolumbar spinal surgery in dogs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"816-827"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural progression of tarsal osteochondrosis in Standardbred pacers and trotters.","authors":"Annette M McCoy, Christine T Lopp-Schurter, Rebecca C Bishop, Amy Narotsky, Kyle Grogger, Ann M Kemper","doi":"10.1111/vsu.70073","DOIUrl":"10.1111/vsu.70073","url":null,"abstract":"<p><strong>Objective: </strong>To determine the natural progression of tarsal osteochondrosis (OC) in a cohort of Standardbred foals and assess the impact of gait preference (trotting vs. pacing).</p><p><strong>Study design: </strong>Longitudinal observational cohort study.</p><p><strong>Animals: </strong>Client-owned Standardbred foals (n = 148).</p><p><strong>Methods: </strong>Tarsal radiographs were taken every 2 months from 2 to 12 months of age and foals were video monitored to document time spent pacing or trotting. Differences between groups were assessed using χ² analysis. Survival analysis was used to determine if lesion healing differed between groups over time.</p><p><strong>Results: </strong>Of 148 horses, 103 (69.6%) had OC lesions at 2 months of age but only 32 (21.6%) still had OC lesions by 12 months. In 28 of these horses, the lesions had progressed to osteochondrosis dissecans (OCD). Of 71 horses with lesions that healed, 60 (84.5%) did so by 6 months of age. Gait was not associated with presence or absence of OC lesions or healing of lesions over time. Foals spent less than 1% of their observed time trotting or pacing.</p><p><strong>Conclusion: </strong>Tarsal OC lesions were prevalent in this cohort of young Standardbreds, and most lesions healed within the first few months of life. There was no evidence for direct biomechanical forces from movement at the pace or trot affecting the location of OCD fragment development.</p><p><strong>Clinical significance: </strong>The critical window for tarsal OC lesion healing was prior to 6 months of age and further investigation of risk factors present during this time frame is warranted.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"685-692"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of 11 cats with Achilles tendon (AT) rupture repair treated with a synthetic ultra-high-molecular-weight polyethylene (UHMWPE).","authors":"Clara Bohin, Guillaume Reinsch, Bertrand Vedrine, Guillaume Ragetly, Philippe Buttin, Frans J Venter, Jonathan Deacon, Fabrice Bernard","doi":"10.1111/vsu.70107","DOIUrl":"10.1111/vsu.70107","url":null,"abstract":"<p><strong>Objective: </strong>To report the outcomes of cats treated for Achilles tendon (AT) rupture with a recently commercialized synthetic ultra-high-molecular-weight polyethylene (UHMWPE) implant and no transarticular fixation.</p><p><strong>Study design: </strong>Retrospective multicenter study.</p><p><strong>Animals: </strong>A total of 11 cats (13 limbs).</p><p><strong>Methods: </strong>Medical records from seven veterinary centers were reviewed for cats undergoing AT repair with the Novaten implant between 2021 and 2024. Feline musculoskeletal pain index (FMPI) was used for long-term assessment. Lameness, posture, and pain were assessed at perioperative (0-3 months), short-term (3-6 months), and long-term (>12 months) intervals. Statistical analysis used non-parametric tests.</p><p><strong>Results: </strong>A total of 13 limbs in 11 cats met the inclusion criteria. All injuries involved the tendino-osseous junction, with 7/13 (53.8%) complete ruptures. No intraoperative complications occurred. Postoperative external coaptation was used in 9/13 (69.2%) limbs (4/13 rigid splints, 5/13 soft padded) for a median duration of 6 weeks (range, 0-8 weeks). One calcaneal fracture due to implant malposition and one surgical site infection were reported at short-term follow-up. Long-term follow-up (median, 18.5 months; range, 12.1-33) showed 11/12 limbs achieving functional recovery and normal tarsal motion.</p><p><strong>Conclusion: </strong>Repair of Achilles tendon rupture in cats using a UHMWPE implant without rigid immobilization was associated with restoration of functional limb use, normal tarsal range of motion at long-term follow-up, and a low incidence of postoperative complications in this case series.</p><p><strong>Clinical significance: </strong>This technique may provide a reliable surgical option for cats with AT rupture, as it may minimize the need for external fixation or external coaptation and improve short-term recovery.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"752-762"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plating and double-loop cerclage wiring improve the mechanical performance of the femoral stem after Zurich cementless total hip replacement in cats.","authors":"Clair Park, Denis J Marcellin-Little, Tanya Garcia-Nolen, Stephen J Bresina, Otto I Lanz","doi":"10.1111/vsu.70074","DOIUrl":"10.1111/vsu.70074","url":null,"abstract":"<p><strong>Objective: </strong>To compare the biomechanical performance of adjunctive locking plating and double-loop cerclage wiring in feline femora implanted with Zurich cementless total hip replacement (THR) stems.</p><p><strong>Study design: </strong>Cadaveric biomechanical study.</p><p><strong>Animals: </strong>Paired femora (n = 32) from 16 feline cadavers.</p><p><strong>Methods: </strong>Two sequential studies were performed. First, femora implanted with Zurich cementless stems alone were compared with those stabilized by an adjunctive locking plate. Second, femora with locking plates were compared with those with cerclage wires. Constructs underwent cyclic axial and torsional loading followed by load-to-failure testing. Outcome measures included residual axial and torsional displacement, yield and ultimate forces and torques, energy absorption, and brittle failure frequency. Parameters were normalized to bone volume.</p><p><strong>Results: </strong>The locking plate group demonstrated substantially reduced residual torsional displacement and a trend toward lower axial displacement compared with the stem-only group. Yield and ultimate failure strength did not differ. The cerclage group exhibited 36% greater ultimate axial displacement, 76% greater energy absorption, and 32% greater torsional displacement than the locking plate group. Normalization accentuated these differences. Cerclage wire fixation was associated with a lower frequency of brittle failure.</p><p><strong>Conclusion: </strong>Locking plates improved cyclic stability by reducing micromotion, while cerclage wires enhanced compliance and energy absorption under destructive loading. Neither method increased load to failure.</p><p><strong>Clinical significance: </strong>Adjunctive plate or cerclage wire provided biomechanical advantages in femora implanted with Zurich cementless THR stems. Locking plates may support implant stability, whereas cerclage wiring improves energy dissipation under supraphysiologic loading. Adjunctive fixation strategies should be tailored to patient-specific femoral morphology and fracture risk in feline THR.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"781-790"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and feasibility of near-infrared fluorescence imaging with inhaled indocyanine green to assess the pulmonary parenchyma in six normal dogs.","authors":"Jourdan B McPhetridge, Michelle L Oblak, Jacob Levine, Alex Lynch, Robert A Foster, Valery F Scharf","doi":"10.1111/vsu.70104","DOIUrl":"10.1111/vsu.70104","url":null,"abstract":"<p><strong>Objective: </strong>To assess the safety and feasibility of near-infrared fluorescence (NIRF) imaging with inhaled indocyanine green (ICG) to visualize normal pulmonary parenchyma in dogs, report clinically useful information regarding dosage and timing of administration, and to evaluate effects on pulmonary function and tissue histology.</p><p><strong>Study design: </strong>Preclinical exploratory study.</p><p><strong>Animals: </strong>Six purpose-bred dogs.</p><p><strong>Methods: </strong>Dogs undergoing thoracoscopy were randomly assigned to receive inhaled ICG at 0.1, 0.5, or 1.0 mg/kg. Subjective fluorescence was recorded, images were saved to analyze quantitative fluorescence, and a lung biopsy was obtained. Clinical assessment of respiratory function was performed for 14 days. Peripheral lung biopsies were repeated 6 months later.</p><p><strong>Results: </strong>Inhalation of ICG resulted in real-time NIRF of pulmonary parenchyma in all dogs. Administration time ranged from 1 to 10 min and mean time to first fluorescence was 1.5 min. Peak subjective fluorescence was strong in dogs receiving 0.5 and 1.0 mg/kg, and moderate in dogs receiving 0.1 mg/kg. Peak quantitative fluorescence was positively correlated with dose, with a three-fold and 10-fold increase above baseline 20 min after administration of 0.5 and 1.0 mg/kg doses, respectively. No histologic abnormalities or clinical evidence of respiratory compromise following inhalation of ICG were observed.</p><p><strong>Conclusion: </strong>Inhaled ICG provided rapid intraoperative fluorescence of normal pulmonary parenchyma, was clinically feasible, and was safe in normal dogs at 0.1-1.0 mg/kg.</p><p><strong>Clinical significance: </strong>Inhaled ICG produced rapid pulmonary fluorescence without detectable adverse effects, supporting further investigation of its effectiveness to identify pulmonary lesions in dogs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"771-780"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of diode laser-facilitated ankylosis of the distal tarsal joints in horses: A retrospective study of 64 cases.","authors":"Rodrigo Sanchez-Arjona, Carla Lopez Cruz, Brent A Hague, Judith Jayawickrama, J Lacy Kamm","doi":"10.1111/vsu.14312","DOIUrl":"10.1111/vsu.14312","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the outcomes of diode laser-facilitated (DLF) ankylosis using different surgical techniques to treat distal tarsal osteoarthritis (OA) in horses.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Animals: </strong>A total of 64 client-owned horses with distal tarsal OA treated with DLF ankylosis between 2011 and 2021 in a referral hospital were included.</p><p><strong>Methods: </strong>DLF ankylosis techniques included: intra-articular diode laser (L), diode laser with periarticular drilling (L + D) and diode laser with cuboidal bone fenestration (L + F). Horses requiring a second surgery formed a fourth group (T). Outcome was assessed through client telephone surveys. Preoperative variables and surgical technique were assessed using logistical regression and OR models.</p><p><strong>Results: </strong>A total of 64 horses met the inclusion criteria, and data was collected at a median follow-up time of 5 years (interquartile range [IQR]: 3-8 years). Improvement in lameness was observed in 83% (53/64) of horses, with 64% (39/61) returning to their previous level of athleticism. Sex significantly influenced outcome with males more likely to return to athleticism (p = .03, OR: 4.25). The return to previous level of athleticism for L, L + D and L + F was 67.9%, 50% and 66.7%, respectively. A smaller proportion of horses treated with L + D and L + F required additional surgical intervention compared to L (0%, 0%, and 20.8%, respectively).</p><p><strong>Conclusion: </strong>DLF ankylosis offered a reliable treatment for distal tarsal OA in horses. Incorporating cuboidal bone fenestration provided good athletic outcomes while reducing the need for reintervention.</p><p><strong>Clinical significance: </strong>DLF ankylosis offers a less invasive alternative to treat distal tarsal OA in horses with good athletic outcomes.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"702-712"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of luxation of the superficial digital flexor muscle tendon (SDFT) using a modified block recession calcaneoplasty without subsequent tarsal joint immobilization.","authors":"Sivert Viskjer, Adam Glovéus","doi":"10.1111/vsu.70103","DOIUrl":"10.1111/vsu.70103","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate surgical management of superficial digital flexor tendon (SDFT) luxation by modifying the morphology of the calcaneal tuberosity to (1) reduce the risk of recurrent luxation and (2) challenge the need for tarsal joint immobilization postoperatively.</p><p><strong>Study design: </strong>Prospective observational study.</p><p><strong>Sample population: </strong>A total of 11 surgeries in nine client-owned dogs.</p><p><strong>Methods: </strong>Dogs with SDFT luxation and no concurrent disease underwent modified block recession calcaneoplasty without joint immobilization. Follow-up at 6 weeks and 12 months included pressure-sensitive walkway analysis, ultrasonography, and computed tomography.</p><p><strong>Results: </strong>A total of 11 limbs in nine dogs were treated using the described technique. All achieved full function at 12 months, with the symmetry index improving from 0.20 ± 0.13 preoperatively to 0.05 ± 0.03 at long-term follow-up (p = .03). Five complications occurred (45% overall): two major (18%) requiring revision surgery and three minor (27%) resolving without intervention.</p><p><strong>Conclusion: </strong>The modified block recession calcaneoplasty without subsequent tarsal joint immobilization led to a significantly improved symmetry index ratio and clinical function at the long-term follow-up compared with preoperative values. No recurrent luxation occurred except one case that suffered fracture of the medial wall of the calcaneal tuberosity. This was successfully revised and no further reluxation occurred.</p><p><strong>Clinical significance: </strong>The modified block recession calcaneoplasty technique can be considered a complement to previously described surgical methods for treatment of SDFT luxation in dogs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"720-729"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivery of AgNP led to more pronounced local retention in the subcutaneous versus intraperitoneal location with limited uptake and toxic effects in rats.","authors":"Marije Risselada, Makensie L Anderson, Miriam G Bates, Abigail Cox, Robyn McCain, Kristen Messenger","doi":"10.1111/vsu.70087","DOIUrl":"10.1111/vsu.70087","url":null,"abstract":"<p><strong>Objective: </strong>To determine adverse effects of intraperitoneally (IP) or subcutaneously (SC) delivered silver nanoparticles (AgNP) in poloxamer 407 (P407; AgNP-P407) and local retention and systemic uptake in rats.</p><p><strong>Study design: </strong>Controlled randomized trial.</p><p><strong>Animals: </strong>A total of 25 rats.</p><p><strong>Methods: </strong>A total of 10 rats were randomly assigned in Phase 1 to a SC or IP surgical delivery group (5 rats/group) to receive 0.01 mg AgNP/rat in P407 (1:2 volume ratio). A total of 15 rats (5/group) were used in Phase 2 to receive IP: gel only (1.0 mL), AgNP-P407 (0.01 mg AgNP in 1.0 mL P407) or AgNP (0.01 mg in aqueous buffer). Incisions were assessed daily. Euthanasia was performed on day 7. The SC surgery sites and organs were harvested and evaluated histologically with scores reported. Plasma was obtained and batch analyzed together with organs for Ag content using mass spectroscopy.</p><p><strong>Results: </strong>All rats survived the duration of the study. Minimal local histologic toxicity was seen after SC delivery. Plasma Ag peaked earlier for IP than SC delivery (p = .08) and for Ag delivered IP without gel (p = .04). Organ Ag uptake was minimal; macrophage aggregation was identified in the spleen and lymph node consistently. Rats that received P407 had increased cholesterol, whereas changes in total protein, albumin, glucose, amylase and lipase were seen for all groups.</p><p><strong>Conclusion: </strong>No adverse events were noted after use of AgNP-P407, while Ag uptake was delayed.</p><p><strong>Clinical relevance: </strong>Use of AgNP-P407 may be possible without systemic effects and prolonged local presence, but further testing is needed.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"791-806"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Presentation Abstracts: 2025 ECVS 34th Annual Scientific Meeting July 3-5, Antwerp, Belgium.","authors":"","doi":"10.1111/vsu.14293","DOIUrl":"10.1111/vsu.14293","url":null,"abstract":"","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"E158-E209"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}