Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-03-31DOI: 10.1111/vsu.14089
Daniel Low, Scott Rutherford
{"title":"Investigating the weekend effect in decompressive thoracolumbar hemilaminectomy for acute intervertebral disc extrusion: An observational cohort study of 460 cases (2018-2023).","authors":"Daniel Low, Scott Rutherford","doi":"10.1111/vsu.14089","DOIUrl":"10.1111/vsu.14089","url":null,"abstract":"<p><strong>Objective: </strong>To investigate if weekend surgery is associated with poorer outcomes in dogs with acute thoracolumbar intervertebral disc extrusion (IVDE) undergoing decompressive thoracolumbar hemilaminectomy.</p><p><strong>Study design: </strong>Retrospective observational cohort study.</p><p><strong>Sample population: </strong>A total of 460 consecutive cases were reviewed, with 401 dogs undergoing weekday surgery (Cohort WD), and 59 dogs undergoing weekend surgery (Cohort WE).</p><p><strong>Methods: </strong>Medical records of a surgical referral center in the UK were reviewed. Preoperative patient demographic and clinical data, and postoperative outcome data were collected with a minimum 28-day follow-up period. Multivariable logistic regression analysis was used to model the odds of a negative outcome.</p><p><strong>Results: </strong>Cohort WE had a higher preoperative proportion of nonambulatory dogs (p = .0115) but there were no significant differences between the nonambulatory (p = .3762) and deep-pain negative subgroups (p = .6199). Cohort WE had a higher risk of not recovering ambulation compared to Cohort WD [79.2% vs. 91.6% recovery; adjusted OR 3.010 (95% CI: 1.259-7.190); p = .0132] and had a higher risk of postoperative morbidity [32.2% vs. 17.2%; adjusted OR 2.015 (95% CI: 1.089-3.729); p = .0257]. There were no significant differences in other outcome measures between cohorts.</p><p><strong>Conclusion: </strong>Weekend surgery in canine decompressive thoracolumbar hemilaminectomy may be associated with poorer patient outcomes, specifically higher postoperative morbidity and a poorer rate of recovery of ambulation.</p><p><strong>Clinical significance: </strong>This study demonstrates a weekend effect in veterinary surgery, which may be important in surgical decision-making in acute thoracolumbar IVDE. Further scrutiny of the patient's journey through the veterinary healthcare system is warranted.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1420-1429"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-10-04DOI: 10.1111/vsu.14173
Jordan D Pieczynski, Bryden J Stanley, Kathleen M Ham
{"title":"Description of a cricotracheostomy technique for permanent tracheostomy in eight dogs.","authors":"Jordan D Pieczynski, Bryden J Stanley, Kathleen M Ham","doi":"10.1111/vsu.14173","DOIUrl":"10.1111/vsu.14173","url":null,"abstract":"<p><strong>Objective: </strong>To describe and report the outcome of a cricotracheostomy (CT) technique for the creation of a permanent upper airway ventral cervical stoma in dogs.</p><p><strong>Study design: </strong>Short case series.</p><p><strong>Animals: </strong>Eight client-owned dogs.</p><p><strong>Methods: </strong>Upper airway obstruction due to various disease processes was confirmed via upper airway examination and appropriate imaging. Medical records were reviewed to assess complications experienced during and following permanent CT. Owner questionnaires regarding quality of life (QoL) following permanent CT were performed.</p><p><strong>Results: </strong>All dogs experienced a routine recovery. The CT provided a robust dorsolateral. wall to the stoma from the cricoid cartilage. The stomata did not show any evidence of dorsal wall collapse or stenosis. Four dogs required further skin fold resection. The high position of this stoma also appears to be appropriate functionally with bilateral cervical skin fold resections. The owner questionnaires reported high satisfaction in the postoperative QoL.</p><p><strong>Conclusion: </strong>CT was feasible and led to a reliable outcome for surgical patients and improvement in QoL. Comparative clinical investigation of the CT technique with traditional permanent tracheostomy techniques is indicated to definitively prove the validity and any superiority of the CT technique.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1485-1494"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-08-22DOI: 10.1111/vsu.14154
Matthew D Barnhart, Roy Pool, William D Liska
{"title":"Pleomorphic sarcoma secondary to proximal femoral epiphysiolysis with bone infarction over 4 years after cementless total hip replacement in a dog.","authors":"Matthew D Barnhart, Roy Pool, William D Liska","doi":"10.1111/vsu.14154","DOIUrl":"10.1111/vsu.14154","url":null,"abstract":"<p><strong>Objective: </strong>To report a capital physeal fracture as the result of a bone infarction with subsequent neoplastic transformation 4 years following total hip replacement.</p><p><strong>Study design: </strong>Case report.</p><p><strong>Animals: </strong>Five-year-old female spayed golden retriever.</p><p><strong>Methods: </strong>The dog was initially presented for evaluation of a 2 week history of spontaneous right hind-limb lameness. Pelvic radiographs demonstrated a displaced capital epiphysis and proximal femur changes consistent with a bone infarction. A cementless total hip replacement was performed, and limb function returned to normal until 51 months after surgery. A radiolucency adjacent to the femoral stem at the greater trochanter, partial calcar resorption, and stable implants were present on pelvic radiographs acquired 52 months after surgery. Surgical exploration of the surgical site for tissue collection for histopathology and bacteria culture was performed 58 months following surgery. No bacterial growth occurred and histologic findings were nonspecific. A right hind-limb amputation was performed 61 months after total hip replacement due to the dog's progression to a non-weight-bearing lameness, Additional tissue samples were taken from the femur for histopathologic examination.</p><p><strong>Results: </strong>Histopathologic examination was consistent with a pleomorphic sarcoma. No metallic or polyethylene particulate debris was present. Nine months after surgery there was evidence of regional and distant spread of the neoplasia.</p><p><strong>Conclusion: </strong>In similar cases, submitting the femoral head for histopathologic examination should be considered at the time of the hip replacement surgery. If bone infarction is diagnosed as a causative agent, given the possibility of malignant transformation, long-term serial radiographic monitoring should be given serious consideration.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1461-1468"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-03-22DOI: 10.1111/vsu.14090
Sophie Wyatt, Joe Fenn, Elsa Beltran
{"title":"Transcerebellar ventriculoperitoneal shunt for management of presumed arachnoid diverticulum in the fourth ventricle of a dog.","authors":"Sophie Wyatt, Joe Fenn, Elsa Beltran","doi":"10.1111/vsu.14090","DOIUrl":"10.1111/vsu.14090","url":null,"abstract":"<p><strong>Objective: </strong>To describe the approach for placement of a transcerebellar fourth ventriculoperitoneal shunt for management of presumed fourth ventricle arachnoid diverticulum and secondary obstructive hydrocephalus of a dog. To describe the outcome of this procedure.</p><p><strong>Study design: </strong>Case report.</p><p><strong>Animals: </strong>Male entire English springer spaniel, 3 years 9 months of age.</p><p><strong>Methods: </strong>The dog was initially presented for management of acute, progressive, and multifocal brainstem and forebrain dysfunction. Magnetic resonance imaging revealed internal obstructive hypertensive hydrocephalus. The dog was managed via ventriculoperitoneal shunting from the left lateral ventricle and made an excellent recovery. The dog acutely deteriorated 18 months after initial discharge and follow-up magnetic resonance imaging confirmed the ventricular shunt remained in situ with normal-sized lateral ventricles but revealed a cystlike lesion within the fourth ventricle, presumed to be a fourth ventricle arachnoid diverticulum. The diverticulum was causing mass effect and resultant compression of adjacent neuroparenchyma. A second ventriculoperitoneal shunt was subsequently placed into the fourth ventricle via the caudal cranial fossa and cerebellum. This was attached to a three-way connector, to which the existing shunt (within the left lateral ventricle) was also attached, and then secured to the existing medium-pressure valve.</p><p><strong>Results: </strong>Postoperatively, the dog immediately developed mild vestibular-cerebellar ataxia, with a marked improvement after 3 months. There were no shunt-associated complications. Long-term follow up at 40 months after the second surgical procedure revealed a normal neurological examination.</p><p><strong>Conclusion: </strong>Transcerebellar ventriculoperitoneal shunt placement for treatment of a presumed fourth ventricle arachnoid diverticulum was performed and was associated with a favorable long-term outcome.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1430-1437"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-08-16DOI: 10.1111/vsu.14149
Jenniffer M Rodriguez-Diaz, Mandy L Wallace, Sarah A Emond, Danielle McNabney, Katie M Hodges, Elizabeth W Howerth
{"title":"Effect of hydrocolloid-nitric oxide wound dressings on wound healing in dogs.","authors":"Jenniffer M Rodriguez-Diaz, Mandy L Wallace, Sarah A Emond, Danielle McNabney, Katie M Hodges, Elizabeth W Howerth","doi":"10.1111/vsu.14149","DOIUrl":"10.1111/vsu.14149","url":null,"abstract":"<p><strong>Objective: </strong>To determine the rates of wound healing in surgically created wounds between nitric oxide releasing wound dressings and control wound dressings.</p><p><strong>Study design: </strong>Prospective, controlled, randomized experimental study.</p><p><strong>Animals: </strong>Purpose-bred, adult, male Beagles (n = 6).</p><p><strong>Methods: </strong>Four 2 × 2 cm wounds were surgically created on the trunk of each dog with each wound randomized to treatment with a nitric oxide wound pad (NP), nitric oxide wound gel (NG), plain hydrocolloid wound dressing (HC), or Telfa pad (T). Wound images were taken daily for 8 days then every other day until day 21 with images masked and randomized for evaluation. Total wound area, contraction percentage, and days until granulation were calculated.</p><p><strong>Results: </strong>Time to first appearance of granulation tissue was significantly shorter for NP (3.2 days) than for NG (4 days; p = .023), HC (4.5 days; p = .001), and T (5.2 days; p < .0001). There were significant differences in total wound area and contraction percentage between sites and treatments (p < .001). Total wound area for NG was lower than treatment T (0.7 ± 0.1 cm<sup>3</sup>; p < .001), HC (0.9 ± 0.1 cm<sup>3</sup>, p < .001), and NP (0.6 ± 0.1 cm<sup>3</sup>, p < .001).</p><p><strong>Conclusion: </strong>Use of a nitric oxide wound dressing resulted in faster wound healing as evidenced by lower total wound area and higher contraction in the NG group and faster time to granulation tissue development in the NP group.</p><p><strong>Clinical significance: </strong>Nitric oxide wound dressings are innovative and inexpensive products that can significantly decrease the amount of time and cost necessary for open or second intention wound resolution in dogs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1351-1365"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-09-16DOI: 10.1111/vsu.14164
Ryan A Boharski, Jason L Wheeler, Alan R Cross, Joshua Jackson, Steven Peterson
{"title":"Hybrid, transarticular external fixation with platelet-rich plasma injection as a treatment for partial calcaneal tendon disruption in dogs without primary tenorrhaphy.","authors":"Ryan A Boharski, Jason L Wheeler, Alan R Cross, Joshua Jackson, Steven Peterson","doi":"10.1111/vsu.14164","DOIUrl":"10.1111/vsu.14164","url":null,"abstract":"<p><strong>Objective: </strong>To report the use of a hybrid, transarticular external skeletal fixator and platelet-rich plasma injection without primary tenorrhaphy for management of partial calcanean tendon disruption in dogs.</p><p><strong>Study design: </strong>Multi-institutional retrospective study.</p><p><strong>Animals: </strong>A total of 11 client-owned dogs.</p><p><strong>Methods: </strong>Medical records from two referral centers from 2019 to 2022 were reviewed for inclusion in the study. Dogs diagnosed with partial, non-traumatic calcanean tendon disruption treated with hybrid, transarticular external skeletal fixation and platelet-rich plasma injection were included in the study. Cases that did not include complete postoperative follow-up over 8-12 weeks and owner-reported outcomes at >6 months were excluded from the study. Dogs with traumatic laceration or those in which a primary tenorrhaphy was performed were also excluded.</p><p><strong>Results: </strong>A total of 11 (n = 11) dogs met the inclusion criteria. Median follow-up time was 18.5 months (6 months-34 months). Mean time of fixation was 9 weeks (6 weeks-12 weeks). Five dogs returned to full, pain-free function (5/11 = 45%). Five dogs had an acceptable return to function (5/11 = 45%). One dog had an unacceptable outcome (1/11 = 9%). Pin tract complications occurred in five dogs (5/11 = 45%) and resolved with medical intervention.</p><p><strong>Conclusion: </strong>The results of this study suggest that temporary tibiotarsal immobilization with a hybrid, transarticular external skeletal fixator and platelet-rich plasma injection without primary tenorrhaphy can lead to a successful outcome in dogs with partial calcanean tendon disruption.</p><p><strong>Clinical significance: </strong>Temporary hybrid, transarticular external skeletal fixation and platelet-rich plasma injection without primary tenorrhaphy may play a role in the management of partial calcanean tendon disruption in dogs.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1390-1398"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-10-07DOI: 10.1111/vsu.14167
Kevin R L Schreiber, Alexandre Thibault, Martin Hamon, Philippe Haudiquet
{"title":"Stabilization of 82 sacroiliac luxations in 67 cats using two sacroiliac screws (2014-2023).","authors":"Kevin R L Schreiber, Alexandre Thibault, Martin Hamon, Philippe Haudiquet","doi":"10.1111/vsu.14167","DOIUrl":"10.1111/vsu.14167","url":null,"abstract":"<p><strong>Objective: </strong>To describe sacroiliac luxation stabilization in cats using two screws and to report clinical and radiographic short-term outcomes.</p><p><strong>Study design: </strong>Retrospective clinical cohort study.</p><p><strong>Sample population: </strong>Cats (n = 67) with sacroiliac luxation.</p><p><strong>Methods: </strong>Case records of cats presented for sacroiliac luxation stabilized using two screws per side affected, one lag and one positional, between 2014 and 2023 were reviewed. The percentage of sacral purchase (PoSP) for each screw, percentage of reduction (PoR), and pelvic canal width ratio (PCWR) were measured and calculated.</p><p><strong>Results: </strong>Eighty-two sacroiliac luxations were stabilized. Two 2.0 mm screws were used in 69 cases; two 2.4-mm screws in nine cases, and one 2.4 mm with one 2.0 mm screw in four cases. The mean PoSPs for lag and positional screws were 46% ± 12 and 31% ± 11, respectively. The median PoR was 89% (41 to 100). The mean PCWR was 1.23 ± 0.11. Clinical follow up was available for 42 cats with 53 sacroiliac luxations at a median of 87 days (36 to 2503). The full function was noted in 34 patients (81%). Screw failure occurred in five sacroiliac joints (4.7%), including loosening (n = 3), and breakage (n = 2) of the positional screws (n = 1). Pelvic canal diameter was maintained in all cases.</p><p><strong>Conclusion: </strong>Excellent functional and radiographic outcomes were obtained for cats with sacroiliac luxation stabilized with two sacroiliac screws.</p><p><strong>Clinical significance: </strong>Feline sacroiliac luxation can be stabilized using two sacroiliac screws.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1366-1376"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-10-05DOI: 10.1111/vsu.14170
Megan J Fahey, Rebecca M Harman, Matthew A Thomas, Brenna R Pugliese, Jeanine Peters-Kennedy, Michelle L Delco, Gerlinde R Van de Walle
{"title":"Preliminary in vivo investigation of the mesenchymal stromal cell secretome as a novel treatment for methicillin-resistant Staphylococcus aureus in equine skin wounds.","authors":"Megan J Fahey, Rebecca M Harman, Matthew A Thomas, Brenna R Pugliese, Jeanine Peters-Kennedy, Michelle L Delco, Gerlinde R Van de Walle","doi":"10.1111/vsu.14170","DOIUrl":"10.1111/vsu.14170","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to study the antimicrobial and pro-healing potential of equine mesenchymal stromal cell secreted products (i.e. secretome), collected as conditioned media (mesenchymal stromal cell-conditioned media, MSC CM), in a novel in vivo model of methicillin-resistant Staphylococcus aureus (MRSA)-inoculated equine thorax wounds.</p><p><strong>Study design: </strong>Prospective in vivo study.</p><p><strong>Animals: </strong>Two Thoroughbred geldings.</p><p><strong>Methods: </strong>Six full-thickness cutaneous wounds were created bilaterally on the dorsal thorax of two horses (n = 12 wounds/horse). Wounds on the left thoraces were inoculated with MRSA on day 0. All wounds were then treated with either mupirocin ointment, MSC CM, or vehicle control (n = 4 wounds per group) once daily for 3 days. Photographs were taken to quantify wound scores and sizes, as well as samples to determine bacterial colony forming units (CFUs), at days 0, 1, 2, 3, 7, 14, 21, and 28. The wound edge was biopsied on days 0, 7, and 28, and scored histologically.</p><p><strong>Results: </strong>Inoculated wounds had more bacterial CFUs at day 1 (p < .0001) and were larger in size at day 28 (p = .0009) than noninoculated wounds. Mupirocin-treated wounds were smaller than MSC CM and vehicle control-treated wounds at day 28 (p = .003). Mesenchymal stromal cell-conditioned media did not affect CFU numbers in inoculated and noninoculated wounds. Moreover, MSC CM did not affect the parameters of wound size or gross or microscopic wound scores over time.</p><p><strong>Conclusion: </strong>Mesenchymal stromal cell-conditioned media did not exhibit antimicrobial or pro-healing properties in the current study; however, the in vivo model of inoculated equine thorax wounds requires further optimization.</p><p><strong>Clinical significance: </strong>This pilot study contributes to a growing understanding of the equine MSC secretome as an antimicrobial and pro-healing therapeutic for equine wounds.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1377-1389"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veterinary SurgeryPub Date : 2024-11-01Epub Date: 2024-09-09DOI: 10.1111/vsu.14159
{"title":"Correction to \"Gastrointestinal thickness, duration, and leak pressure of five intestinal anastomosis techniques in cats\".","authors":"","doi":"10.1111/vsu.14159","DOIUrl":"10.1111/vsu.14159","url":null,"abstract":"","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":"1350"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}