{"title":"A hindered phenol containing PVC/CuO nanocomposites; study on the mechanical and thermooxidative properties.","authors":"Mohsen Hajibeygi, Alireza Ghasemi","doi":"10.55730/1300-0527.3708","DOIUrl":"10.55730/1300-0527.3708","url":null,"abstract":"<p><p>The effect of synthesized 5-((4-hydroxy-3,5-di-tert-butylphenyl)diazenyl)isophthalic acid (HBA) containing a hindered phenol derivative on the thermooxidation, hydrochloric acid release time, and mechanical strength of PVC/CuO nanocomposites was studied. Moreover, 5-((4-hydroxy-2,5-dimethylphenyl)diazenyl)isophthalic acid (HMA) was synthesized for comparison of corresponding PVC nanocomposite properties. PVC nanocomposite thin films were prepared through in situ surface modification of CuO nanoparticles with HBA and HMA, individually, in the PVC solution. The XRD and FE-SEM results clarified the desirable dispersion of CuO nanoparticles. The PVC sample with loading of 5 wt% from each HBA and CuO was found to be the most thermally stable, which was confirmed by thermogravimetric analysis in inert conditions. The thermooxidation and Congo red test results revealed that the simultaneous loading of HBA and CuO nanoparticles into the PVC matrix could increase the initial thermal degradation and the stability times. Moreover, the PVC sample containing 2.5 wt% each from HBA and CuO nanoparticles exhibited tensile strength almost 20 MPa more than that of neat PVC.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"29-44"},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new water-soluble silicon phthalocyanine that catalyzes the photodegradation of pollutant dyes.","authors":"Damla Nur Kaya, Behice Şebnem Sesalan","doi":"10.55730/1300-0527.3715","DOIUrl":"10.55730/1300-0527.3715","url":null,"abstract":"<p><p>The removal of color arising from water-soluble dyes in wastewaters is necessary to counter the threat to health. Because of the difficulty in elimination of these dyes by conventional methods, their photodegradation using photosensitizers such as phthalocyanines (Pcs) has been employed recently. When compared to peripherally substituted derivatives, silicon Pcs are reported to be more biocompatible with low toxicity. Thus a new silicon Pc substituted with two quaternized dimethylamino phenoxy units (compound 1) and its quaternized derivative (compound 2) were synthesized to test its photocatalytic ability employing the dyes methylene blue (MB), eosin B (EB), erythrosine (ERB), sulforhodamine B (SRB), and brilliant blue FCF (BRB), some of whose absorption bands overlap with those of Pcs. The overlapped absorption bands were split using first-order derivative UV-vis spectra. The photodegradation rates of BRB, MB, and ERB were 41%, 38%, and 29%, respectively, under 30-s short time irradiation in the presence of compound <b>2</b>. The plots of the natural logarithm of the concentrations of dyes versus time fit the first-order reaction model. According to the experimental data, compound <b>2</b> could be used as a photocatalyst due to singlet oxygen generation for photodegradation of pollutant dyes MB, ERB, and BRB with higher photodegradation rates.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"118-132"},"PeriodicalIF":1.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Göksu Özçelikay Akyildiz, Mehmet Altay Ünal, Seçil Gülden, Sibel A Özkan
{"title":"The magnetic beads-based sandwich-shaped immune complexes for rapid and sensitive amperometric detection of SOX2 protein.","authors":"Göksu Özçelikay Akyildiz, Mehmet Altay Ünal, Seçil Gülden, Sibel A Özkan","doi":"10.55730/1300-0527.3712","DOIUrl":"10.55730/1300-0527.3712","url":null,"abstract":"<p><p>Sex-Determining Region Y-box 2 (SOX2) is a transcription factor protein. SOX2 expression is related to lymph node metastasis and distant metastasis in colorectal carcinomas. SOX2 was determined with the first magnetic disposable immunoplatform. The designed sandwich-shaped immune complexes were formed by a capture antibody, SOX2 protein, and biotinylated secondary antibodies (dAb/HRP). The sandwich-shaped immune complex was linked to carboxylic acid functionalized magnetic beads (HOOC-MBs). This magnetic bioconjugate was dropped on the surface of the screen-printed carbon electrode (SPCE). The amperometric measurement was performed at -0.20 V in the presence of hydroquinone (HQ) and H<sub>2</sub>O<sub>2</sub> against a silver pseudo-reference electrode. The optimization parameters affecting the immunoassay response were evaluated. The analytical evaluation of the magnetic disposable immunoplatform for the amperometric detection of SOX2 standards was done. The developed immunosensor shows high sensitivity (LOD of 1.37 ng mL<sup>-1</sup>) and a short analysis time (15 min). Potential interfering compounds found in serum samples were tested. The storage stability of magnetic disposable immunoplatform was evaluated. The developed immunosensor was compared with the ELISA method.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"79-88"},"PeriodicalIF":1.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Uçar Kaya, Mehmet Yurderi, Mehmet Zahmakiran
{"title":"Preparation and characterization of RhFe/g-C<sub>3</sub>N<sub>4</sub> nanoparticles for efficient hydrolysis of sodium borohydride.","authors":"Merve Uçar Kaya, Mehmet Yurderi, Mehmet Zahmakiran","doi":"10.55730/1300-0527.3711","DOIUrl":"10.55730/1300-0527.3711","url":null,"abstract":"<p><p>Highly effective graphitic carbon nitride-supported RhFe nanoparticles (RhFe/g-C<sub>3</sub>N<sub>4</sub>) were prepared using a simple wet impregnation-reduction method for the hydrolysis of sodium borohydride (NaBH<sub>4</sub>). The obtained Rh<sub>0.48</sub>Fe<sub>0.52</sub>/g-C<sub>3</sub>N<sub>4</sub> catalyst was characterized using advanced analytical/spectroscopic techniques such as inductively coupled plasma-optical emission spectroscopy, scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, X-ray spectroscopy, and Fourier transform infrared spectroscopy. The catalytic activities of RhFe/g-C<sub>3</sub>N<sub>4</sub> catalysts with varying Rh/Fe molar ratios were investigated, demonstrating superior catalytic activity compared to monometallic Rh and Fe. The initial turnover frequency value of the Rh<sub>0.48</sub>Fe<sub>0.52</sub>/g-C<sub>3</sub>N<sub>4</sub> catalyst was calculated as 33.04 min<sup>-1</sup> and it showed an H<sub>2</sub> generation rate of <math> <mrow><mrow><mn>4214.02</mn> <mi> </mi> <mtext>mL </mtext> <msup><mrow><mtext>min</mtext></mrow> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> <mi> </mi> <msubsup><mtext>g</mtext> <mrow><mtext>cat</mtext></mrow> <mrow><mo>-</mo> <mn>1</mn></mrow> </msubsup> </mrow> </mrow> </math> at 298 K. Furthermore, the kinetic parameters (<i>E</i> <sub>a</sub> <sup>#</sup>, Δ<i>H</i> <sup>#</sup>, Δ<i>S</i> <sup>#</sup>) of the hydrolysis of NaBH<sub>4</sub> catalyzed by the Rh<sub>0.48</sub>Fe<sub>0.52</sub>/g-C<sub>3</sub>N<sub>4</sub> catalyst were elucidated. The findings demonstrated that the resulting Rh<sub>0.48</sub>Fe<sub>0.52</sub>/g-C<sub>3</sub>N<sub>4</sub> catalyst was recyclable and retained 80.72% of the initial activity even after 10 runs.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"68-78"},"PeriodicalIF":1.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous determination of sunset yellow and tartrazine in real samples on an <i>n</i>-butylamine-graphite/polyaminophenol composite electrode.","authors":"Mürşide Ceren Afşar, Zekerya Dursun","doi":"10.55730/1300-0527.3714","DOIUrl":"10.55730/1300-0527.3714","url":null,"abstract":"<p><p>A composite electrode was fabricated for simultaneous determination of sunset yellow (SY) and tartrazine (Tz) in foods and syrup. It is based on <i>n</i>-butylamine intercalation into graphite and then dropped on a poly (4-aminophenol)/glassy carbon electrode (GCE). The electrode surface morphologies, chemistry, and electrical properties were identified by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy (RS), and electrochemical impedance spectroscopy (EIS). The new composite electrode significantly increased the electrochemical response of SY and Tz relative to a bare GCE. The peak current of SY and Tz increased linearly depending on their concentrations from 0.006 μmol L<sup>-1</sup> to 1.0 μmol L<sup>-1</sup> (r = 0.994) and over two linear ranges from 0.06 to 1.50 μmol L<sup>-1</sup> (r = 0.9955) and from 2.0 to 10.0 μmol L<sup>-1</sup> (r = 0.9902), respectively. The limits of detection of SY and Tz were 2.60 nmol L<sup>-1</sup> and 0.025 μmol L<sup>-1</sup>, respectively (S/N = 3). SY and Tz contents in real samples were determined in syrup, juice powder, and candy. Spiked recovery for samples was from 96.4% to 106.8%. The relative standard deviations were lower than 5.0%.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"103-117"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdallah Timmaoui, Mahmoud Ferhat, Nesrine Souad Ferhat, Ahmed Hamdi
{"title":"Understanding ammonia's role in mitigating concentration polarization in anion-exchange membrane electrodialysis.","authors":"Abdallah Timmaoui, Mahmoud Ferhat, Nesrine Souad Ferhat, Ahmed Hamdi","doi":"10.55730/1300-0527.3703","DOIUrl":"https://doi.org/10.55730/1300-0527.3703","url":null,"abstract":"<p><p>In processes such as electrodialysis, the applied electrical potential is constrained by concentration polarization at the membrane/solution interface. This polarization, which intensifies at higher current densities, impedes ion transport efficiency and may lead to problems such as salt precipitation, membrane degradation, and increased energy consumption. Therefore, understanding concentration polarization is essential for enhancing membrane performance, improving efficiency, and reducing operational costs. This study investigates the impact of ammonia buffer (NH<sub>4</sub> <sup>+</sup>/NH<sub>3</sub>) on sulfate ion transport through anion-exchange membranes with a particular focus on limiting current density and concentration polarization under constant current conditions. The findings demonstrate that ammonia effectively eliminates concentration polarization and enhances chemical reactions at the membrane interface. Notably, the plateau region was absent in the current-voltage curves, as was the transition time in the chronopotentiograms. Furthermore, the Warburg impedance arc in the Nyquist plot of the electrochemical impedance spectra was absent in both limiting and overlimiting current regions and the increasing dominance of the Gerischer arc was registered. At an ammonia concentration of 0.1 M, the influence of concentration polarization on mass transport was effectively mitigated, enabling sulfate counterions to pass through the membrane without encountering concentration polarization. The addition of ammonia catalytically accelerated the proton-transfer reactions, which accelerated the water dissociation reaction at earlier polarization stages, preventing the formation of diffusion boundary layers and facilitating the transport of sulfate counterions through the AMX anion-exchange membrane. As a result, the polarization plateau disappeared and the overlimiting current region shifted closer to the ohmic region, all without affecting the limiting current density (<i>j</i> <i><sub>lim</sub></i> ).</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 6","pages":"843-855"},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation of manganese-doped carbon quantum dots@halloysite nanotube composites films for advanced UV shielding properties.","authors":"Xiao Zhang, Bin Wang","doi":"10.55730/1300-0527.3701","DOIUrl":"https://doi.org/10.55730/1300-0527.3701","url":null,"abstract":"<p><p>The development of ultraviolet (UV) shielding materials is of great importance to protect human health and prevent the degradation of organic matter. However, the synthesis of highly efficient UV shielding polymer nanocomposites is currently limited by the agglomeration of inorganic anti-UV nanoparticles (NPs) within the polymer matrix and the limited absorption spectrum of UV shielding agents. In this study, highly effective manganese doped carbon quantum dots@halloysite nanotube composites (Mn-CDs@HNTs/PAS) were successfully synthesized by loading manganese-doped carbon quantum dots (Mn-CDs) into UV shielding effective halloysite nanotubes (HNTs) via the solvothermal method, followed by polymerization modification (PAS). The results show that inorganic NPs are evenly dispersed into the polymer matrix. The resulting UV shielding film prepared by mixing Mn-CDs@HNTs/PAS composites with polyvinyl chloride (PVC) shows enhanced UV absorption and thermal stability compared with pure PVC film. It thus appears that Mn-CDs@HNTs/PAS composites have a promising future in UV protection.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 6","pages":"821-829"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Funda Alkan, Murat Demirbilek, Oktay Aydin, Berrak Gümüşkaya Öcal, Nelisa Laçin Türkoğlu, Mustafa Türk, Mehmet Ali Onur
{"title":"Nonadhesive membranes: preparation and characterization of modified PHBHX membranes.","authors":"Funda Alkan, Murat Demirbilek, Oktay Aydin, Berrak Gümüşkaya Öcal, Nelisa Laçin Türkoğlu, Mustafa Türk, Mehmet Ali Onur","doi":"10.55730/1300-0527.3710","DOIUrl":"10.55730/1300-0527.3710","url":null,"abstract":"<p><p>After abdominal surgery, there is a possibility of adhesions between the abdominal organs and the abdominal wall. The adhesions can lead to problems such as chronic pain, intestinal blockage, and infertility. To prevent adhesion, antiadhesion patches can be used. In this study, poly hydroxybutyrate-co-hexanoate membranes were fabricated as antiadhesion patches and modified with either fatty acids or polyethylene glycol. The homogeneity and protein absorption of the membranes were assessed. The effects on blood coagulation factors were determined and the adhesion-proliferation properties of human fibroblast cells on the membranes were determined. The results show that myristic acid slightly increases surface free energy (40.7 ± 4.2 mN/m), decreases polar interaction (6.7 ± 0.7%), and has no effect on cell adhesion or proliferation at low concentrations, but does at high concentrations. Oleic acid slightly increases surface free energy (45.91 ± 4.8 mN/m), does not affect polar interaction (11.4 ± 0.9%), and increases cell proliferation at low concentrations. Both polyethylene glycol 400 and polyethylene glycol 8000 decrease cell adhesion and proliferation and do not change the surface free energy of membranes (39.6 ± 2.6 mN/m and 37.8 ± 1.8 mN/m, respectively), but decrease polar interaction (6.6 ± 0.3% and 5.1 ± 0.2%, respectively). In conclusion, the modified membrane is a good candidate for an antiadhesion patch for abdominal surgery.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 1","pages":"54-67"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis and optimization of the adsorption of lead ions on a new material based on silica synthesized from blast furnace slag.","authors":"Toufik Chouchane, Ouahida Khireddine, Sabiha Chouchane, Mohamed Tayeb Abedghars, Hazem Meradi","doi":"10.55730/1300-0527.3705","DOIUrl":"https://doi.org/10.55730/1300-0527.3705","url":null,"abstract":"<p><p>A novel silica-based material (SBM), synthesized from chemically-, thermally-, and mechanically-treated blast furnace slag (TBFS), was examined for its batch-mode lead adsorption capacity based on various parameters. Physicochemical examinations revealed that the formulation of the new SBM consisted mainly of silica, which represented 81.79% of its total composition. After modification, the measured specific surface area changed significantly, from 275.8 to 480.13 m<sup>2</sup>/g, with a point of zero charge (PZC) of approximately 3.4 on the pH scale. The experiment revealed that the driving factors (contact time, stirring speed, solution pH, temperature, and initial concentration) greatly influenced improvement of the lead adsorption capacity, which reached 164.84 mg/g after 40 min of interaction. The adsorption isotherms demonstrated that the lead adsorption took place on a homogeneous surface and in a single layer, which was confirmed by the correlation coefficient and the ability of the Langmuir model to adsorb. The separation factor (R<sub>L</sub>) and heterogeneity factor (1/n) demonstrated that adsorption was favorable, while the Temkin parameter (b<sub>t</sub>) revealed that removal occurred through physical adsorption. According to the kinetic analysis, this process followed a pseudo-second-order kinetic model and was regulated by both external diffusion and intraparticle diffusion. Thermodynamic parameters demonstrated that lead adsorption was a spontaneous, exothermic, less entropic, and physical process, driven by electrostatic interaction. Activation energy revealed that the lead removal process occurred through physical adsorption. Desorption analysis demonstrated that SBM can be reused up to four consecutive times.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 6","pages":"867-884"},"PeriodicalIF":1.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halilibrahim Çiftçi, Masami Otsuka, Mikako Fujita, Belgin Sever
{"title":"New naphthalene-linked pyrazoline-thiazole hybrids as prominent antilung and antibreast cancer inhibitors.","authors":"Halilibrahim Çiftçi, Masami Otsuka, Mikako Fujita, Belgin Sever","doi":"10.55730/1300-0527.3704","DOIUrl":"https://doi.org/10.55730/1300-0527.3704","url":null,"abstract":"<p><p>The epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), pioneer members of the receptor tyrosine kinase subfamily, are frequently mutated and/or overexpressed in several types of human cancers, including nonsmall cell lung cancer (NSCLC) and breast cancer, which are leading causes of cancer-related deaths worldwide. EGFR and HER2-focused anti-NSCLC and antibreast cancer studies encouraged us to search for new potential agents. For this purpose, in the current work, naphthalene-linked pyrazoline-thiazole hybrids (<b>BTT-1</b>-<b>10</b> and <b>BTP-1</b>-<b>10</b>) were synthesized and examined for their antiproliferative effects on A549 NSCLC and MCF-7 breast cancer cell lines. According to the results, the MTT assay showed that <b>BTT-5</b> induced strong toxicity in A549 cells with an IC<sub>50</sub> value of 9.51 ± 3.35 μM compared to lapatinib (IC<sub>50</sub> = 16.44 ± 3.92 μM). <b>BTT-5</b> also presented a high selectivity profile between the Jurkat cell line and PBMCs (healthy) (SI = 65.65). Furthermore, <b>BTT-5</b> augmented apoptosis significantly in A549 cells (18.40%). <b>BTT-5</b> displayed significant EGFR inhibition (58.32%) and no significant HER2 inhibition at 10 μM concentration, showing its selective kinase inhibitory effects. The molecular docking assessment indicated that <b>BTT-5</b> showed high affinity with a different binding profile than lapatinib in the ATP binding cleft of EGFR. Consequently, <b>BTT-5</b> can serve as a lead for future anti-NSCLC studies.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 6","pages":"856-866"},"PeriodicalIF":1.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}