Turkish Journal of Medical Sciences最新文献

{"title":"Gastrointestinal bleeding among oral anticoagulant users: a comprehensive 7-year retrospective review using Türkiye's national health data system.","authors":"Nuray Yilmaz Çakmak, Naim Ata, Serdar Can Güven, Emin Gemcioğlu, Murat Çağlayan, Mahir Ülgü, Şuayip Birinci","doi":"10.55730/1300-0144.5879","DOIUrl":"https://doi.org/10.55730/1300-0144.5879","url":null,"abstract":"<p><strong>Background/aim: </strong>The comparative risk of gastrointestinal bleeding (GIB) among users of direct-acting oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) is a topic of ongoing debate. This study leverages a comprehensive national health database to evaluate the incidence of GIB, associated risk factors, and postbleeding management strategies among anticoagulated patients.</p><p><strong>Materials and methods: </strong>Utilizing the Turkish Ministry of Health's e-Nabız system, we conducted a retrospective analysis of patients treated with DOACs and warfarin from January 2017 to July 2023. GIB events were identified using ICD codes, and comorbidities, prior medication use, interventions, and mortality rates were analyzed. Drug survival and patterns of changes following GIB were also evaluated.</p><p><strong>Results: </strong>Among 102,545 patients with a GIB event during anticoagulant treatment, DOAC users were older with a higher prevalence of comorbidities, except for chronic obstructive lung disease, compared to VKA users. GIB-related mortality was 0.6% in the DOAC group and 0.4% in the VKA group at admission after the GIB (p < 0.01). In all drug groups, approximately half of the patients discontinued anticoagulation due to GIB after 3 months, the rate being highest with apixaban (61.9%). In patients who continued anticoagulation, the anticoagulant prior to GIB remained the most common agent in all groups, with rivaroxaban having the highest retention rate (40.7%).</p><p><strong>Conclusion: </strong>This nationwide study indicates a higher frequency of GIB in DOAC users versus VKA users, with age and comorbidities potentially contributing to this trend. Mortality rates were comparable to the previous literature but warrant further investigation. The significant rate of discontinuation following GIB raises concerns about ongoing anticoagulation management. These findings underscore the need for cautious case management.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and diagnostic utility of pancreatic stone protein in pediatric sepsis and mortality.","authors":"Mehmet Akif Dündar, Emin Ceran, Başak Nur Akyildiz","doi":"10.55730/1300-0144.5844","DOIUrl":"10.55730/1300-0144.5844","url":null,"abstract":"<p><strong>Background/aim: </strong>Early detection and prognosis of sepsis in critically ill children is crucial. The aim of this research was to investigate the prognostic ability of pancreatic stone protein (PSP) in validating sepsis and predicting mortality in a prospective observational study.</p><p><strong>Materials and methods: </strong>In a single-center study, pediatric intensive care unit patients were divided into cohorts of confirmed and suspected sepsis, as well as survivors and nonsurvivors. Patients with positive blood culture growth were considered to have confirmed sepsis, while their negative counterparts were considered to have suspected sepsis. Comparisons were made between complete blood counts, laboratory parameters, mortality indices, and C-reactive protein (CRP), procalcitonin (PCT), and PSP levels. The correlations between PSP and alternative inflammatory markers and mortality indices were then analyzed. The diagnostic and prognostic applicability of PSP for sepsis confirmation and mortality prediction was assessed using receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>PSP levels were significantly elevated in patients with confirmed sepsis and within the nonsurvivor segment. In confirming sepsis and predicting mortality, PSP outperformed CRP and PCT in terms of sensitivity. It had sensitivity of 95% in diagnosing sepsis at a cut-off level of 50 ng/L, with an area under the curve (AUC) of 0.67 (95% CI: 0.52-0.81), and sensitivity of 92% in predicting mortality, with an AUC of 0.71 (95% CI: 0.56-0.83). In addition, PSP showed significant correlations with CRP, PCT, and mortality scores.</p><p><strong>Conclusion: </strong>PSP is emerging as a highly sensitive marker for confirming sepsis and predicting mortality in critically ill pediatric patients. Incorporating the PSP biomarker into routine clinical practice could potentially improve the management of pediatric sepsis.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systemic zinc and oxidative stress levels and periodontal inflamed surface area.","authors":"Ayşegül Sari, Serdar Doğan, Luigi Nibali","doi":"10.55730/1300-0144.5868","DOIUrl":"https://doi.org/10.55730/1300-0144.5868","url":null,"abstract":"<p><strong>Background/aim: </strong>Zinc is a structural component of some enzymes. The aim of this study was to evaluate the potential associations between serum zinc and oxidative stress levels and periodontal inflamed surface area (PISA).</p><p><strong>Materials and methods: </strong>This study included 90 patients divided into three groups: a periodontitis group (P; n = 30), a gingivitis group (G; n = 30), and a periodontal health group (PH; n = 30). Periodontal parameters were recorded and PISA values were calculated. Serum total antioxidant status (TAS), total oxidant status (TOS), and zinc levels were examined biochemically. Oxidative stress index (OSI) levels were calculated.</p><p><strong>Results: </strong>All clinical periodontal parameters, periodontal epithelium surface area, and PISA values were lower in the PH group than the P and G groups (p < 0.05). Serum zinc and TAS values were higher in the PH group than the P and G groups (p < 0.05). Serum TOS and OSI values were lower in the PH group than the G and P groups (p < 0.05). Serum OSI levels were lower in the G group than the P group (p < 0.05). PISA was associated with serum zinc (β = -28.96, 95% CI = (-38.95, -18.98), p < 0.001) and OSI (β = 89.84, 95% CI = (20.63, 159.05), p = 0.011) levels in the multivariate generalized linear model.</p><p><strong>Conclusion: </strong>PISA values were associated with decreasing serum zinc and TAS and increased TOS and OSI levels. Zinc deficiency can be associated with the severity of periodontal disease and higher oxidative stress levels.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of risk factors influencing substance use among Turkish-origin immigrants in Germany.","authors":"Enes Efendioğlu, Lütfiye Hilal Özcebe","doi":"10.55730/1300-0144.5893","DOIUrl":"https://doi.org/10.55730/1300-0144.5893","url":null,"abstract":"<p><strong>Background/aim: </strong>Increasing international migration poses unique challenges, especially regarding health outcomes and behaviors such as substance use. This study aims to identify risk factors influencing substance use among Turkish-origin immigrants in Germany.</p><p><strong>Materials and methods: </strong>Data were obtained from the STEPS survey conducted by the Presidency for Turks Abroad and Related Communities (YTB) in 2021 in Germany. A total of 1157 participants were selected through a quota sampling method. Data analysis involved descriptive statistics and logistic regression utilizing IBM SPSS Statistics 21.</p><p><strong>Results: </strong>The study found a significant association between substance use and variables such as generation status, age, and sex. Third-generation immigrants showed a higher propensity for substance use compared to the first and second generations. Significant relationships were also observed between substance use and other risk behaviors such as tobacco and alcohol consumption.</p><p><strong>Conclusion: </strong>Substance use among Turkish-origin immigrants in Germany is influenced by generational status, with younger and third-generation individuals being at higher risk. Additionally, tobacco and alcohol use are strong predictors of substance use, highlighting the need for targeted interventions, especially for young migrants.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine in pediatric rheumatology: the video pediatric gait, arms, legs, and spine (v-pGALS) examination.","authors":"Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emil Aliyev, Özge Başaran, Yelda Bilginer, Seza Özen, Ezgi Deniz Batu","doi":"10.55730/1300-0144.5874","DOIUrl":"https://doi.org/10.55730/1300-0144.5874","url":null,"abstract":"<p><strong>Background/aim: </strong>Video pediatric gait, arms, leg, and spine (v-pGALS) is a virtual application of the pediatric gait, arms, leg, and spine (pGALS) examination performed by video. We aimed to verify the applicability, validity, and accuracy of the Turkish translation of v-pGALS in a large pediatric patient cohort.</p><p><strong>Materials and methods: </strong>Children aged 4-18 years seen between May and June 2022 were included. A hands-on physical examination and v-pGALS were performed. Demographics, active symptoms, physical examination findings, diagnosis, and v-pGALS findings were recorded. The acceptability of v-pGALS, in terms of additional distress and duration, was measured by the parent/patient using a visual analog scale (VAS).</p><p><strong>Results: </strong>102 patients (median age 12.41 years) were included. Juvenile idiopathic arthritis (JIA) was the most common diagnosis. The median duration of v-pGALS was 7 min. An abnormal v-pGALS was identified in 25 patients while the hands-on physical examination was abnormal in 27 patients. Scoliosis and pes planus were missed in v-pGALS. Both children and parents gave a median VAS score of 0 for additional discomfort and duration. That is, the duration of v-pGALS was acceptable for ≥98% of the patients/parents, and ≥98% mentioned that it caused little/no discomfort. The sensitivity and specificity of v-pGALS were 92.6% and 100%, respectively, for the detection of musculoskeletal (MSK) abnormalities.</p><p><strong>Conclusion: </strong>The v-pGALS is an applicable, accurate, and practical tool for evaluating MSK problems in children. The Turkish translation was also conveniently acceptable.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of WWOX contributes to cisplatin resistance in triple-negative breast cancer cells by modulating miR-182 and miR-214.","authors":"Bahadır Batar, Elif Serdal, Berna Erdal, Hasan Oğul","doi":"10.55730/1300-0144.5891","DOIUrl":"https://doi.org/10.55730/1300-0144.5891","url":null,"abstract":"<p><strong>Background/aim: </strong>WW domain-containing oxidoreductase (WWOX) loss frequently occurs in triple-negative breast cancer (TNBC). WWOX loss enhances cisplatin resistance in TNBC patients. Although WWOX loss has an effect on the selection of a DNA repair pathway that contributes to enhanced mutagenesis, the downstream expression changes in resistant cancer cells have not been fully explored. This study aimed to investigate the potential role of microRNAs (miRNAs) in the regulation of cisplatin resistance in WWOX-deficient TNBC cells.</p><p><strong>Materials and methods: </strong>Transient transfections were performed to overexpress WWOX in MDA-MB-231 cells. WWOX-overexpressing MDA-MB-231 cells were determined by western blot. Expression profiling of the miRNA was assessed via real-time polymerase chain reaction.</p><p><strong>Results: </strong>miRNA expression profiling of WWOX-deficient and -sufficient MDA-MB-231 cells revealed that miR-182 upregulation and miR-214 downregulation were markedly positively associated with cisplatin resistance of WWOX-deficient MDA-MB-231 cells. An elevated expression of miR-182 and decreased expression of miR-214 may contribute to cisplatin resistance in WWOX-absent MDA-MB-231 cells by signaling pathway dysregulation of DNA repair/apoptosis/ protein kinase B (AKT).</p><p><strong>Conclusion: </strong>The results emphasize that WWOX deficiency promotes resistance to cisplatin in TNBC cells and the possible predicting biomarker of WWOX for resistance to cisplatin.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maternal muscle strength on cesarean delivery outcomes: a comparative study of nulliparous women.","authors":"Gülsemin Ertürk Çelik, Sezin Ertürk Aksakal, Yaprak Engin Üstün","doi":"10.55730/1300-0144.5867","DOIUrl":"https://doi.org/10.55730/1300-0144.5867","url":null,"abstract":"<p><strong>Background/aim: </strong>This study explored the correlation between maternal muscle mass and strength and the mode of delivery in childbirth. Specifically, it focused on full-term nulliparous pregnant women, analyzing ultrasonographic measurements of the quadriceps femoris muscle together with serum myostatin levels and muscle strength as determined by a handgrip test. The aim was to discern whether these factors could influence the likelihood of delivering vaginally or via cesarean section.</p><p><strong>Materials and methods: </strong>This study included 86 healthy nulliparous women at term, categorizing them into two groups based on their mode of delivery: vaginal delivery (58 women, Group 1) and cesarean section (28 women, Group 2). Comparative analyses of demographic information, delivery characteristics, ultrasonographic measurements of the quadriceps femoris, limb circumferences, handgrip strength, and serum myostatin concentrations were conducted.</p><p><strong>Results: </strong>The findings revealed that women in Group 1 had less gestational weight gain but greater handgrip strength compared to Group 2. Additionally, women who underwent cesarean section due to nonprogressive labor had greater arm and calf circumferences relative to those who had vaginal deliveries.</p><p><strong>Conclusion: </strong>The data of this study suggest a trend whereby lower maternal muscle strength and mass are associated with a decreased likelihood of vaginal delivery in pregnant women.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyoscine-n-butylbromide in treating abdominal pain caused by gastroenteritis: a double-blind randomized placebo-controlled study.","authors":"Çağdaş Yildirim, Gül Pamukçu Günaydin","doi":"10.55730/1300-0144.5864","DOIUrl":"https://doi.org/10.55730/1300-0144.5864","url":null,"abstract":"<p><strong>Background/aim: </strong>Hyoscine-N-butylbromide (HBB) is an anticholinergic agent widely used to treat pain caused by spasms in the gastrointestinal and urogenital systems. The aim of this study was to compare the efficacy of HBB with a placebo in treating abdominal cramping pain caused by acute gastroenteritis in the emergency department (ED).</p><p><strong>Materials and methods: </strong>This was a prospective, double-blind, placebo-controlled, randomized trial conducted in a single-center academic ED from September to November 2021. Patients aged 18-65 years with acute gastroenteritis symptoms were included. The study compared the efficacy of intravenous HBB (20 mg) to a placebo. The primary outcome was the absolute change in pain score at 30 min after treatment, with secondary outcomes including pain relief at 60 min, adverse events, and the need for rescue analgesics.</p><p><strong>Results: </strong>Fifty patients were randomized (25 in each group). There was no significant difference in 30-min and 60-min pain scores between the groups. At 60 min, pain reduction and the need for rescue analgesia were similar in both groups. Changes in pain scores from admission to 30 and 60 min did not significantly differ between the groups.</p><p><strong>Conclusion: </strong>Intravenous HBB did not show a statistically or clinically significant difference in pain reduction compared to a placebo in patients with acute gastroenteritis and cramping abdominal pain in the ED.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of gait speed and handgrip strength with falls in older adults: the role of cognition.","authors":"Neslihan Kayahan Satiş, Sultan Keskin Demircan, Mehmet İlkin Naharci","doi":"10.55730/1300-0144.5882","DOIUrl":"https://doi.org/10.55730/1300-0144.5882","url":null,"abstract":"<p><strong>Background/aim: </strong>Fall risk assessment is crucial for older adults because falls are associated with morbidity and mortality. This study investigated the relationship of gait speed (GS) and handgrip strength (HGS) with falls and assessed whether cognition mediates this causality.</p><p><strong>Materials and methods: </strong>The study was conducted in a tertiary referral geriatric outpatient clinic. The physical performance of participants was evaluated by GS and HGS. All falls in the previous year were noted and factors associated with falls were analyzed using multivariate regression analysis.</p><p><strong>Results: </strong>A total of 1018 older adults with a mean age of 78.8 ± 7.2 years, 64.2% of whom were female, were stratified into two groups: those who were cognitively impaired (n = 331) and those who were cognitively healthy (n = 660). In the study population, 22.8% (n = 226) had a history of falls in the previous year. The rates of low GS and HGS were 29.1% and 80.6%, respectively. After adjusting for confounding factors, low GS (OR = 2.01, 95% CI: 1.10-3.77, p = 0.019), low HGS (OR = 3.57, 95% CI: 1.10-11.35, p = 0.038), and low GS plus low HGS (OR = 4.52, 95% CI: 1.14-15.78, p = 0.024) in the cognitively impaired group and low GS (OR = 2.13, 95% CI: 1.39-3.52, p = 0.003) in the cognitively healthy group were independently associated with falls.</p><p><strong>Conclusion: </strong>GS is an efficient and practical assessment tool for identifying older adults at risk of falls regardless of their cognitive status.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can prothrombotic gene variants and Apoa1 rs5069 polymorphism be the predictors of early myocardial infarctions?","authors":"Hüseyin Balcioğlu, Elif Fatma Özkan Pehlivanoğlu, Uğur Bilge, Kadir Uğur Mert, Muhammet Dural, Ebru Erzurumluoğlu Gökalp, Oğuz Çilingir, Sevilhan Artan","doi":"10.55730/1300-0144.5837","DOIUrl":"https://doi.org/10.55730/1300-0144.5837","url":null,"abstract":"<p><strong>Background/aim: </strong>We aimed to determine the genetic risk factors in patients aged 45 years and below with a history of early myocardial infarction (MI), compared to individuals over 60 years of age with no history of MI.</p><p><strong>Materials and methods: </strong>In this study, we selected different age groups to more clearly distinguish genetic differences. Accordingly, we compared individuals who had experienced MI at an early age with those who were older and had not experienced any cardiovascular events. The patient group consisted of 99 volunteers under the age of 45 with a history of MI, while the control group included 99 volunteers aged 60 and over without a history of MI. MTHFR (C677T, A1298C), Factor V Leiden (G1691A), Prothrombin (G20210A), PAI (4G/5G), Factor XIII (V34L), APOA1 (rs670, rs1799837, rs5069), and APOB were studied using blood samples taken from the patients.</p><p><strong>Results: </strong>In the logistic regression analysis of thrombophilia markers and gene polymorphisms in the patient and control groups, no statistically significant increase was observed in markers other than APOA1 rs5069 gene polymorphism. APOA1 rs5069 gene polymorphism was found to be higher in the patient group than those without this polymorphism. The frequencies of homozygous MTHFR (C677T, A1298C) and heterozygous Factor XIII V34L were higher in the patient cohort compared to the controls.</p><p><strong>Conclusion: </strong>In our study, we found that prothrombotic gene variants and APOA1 rs5069 polymorphism were statistically significantly associated with coronary artery disease. Thus, prothrombotic gene variants and APOA1 rs5069 polymorphism may serve as predictors of early myocardial infarctions. Individuals with early family histories of coronary artery disease could be screened for these mutations.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}