Turkish Journal of Medical Sciences最新文献

{"title":"Administration of adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells in anosmic mice.","authors":"Burak Hazir, Alper Ceylan, Emin Ümit Bağriaçik, Duygu Dayanir, Betül Öğüt, Nihan Örüklü, Mücahit Yalçin, Berkay Şimşek, Muammer Melih Şahin","doi":"10.55730/1300-0144.6028","DOIUrl":"10.55730/1300-0144.6028","url":null,"abstract":"<p><strong>Background/aim: </strong>Anosmia, a serious condition that affects the sense of smell, has no universally agreed-upon treatment. Adult stem cells are considered a potential option for treating anosmia. This study aims to evaluate the efficacy of mesenchymal stem cells derived from different tissues in an anosmic mouse model induced by 3-methylindole (3-MI).</p><p><strong>Materials and methods: </strong>In our study, 36 mice with 3-MI-induced anosmia were divided into subgroups. Anosmia was confirmed by performing a food-finding test (FFT) in each group. Intranasal phosphate-buffered saline was administered to the first group, adipose tissue-derived mesenchymal stem cells (ADSCs) to the second group, and bone marrow-derived mesenchymal stem cells (BMSCs) to the third group. Stem cells were obtained from green fluorescent protein (GFP)-transgenic mice. Olfactory function was evaluated weekly using the FFTs. Mice were sacrificed at the second and fourth weeks following 3-MI injection and examined histopathologically.</p><p><strong>Results: </strong>Compared to the control group, stem cell-transplanted groups demonstrated significantly improved food-finding times measured at week 2 and week 4 FFTs following the 3-MI injection (respectively; p = 0.001, p = 0.008). Additionally, increased olfactory marker protein expression and olfactory epithelial thickness, along with reduced epithelial damage, were observed in the stem cell-transplanted groups compared to the control group (p < 0.05). Histologically, BMSCs showed greater efficacy than ADSCs in promoting olfactory regeneration. Furthermore, GFP+ cells were detected in the olfactory epithelium and olfactory bulbs of the stem cell-transplanted groups.</p><p><strong>Conclusion: </strong>It was observed that intranasally transplanted stem cells could reach the damaged olfactory region and enhance olfactory regeneration and functional recovery. Both ADSCs and BMSCs were effective in treatment and appear to be promising therapeutic modalities.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"792-801"},"PeriodicalIF":1.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study for the examination of peripheral blood smear samples in pediatric population using artificial intelligence.","authors":"Elif Habibe Aktekin, Mert Burkay Çöteli, Ayşe Erbay, Nalan Yazici","doi":"10.55730/1300-0144.5982","DOIUrl":"https://doi.org/10.55730/1300-0144.5982","url":null,"abstract":"<p><strong>Background/aim: </strong>Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS samples while increasing the sensitivity and specificity rates of the experts as a decision support system of a prediagnostic tool.</p><p><strong>Materials and methods: </strong>The methodology of this study comprises three steps for the creation of an effective learning technique for blood cell disorders. First is the digitization of PBS samples in 100x optical-digital magnification using Mantiscope which is a cloud-based slide scanner system. The second is collection of pediatric hematology experts' annotations and the last one is data augmentation to increase the data variation and size. The data consists of 372 individuals, an approximate number of 12,000 annotated images with 500,000 blood cell objects. A subjective test is also performed to observe the interobserver variability.</p><p><strong>Results: </strong>We measured sensitivity and specificity for 28 cell types for the resulting decision support system. We obtained sensitivity 98% for myeloblast, 94% for basophil and 90% for lymphoblast, specificity 99% for basophil, eosinophil, monocyte, hypersegmented neutrophil, band neutrophil and reactive neutrophil in leukocyte subtypes. When erythrocyte measurements were evaluated, it was found that the sensitivity was 93% for normoblast, 81% for target cell and pencil cell, 80% for sickle cell, specificity was 99% for normoblast, pencil cell, echinocyte, and sickle cell.</p><p><strong>Conclusion: </strong>It is observed that sensitivity and specificity greater than 90% can be obtained for some specific cell types with this clinical study. It is seen that data augmentation increases the effectiveness of the learning method in terms of leukocytes by improving the measurement metrics. This could be a valuable technique to evaluate acute leukemias and hemolytic disorders.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"386-397"},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of colchicine in cardiovascular health: trends, key contributors, and global collaborations.","authors":"Meltem Sertbaş, Özlem Özaydin, Habip Yilmaz, Abdullah Emre Güner, Özden Güdük, Nalan Okuroğlu, Ali Özdemir, Yaşar Sertbaş","doi":"10.55730/1300-0144.6003","DOIUrl":"10.55730/1300-0144.6003","url":null,"abstract":"<p><strong>Background/aim: </strong>The study aims to systematically analyze the body of literature concerning the effects of colchicine on the cardiovascular system, providing a comprehensive evaluation of the current knowledge and highlighting the clinical and scientific relevance of colchicine in this field.</p><p><strong>Materials and methods: </strong>Data were obtained from the Web of Science (WOS), Scopus, and PubMed databases on March 17, 2025. The search terms included \"Colchicine\" AND (\"Cardiovascular Diseases\" OR \"Heart Diseases\" OR \"Coronary Artery Disease\" OR \"Myocarditis\" OR \"Pericarditis\" OR \"Atherosclerosis\" OR \"Heart Failure\" OR \"Myocardial Infarction\" OR \"Ischemic Heart Disease\" OR \"Acute Coronary Syndrome\" OR \"Cardiac Arrhythmias\" OR \"Thrombosis\" OR \"Stroke\"). No restrictions were applied regarding publication date or language, ensuring the comprehensive retrieval of relevant data. Publications were categorized according to their document type and indexes. Additionally, a cooccurrence analysis of key words was conducted using VOSviewer 1.6.18.</p><p><strong>Results: </strong>A total of 425 publications on the effects of colchicine on the cardiovascular system were identified, published between 1976 and 2025. There has been a significant increase in research since 2015. Most publications were in the Cardiac Cardiovascular Systems category. \"Colchicine\" was the most frequently used key word, appearing 170 times. The USA ranked first in publication count, with 163 studies. The USA, Italy, Canada, and China played significant roles in global research collaboration.</p><p><strong>Conclusion: </strong>This bibliometric analysis demonstrates the increasing importance of colchicine as a therapeutic agent in the management of cardiovascular disease.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"559-571"},"PeriodicalIF":1.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating leflunomide and methotrexate combination vs. monotherapy in rheumatoid and psoriatic arthritis.","authors":"Mete Kara, Gülay Alp, Mete Pekdiker, Sertaç Ketenci, Annamaria Porreca, Haluk Cinakli","doi":"10.55730/1300-0144.6010","DOIUrl":"10.55730/1300-0144.6010","url":null,"abstract":"<p><strong>Background/aim: </strong>Methotrexate (MTX) and leflunomide (LEF) are conventional synthetic disease-modifying antirheumatic drugs (DMARDs) commonly used for treating rheumatoid arthritis (RA) and psoriatic arthritis (PsA), either as monotherapies or in combination. This study aimed to compare the adverse effects (AEs) and efficacy of combined use of MTX plus LEF with monotherapy in RA and PsA patients.</p><p><strong>Materials and methods: </strong>This study included 528 patients (385 RA and 143 PsA) with at least 6 months of follow-up. Disease activity was assessed using DAS-28 CRP and DAPSA, and treatment-related AEs were classified based on specific MedDRA categories.</p><p><strong>Results: </strong>The cumulative incidence of AEs in patients with RA treated with MTX, LEF, and MTX plus LEF was 23.8%, 28.2%, and 19.2%, respectively; in PsA patients, 18.1%, 30%, and 23.3%, respectively. None of the groups were superior to each other in terms of general AEs between monotherapy and in combination. LEF monotherapy in RA was associated with more neurological AEs and hypertension. Compared to monotherapy, MTX plus LEF demonstrated greater reductions in disease activity, a more substantial decrease in glucocorticoid doses, and lower utilization of biological/targeted DMARDs (b/tsDMARDs) in both RA and PsA. In univariate analysis, MTX dosage, initial DAS28 CRP, and b/tsDMARD initiation were predictors of low disease activity (LDA) in RA. In multivariate analysis, MTX dosage (95% CI 1.02-1.59, OR = 1.27, p = 0.031) and initial DAS28-CRP (95% CI 2.14-10.90, OR = 4.38, p < 0.001) were found to be independently associated with LDA in RA. In PsA, the factors associated with LDA were initial DAPSA and disease duration in univariate analysis. Only disease duration was found to be an independent predictor in multivariate analysis (95% CI, 1.02-1.38, OR = 1.17 p = 0.039).</p><p><strong>Conclusion: </strong>Adding LEF to MTX or vice versa may serve as a valuable, safe, and effective alternative in situations where b/tsDMARD therapy is challenging.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"632-643"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does dexmedetomidine infusion reduce the postoperative analgesic need in lumbar disc surgery?","authors":"Sibel Çatalca, Özlem Özmete, Numan Berk, Soner Çivi, Emre Durdağ, Caner Incekaş, Nesrin Bozdoğan Özyilkan","doi":"10.55730/1300-0144.5991","DOIUrl":"https://doi.org/10.55730/1300-0144.5991","url":null,"abstract":"<p><strong>Background/aim: </strong>Patients experience moderate-to-severe pain, especially in the first days after lumbar disc surgery. Poorly controlled pain in the postoperative period negatively affects patient outcomes. Dexmedetomidine is a highly selective α2 adrenoceptor agonist with demonstrated analgesic efficacy. However, conflicting results have been reported in the current literature regarding the efficacy of dexmedetomidine in this surgery. In this study, we tested the hypothesis that dexmedetomidine safely improves pain scores and reduces opioid consumption in lumbar microdiscectomy.</p><p><strong>Materials and methods: </strong>Medical records of patients who underwent lumbar microdiscectomy with general anesthesia between January 2023 and October 2023 were retrospectively reviewed. Patients who met the inclusion criteria were divided into two groups as those who did not receive dexmedetomidine infusion (Group A) and those who received dexmedetomidine infusion (Group B). Patients in Group B received a loading dose of 1 μg/kg dexmedetomidine followed by a maintenance infusion of 0.5 μg/kg/h. The primary outcome of our study was postoperative fentanyl consumption at the 24^th h. Secondary outcomes of our study included need for fentanyl in the recovery unit, postoperative pain scores at the 2^nd, 6^th, 12^th, and 24^th h and fentanyl consumption at the 2^nd, 6^th, and 12^th h and perioperative complications.</p><p><strong>Results: </strong>A total of 68 patients were included in our study, 34 patients in each group. The number of patients requiring fentanyl in the recovery unit and the dose of fentanyl administered were similar in both groups (p = 0.223 and p = 0.373, respectively). There was no statistical difference in the pain scores, opioid consumption, and perioperative complications at the 2^nd, 6^th, 12^th, and 24^th h after surgery in patients receiving dexmedetomidine compared to the control group (p > 0.05).</p><p><strong>Conclusion: </strong>Intraoperative dexmedetomidine infusion did not reduce postoperative pain intensity and opioid consumption in patients undergoing lumbar microdiscectomy under general anesthesia.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"470-481"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery wall thickness and systemic sclerosis: influence of inflammation on vascular changes.","authors":"Elif Altunel Kilinç, Haydar Ali Candan, İpek Türk, Çağlar Özmen","doi":"10.55730/1300-0144.6011","DOIUrl":"10.55730/1300-0144.6011","url":null,"abstract":"<p><strong>Background/aim: </strong>Systemic sclerosis (SSc) is a complex autoimmune disease marked by vascular abnormalities and fibrosis. This study aimed to compare pulmonary artery wall thickness (PAWT) among SSc patients without PAH, patients with idiopathic PAH (IPAH), and healthy controls, and to explore the clinical implications of increased PAWT in SSc patients.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 60 SSc patients, 30 patients with IPAH, and 40 age- and sex-matched healthy controls. All participants underwent transthoracic echocardiographic assessment. In SSc patients, modified Rodnan skin score (mRSS), demographic characteristics, disease duration, type of skin and lung involvement, and autoantibody status were analyzed.</p><p><strong>Results: </strong>PAWT was significantly higher in the SSc group than in the control group. There was a strong correlation between PAWT and mRSS, with mRSS identified as an independent risk factor for increased PAWT. Additionally, a correlation was found between PAWT and echocardiographic parameters, particularly systolic pulmonary artery pressure (sPAP).</p><p><strong>Conclusion: </strong>PAWT is elevated in SSc patients compared to healthy controls. This may be associated with underlying vascular and fibrotic changes in SSc. Furthermore, the strong correlation between PAWT and echocardiographic markers of PAH suggests that PAWT could serve as a predictive marker for future PAH. In addition, the strong correlation between increased PAWT and mRSS suggests that elevated PAWT may represent a vascular component of SSc. Future longitudinal studies are needed to clarify the clinical significance of PAWT in SSc and to define its potential role in disease management.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"644-651"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-40 levels in treatment-naive and methotrexate-treated rheumatoid arthritis patients.","authors":"Hamdi Oğuzman, Mete Pekdiker","doi":"10.55730/1300-0144.6013","DOIUrl":"10.55730/1300-0144.6013","url":null,"abstract":"<p><strong>Background/aim: </strong>Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by persistent inflammation and progressive damage to the joints. In this study, it was aimed to explore the role of interleukin (IL)-40, a newly discovered cytokine, in the pathogenesis of RA. We also aimed to investigate the relationship between IL-40 and other cytokines such as IL-4, transforming growth factor (TGF)-β1 and tumor necrosis factor (TNF)-α.</p><p><strong>Materials and methods: </strong>This single-center, cross-sectional study included 87 participants divided into three groups: healthy controls (n = 29), newly diagnosed RA patients (n = 29), and RA patients with remission under methotrexate (MTX) monotherapy (n = 29). Serum samples were collected and analyzed for IL-40, IL-4, TGF-β1 and TNF-α levels using ELISA. Disease activity score, presence of autoantibodies and other relevant clinical data were obtained from hospital electronic records.</p><p><strong>Results: </strong>Elevated IL-40 levels were found in the newly diagnosed RA patients and in those treated with MTX compared to the control group (p < 0.001). Logistic regression analysis confirmed IL-40 as an independent predictor in the newly diagnosed (OR = 1.023, 95% CI: 1.010-1.035, p = 0.002) and RA MTX-treated patients (OR = 1.023, 95% CI: 1.011-1.036, p < 0.001). IL-40 levels remained unchanged in the newly diagnosed RA group compared to RA patients in the MTX-treated group. In the dual-seropositive patients, TGF-β1 was lower in the MTX-treated RA patients compared to the naive patients (p = 0.013) and in the dual-seronegative patients, TNF-α was decreased in the MTX-treated RA patients in comparison to naive patients (p = 0.043).</p><p><strong>Conclusion: </strong>This study demonstrates that IL-40 levels are elevated in RA patients and highlights its potential role in RA. The fact that IL-40 levels did not change despite the antiinflammatory effects of MTX suggests that IL-40 is involved in immunological pathways that are less responsive to treatment.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"658-665"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of liraglutide on expressions of insulin secretion and beta cell survive associated GPCR genes in pancreatic beta cells.","authors":"Melikenur Türkol, Türker Bilgen","doi":"10.55730/1300-0144.5997","DOIUrl":"https://doi.org/10.55730/1300-0144.5997","url":null,"abstract":"<p><strong>Background/aim: </strong>Liraglutide as a long-acting glucagon-like peptide drug has anti-hyperglycemic and antiobesity effects. G protein-coupled receptors (GPCRs) are well-known drug target molecules that conduct critical signaling pathways related with diseases. Research has confirmed the role of many GPCRs genes in the regulation of pancreatic beta cell functions and insulin secretion. Liraglutide dependent expressional changes in GPCR genes may let us determine new drug targets.</p><p><strong>Materials and methods: </strong>Therefore, we investigated the changes in expression of GPR75, GPR56, GLP1R, M3R, and CB1R genes, which are the GPCR family members, in response to liraglutide treatment in the NIT-1 mouse pancreatic beta cells in this study. Changes at the mRNA levels of these GPCR genes were determined by a qPCR and the ddCT method, and using a control gene and untreated control groups.</p><p><strong>Results: </strong>We found statistically significant increases at the mRNA levels of GPR75, GPR56, M3R, and CB1R genes with 10nM of liraglutide at min 60, while there was no time and dose-dependent change in all of the genes investigated. We detected that the GLP1R gene expressions were stable amongst different time points and doses of liraglutide, except for a statistically significant decrease in the GLP1R gene expression in response to 1000nM of liraglutide treatment compared to 10nM and 100nM concentrations.</p><p><strong>Conclusion: </strong>Our results indicate that in vitro liraglutide administration in pancreatic beta cells appears to increase the expressions of GPR75, GPR56, M3R and CB1R genes which have already been related to insulin secretion and beta cell survive. Liraglutide may exert this effect through the GLP1R or other cellular pathways undescribed yet. Combined usage of liraglutide and the specific ligands of GPR75, GPR56, M3R, and CB1R may provide a better response in terms of insulin secretion and beta cell survival, making them good targets for antidiabetic and antiobesity therapy.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"525-530"},"PeriodicalIF":1.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein Barr virus associated venous thromboembolism.","authors":"Yeliz Çiçek, Ali Mert","doi":"10.55730/1300-0144.5998","DOIUrl":"https://doi.org/10.55730/1300-0144.5998","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"531-532"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the hemoglobin-albumin-lymphocyte-platelet (HALP) score in deep neck infections and its relationship with clinical parameters.","authors":"Ayşe Seçil Kayali Dinç, Nagihan Gülhan Yaşar, Agah Yeniçeri, Çetin Şahutoğlu, İbrahim Sevim, Melih Çayönü","doi":"10.55730/1300-0144.6024","DOIUrl":"10.55730/1300-0144.6024","url":null,"abstract":"<p><strong>Background/aim: </strong>Deep neck infections (DNI) are suppurative infections of the cervical spaces, which may lead to life-threatening complications. The HALP score is a laboratory parameter reflecting a patient's nutritional and inflammatory status. The aim of this study was to compare the HALP scores of patients with DNI with those of a control group. A secondary objective was to investigate the potential relationship between the HALP score and clinical parameters, and to assess its role in determining disease severity.</p><p><strong>Materials and methods: </strong>The study retrospectively included patients who were hospitalized and treated for DNI. Data were extracted from the hospital's electronic records. The control group comprised patients admitted for surgery with a diagnosis of septal deviation. Patients with DNI were designated as Group 1, and the control subjects as Group 2. HALP scores were calculated using a defined formula. The HALP scores of patients with DNI were compared with those of the control group, and the relationship between the HALP score and various clinical parameters was subsequently evaluated.</p><p><strong>Results: </strong>A total of 433 patients were included in the study. The groups were similar in terms of number of patients, age, and sex. Hemoglobin, albumin, lymphocyte count, and HALP scores were significantly lower in Group 1, whereas leukocyte, neutrophil, monocyte, and platelet counts were significantly higher. A negative correlation was observed between the HALP score and length of hospital stay (r = -0.293, p < 0.01), abscess dimensions (height: r = -0.271; length: r = -0.267, p < 0.01), and CRP levels (r = -0.222, p < 0.01).</p><p><strong>Conclusion: </strong>Patients with DNI exhibited lower HALP scores than the normal population. HALP scores below 46.14 were significantly associated with indicators of severe disease, including an elevated inflammatory response, larger abscess size, and prolonged hospital stay.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"754-759"},"PeriodicalIF":1.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}