Turkish Journal of Medical Sciences最新文献

{"title":"Boric acid enhances the antitumor effects of paclitaxel by modulating apoptosis, autophagy-related protein expression, and proinflammatory cytokine expression in OVCAR-3 ovarian cancer cells.","authors":"Nazmiye Bitgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Melike Akbulut, Arzu Yay","doi":"10.55730/1300-0144.6377","DOIUrl":"10.55730/1300-0144.6377","url":null,"abstract":"<p><strong>Background/aim: </strong>Ovarian cancer is the eighth most prevalent malignancy among women globally and ranks third among gynecological cancers in terms of incidence. The limited efficacy of standard chemotherapy, primarily due to intrinsic drug resistance and high recurrence rates, highlights the urgent need for novel therapeutic strategies that are both effective and selectively cytotoxic.</p><p><strong>Materials and methods: </strong>This study aimed to investigate the combined effects of boric acid (BA), a biologically active boron compound with emerging antitumor potential, and paclitaxel (PTX), a conventional chemotherapeutic agent, on cell viability, cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling in the chemoresistant OVCAR-3 ovarian cancer cell line. OVCAR-3 cells were treated with increasing concentrations of BA over varying time periods. The half-maximal inhibitory concentrations (IC₅₀) of both BA and PTX were determined using the MTT assay. Flow cytometry was employed to assess cell cycle distribution and apoptosis via Annexin V staining. Additionally, immunofluorescence staining was performed to evaluate the expression of autophagy-related proteins (Beclin-1, LC3, and p62) and proinflammatory cytokines (TNF-α, IL-6, and IL-1β).</p><p><strong>Results: </strong>The combination of BA and PTX resulted in significant G₀/G₁ phase cell cycle arrest and a marked increase in apoptotic cell death and the expression of autophagy-related proteins, leading to reduced cell viability in OVCAR-3 cells. Furthermore, cotreatment significantly modulated the expression of proinflammatory cytokines, suggesting a potential immunomodulatory effect associated with the observed cytotoxicity.</p><p><strong>Conclusion: </strong>The findings of this study provide evidence that boric acid enhances the antitumor efficacy of paclitaxel in drug-resistant ovarian cancer cells through coordinated modulation of cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling. These findings support the potential of BA as a promising adjuvant for combination chemotherapy in ovarian cancer.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1332-1342"},"PeriodicalIF":1.4,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide characteristics of infectious disease patients transported by helicopter ambulance in Türkiye.","authors":"Ayşe Gülden Bekgöz, Kerem Dost Bilmez, Muhammed Saltuk Deniz","doi":"10.55730/1300-0144.6369","DOIUrl":"10.55730/1300-0144.6369","url":null,"abstract":"<p><strong>Background/aim: </strong>To evaluate the clinical, demographic, and operational characteristics of patients with infectious diseases transported by helicopter ambulance and to examine differences in the transfer patterns, flight durations, and diagnostic categories.</p><p><strong>Materials and methods: </strong>Registry data of patients with infectious diseases transported by helicopter ambulance were analyzed. Demographic characteristics, diagnoses, referring and receiving hospital types, intraprovincial and interprovincial transfer status, flight durations, and temporal distribution of transfers (hours, days, and months) were evaluated. Flight duration was calculated in minutes and compared between intraprovincial and interprovincial transfers.</p><p><strong>Results: </strong>A total of 543 patients with infectious diseases were transported by helicopter ambulance. Respiratory tract infections were the most common diagnostic group, followed by coronavirus disease 2019. Of the patients, 72.9% were transported within the same province, while 27.1% were transferred between provinces. The overall median helicopter flight duration was 63 min (interquartile range (IQR): 45-87). Interprovincial transfers had significantly longer flight durations compared with intraprovincial transfers (median: 115 min (IQR: 63-222.5) vs. 57 min (IQR: 41-71); p < 0.001). In multivariable analysis, patients diagnosed with meningoencephalitis were more likely to be transferred to interprovincial centers (odds ratio (OR): 4.77; 95% confidence interval (CI): 1.26-18.07), whereas patients with sepsis (OR: 0.11; 95% CI: 0.03-0.48) and skin and soft tissue infections (OR: 0.08; 95% CI: 0.01-0.93) were more commonly managed with intraprovincial transfers.</p><p><strong>Conclusion: </strong>The findings indicate that helicopter ambulance use for patients with infectious diseases is applied through a selective and needs-based approach. In time-critical and high-risk infections such as meningoencephalitis, helicopter ambulance transport appears to be an important component of the healthcare system by facilitating access to appropriate referral centers. Differences between intraprovincial and interprovincial transfers suggest that air ambulance utilization is determined not only by distance and geography but also by the need for specialized care and advanced treatment capabilities.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1245-1254"},"PeriodicalIF":1.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hidden danger in cancer patients: intestinal parasites.","authors":"Aslı Geçgel, Ayşe Merve Parmaksizoğlu Aydin, Ahmet Türk, Esra Erdem Kivrak, Gökhan Vatansever, Nevin Turgay, Erdem Göker, Meltem Taşbakan","doi":"10.55730/1300-0144.6370","DOIUrl":"10.55730/1300-0144.6370","url":null,"abstract":"<p><strong>Background/aim: </strong>Intestinal parasites are a significant cause of morbidity and mortality in immunosuppressed individuals. This study aimed to evaluate the frequency, distribution, and associated clinical factors of intestinal parasite detection among patients with solid tumors who presented with diarrhea over a 10-year period.</p><p><strong>Materials and methods: </strong>This retrospective study included patients aged ≥18 years with solid tumors who presented with diarrhea and had stool samples examined at the Ege University Medical Parasitology Laboratory between January 2014 and September 2024. Patients with incomplete records or inadequate stool processing were excluded. Demographic, clinical, and treatment data were retrieved from electronic medical records and analyzed using SPSS version 22.0 (IBM Corp., Armonk, NY, USA).</p><p><strong>Results: </strong>Among 154 patients (mean age, 57.2 ± 16.3 years; 57.1% female), intestinal parasites were detected in 22.1% of patients (n = 34), with <i>Cryptosporidium</i> spp. (16.9%) and <i>Entamoeba</i> spp. or the <i>E. histolytica/E. dispar</i> complex (2.6%) being the most frequently identified organisms. <i>Cryptosporidium</i> spp. showed a borderline, nonsignificant trend toward a higher detection rate among patients with gastrointestinal system (GIS) malignancies (p = 0.067). No clinical or treatment-related variable was significantly associated with overall intestinal parasite detection in either categorical comparisons or univariate logistic regression. However, borderline, nonsignificant trends were observed for GIS malignancy (OR: 1.994; 95% CI: 0.917-4.336; p = 0.079) and recent hospitalization (OR: 0.482; 95% CI: 0.221-1.050; p = 0.066). In patients with available follow-up, clinical improvement was observed after antiparasitic or symptomatic treatment.</p><p><strong>Conclusion: </strong>Among patients with solid tumors presenting with diarrhea, intestinal parasitic infections should be considered in the differential diagnosis. Early parasitological evaluation and increased oncologist awareness may facilitate timely treatment, symptom control, and prevention of complications.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1255-1263"},"PeriodicalIF":1.4,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory evaluation of miR-146, inflammatory biomarkers, and subjective cognitive symptoms in chronic migraine.","authors":"Hale Gök Dağidir, Duygu Bandirmali, Merve Hilal Ceren Akgör, Doğa Vuralli, Meltem Yalinay, Güvem Gümüş Akay, Hayrunnisa Bolay","doi":"10.55730/1300-0144.6378","DOIUrl":"10.55730/1300-0144.6378","url":null,"abstract":"<p><strong>Background/aim: </strong>Chronic migraine (CM) is a disabling neurological disorder associated with substantial impairment of quality of life. Increasing evidence suggests that inflammatory and epigenetic mechanisms may contribute to migraine pathophysiology. miR-146, a microRNA involved in the TLR-4/NFkb pathway, is known to regulate proinflammatory signaling, whereas HMGB1 activates inflammatory pathways through TLR2 and TLR4 receptors. IL-17 is another proinflammatory cytokine implicated in both inflammation and cognitive processes. In this research, our aim was to investigate the relationship between serum HMGB1, IL-17, and miR-146 levels and migraine-related subjective cognitive symptoms in patients with CM.</p><p><strong>Materials and methods: </strong>Serum samples were collected from 20 CM patients and 15 age-matched healthy controls. All the participants were female. Medical history, Mini-Mental State Examination (MMSE) scores, and migraine attacks - subjective cognitive impairments scale (Mig-SCog) scores were recorded. Serum HMGB1 and IL-17 levels were measured using an enzyme-linked immunosorbent assay. A quantitative real-time polymerase chain reaction was used to measure serum miR-146 levels. Statistical analysis of the data was conducted with SPSS 25.0. The relationships between Mig-SCog scores and serum HMGB1, IL-17, and miR-146 levels were investigated.</p><p><strong>Results: </strong>Serum HMGB1 levels were significantly elevated in the CM group compared to the control group (p = 0.012). However, no significant differences were observed between the two groups for serum IL-17 (p = 0.737) or miR-146 levels (p = 0.560). There was no significant correlation between HMGB1 and IL-17 (r = 0.167) or HMGB1 and miR146 levels (r = 0.073). Mig-SCog scores (p = 0.001) differed significantly between the groups and were positively correlated with HMGB1 levels (r = 0.403).</p><p><strong>Conclusion: </strong>Serum HMGB1 levels were elevated in CM patients and were associated with migraine-related subjective cognitive complaints, whereas no significant association was observed with miR-146 or IL-17 levels. These findings support a potential role of HMGB1 in migraine-related neuroinflammatory processes. Further studies are needed to clarify the relationship between inflammatory pathways and cognitive symptoms in migraine.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1343-1351"},"PeriodicalIF":1.4,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss in Behçet's syndrome: prevalence and associated factors in a nationwide cross-sectional analysis.","authors":"Alper Doğanci, Serdar Can Güven, Nuray Yilmaz Çakmak, Nurhan Güven, Salih Başer, Neslihan Öztürk, Şuayip Birinci, Naim Ata","doi":"10.55730/1300-0144.6339","DOIUrl":"10.55730/1300-0144.6339","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim of this study was to investigate the prevalence of hearing loss in Behçet's syndrome and its associations with other disease manifestations, comorbidities, and treatment agents. To the best of our knowledge, this is the most comprehensive study to date addressing this issue.</p><p><strong>Materials and methods: </strong>The study was designed as a cross-sectional, nationwide study. The Turkish Ministry of Health National Electronic Database (e-Nabız) was used under the supervision of the Ministry of Health to extract patient data. A nationwide cohort was established from patients who had been assigned an ICD-10 code for BS (M35.2) on at least two occasions, separated by a minimum of 3 months, between 1 January 2016, and 31 December 2022, and were therefore considered to have BS. Data on demographics, comorbidities, major disease manifestations other than mucocutaneous and musculoskeletal involvement, and treatment agents ever used for BS were recorded. Within this cohort, patients who had been assigned an ICD-10 code for hearing loss (H90 or H91 and their subcategories) were classified as BS patients with hearing loss. Demographics, clinical characteristics and treatment history were compared between BS patients with and without hearing loss.</p><p><strong>Results: </strong>A total of 84,240 patients with BS were identified and included in the analysis. Among these patients, 976 were identified as having hearing loss; 487 had sensorineural hearing loss, 71 had conductive hearing loss, 46 had mixed hearing loss, and 464 had unspecified hearing loss. In multivariable analysis, none of the BS-related manifestations remained independently associated with hearing loss. However, male sex, age >50 years at the time of analysis, hypertension, coronary artery disease, chronic kidney disease, malignancy, depression, viral hepatitis, asthma, osteoporosis, and treatment with certolizumab pegol were independently associated with an increased risk of hearing loss.</p><p><strong>Conclusion: </strong>In this nationwide study, a prevalence of hearing loss of 1.16% was observed among patients with BS. Our findings suggest that older age and the presence of certain comorbidities, rather than BS-specific manifestations, were associated with hearing loss.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"956-962"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hounsfield unit thresholds in differentiating adenoma from nonadenoma adrenal masses: a retrospective adrenalectomy-based study.","authors":"Burak Özbaş, Muhammet Mustafa Etleç, Hüseyin Dursun, Mustafa Gök, Abdullah Bahadır Öz, Alper Celal Akcan, Ayşa Hacioğlu, Ökkeş İbrahim Karahan, Züleyha Cihan Özdamar Karaca, Kürşad Ünlühizarci","doi":"10.55730/1300-0144.6362","DOIUrl":"10.55730/1300-0144.6362","url":null,"abstract":"<p><strong>Background/aim: </strong>Adrenal incidentalomas are increasingly detected during imaging studies performed for various indications, and their frequency in endocrinology practice has risen in recent years. While adenomas account for approximately 80% of adrenal incidentalomas, the remaining 20% include lesions such as primary malignancies, metastases, and pheochromocytomas that should not be overlooked. Given the risks associated with adrenal biopsy, accurate diagnosis with noninvasive methods is essential. In this retrospective study, we evaluated the Hounsfield unit (HU) values and lesion sizes measured on noncontrast computed tomography (CT) to identify a more accurate threshold than the widely used 10 HU.</p><p><strong>Materials and methods: </strong>In this retrospective study, patients who underwent unilateral adrenalectomy between 2013 and 2022 were evaluated. Noncontrast CT images were assessed for lesion size and attenuation, and statistical analyses included tests for nonnormally distributed data, logistic regression, and ROC analysis to determine the diagnostic performance of mass size and density in differentiating adenoma from nonadenoma lesions.</p><p><strong>Results: </strong>A total of 106 patients who underwent adrenalectomy for various indications were included, of whom 55 had adenomas and 51 had nonadenoma masses. The mean size of the adenoma versus nonadenoma lesions was 37.2 ± 15 mm and 55.8 ± 30 mm, respectively (p < 0.05), while mean HU values were 11.4 ± 17 and 35.9 ± 14, respectively (p < 0.05). The ROC analysis showed that HU values exhibited strong discriminative ability in distinguishing adenoma from nonadenoma masses (AUC = 0.869). According to Youden's index, 20 HU was identified as the optimal threshold value. The sensitivity/specificity values for 10 HU, 15 HU, and 20 HU were 98%/56%, 98%/61%, and 92%/82%, respectively.</p><p><strong>Conclusion: </strong>Within this selected adrenalectomy cohort, adopting a 20 HU threshold instead of the conventional 10 HU value significantly improved specificity in differentiating adenomas from nonadenomas. However, broader prospective validation in unselected incidentaloma populations is warranted before recommending a definitive change in routine clinical guidelines.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1176-1184"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative effects of the quadratus lumborum block in percutaneous biliary drainage: a prospective randomized controlled study.","authors":"Seyyid Furkan Kina, Can Ozan Yazar, Cem Koray Çataroğlu, Erdi Tangobay, Sadık Ahmet Uyanik, Savaş Altinsoy, Reyhan Polat, Jülide Ergil","doi":"10.55730/1300-0144.6351","DOIUrl":"10.55730/1300-0144.6351","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim of this study was to evaluate the effect of the quadratus lumborum block (QLB) on intraoperative opioid consumption in patients undergoing percutaneous biliary drainage (PBD).</p><p><strong>Materials and methods: </strong>A total of 57 patients who met the inclusion criteria were randomized into two groups: the sedation group (Group 1, n = 26) and the sedation with QLB group (Group 2, n = 26). The groups were compared in terms of intraoperative anesthetic consumption, vital parameters, postanesthesia care unit (PACU) recovery times, postoperative visual analog scale (VAS) scores, postoperative analgesic consumption, and clinician and patient satisfaction. The study was entered into the ClinicalTrials.gov database (Identifier: NCT06618781).</p><p><strong>Results: </strong>Demographic characteristics and anesthesia and surgical durations were comparable between the two groups (p > 0.05). Intraoperative total propofol and remifentanil consumption was significantly lower in Group 2 (p < 0.001). The incidence of complications was comparable between the groups (p > 0.05). Intraoperative hemodynamic stability was assessed by comparing heart rate (p > 0.05), systolic blood pressure (p = 0.043), diastolic blood pressure (p > 0.05), mean arterial pressure (p > 0.05), and end-tidal carbon dioxide (p > 0.05). Group 2 was found to be more stable in terms of systolic blood pressure. PACU recovery times were significantly shorter in Group 2 (p = 0.002). Postoperative VAS scores at the 2nd, 6th, 12th, and 24th hours, as well as the need for rescue analgesics, were significantly lower in Group 2 (p < 0.001). Clinician and patient satisfaction scores were significantly higher in Group 2 (p < 0.001).</p><p><strong>Conclusion: </strong>The current findings suggest that the incorporation of QLB into anesthetic management for PBD procedures may improve perioperative outcomes by reducing intraoperative opioid requirements without an associated increase in complication rates.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1074-1084"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic stress in newly diagnosed epilepsy: associations with early maladaptive schemas, anxiety, and quality of life in a 6-month prospective study.","authors":"Mehmet Öztürk, Pınar Öztürk, Fügen Sönmez Çetinkaya, İlker Özdemir","doi":"10.55730/1300-0144.6345","DOIUrl":"10.55730/1300-0144.6345","url":null,"abstract":"<p><strong>Background/aim: </strong>Epilepsy is a chronic neurological disorder that significantly affects psychosocial functioning, self-perception, and quality of life. Emerging evidence suggests that posttraumatic stress (PTS) symptoms may be more prevalent in individuals with epilepsy than previously recognized, particularly following seizure-related experiences perceived as traumatic. The aim of this study was to evaluate short- and long-term PTS levels in individuals with newly diagnosed epilepsy and examine their associations with anxiety, depression, early maladaptive schemas, and quality of life.</p><p><strong>Materials and methods: </strong>In this prospective study, 31 individuals with newly diagnosed epilepsy were enrolled. Participants completed a sociodemographic data form, the Post-Traumatic Stress Disorder Checklist for DSM-5, the Young Schema Questionnaire-Short Form 3, the Beck Anxiety Inventory, the Beck Depression Inventory, and the Quality of Life in Epilepsy Inventory. Statistical analyses were performed with significance set at p < 0.05.</p><p><strong>Results: </strong>Anxiety showed the strongest association with PTS symptoms at both the first- and sixth-month assessments. The Enmeshment/Dependence schema was also significantly associated with higher PTS levels, and increased total schema scores correlated with greater traumatic stress. Female sex was associated with higher PTS scores. Quality of life showed significant declines, particularly in cognitive functioning, overall health status, and overall quality of life, and these declines were negatively correlated with PTS symptom severity.</p><p><strong>Conclusion: </strong>PTS symptoms in newly diagnosed epilepsy are closely associated with anxiety, early maladaptive cognitive schemas, and impaired quality of life. These findings emphasize the importance of incorporating trauma-informed psychiatric assessment and early psychological interventions into routine epilepsy care, in addition to seizure management.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1011-1022"},"PeriodicalIF":1.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserved inflammatory homeostasis during emergency transport: a multibiomarker assessment of neonatal RDS transfers.","authors":"Eyüp Sari, Şerife Suna Oğuz, Mehmet Semih Demirtaş, Bensu Bulut, Medine Akkan Öz, Murat Genç, Ayşenur Gür, Ümit Alper Özcan, Hüseyin Mutlu, Ramiz Yazici","doi":"10.55730/1300-0144.6354","DOIUrl":"10.55730/1300-0144.6354","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim was to compare the pre- and posttransport levels of systemic inflammatory markers in neonatal infants transported to a tertiary intensive care unit via emergency health services with a neonatal respiratory distress syndrome (nRDS) diagnosis and to assess the quality of transport.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted between January 2019 and December 2023. A total of 117 nRDS patients' emergency transports were included in the study. Demographic data, transfer time, intubation, cold treatment, cardiopulmonary resuscitation (CPR), and pre- and posttransport laboratory parameters were obtained retrospectively. The statistical analysis was performed using IBM SPSS Statistics (Version 22.0), with a significance level of p < 0.05.</p><p><strong>Results: </strong>The mean gestational age at birth was 35.46 ± 4.189 weeks. Among the neonates transported, 41.9% (n = 49) were intubated and 41.9% (n = 49) required mechanical ventilation during transport. CPR was performed in 12.8% (n = 15) of cases, with 4.3% (n = 5) requiring prolonged CPR. The mortality rate was 11.1% (n = 13). The mean neutrophil-to-lymphocyte ratio (NLR) was 3.0 ± 3.40, the platelet-to-lymphocyte ratio (PLR) was 101.2 ± 103.9, the systemic inflammatory index (SII) (×10³) was 1.91 ± 2.43, and the haemoglobin, albumin, lymphocyte, platelet (HALP) score was 10.42 ± 21.36. No statistically significant differences were observed between the pre- and posttransfer values of the NLR, PLR, HALP index, or SII (overall p > 0.05).</p><p><strong>Conclusion: </strong>No significant differences were detected between pre- and posttransport inflammatory marker levels. These findings suggest that the transport process may not be associated with a measurable inflammatory response, possibly reflecting the effectiveness of appropriate treatment and stabilisation during transport.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1105-1112"},"PeriodicalIF":1.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of resection volume using computed tomography 3D modeling in lung cancer patients and survival analysis.","authors":"Aykut Kankoç, Muhammet Tarık Aslan, Muhammet Sayan, Ali Çelik, İsmail Cüneyt Kurul, Abdullah İrfan Taştepe","doi":"10.55730/1300-0144.6356","DOIUrl":"10.55730/1300-0144.6356","url":null,"abstract":"<p><strong>Background/aim: </strong>The prognostic significance of the volumetric extent of lung resection in nonsmall cell lung cancer remains uncertain. Three-dimensional computed tomography allows quantitative assessment of resected lung parenchyma, but the relationship between resection volume ratios and oncologic outcomes has not been clearly established. The aim in this study was to evaluate the prognostic value of three-dimensional computed tomography-derived resection volume ratios for disease-free survival after surgery for nonsmall cell lung cancer.</p><p><strong>Materials and methods: </strong>This single-center retrospective study included 141 patients who underwent anatomical resection with systematic mediastinal lymph node dissection between 2010 and 2021. Resection volume, ipsilateral lung volume, total lung volume, and derived ratios were calculated from preoperative computed tomography images. The early- and advanced-stage subgroups were analyzed separately. Receiver operating characteristic analysis was used when appropriate, whereas median values were used for exploratory survival comparisons when no meaningful threshold was identified. Disease-free survival was evaluated using Kaplan-Meier and Cox's regression analyses.</p><p><strong>Results: </strong>In the Kaplan-Meier analysis, a higher resection-to-total lung volume ratio was associated with better disease-free survival in early-stage disease (75.6% vs. 53.4%, p = 0.015) but worse disease-free survival in advanced-stage disease (25.0% vs. 47.8%, p = 0.009). In the multivariable continuous Cox's analysis, the resection-to-total lung volume ratio was not independently associated with disease-free survival in the early-stage patients. In contrast, in the advanced-stage patients, each 0.1 increase in this ratio was independently associated with worse disease-free survival (hazard ratio = 4.32, 95% confidence interval: 1.16-16.12, p = 0.029). No independent association was observed in the pooled multivariable model.</p><p><strong>Conclusion: </strong>The prognostic effect of the resection-to-total lung volume ratio appears to be stage-dependent in nonsmall cell lung cancer. Although favorable unadjusted associations were observed in early-stage disease, these were not confirmed in multivariable continuous analysis. In advanced-stage disease, however, higher values were independently associated with worse disease-free survival.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1124-1132"},"PeriodicalIF":1.4,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}