Turkish Journal of Medical Sciences最新文献

{"title":"Targeted temperature management in obstetrics for the prevention of perinatal encephalopathy.","authors":"Aleksandr Urakov, Natalya Urakova","doi":"10.55730/1300-0144.5859","DOIUrl":"https://doi.org/10.55730/1300-0144.5859","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of acute pain in adults with sickle cell disease: the experience of the Clinical Hematology Department of the University of Dakar.","authors":"Alioune Badara Diallo, Moussa Seck, Mohamed Keita, Sokhna Aissatou Toure, Elimane Seydi Bousso, Baron Ngasia, Blaise Félix Faye, Fatma Dieng, Saliou Diop","doi":"10.55730/1300-0144.5897","DOIUrl":"https://doi.org/10.55730/1300-0144.5897","url":null,"abstract":"<p><strong>Background/aim: </strong>The evolution of sickle cell disease (SCD) is marked by the occurrence of painful episodes linked to the obstruction of microvessels by sickle cells, known as vaso-occlusive crisis (VOC). The aim of this work was to report the practical aspects of the management of acute pain in adults with SCD. Recommendations based on these practices are also provided.</p><p><strong>Materials and methods: </strong>This prospective, cross-sectional, descriptive, and analytical study was conducted over a four-month period of all sickle cell patients admitted to emergency departments for VOC. The parameters studied were sociodemographic, clinicobiological, therapeutic, and evolutionary.</p><p><strong>Results: </strong>There were 118 cases of VOC identified, representing a prevalence of 78.14% of sickle cell emergencies. The mean age of the patients was 28.41 years. The SS sickle cell phenotype accounted for 86.61% of the cases. Osteoarticular pain was the reason for admission for 88.39% of the patients; it was located in the lower limbs in 39.08% and in the spine in 27.1%. Pain intensity was moderate in 6.25% of the patients, intense in 31.25%, and unbearable in 55.55%. Multimodal analgesia was the most commonly used treatment method, combining those of levels one and two (74.31%) and levels one and three (8.25%). The mean dose of morphine administered was 17.14 mg when morphine alone was prescribed for titration, 13.57 mg when paracetamol and morphine were combined, and 15.83 mg when nefopam and morphine were combined. Clinical outcome was favorable in 68.87% of the cases.</p><p><strong>Conclusion: </strong>Wide variability was observed in the modalities of analgesic treatment of sickle cell VOC. These variations reflect different views on the appropriateness of opioids. This study highlights the efficacy of multimodal analgesia in the management of acute pain in patients with SCD, particularly in regard to morphine sparing. Context-specific recommendations will be needed to harmonize practices.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of volume measurements of neuroanatomical structures related to speech in multiple sclerosis patients.","authors":"Hıdır Pekmez, Anıl Altiparmak, Feyza Inceoğlu, Mehmet Akçiçek, Aslı Bolayir, Zeynep Özbay, Merve Aydin, Muhammed Furkan Arpaci","doi":"10.55730/1300-0144.5839","DOIUrl":"https://doi.org/10.55730/1300-0144.5839","url":null,"abstract":"<p><strong>Background/aim: </strong>Individuals with multiple sclerosis (MS) may experience various speech-related issues, including decreased speech rate, increased pauses, and changes in speech rhythms. The purpose of this study was to compare the volumes of speech-related neuroanatomical structures in MS patients with those in a control group.</p><p><strong>Materials and methods: </strong>The research was conducted in the Neurology and Radiology Departments of Malatya Training and Research Hospital. The records of patients who presented to the Neurology Department between 2019 and 2022 were examined. The study included the magnetic resonance imaging (MRI) findings of 100 individuals, with 50 in the control group and 50 patients with MS, who had applied to the hospital in the specified years. VolBrain is a free system that works automatically over the internet (http://volbrain.upv.es/), enabling the measurement of brain volumes without human interaction. The acquired images were analyzed using the VolBrain program.</p><p><strong>Results: </strong>As a result of our research, a significant decrease was found in the volume of 18 of 26 speech-related regions in MS patients. It was determined that whole brain volumes decreased in the MS group compared to the control group.</p><p><strong>Conclusion: </strong>In our study, volume measurements of more speech-related areas were performed, unlike the few related studies previously conducted. We observed significant atrophy findings in the speech-related areas of the frontal, temporal, and parietal lobes of MS patients.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood component-associated acute transfusion reactions in pediatric patients: experience of a tertiary care hospital.","authors":"Zeliha Güzelküçük, Dilek Gürlek Gökçebay, Turan Bayhan, İkbal Ok Bozkaya, Özlem Arman Bilir, Vildan Koşan Çulha, Melek Işik, Ayca Koca Yozgat, Hüsniye Neşe Yarali, Namık Yaşar Özbek","doi":"10.55730/1300-0144.5869","DOIUrl":"https://doi.org/10.55730/1300-0144.5869","url":null,"abstract":"<p><strong>Background/aim: </strong>The transfusion of blood products is a life-saving clinical practice in patients with bleeding, hemoglobinopathy, and cancer. It was aimed herein to analyze the frequency and types of blood component-related acute transfusion reactions (ATRs) in pediatric patients.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted at a tertiary care academic pediatric hospital.</p><p><strong>Results: </strong>During the study period, 30,811 transfusions were administered to 25,448 patients. There were 103 ATRs detected in 81 patients (0.33%; 3.34 reactions per 1000 transfusions, mean age 8.3 ± 5.98 years, 36 females and 45 males). All the reactions were observed within an average of 4 h after the transfusion began. The most common ATRs were allergic reactions (79; 76.6%) and febrile nonhemolytic transfusion reactions (12; 11.6%). All the allergic transfusion reactions occurred within the first hour after the start of the transfusion. Granulocyte concentrates were the blood component associated with the highest ATR rate (2.1%).</p><p><strong>Conclusion: </strong>Within our hospital, pediatric hematology-oncology wards and the stem cell transplantation unit had the most frequent ATR reports; therefore, when transfusions are carried out, increased attention should be given to these units. Educating health staff about the adverse effects of transfusion therapy should increase the awareness and reporting of ATRs in children.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between functional status and fatigue after COVID-19 infection: a multicenter study from Türkiye.","authors":"İpek Candemir, Pınar Ergün, Dicle Kaymaz, Mustafa Engin Şahin, İpek Özmen, Elif Yildirim, Aslı Görek Dilektaşli, Büşra Yiğitliler, Ayten Odabaş, Deniz Kizilirmak, Seçil Sari, Celalettin Korkmaz, Cantürk Taşçi, Yakup Arslan, Sema Savci, Buse Kahraman, Aylin Tanriverdi, Can Sevinç, Melda Sağlam, Deniz Inal Ince, Naciye Vardar Yağli, Ebru Kütükçü, Dilber Durmaz, Neslihan Durutürk, Gaye Ulubay, Lütfiye Kiliç, Benan Çağlayan, Aylin Moray, Sabri Serhan Olcay, Güven Özkaya","doi":"10.55730/1300-0144.5831","DOIUrl":"10.55730/1300-0144.5831","url":null,"abstract":"<p><strong>Background/aim: </strong>Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address..</p><p><strong>Materials and methods: </strong>Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence of dyspnea, presence of cough, presence of sputum, and modified Medical Research Council, Post-COVID Functional Status (PCFS), Fatigue Severity Scale (FSS), and EQ-5D-5L Questionnaire scores were recorded.</p><p><strong>Results: </strong>We enrolled 1095 patients, including 603 (55%) men and 492 (45%) women with a mean age of 50 ± 14 years. The most common chronic lung disease was COPD (11%) and 266 (29%) patients had nonpulmonary disease. The median time elapsed since COVID-19 diagnosis was 5 months; the hospitalization rate was 47%. The median PCFS grade was 1 (0-4) and the median FSS score was 4.4 (1-7). The PCFS and FSS were positively correlated (r = 0.49, p < 0.01; OR: 1.88, 95% CI: 1.68-2.10). Both functional status and fatigue were associated with quality of life, which was lower in older patients, those with higher BMI, those with systemic disease, those not exercising regularly, and those with more severe COVID-19 infection (defined by dyspnea, pneumonia as indicated by computed tomography, hospitalization, length of stay, ICU admission, intubation, and the need for home oxygen after discharge).</p><p><strong>Conclusion: </strong>Fatigue may cause poorer functional status regardless of the time since COVID-19 diagnosis. In this study, patients with FSS scores of >4.78 showed moderate to severe functional limitations. It is important to address modifiable patient risk factors and reduce the severity of COVID-19 infection.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of treatment methods in patients with developmental dysplasia of the hip.","authors":"Burhan Kurtuluş","doi":"10.55730/1300-0144.5885","DOIUrl":"https://doi.org/10.55730/1300-0144.5885","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to compare the results of Pemberton osteotomy (PO), Salter innominate osteotomy (SO), open reduction (OR), and closed reduction (CR) applied in the treatment of developmental dysplasia of the hip (DDH).</p><p><strong>Materials and methods: </strong>Included in the study were 101 hips of 82 patients treated at our orthopedic clinic between 2017 and 2023. The patients were evaluated preoperatively, postoperatively, and at the final follow-up. The results were evaluated based on Barret's clinical and Severin's radiological classifications. Those who developed avascular necrosis (AVN) were evaluated based on Bucholz-Ogden's classification.</p><p><strong>Results: </strong>In terms of the preoperative acetabular angles (AAs), those for hips treated with PO were significantly higher than those of the other three, and those treated with SO were significantly higher than those of the other two (OR and CR) (p < 0.001). There was a significant difference in the final follow-up AAs of those treated with SO and PO compared to those treated with OR and CR (p < 0.001). The best corrections were achieved with PO (average: 27.94 ± 4.89°). There was a significant difference between PO and OR, and PO and CR in terms of the preoperative collodiaphyseal angles (CDAs) (p < 0.05). The greatest decrease was in those treated with PO (average: 22.44 ± 9.45°). AVN developed at various stages in 15 of 79 hips (14.85%) that were treated surgically. While AVN developed at a rate of 22.22% with PO, 18.18% with SO, and 17.85% with OR, no AVN developed in the 22 hips treated with CR.</p><p><strong>Conclusion: </strong>Understanding normal and abnormal values by age is essential for selecting appropriate treatments. Acetabulum-related surgeries should be planned for patients over 1.5 years of age with an AA above 30°. Early diagnosis and CR treatments yield excellent results and low AVN rates. Various DDH treatments in our clinic have shown low AVN rates, indicating safety and efficacy.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of inherited metabolic disorders using tandem mass spectrometry data with the help of artificial neural networks.","authors":"Pembe Soylu Üstkoyuncu, Nurettin Üstkoyuncu","doi":"10.55730/1300-0144.5840","DOIUrl":"https://doi.org/10.55730/1300-0144.5840","url":null,"abstract":"<p><strong>Background/aim: </strong>Tandem mass spectrometry is helpful in diagnosing amino acid metabolism disorders, organic acidemias, and fatty acid oxidation disorders and can provide rapid and accurate diagnosis for inborn errors of metabolism. The aim of this study was to predict inborn errors of metabolism in children with the help of artificial neural networks using tandem mass spectrometry data.</p><p><strong>Materials and methods: </strong>Forty-seven and 13 parameters of tandem mass spectrometry datasets obtained from 2938 different patients were respectively taken into account to train and test the artificial neural networks. Different artificial neural network models were established to obtain better prediction performances. The obtained results were compared with each other for fair comparisons.</p><p><strong>Results: </strong>The best results were obtained by using the rectified linear unit activation function. One, two, and three hidden layers were considered for artificial neural network models established with both 47 and 13 parameters. The sensitivity of model B2 for definitive inherited metabolic disorders was found to be 80%. The accuracy rates of model A3 and model B2 are 99.3% and 99.2%, respectively. The area under the curve value of model A3 was 0.87, while that of model B2 was 0.90.</p><p><strong>Conclusion: </strong>The results showed that the proposed artificial neural networks are capable of predicting inborn errors of metabolism very accurately. Therefore, developing new technologies to identify and predict inborn errors of metabolism will be very useful.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal stabilization exercises for transversus abdominis and lumbar multifidus thickness via telerehabilitation and face-to-face approaches in patients with nonspecific chronic neck pain: a randomized controlled trial.","authors":"Dilara Onan, Erkan Demirci, Egemen Turhan, Özlem Ülger","doi":"10.55730/1300-0144.5853","DOIUrl":"10.55730/1300-0144.5853","url":null,"abstract":"<p><strong>Background/aim: </strong>Strengthening the muscles of the lumbar region in individuals with neck pain may be protective against future back problems. In addition, telerehabilitation applications, which gained momentum in the literature and clinical practice during the COVID-19 pandemic, are among the applications preferred by patients thanks to their various advantages. This study aimed to compare the effects of telerehabilitation and spinal stabilization exercises applied with face-to-face approaches on the thickness of the transversus abdominis (M.TrA) and lumbar multifidus (M.LM) muscles in patients with nonspecific neck pain.</p><p><strong>Materials and methods: </strong>The primary outcomes were the thickness of the M.TrA and M.LM. Neck pain intensity and neck disability were secondary outcomes. Muscle thickness was evaluated with an ultrasound device, neck pain intensity was assessed with a visual analog scale, and disability was assessed with the Neck Disability Index. Patients were randomly assigned to the telerehabilitation group (TRG) (n = 13) or the control group (CG) (n = 13). While the TRG did the exercises with live videos and video recordings, the CG did exercises face-to-face in the clinic. Both groups performed the same exercises for 45 minutes per session 3 days a week for 8 weeks.</p><p><strong>Results: </strong>At the end of the treatment, the thicknesses of the M.TrA and M.LM were increased and neck pain intensity and neck disability were decreased in both groups (p < 0.05). The groups were similar in terms of these variables (p > 0.05).</p><p><strong>Conclusion: </strong>Telerehabilitation and face-to-face spinal stabilization exercises are both beneficial for spinal muscle architecture and clinical variables as a preventive measure against future lower back problems in individuals with neck pain.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation with structural equation modeling of variables affecting health-seeking behaviors during the COVID-19 pandemic in İstanbul, Türkiye.","authors":"Pınar Atali, Seyhan Hidiroğlu, Alican Sarisaltik, Melda Karavuş","doi":"10.55730/1300-0144.5878","DOIUrl":"10.55730/1300-0144.5878","url":null,"abstract":"<p><strong>Background/aim: </strong>The relation between the demographic characteristics of individuals and their health-seeking behaviors was presented and the effects of health cognitions, healthy lifestyle behaviors, and coronavirus fear levels on health-seeking behaviors during the COVID-19 pandemic were examined.</p><p><strong>Materials and methods: </strong>This descriptive survey study was conducted in the Tuzla District of İstanbul, Türkiye, between March and June 2021.</p><p><strong>Results: </strong>From analysis of the 391 participants, 60.0% were females, 27.1% were between 31 and 40 years of age, 47.0% were healthcare professionals, and the perceived socioeconomic status of 50.9% was above average. According to the results, the women exhibited more health-seeking behavior than the men (p < 0.05). While the young participants showed more online health-seeking behavior (p < 0.05), the older ones showed greater health responsibility (p < 0.05). The participants with a high level of education exhibited traditional health-seeking behavior (p < 0.05) more than the others, and below-low socioeconomic status increased the COVID-19 fear level 1.94 times (95.0% CI: 1.08-3.48). The Health-Seeking Behavior Scale (HSBS) score was related to the Health Cognitions Questionnaire (HCQ) (p < 0.0001) and the Healthy Lifestyle Behaviors Scale-II (HLBS-II) scores (p = 0.002; Table 3). While the HSBS score was positively associated with an increase in the HCQ score and HLBS-II score (p < 0.05), the HSBS score was not significantly related to the Fear of COVID-19 Scale score (p > 0.05).</p><p><strong>Conclusion: </strong>While fear of COVID-19 was not significantly influential, health cognitions and healthy lifestyle behaviors were the main factors that led to health-seeking behavior during the COVID-19 pandemic.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internalizing disorders rather than ADHD are risk factors for chronicity in pediatric migraine patients.","authors":"Nevra Öksüz, Gülen Güler Aksu, Asena Ayça Özdemir, Aynur Özge","doi":"10.55730/1300-0144.5870","DOIUrl":"https://doi.org/10.55730/1300-0144.5870","url":null,"abstract":"<p><strong>Background/aim: </strong>Migraine is a prevalent neurological disorder that can lead to disability in children and adolescents. It is frequently accompanied by psychiatric comorbidities, both internalizing and externalizing disorders. While the relationship between migraine and internalizing disorders has been studied, there is limited research on the link between migraine and attention deficit hyperactivity disorder (ADHD).</p><p><strong>Materials and methods: </strong>A total of 280 pediatric headache patients, 107 with externalizing (ADHD) and 173 with internalizing disorders (depression and/or anxiety), were included. The dataset was composed using the Turkish headache database, Mersin Branch. Pain characteristics, associated symptoms, and accompanying comorbidities were evaluated retrospectively.</p><p><strong>Results: </strong>Two hundred four patients were followed up with episodic migraine (EM) and 76 patients with chronic migraine (CM). One hundred forty-six boys and 134 girls were evaluated, and internalizing disorders were more common in the girls (p < 0.001). It was a much more prominent accompaniment in chronic migraine internalizing disorders (p = 0.038). EM, on the other hand, was more frequent in ADHD. Pain intensity and frequency were greater in those with internalizing disorders (p = 0.007), while photophobia was more prevalent in those with ADHD (OR; 0.555, p = 0.044). Moreover, we observed that individuals with internalizing disorders were predominantly female (p = 0.003) and had a higher mean age (p < 0.001) than those with externalizing disorders.</p><p><strong>Conclusion: </strong>Internalizing disorders seem to be a risk factor for migraine chronification in pediatric migraine. ADHD is a prototypic externalizing disorder more associated with EM. This outcome provides an opportunity to follow our patients in terms of prognosis and offers us the chance for a better evaluation. Identifying factors that contribute to the chronicity of migraine may lead to better management and reduced disability for migraine sufferers.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}