Turkish Journal of Medical Sciences最新文献

{"title":"Benzyl alcohol improves Ang II-induced vascular and renal injury.","authors":"Zhenyu Gu, Qi Hua","doi":"10.55730/1300-0144.5995","DOIUrl":"https://doi.org/10.55730/1300-0144.5995","url":null,"abstract":"<p><strong>Background/aim: </strong>The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalities playing a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA), identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renal injury in murine models.</p><p><strong>Materials and methods: </strong>Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusion using a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid artery diastolic, and systolic pressures in mice were determined with a blood pressure monitor. Vascular structure changes were assessed with HE and Masson staining, while kidney pathology was examined using HE. Serum urea nitrogen, creatinine, and cystatin C levels were measured with ELISA kit.</p><p><strong>Results: </strong>Metabolomics analysis identified metabolite BA as a potential target for hypertension management. Compared to the Ang II group, BA reduced systolic blood pressure by 11.58% and diastolic blood pressure by 14.62% in the fourth week. After sodium nitroprusside treatment, the Ang II group showed reduced vasodilation reactivity versus the control. BA significantly restored this reactivity, unlike acetylcholine. Furthermore, BA was observed to attenuate Ang II-induced vascular mediator thickening, the mediator-to-lumen ratio, and collagen deposition. Ang II administration resulted in renal structural damage and increased concentrations of urea nitrogen, creatinine, and serum cystatin C, which was reversed by BA treatment.</p><p><strong>Conclusion: </strong>BA exhibits potential in enhancing the vasodilatory response, vascular remodeling, and renal injury associated with Ang II.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"509-517"},"PeriodicalIF":1.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can mac-2 binding protein glycosylation isomer serve as a biomarker for predicting pulmonary arterial pressure and pulmonary hypertension in systemic sclerosis?","authors":"Rıdvan Mercan, Dilara Bulut Gökten, Sonat Pınar Kara, Neslihan Melik Üzüm, Savaş Güzel","doi":"10.55730/1300-0144.5984","DOIUrl":"https://doi.org/10.55730/1300-0144.5984","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to explore the role of Mac-2 binding protein glycosylation isomer (M2BPGi) serum levels as a biomarker that could contribute to understanding organ involvement and the overall disease process in systemic sclerosis (SSc).</p><p><strong>Materials and methods: </strong>The cross-sectional study examined 108 patients with SSc. Seventy-two people were included in the control group. Demographic and clinical characteristics of the patients, laboratory and radiological findings, pulmonary function tests and echocardiography results, and presence of pulmonary hypertension (PHT) based on echocardiographic evaluation were recorded. Venous blood samples of 5 mL were collected from individuals. Human M2BPGi levels in the samples were measured using a specific kit.</p><p><strong>Results: </strong>There was no significant difference between the M2BPGi levels in the patient (median = 4749.69 pg/mL, mean = 5351.75 ± 2483.97) and the control group (median = 4638.07, mean = 4611.86 ± 1333.15) (p = 0.071). Considering pulmonary arterial pressure (PAP) status, the average M2BPGi level in the normal PAP group was 5898.15 ± 2555.61 pg/mL, while it was 4258.96 ± 1973.08 pg/mL in the increased PAP group. The difference between these groups was statistically significant (p: 0.021). Examining PHT status, the average M2BPGi level was 5942.01 ± 2579.14 pg/mL in the group without PHT, decreasing to 4264.44 ± 1917.63 pg/mL in the group with PHT. There is a significant relationship regarding PHT (p: 0.016).</p><p><strong>Conclusion: </strong>This study explores the relationship between M2BPGi and systemic involvements in SSc. It demonstrates a significant relationship between M2BPGi and PAP and PHT, suggesting that M2BPGi might serve as a noninvasive biomarker for predicting both PAP and PHT.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"404-412"},"PeriodicalIF":1.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadratus lumborum block for total abdominal hysterectomy: a double-blind, randomized, controlled trial.","authors":"Nada Pejcic, Marija Kutlesic, Ivan Velickovic, Vladimir Milic, Slavisa Kovacevic, Radmilo J Jankovic, Dejan Mitic, Radomir Mitic, Nenad Zornic","doi":"10.55730/1300-0144.5978","DOIUrl":"10.55730/1300-0144.5978","url":null,"abstract":"<p><strong>Background/aim: </strong>The Quadratus lumborum block (QLB) is an interfascial block recommended for multimodal pain therapy after cesarean section in patients who cannot receive intrathecal morphine. We wanted to investigate whether QLB contributes to better analgesia after total abdominal hysterectomy (TAH). The study was registered on the website ClinicalTrials.gov (registration number NCT05765318).</p><p><strong>Materials and methods: </strong>Patients scheduled for TAH were randomized into two groups of 30 members each. The treatment group received QLB, while the control group did not undergo any block. The primary outcome was the amount of morphine during the first 12 postoperative h. Secondary outcomes included the total amount of morphine for 24 h, time to the first request for additional analgesia, pain intensity at rest and during activity, frequency of nausea and vomiting, and the degree of sedation at 2, 6, 12, and 24 h postoperatively.</p><p><strong>Results: </strong>Patients in the QLB group received significantly less morphine (4.13 mg) compared to the control group (9.73 mg) during the first 12 postoperative h (p < 0.001) and also during the first 24 h. The patients in the QLB group had longer time interval to the first breakthrough pain (7.87 h) compared to the control group (2.63 h) (p < 0.001), lower NRS scores at rest and during activity after 2, 12, and 24 h, and better satisfaction with provided pain relief during the first 24 h postoperatively.</p><p><strong>Conclusion: </strong>QLB reduces postoperative morphine use and postoperative pain intensity on the NRS scale, both at rest and during activity, as part of multimodal pain therapy for TAH.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"349-359"},"PeriodicalIF":1.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical features and treatment modality of pediatric patients with Steven Johnson syndrome/toxic epidermal necrolysis: a single-center experience.","authors":"Funda Aytekin Güvenir, Vildan Selin Çayhan, Selman Kürşat Balci, Ragıp Dere, Hatice Irmak Çelik, Serhat Emeksiz, Ahmet Selmanoğlu, Zeynep Şengül Emeksiz, Emrah Şenel, Emine Dibek Misirlioğlu","doi":"10.55730/1300-0144.5990","DOIUrl":"https://doi.org/10.55730/1300-0144.5990","url":null,"abstract":"<p><strong>Background/aim: </strong>Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening severe cutaneous drug hypersensitivity reactions. The aim of our study was to evaluate the clinical features of pediatric patients diagnosed with SJS, TEN or SJS/TEN overlap and to examine treatment modalities.</p><p><strong>Materials and methods: </strong>Patients aged 0-18 years who were followed up with SJS, TEN or SJS/TEN overlap at Ankara Bilkent City Hospital between August 2019 and January 2024 were retrospectively analyzed.</p><p><strong>Results: </strong>Twelve patients who met the inclusion criteria were included in the study. Five of the patients had SJS, four had SJS/TEN overlap, and three had TEN. Eight of the patients were female, and the median age at presentation was 10.5 (IQR:6-16) years. Ten of the patients had a history of drug use. Eight patients had antibiotics, two had proton pump inhibitors, two had allopurinol, and two had antiepileptic (lamotrigine and valproic acid) use. All 12 patients received IVIG and systemic steroid therapy. Three TEN and four SJS/TEN overlap patients received cyclosporine. Two TEN patients underwent plasmapheresis. The most common long-term sequelae were dermatological sequelae.</p><p><strong>Conclusion: </strong>SJS/TEN patients should be monitored with a multidisciplinary approach, and if necessary, in the burn intensive care unit. Primary treatment is supportive care. Early initiation of cyclosporine may have a positive effect on the prognosis in patients with SJS/TEN overlap and TEN.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"461-469"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the home environment in children with developmental delays: insights from a cross-sectional study in Türkiye.","authors":"Emel Ömercioğlu, Ebru Cihan Çam, Ömer Nazım Gülçek, Elif N Özmert","doi":"10.55730/1300-0144.5956","DOIUrl":"10.55730/1300-0144.5956","url":null,"abstract":"<p><strong>Background/aim: </strong>A stimulating home environment in early childhood plays a crucial role in fostering child development. This study aimed to evaluate the home environment of children with developmental delays and who had not received special education support in any developmental domain.</p><p><strong>Materials and methods: </strong>The study comprised of 50 preschool children with developmental delay monitored at Hacettepe University Division of Developmental Pediatrics and 70 typically developing preschool children from Ankara 29 Mayıs State Hospital, General Pediatrics Department. Physicians and experienced child development professionals employed the Ages and Stages Questionnaire (ASQ) to perform developmental assessments on each child. The characteristics of the home environment for all participants were evaluated using the Home Environment Questionnaire (HEQ), and their sociodemographic details were recorded.</p><p><strong>Results: </strong>The home stimulation scores for children with developmental delay were significantly lower compared to those for their typically developing peers (p < 0.001). Physical violence against children was reported by 34% of parents of children with developmental delays (p < 0.001). The presence of developmental delay (p < 0.001, CI 12.629-7.927), the family socioeconomic status (p = 0.002, CI 3.813-1.486), and the number of family members (p = 0.001, Cl 2.595-0.708) were significantly associated with home stimulation scores.</p><p><strong>Conclusion: </strong>Initial assessment of children with developmental delays suggest that the stimuli in their home environment are of lower quality relative to those of typically developing peers, and these children are subjected to markedly higher levels of physical violence. These results underscore the need for early childhood caretakers, public health practitioners, and other professionals to design and implement targeted interventions, particularly prioritizing low-income families living in disadvantaged environments.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"184-192"},"PeriodicalIF":1.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison study of sensory processing in older adults with and without dementia.","authors":"Medine Nur Özata Değerli, Didem Karaduman, Burcu Balam Doğu, Onur Altuntaş","doi":"10.55730/1300-0144.5948","DOIUrl":"10.55730/1300-0144.5948","url":null,"abstract":"<p><strong>Background/aim: </strong>Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.</p><p><strong>Materials and methods: </strong>This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.</p><p><strong>Results: </strong>The study included 120 older adults (60 with dementia and 60 without dementia) aged 75.35 ± 7.86 years. Older adults with dementia showed an above-norm low registration (<i>x</i> ² = 27.62) and sensory sensitive (<i>x</i> ² = 14.96) compared to without dementia. However, no significant differences were observed between the groups in sensation seeking and sensation avoiding (p > 0.05). There was a difference between the two groups in taste/smell, movement, visual, touch, and auditory modulation (p < 0.05).</p><p><strong>Conclusion: </strong>These findings highlight significant differences in sensory processing and modulation associated with dementia. Understanding these differences may offer valuable insights for developing individualized approaches to dementia management.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"103-111"},"PeriodicalIF":1.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing knowledge levels of intensive care unit nurses and doctors regarding drug administration via enteral feeding tubes: a survey study.","authors":"Ayşe Gül Koçoğlu Kinal, Yunus Emre Ayhan, Aslınur Albayrak","doi":"10.55730/1300-0144.5957","DOIUrl":"10.55730/1300-0144.5957","url":null,"abstract":"<p><strong>Background/aim: </strong>Knowledge deficiency regarding appropriate drug administration through enteral feeding tubes (EFTs) is common in intensive care units (ICUs). The aim of this study is to evaluate the knowledge levels of nurses and doctors in ICUs about drug administration via EFTs.</p><p><strong>Materials and methods: </strong>This study was conducted as a cross-sectional online survey. Survey questions were created using Google Forms and distributed to nurses and doctors in various ICUs across hospitals in İstanbul, Türkiye. The researchers designed the survey questions based on literature reviews and existing examples. The survey consisted of three sections and a total of 25 questions: the first section included seven demographic questions, while the second and third sections focused on participants' knowledge regarding drug administration via EFT and the selection of appropriate dosage forms, respectively.</p><p><strong>Results: </strong>The online survey form was sent to 400 healthcare workers in ICUs, and 221 (55.2%) completed the survey. Among the participants, 66 (29.9%) were male, and 112 (50.6%) were doctors. There was no significant difference in the mean (± SD) of correct answers to 9 questions on drug administration between doctors (5.4 ± 1.3) and nurses (5.3 ± 1.4) (p = 0.471). In the mean (± SD) of correct answers to 9 questions on dosage form selection, doctors (3.9 ± 2.1) had higher scores than nurses (2.7 ± 1.9) (p < 0.001). The mean (± SD) of the responses given to all questions was found to be higher in doctors (9.4 ± 2.9) than in nurses (8 ± 2.7) (p < 0.001).</p><p><strong>Conclusion: </strong>In ICUs, the knowledge of nurses and doctors about drug administration and dosage form selection via EFT is at a low to moderate level. Enhancing collaboration among healthcare professionals may be effective in bridging this knowledge gap.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"193-202"},"PeriodicalIF":1.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro anticancer, antioxidant and chelating activities of natural organosulfur compounds originated from Türkiye: an investigation on breast and colorectal cancer cells.","authors":"Ümmügülsüm Polat Korkunç, Hilal Çalik, Leyla Polat Köse, Rabia Çakir Koç, Emine Karakuş","doi":"10.55730/1300-0144.5970","DOIUrl":"10.55730/1300-0144.5970","url":null,"abstract":"<p><strong>Background/aim: </strong>Taşköprü garlic, cultivated in the Taşköprü region of Kastamonu Province, is highly renowned in Türkiye. This study aimed to determine the anticancer and antioxidant effects of extracts from Kastamonu Taşköprü garlic on human breast cancer and colorectal cancer cells.</p><p><strong>Materials and methods: </strong>Taşköprü garlic, which contains natural organosulfur compounds (OSCs), has a geographical registration. Garlic contains oil- and water-soluble OSCs known to exhibit anticancer activity by interfering with MCF-7 and Caco-2 proliferation and tumor metastasis. This study assessed the antiproliferative activity of oil- and water-soluble garlic extracts with and without glutathione at different concentrations using the XTT assay on NIH/3T3, MCF-7, and Caco-2 cell lines over 24 h. In addition, the reducing capacity, radical scavenging activity, and metal chelation activity of OSCs in Taşköprü garlic were analyzed.</p><p><strong>Results: </strong>Both oil- and water-soluble garlic extracts significantly inhibited the proliferation of MCF-7 and Caco-2 in a dose-dependent manner after 24 h of incubation. The half-maximal inhibition concentration (IC₅₀) values of OSCs and positive controls for N,N-dimethyl-p-phenylenediamine cation (DMPD^.+) radical removal and 2,2'-bipyridyl-Fe²⁺ chelation activity were 129.593-1004.346 and 165.065-495.195 μg/mL, respectively. Furthermore, the reducing impact of OSCs and positive controls were evaluated based on their cupric ion (Cu²⁺) reducing capabilities. All results were compared with the respective positive controls.</p><p><strong>Conclusion: </strong>The findings revealed that oil-soluble garlic extracts exhibited anticancer properties against both Caco-2 and MCF-7 cancer cells, without inducing any cytotoxicity in non-cancerous NIH/3T3. In addition, water-soluble extracts have higher antiproliferative activity on Caco-2 and MCF-7 cells in a dose-dependent manner compared to oil-soluble extracts. However, they also exhibited notable cytotoxicity on fibroblast cells. OSCs showed limited activity in reduction and radical scavenging assays but demonstrated strong chelating activity. These results suggest that both water-soluble and oil-soluble garlic extracts hold promising anticancer potential against both MCF-7 and Caco-2.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"287-298"},"PeriodicalIF":1.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procedural and patient-related factors play differential roles in postdural puncture headache.","authors":"Ece Yanik, Doğa Vuralli, Tuğba Tunç","doi":"10.55730/1300-0144.5987","DOIUrl":"10.55730/1300-0144.5987","url":null,"abstract":"<p><strong>Background/aim: </strong>The incidence of postdural puncture headache varies depending on the multifactorial nature of the risk factors. Patient-related and procedure-related risk factors are still controversial. In this prospective observational study, we aimed to evaluate the risk factors for postdural puncture headache, the effect of previous headache features on the development of postdural puncture headache, and the risk factors for the immediate or delayed postdural puncture headache.</p><p><strong>Materials and methods: </strong>We prospectively analyzed 116 patients who underwent lumbar puncture for diagnostic or therapeutic purposes. All clinical and laboratory findings, previous headache history, and the features and information related to the lumbar puncture procedure were evaluated.</p><p><strong>Results: </strong>We found that the presence of longer and more frequent attacks, independent of the type of the prior headache, and a history of migraine accompanied by osmophobia are independent risk factors for postdural puncture headache. A lower volume of cerebrospinal fluid collected, higher frequency of previous headache attacks, diagnosis of idiopathic intracranial hypertension, and acetazolamide use were risk factors for the immediate-onset postdural puncture headache.</p><p><strong>Conclusion: </strong>This is the first study to detail the previous headache features in the development of postdural puncture headache and to extensively examine the risk factors for immediate and delayed postdural puncture headache. It was shown for the first time that patient-related factors may be more important in terms of the development of postdural puncture headache, and procedure-related factors gain importance in terms of its time of occurrence.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"432-442"},"PeriodicalIF":1.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of cervical cerclage and pessary in addition to vaginal progesterone to prevent preterm birth in twin pregnancies: a case-control study from a tertiary center.","authors":"Göksun Ipek, Atakan Tanaçan, Ilım Demet, Zahid Ağaoğlu, Ezgi Başaran, Özgür Kara, Dilek Şahin","doi":"10.55730/1300-0144.5968","DOIUrl":"10.55730/1300-0144.5968","url":null,"abstract":"<p><strong>Background/aim: </strong>This study evaluated the efficiency of cervical cerclage and pessary in addition to vaginal progesterone to prevent preterm birth in twin pregnancies.</p><p><strong>Materials and methods: </strong>This retrospective case-control study included 46 cases of twin pregnancy with cervical insufficiency delivered at Ankara Bilkent City Hospital between January 2022 and January 2024. Patients were grouped as those receiving cervical cerclage in addition to vaginal progesterone (n = 10), cervical pessary in addition to vaginal progesterone (n = 11), and only vaginal progesterone (n = 25). Patients' data were obtained from the hospital's database. Obstetric parameters (gravidity, parity, abortion, artificial reproductive technologies, second-trimester abortion) and ultrasound parameters (cervical length, intraamniotic sludge) were recorded. Gestational week at birth, latency period (diagnosis to delivery), and delivery after 34 weeks were evaluated for effectiveness. All parameters were compared between groups and evaluated for effectiveness as an independent factor for preterm birth.</p><p><strong>Results: </strong>The primary effectiveness parameters of latency period, birth week, and delivery after 34 weeks did not differ statistically between groups. When the parameters were evaluated independently of treatment groups for their effects on delivery after 34 weeks with multivariate regression analysis, the presence of intraamniotic sludge was found to be a negative independent factor for delivery after 34 weeks (p = 0.03).</p><p><strong>Conclusion: </strong>Cervical cerclage or pessary in addition to vaginal progesterone had no additional benefit for achieving birth after 34 gestational weeks. The only factor that had a negative effect on birth after 34 gestational weeks was the presence of intraamniotic sludge. Our clinical experience with twin pregnancies may provide insight into treatment options for clinicians.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"271-276"},"PeriodicalIF":1.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}