Turkish Journal of Medical Sciences最新文献

{"title":"Erratum to \"Vitamin D deficiency and surgical cellulose mimicking parathyroid adenoma after initial parathyroidectomy\" [Turkish Journal of Medical Sciences 55 3 696 701].","authors":"Mustafa Şahin, Volkan Genç, Koray Ceyhan, Demet Çorapçioğlu","doi":"10.55730/1300-0144.6058","DOIUrl":"https://doi.org/10.55730/1300-0144.6058","url":null,"abstract":"<p><p>[This corrects the article on p. 696 in vol. 55, PMID: 40686699.].</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1038"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model\" [Turkish Journal of Medical Sciences 49 6 1789 1799].","authors":"İnayet Güntürk, Cevat Yazici, Kader Köse, Fatma Dağli, Bilal Yücel, Arzu Yay","doi":"10.55730/1300-0144.6057","DOIUrl":"https://doi.org/10.55730/1300-0144.6057","url":null,"abstract":"<p><p>[This corrects the article on p. 1789 in vol. 49, PMID: 31655538.].</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1037"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic role of the systemic immune-inflammation index and pan-immune-inflammation value in acute methanol poisoning.","authors":"Hatice Şahin, Gülay Ulusal Okyay, Fatma Ayerden Ebinç, Fevzi Coşkun Sökmen, Emre Yaşar, Gülşen Akçay, Mehmet Deniz Ayli","doi":"10.55730/1300-0144.6050","DOIUrl":"https://doi.org/10.55730/1300-0144.6050","url":null,"abstract":"<p><strong>Background/aim: </strong>Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the systemic immune-inflammation index (SII) and the pan-immune-inflammation value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.</p><p><strong>Material and methods: </strong>This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye: University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (1 January 2015 to 1 October 2022) and Etlik City Hospital (1 October 2022 to 11 March 2025). Demographic, clinical, and laboratory data, along with treatment details and outcomes (discharge or inhospital death), were systematically recorded.</p><p><strong>Results: </strong>A total of 76 patients were included, of whom 92.1% were male, with a mean age of 49.0 ± 12.4 years. During hospitalization, 48.6% (n = 37) died. Both SII and PIV values at admission were significantly higher in nonsurvivors (p < 0.001 for SII; p = 0.031 for PIV). In multivariate Cox regression analysis, higher SII (HR: 2.44; 95% CI: 1.05-5.67; p = 0.034) and PIV (HR: 2.08; 95% CI: 1.05-4.13; p = 0.030) were independently associated with increased risk of mortality. Receiver operating characteristic (ROC) analysis showed an AUC of 0.750 (95% CI: 0.649-0.865) for SII, with an optimal cutoff of 665.6 (sensitivity: 50%; specificity: 46%), and an AUC of 0.640 (95% CI: 0.519-0.769) for PIV, with an optimal cutoff of 512.5 (sensitivity: 53%; specificity: 47%).</p><p><strong>Conclusion: </strong>SII and PIV measured at hospital admission may have potential prognostic value in predicting inhospital mortality in patients with acute MP.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"971-981"},"PeriodicalIF":1.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood group profile of Türkiye with regional and demographic differences: a 23-year retrospective study.","authors":"Levent Sağdur, Aziz Karaca, Mustafa Nuri Günçikan, Mustafa Yilmaz, Kerem Kinik","doi":"10.55730/1300-0144.6049","DOIUrl":"https://doi.org/10.55730/1300-0144.6049","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to comprehensively analyze the distribution of ABO and Rh blood groups, as well as demographic characteristics and regional variations, using data from 9.5 million blood donors across Türkiye.</p><p><strong>Materials and methods: </strong>In this multicenter, retrospective, cross-sectional study, data were collected from 9,587,592 healthy, voluntary donors who donated to the Turkish Red Crescent between 1998 and 2021. Donors met the criteria of being 18-70 years old, weighing over 50 kg, with hemoglobin levels above 13.5 g/dL for males and 12.5 g/dL for females. The data were evaluated based on age, sex, education level, and geographic region.</p><p><strong>Results: </strong>The ABO blood group distribution was determined as follows: A (42.1%), O (34.0%), B (16.4%), and AB (7.5%). When analyzed together with the Rh factor, A Rh (+) was the most common (37.1%), while AB Rh (-) was the least common (0.9%). Regional analyses showed that A Rh (+) was highest in the Black Sea Region, whereas the Aegean Region had a notably high AB Rh (+) rate. The Marmara Region had the highest total number of donors, while Eastern Anatolia had the highest donation rate relative to its population. Demographically, 82.0% of donors were male; the 18-34 age group represented the most active segment (50.5%), and high school graduates had the highest donation rate (31.2%).</p><p><strong>Conclusion: </strong>This study provides a detailed profile of Türkiye's blood donors, filling a gap in national blood group data. The findings support optimizing transfusion services, improving blood supply management, and refining donor recruitment strategies. Regional and demographic disparities highlight the need for targeted awareness campaigns. Addressing sex imbalances and increasing participation from underrepresented groups can enhance sustainability. Additionally, these findings contribute valuable data for clinical applications, epidemiological studies, and future healthcare policy development.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"961-970"},"PeriodicalIF":1.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of antimicrobials to oral sprays containing nonsteroidal antiinflammatory drugs does not reduce the severity of postoperative sore throat: a prospective, randomized, placebo-controlled trial.","authors":"Pelin Yildiz, Mobin Hemmati, Leyla Kutlucan, Tankut Uzun, Togay Müderris","doi":"10.55730/1300-0144.6044","DOIUrl":"https://doi.org/10.55730/1300-0144.6044","url":null,"abstract":"<p><strong>Background/aim: </strong>Postoperative sore throat (POST) is a common complication following general anesthesia that significantly affects patient satisfaction, prolongs recovery, and increases treatment costs. This study aimed to evaluate whether the addition of antimicrobial agents to NSAID-based oral sprays could enhance the preventive efficacy against POST.</p><p><strong>Materials and methods: </strong>In this prospective, randomized, placebo-controlled trial, 105 patients (ASA I-II; age 18-65 years) scheduled for elective ear surgery under general orotracheal anesthesia were enrolled. Patients were randomly allocated into three groups: a placebo group; a flurbiprofen oral spray group; and a group receiving an oral spray containing benzydamine hydrochloride, chlorhexidine digluconate, and cetylpyridinium chloride. The sprays were administered under direct laryngoscopy before intubation and after the final oropharyngeal aspiration. POST severity was assessed using a 10mm Visual Analog Scale (VAS) at 1 h, 6 h, 24 h, and 1 week postoperatively. Patients were also subgrouped based on surgical duration (<120 min vs. ≥120 min).</p><p><strong>Results: </strong>Both NSAIDbased treatments significantly reduced VAS scores at early postoperative time points compared to the placebo. In subgroup analysis, patients undergoing surgeries lasting less than 120 min exhibited lower VAS scores with both active treatments, while in those with surgeries ≥120 min, significant differences were noted at 1 and 6 h. No significant difference was found between the flurbiprofen spray and the combination spray.</p><p><strong>Conclusion: </strong>NSAIDcontaining oral sprays effectively reduce the severity of postoperative sore throat. However, the addition of antimicrobial agents does not provide extra analgesic benefit, suggesting that simpler, costeffective NSAID formulations may be preferable in clinical practice.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"912-919"},"PeriodicalIF":1.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of novel DiaRD-HBV DNA qPCR kit with the <i>artus</i> HBV QS-RGQ kit for quantification of HBV DNA in clinical samples.","authors":"Ülker Çuhaci, Hande Toptan, Bengül Durmaz, Mehmet Köroğlu, Rıza Durmaz","doi":"10.55730/1300-0144.6053","DOIUrl":"https://doi.org/10.55730/1300-0144.6053","url":null,"abstract":"<p><strong>Background/aim: </strong>Hepatitis B virus (HBV) leads to widespread chronic infections that may result in long-term complications such as cirrhosis and hepatocellular carcinoma. The use of sensitive molecular methods for HBV DNA quantitation has provided significant contributions for diagnosis and monitoring of disease. The current study aimed to evaluate the diagnostic performances of a novel DiaRD HBV qPCR kit (novel kit) in comparison with the <i>artus</i> HBV QS-RGQ kit (comparator kit).</p><p><strong>Materials and methods: </strong>A total of 288 plasma samples-105 HBV DNA-positive and 183 HBV DNA-negative-were tested using both kits. The diagnostic and quantitative results of the novel kit were compared to those of the comparator kit.</p><p><strong>Results: </strong>The novel kit had very high sensitivity, specificity, and accuracy with rates of >99.9%. Comparative analyses conducted on 105 HBV DNA-positive samples showed no significant differences of ≥ 1 log₁₀ between the novel kit and comparator kit. The median viral load detected by the novel kit was 6.21 × 10⁷ IU/mL (range: 0.9 × 10¹ to 2.98 × 10⁹) as compared to the comparator kit where it was 5.43 × 10⁷ IU/mL (range: 1.00 × 10¹ to 2.87 × 10⁹). The correlation plot demonstrated a strong linear relationship (R² value of 0.9655) between the two kits. Reproducibility testing performed on three different HVB DNA loads showed the overall coefficient of variations <5%. The mean difference between the quantitative results of two kits was -0.03 log IU/mL by Bland-Altman analysis.</p><p><strong>Conclusion: </strong>The result of the current study indicates that this novel DiaRD HBV qPCR kit can be used in routine diagnosis and monitoring of HBV infections.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1003-1013"},"PeriodicalIF":1.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting extremity fracture risk in children with attention-deficit/hyperactivity disorder.","authors":"Yüksel Sümeyra Naralan, Esra Demirel","doi":"10.55730/1300-0144.6047","DOIUrl":"https://doi.org/10.55730/1300-0144.6047","url":null,"abstract":"<p><strong>Background/aim: </strong>Attention-deficit/hyperactivity disorder (ADHD) is increasingly recognized not only for its behavioral and cognitive challenges but also for its potential implications in physical health, particularly injury risk. This study aimed to investigate the incidence of extremity fractures among children and adolescents diagnosed with ADHD, and to evaluate the influence of demographic, clinical, and pharmacological variables-including ADHD subtypes and medication types-on fracture risk.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study included 754 children and adolescents aged 6-18 years old who were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders-5 criteria. Data were collected from electronic health records at a tertiary referral hospital. Variables analyzed included age, sex, ADHD subtype, intelligence quotient (IQ) level, pharmacological treatment status (methylphenidate or atomoxetine), comorbid psychiatric and medical conditions, and fracture history confirmed by clinical and radiological evidence. Binary logistic regression analysis was conducted to identify independent predictors of fracture risk.</p><p><strong>Results: </strong>The overall incidence of extremity fractures was 15%, with 69% occurring in the upper extremities. Children using ADHD medication had significantly lower fracture rates (9.7%) compared to untreated peers (32.6%, p < 0.001). Logistic regression showed that both methylphenidate (OR = 0.396) and atomoxetine (OR = 0.138) were associated with reduced fracture risk. The inattentive subtype also showed a protective effect. Other factors, such as age, sex, IQ, and comorbidities, were not significantly associated with fracture incidence.</p><p><strong>Conclusions: </strong>This study highlights a notable reduction in extremity fracture risk among children with ADHD receiving pharmacological treatment, suggesting a possible protective role of stimulant and nonstimulant medications. Subtype-specific risk profiles further emphasize the importance of personalized approaches in ADHD management strategies.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"940-948"},"PeriodicalIF":1.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and quantification of microplastics in cerumen.","authors":"Bengi Arslan, Yüce Islamoğlu, Ali Sami Berçin, Selen Akbulut, Mehmet Melikoğlu","doi":"10.55730/1300-0144.6043","DOIUrl":"https://doi.org/10.55730/1300-0144.6043","url":null,"abstract":"<p><strong>Background/aim: </strong>Microplastics (MPs) are a growing concern due to their pervasive environmental presence and their potential impact on environmental and human exposure. Given evidence of systemic MP presence in human tissues and fluids, and the ear canal's environmental exposure, this novel study aimed to identify these particles in human cerumen. Cerumen was collected from the proximal ear canal to minimize potential airborne contamination.</p><p><strong>Materials and methods: </strong>Cerumen samples were prospectively collected from 12 adult patients (23 patient-derived samples) and three control water samples, following ethical approval and consent. Samples were extracted using sterile instruments, stored in glass, diluted, and filtered through 0.22 μm cellulosic membranes. Microplastics were identified and measured morphologically using a 10× laboratory microscope with digital image processing; however, chemical confirmation of polymer type was beyond the scope of this initial study. Descriptive statistics were employed for analysis.</p><p><strong>Results: </strong>Among the 12 adult patients (23 patient-derived samples), microplastic particles were detected in 10 (83.3%, patient level detection rate). A cumulative total of 31 individual MPs were identified across the 23 patient-derived cerumen samples analyzed (comprising 29 detected and two instances of zero particle detection), ranging significantly in size from 16 μm to 930 μm and displaying various colors. Water control samples contained seven particles (3-46 μm), showing a clear size disparity from cerumen-borne particles.</p><p><strong>Conclusion: </strong>This study provides solid evidence of microplastic presence in human cerumen, suggesting a novel potential route of elimination from the human body. The high detection rate among patients and distinct characteristics of cerumen-borne MPs compared to controls imply genuine human accumulation rather than procedural contamination. Cerumen highlights a promising potential noninvasive bioindicator for assessing microplastic exposure. Further research in larger populations is essential to confirm these findings, elucidate mechanisms, identify polymer types, and explore potential health implications.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"904-911"},"PeriodicalIF":1.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and genotypic characterization of meropenem-susceptible and meropenem-resistant <i>Serratia marcescens</i> isolates.","authors":"Şeyma Nigiz, Gülşen Hazirolan, Gülşen Altinkanat Gelmez, Ceren Özkul, Engin Koçak, Sevilay Erdoğan Kablan, Emirhan Nemutlu, Aycan Gündoğdu, Fatma Bayrakdar, Ufuk Hasdemir, Deniz Gür","doi":"10.55730/1300-0144.6055","DOIUrl":"https://doi.org/10.55730/1300-0144.6055","url":null,"abstract":"<p><strong>Background/aim: </strong><i>Serratia marcescens</i> which is a nosocomial pathogen, is naturally resistant to a wide spectrum of antibiotics, which makes the management of infections difficult. The aim of this study was to determine the <i>in vitro</i> susceptibilities of <i>S. marcescens</i> to ceftriaxone, ceftazidime, meropenem, amikacin, gentamicin, ciprofloxacin, and to compare the metabolic profiles of meropenem-resistant isolates under basal conditions and after exposure to sublethal concentrations of meropenem.</p><p><strong>Materials and methods: </strong>A total of 84 <i>S. marcescens</i> isolates were included from various samples. Genes for meropenem resistance were determined by polymerase chain reaction (PCR). Genetic similarities among isolates of <i>S. marcescens</i> were investigated by pulsed-field gel electrophoresis (PFGE). MIC changes of meropenem were investigated in the presence of the resistance-nodulation-cell division (RND) type pump inhibitor phenylalanyl-arginyl-β-naphthylamide (PAβN) and proton ionophore (uncoupler) carbonyl cyanide m-chlorophenylhydrazone (CCCP). A GC/MS-based metabolomics approach was implemented to determine the differentiation of metabolome structure. We examined the adaptive responses of isolates, characterized by resistance or susceptibility, under conditions of meropenem-induced stress.</p><p><strong>Results: </strong>The highest resistance rate was observed for ceftriaxone (27.6%). Amikacin was the most effective drug, with a resistance rate of 6.9%. Overall, 10 (11.9%) isolates were resistant to meropenem. Genotyping of β-lactamase genes revealed that <i>bla</i> _OXA-48 was present in one isolate. In total, efflux pump activity was detected in four isolates. The GC/MS-based metabolomics analysis revealed alterations in nucleotide and pyrimidine metabolism, as well as in ATP-binding cassette (ABC) transporter pathways, between the meropenem-susceptible and meropenem-resistant groups.</p><p><strong>Conclusion: </strong>Understanding the metabolic profiles of <i>S. marcescens</i> could facilitate the development of novel diagnostic approaches and antimicrobial strategies in the ongoing global effort to combat meropenem-resistant <i>S. marcescens</i>.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1024-1034"},"PeriodicalIF":1.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of hyperoxemia among potentially critically ill patients treated in hospital wards: a retrospective study.","authors":"Mehmet Nuri Yakar, Doğukan Şenberber, Ozan Balkabak, Nurgazy Shermatov, Kaan Köşker, Selin Elden, Emel Ibişoğlu, Begüm Ergan, Volkan Hanci, Necati Gökmen","doi":"10.55730/1300-0144.6048","DOIUrl":"https://doi.org/10.55730/1300-0144.6048","url":null,"abstract":"<p><strong>Background/aim: </strong>The literature shows a link between hyperoxemia and poor outcomes, whereas this association remains unclear in hospital wards. This study aims to determine the incidence of hyperoxemia in hospital wards and its risk factors.</p><p><strong>Materials and methods: </strong>Patients aged ≥ 18 years who underwent an evaluation by an intensivist between 1 January 2020 and 31 December 2020, while receiving treatment in hospital wards, were included in the study following ethics committee approval. Patients with hypoxemia (partial pressure of oxygen [PaO₂] < 60 mmHg), a condition related to Coronavirus disease 2019, a hospital stay < 1 day, or missing data were excluded. Patients were divided into two groups: normoxemia (60 mmHg ≤ PaO₂ < 120 mmHg) and hyperoxemia.</p><p><strong>Results: </strong>The incidence of hyperoxemia was 42.2%. Patients with hyperoxemia had longer hospital stays and higher intensive care unit admission rates than those with normoxemia. Partial pressure of carbon dioxide < 30 mmHg (OR, 1.61; 95% CI, 1.16-2.25; p = 0.005), hemoglobin ≤ 10.3 g/dL (OR, 1.33; 95% CI, 1.01-1.75; p = 0.044), positive pressure ventilation (OR, 1.73; 95% CI, 1.09-2.74; p = 0.021), fraction of inspired oxygen ≥ 50% (OR, 1.71; 95% CI, 1.10-2.65; p = 0.018), type IV respiratory failure (OR, 1.62; 95% CI, 1.05-2.51; p = 0.030), and receiving treatment on surgical units (OR, 1.47; 95% CI, 1.02-2.12; p = 0.038) were independently associated with hyperoxemia. Charlson comorbidity index > 6 (OR, 0.64; 95% CI, 0.49-0.85; p = 0.002), and chronic obstructive pulmonary disease exacerbation (OR, 0.51; 95% CI, 0.29-0.89; p = 0.017) were independently associated with normoxemia.</p><p><strong>Conclusion: </strong>Monitoring potentially critically ill patients receiving oxygen therapy in wards is essential to mitigate hyperoxemia and optimize the use of healthcare resources. Further research could focus on developing strategies to accomplish this objective.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"949-960"},"PeriodicalIF":1.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}