Turkish Journal of Medical Sciences最新文献

{"title":"A prospective study for the examination of peripheral blood smear samples in pediatric population using artificial intelligence.","authors":"Elif Habibe Aktekin, Mert Burkay Çöteli, Ayşe Erbay, Nalan Yazici","doi":"10.55730/1300-0144.5982","DOIUrl":"https://doi.org/10.55730/1300-0144.5982","url":null,"abstract":"<p><strong>Background/aim: </strong>Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS samples while increasing the sensitivity and specificity rates of the experts as a decision support system of a prediagnostic tool.</p><p><strong>Materials and methods: </strong>The methodology of this study comprises three steps for the creation of an effective learning technique for blood cell disorders. First is the digitization of PBS samples in 100x optical-digital magnification using Mantiscope which is a cloud-based slide scanner system. The second is collection of pediatric hematology experts' annotations and the last one is data augmentation to increase the data variation and size. The data consists of 372 individuals, an approximate number of 12,000 annotated images with 500,000 blood cell objects. A subjective test is also performed to observe the interobserver variability.</p><p><strong>Results: </strong>We measured sensitivity and specificity for 28 cell types for the resulting decision support system. We obtained sensitivity 98% for myeloblast, 94% for basophil and 90% for lymphoblast, specificity 99% for basophil, eosinophil, monocyte, hypersegmented neutrophil, band neutrophil and reactive neutrophil in leukocyte subtypes. When erythrocyte measurements were evaluated, it was found that the sensitivity was 93% for normoblast, 81% for target cell and pencil cell, 80% for sickle cell, specificity was 99% for normoblast, pencil cell, echinocyte, and sickle cell.</p><p><strong>Conclusion: </strong>It is observed that sensitivity and specificity greater than 90% can be obtained for some specific cell types with this clinical study. It is seen that data augmentation increases the effectiveness of the learning method in terms of leukocytes by improving the measurement metrics. This could be a valuable technique to evaluate acute leukemias and hemolytic disorders.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"386-397"},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does dexmedetomidine infusion reduce the postoperative analgesic need in lumbar disc surgery?","authors":"Sibel Çatalca, Özlem Özmete, Numan Berk, Soner Çivi, Emre Durdağ, Caner Incekaş, Nesrin Bozdoğan Özyilkan","doi":"10.55730/1300-0144.5991","DOIUrl":"https://doi.org/10.55730/1300-0144.5991","url":null,"abstract":"<p><strong>Background/aim: </strong>Patients experience moderate-to-severe pain, especially in the first days after lumbar disc surgery. Poorly controlled pain in the postoperative period negatively affects patient outcomes. Dexmedetomidine is a highly selective α2 adrenoceptor agonist with demonstrated analgesic efficacy. However, conflicting results have been reported in the current literature regarding the efficacy of dexmedetomidine in this surgery. In this study, we tested the hypothesis that dexmedetomidine safely improves pain scores and reduces opioid consumption in lumbar microdiscectomy.</p><p><strong>Materials and methods: </strong>Medical records of patients who underwent lumbar microdiscectomy with general anesthesia between January 2023 and October 2023 were retrospectively reviewed. Patients who met the inclusion criteria were divided into two groups as those who did not receive dexmedetomidine infusion (Group A) and those who received dexmedetomidine infusion (Group B). Patients in Group B received a loading dose of 1 μg/kg dexmedetomidine followed by a maintenance infusion of 0.5 μg/kg/h. The primary outcome of our study was postoperative fentanyl consumption at the 24^th h. Secondary outcomes of our study included need for fentanyl in the recovery unit, postoperative pain scores at the 2^nd, 6^th, 12^th, and 24^th h and fentanyl consumption at the 2^nd, 6^th, and 12^th h and perioperative complications.</p><p><strong>Results: </strong>A total of 68 patients were included in our study, 34 patients in each group. The number of patients requiring fentanyl in the recovery unit and the dose of fentanyl administered were similar in both groups (p = 0.223 and p = 0.373, respectively). There was no statistical difference in the pain scores, opioid consumption, and perioperative complications at the 2^nd, 6^th, 12^th, and 24^th h after surgery in patients receiving dexmedetomidine compared to the control group (p > 0.05).</p><p><strong>Conclusion: </strong>Intraoperative dexmedetomidine infusion did not reduce postoperative pain intensity and opioid consumption in patients undergoing lumbar microdiscectomy under general anesthesia.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"470-481"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of liraglutide on expressions of insulin secretion and beta cell survive associated GPCR genes in pancreatic beta cells.","authors":"Melikenur Türkol, Türker Bilgen","doi":"10.55730/1300-0144.5997","DOIUrl":"https://doi.org/10.55730/1300-0144.5997","url":null,"abstract":"<p><strong>Background/aim: </strong>Liraglutide as a long-acting glucagon-like peptide drug has anti-hyperglycemic and antiobesity effects. G protein-coupled receptors (GPCRs) are well-known drug target molecules that conduct critical signaling pathways related with diseases. Research has confirmed the role of many GPCRs genes in the regulation of pancreatic beta cell functions and insulin secretion. Liraglutide dependent expressional changes in GPCR genes may let us determine new drug targets.</p><p><strong>Materials and methods: </strong>Therefore, we investigated the changes in expression of GPR75, GPR56, GLP1R, M3R, and CB1R genes, which are the GPCR family members, in response to liraglutide treatment in the NIT-1 mouse pancreatic beta cells in this study. Changes at the mRNA levels of these GPCR genes were determined by a qPCR and the ddCT method, and using a control gene and untreated control groups.</p><p><strong>Results: </strong>We found statistically significant increases at the mRNA levels of GPR75, GPR56, M3R, and CB1R genes with 10nM of liraglutide at min 60, while there was no time and dose-dependent change in all of the genes investigated. We detected that the GLP1R gene expressions were stable amongst different time points and doses of liraglutide, except for a statistically significant decrease in the GLP1R gene expression in response to 1000nM of liraglutide treatment compared to 10nM and 100nM concentrations.</p><p><strong>Conclusion: </strong>Our results indicate that in vitro liraglutide administration in pancreatic beta cells appears to increase the expressions of GPR75, GPR56, M3R and CB1R genes which have already been related to insulin secretion and beta cell survive. Liraglutide may exert this effect through the GLP1R or other cellular pathways undescribed yet. Combined usage of liraglutide and the specific ligands of GPR75, GPR56, M3R, and CB1R may provide a better response in terms of insulin secretion and beta cell survival, making them good targets for antidiabetic and antiobesity therapy.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"525-530"},"PeriodicalIF":1.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein Barr virus associated venous thromboembolism.","authors":"Yeliz Çiçek, Ali Mert","doi":"10.55730/1300-0144.5998","DOIUrl":"https://doi.org/10.55730/1300-0144.5998","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"531-532"},"PeriodicalIF":1.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of total oxidative state, total antioxidative state, serum paraoxonase activity, and thiol levels before and after 6 months of treatment in patients with multiple sclerosis who have been recently started on new therapy agents.","authors":"Emel Başar, Hasan Bayindir, Hatice Ferhan Kömürcü, Ebru Bilge Dirik, Ömer Anlar, Özcan Erel","doi":"10.55730/1300-0144.5983","DOIUrl":"https://doi.org/10.55730/1300-0144.5983","url":null,"abstract":"<p><strong>Background/aim: </strong>The objective of this study was to establish the oxidative stress determiners as a total oxidative state (TOS), total antioxidative state (TAS), paraoxonase (PON) activity, oxidative stress index (OSI), and thiol/disulfide levels before and after 6 months of immunomodulator therapy in patients who were diagnosed according to the revised McDonald Criteria.</p><p><strong>Materials and methods: </strong>Thirty-nine patients were included in our study who were diagnosed according to the revised McDonald Criteria, approved to participate in the study, and had been treated in the neurology inpatient clinic or presented in the neurology outpatient clinic of Ankara Yıldırım Beyazıt University Atatürk Training and Research Hospital. Blood samples were collected from patients before treatment and six months after treatment. The venous blood samples of the patients were evaluated for routine biochemical tests, TOS, TAS, PON activity, OSI, and thiol/disulfide levels.</p><p><strong>Results: </strong>The oxidative stress parameter levels of blood samples obtained before and after 6 months of the treatment were compared. The blood samples obtained after 6 months of therapy exhibited statistically significant results, including elevated levels of native thiol/total thiol (SH/SH+SS), PON, and TAS (p = 0.001). No significant relation was observed between the duration of disease, sex, used therapy agents, and oxidative stress parameters.</p><p><strong>Conclusion: </strong>In this study, we determined that TOS and OSI, which are indicators of oxidative stress, and TAS and PON, which exhibit antioxidative activity, can be employed to evaluate the therapy response. Additionally, we found that immunomodulator therapies can exhibit a protective effect, as evidenced by a reduction in oxidative stress indicators.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"398-403"},"PeriodicalIF":1.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival of patients with 2014 FIGO stage IIIC high-grade serous ovarian cancer who were treated with platin-based adjuvant chemotherapy.","authors":"Mehmet Ünsal, Meltem Yücesoy, Okan Oktar, Yeşim Uçar, Gülşah Tiryaki Güner, Okan Aytekin, A Alp Tokalioğlu, Hande Esra Koca Yildirim, Fatih Kiliç, Burak Ersak, Caner Çakir, Dilek Yüksel, Çiğdem Kiliç, Sevgi Koç, Günsu Kimyon Cömert, Özlem Moraloğlu Tekin, Yaprak Engin Üstün, Taner Turan","doi":"10.55730/1300-0144.5980","DOIUrl":"https://doi.org/10.55730/1300-0144.5980","url":null,"abstract":"<p><strong>Background/aim: </strong>Epithelial ovarian cancer is the second most prevalent type of gynecological cancer. We aimed to investigate prognostic factors related to survival in patient with 2014 FIGO stage IIIC high-grade serous ovarian cancer (HGSOC).</p><p><strong>Materials and methods: </strong>Two hundred fifty eight patients were evaluated retrospectively. The absence of a visible tumor was determined as maximum cytoreduction, and a residual tumor size of 1 cm or less was determined as optimal cytoreduction. Patients who underwent cytoreduction followed by a combination of platinum and taxane adjuvant chemotherapy were included. Exclusion criteria for the study were patients taking neoadjuvant chemotherapy and those with suboptimal surgery.</p><p><strong>Results: </strong>Optimal cytoreduction was performed in 107 and maximal cytoreduction was performed in 151 patients. The five-year PFS rate was 27% and the five-year DSS rate was 76%. While high ascites volume and optimal cytoreduction were identified as independent prognostic factors for disease failure, only optimal cytoreduction was an independent prognostic factor for survival.</p><p><strong>Conclusion: </strong>The maximal cytoreduction is improves PFS and DSS in patients with 2014 FIGO stage IIIC HGSOC as our study results. Therefore, maximum surgical effort and radical cytoreductive procedures should be performed.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"368-376"},"PeriodicalIF":1.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \" Telemedicine in pediatric rheumatology: the video pediatric gait, arms, legs, and spine (v-pGALS) examination\" [Turkish Journal of Medical Sciences 54 (5) 2024 963-969 ].","authors":"Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emil Aliyev, Özge Başaran, Yelda Bilginer, Seza Özen, Ezgi Deniz Batu","doi":"10.55730/1300-0144.5976","DOIUrl":"https://doi.org/10.55730/1300-0144.5976","url":null,"abstract":"<p><p>[This corrects the article on p. 963 in vol. 54, PMID: 39473760.].</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"348"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of virtual reality-based relaxation and exergaming on primary dysmenorrhea symptoms.","authors":"Muhammed Şeref Yildirim, Merve Çoğ, Büşra Mehder Akbaş, Sinem Salar, Hilal Keklicek","doi":"10.55730/1300-0144.5981","DOIUrl":"10.55730/1300-0144.5981","url":null,"abstract":"<p><strong>Background/aim: </strong>Primary dysmenorrhea (PD) is a menstrual disorder with significant physical and psychological impacts. Physical activity and relaxation techniques are proven methods for managing PD. Advances in virtual reality (VR) suggest that immersive relaxation and exergaming could provide new avenues for symptom relief. This study aimed to investigate the acute effects of VR-based interventions on PD symptoms and compare them with a control group receiving Jacobson's Relaxation.</p><p><strong>Materials and methods: </strong>A randomized, controlled, single-blind trial was conducted with 43 female participants aged 18-30 years with regular menstrual cycles and PD. Participants were allocated to three groups: (I) immersive VR relaxation, (II) nonimmersive VR exergaming, or (III) Jacobson's relaxation (control group). Each participant completed a single 20-min session of their assigned intervention. Primary outcomes included abdomino-pelvic pain intensity, menstrual symptom severity, sleep quality, and perceived intervention effectiveness.</p><p><strong>Results: </strong>All interventions reduced pain (r = 0.78-0.85) and symptom severity (r = 0.73-0.88) (p < 0.05), with no sleep quality changes. Between-group comparisons showed the control group to be more effective than nonimmersive VR exergaming in reducing menstrual symptom severity (p = 0.021, η² = 0.144) and yielded higher perceived effectiveness (p = 0.010, η² = 0.182).</p><p><strong>Conclusion: </strong>Both VR-based interventions and the control group effectively alleviated PD symptoms, with the control group providing the most consistent symptom relief. Despite promising results for VR-based methods, traditional relaxation may be more accessible and better tolerated.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"377-385"},"PeriodicalIF":1.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative vasorelaxant effects of atorvastatin and rosuvastatin in rat aorta: investigating the role of perivascular adipose tissue.","authors":"Deniz Kaleli Durman, Meryem Aras, G Ruveyda Aktaş, B Sönmez Uydeş Doğan","doi":"10.55730/1300-0144.5996","DOIUrl":"https://doi.org/10.55730/1300-0144.5996","url":null,"abstract":"<p><strong>Background/aim: </strong>Statins are known to display pleiotropic effects on the vascular system, beyond their lipid-lowering properties. Studies on isolated vascular preparations have demonstrated their acute relaxant effects on vascular tone. Considering the increased evidence in regard to the contribution of perivascular adipose tissue (PVAT) in the regulation of vascular homeostasis, we aimed to investigate the possible modulatory role of PVAT in the vascular effects of atorvastatin and rosuvastatin in isolated rat aorta.</p><p><strong>Materials and methods: </strong>Thoracic aortas isolated from young male Wistar rats were divided into two groups: rings with intact PVAT (+) and rings without PVAT (-), and then mounted in an isolated organ bath system. Rat aortic rings were standardized with potassium chloride (KCl, 40 mM), and then endothelium-dependent relaxation responses were checked by acetylcholine (Ach, 10^-7-10^-4 M). The concentration-dependent (10^-7-10^-4 M) effects of atorvastatin and rosuvastatin were studied on rat aortic rings precontracted submaximally with phenylephrine (Phe, 10^-6-3 × 10^-5 M). In addition, endothelium-independent relaxation responses were evaluated by sodium nitroprusside (SNP, 10^-6 M) at the end of each experiment.</p><p><strong>Results: </strong>Rat aortic rings with intact PVAT (+) and without PVAT (-) displayed similar endothelium-dependent and -independent relaxations to Ach and SNP, respectively. Increasing concentrations (10^-7-10^-4 M) of atorvastatin and rosuvastatin directly relaxed the aortic rings with and without PVAT. The maximum relaxant effects of rosuvastatin was found significantly greater than atorvastatin.</p><p><strong>Conclusion: </strong>The current study demonstrated that atorvastatin and rosuvastatin displayed prominent relaxations in rat aortic rings with intact PVAT (+) and without PVAT (-). Notably, rosuvastatin produced a greater vasorelaxant effect compared to atorvastatin in rat aortic rings with and without PVAT. Current study provides a novel evidence that PVAT does not significantly influence statin-mediated vasorelaxation under physiological conditions.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"518-524"},"PeriodicalIF":1.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of different scoring systems and biochemical markers in determining the severity and complications of acute pancreatitis.","authors":"Ahmet Ali Aktaş, Pınar Taşar, Deniz Siğirli, Sadık Ayhan Kiliçturgay","doi":"10.55730/1300-0144.5989","DOIUrl":"https://doi.org/10.55730/1300-0144.5989","url":null,"abstract":"<p><strong>Background and study aim: </strong>The aim of the study is to demonstrate the effectiveness of different scoring systems and inflammatory markers in predicting the severity, local complications, pancreatic necrosis, and mortality of acute pancreatitis (AP).</p><p><strong>Materials and methods: </strong>The data of 357 patients whom the severity of pancreatitis was classified according to the Revised Atlanta Classification System diagnosed with AP were retrospectively examined. Also The APACHE II, BISAP, mCTSI, and Ranson scores of all patients were calculated. After determining the cut-off values for scoring systems and inflammatory markers with ROC analysis, comparison for AP severity, local complication, necrosis, and mortality.</p><p><strong>Results: </strong>In the study, 2.8% of patients had severe pancreatitis. It was found that the risk of developing local complications increased 2.82 times in cases with an 48^th-h CRP value >192 mg/L compared to those below this threshold, and 48.96 times in cases with an mCTSI score >2 compared to ≤ 2 cases. It was found that having a Ranson score >4 increased the risk of mortality by 9.07 times compared to having a score of ≤4 (p = 0.038). It was observed that having a BISAP >2 increased the risk of severe AP by 11.79 times compared to ≤2. In cases where the 48^th-h NLR value was >13.33, the risk of severe AP was found to have increased by 5.85 times.</p><p><strong>Conclusion: </strong>Although the superiority of scoring systems could not be demonstrated in our study, CRP and MCTSI for local complications, BISAP for severity and Ranson score for mortality were the determining variables.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"451-460"},"PeriodicalIF":1.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}