Turkish Journal of Medical Sciences最新文献

{"title":"Impact of two sedation protocols on cardiac electrophysiology during spinal anesthesia.","authors":"Selvinaz Durantaş, Burak Nalbant, Fatma Kavak Akelma, Gökhan Erdem, Abdulkadir But","doi":"10.55730/1300-0144.6182","DOIUrl":"10.55730/1300-0144.6182","url":null,"abstract":"<p><strong>Background/aim: </strong>Perioperative factors such as anesthetic drugs, central blocks, surgical stress, pain, and anxiety can affect cardiac electrophysiology and increase the risk of arrhythmias. Arrhythmia susceptibility can be assessed using ventricular markers such as the QT interval (QT), heart rate-corrected QT interval (QTc), QT dispersion (QTd), time between peak and end of T wave (Tp-e), cardiac electrophysiologic balance index (iCEB), and heart rate-corrected index of cardiac electrophysiologic balance (iCEBc), obtained from noninvasive electrocardiography (ECG) data. This study compared the effects of propofol and dexmedetomidine sedation on these parameters in patients undergoing total knee arthroplasty performed under spinal anesthesia.</p><p><strong>Materials and methods: </strong>This prospective, observational clinical study was conducted at Ankara Bilkent City Hospital between March and August 2023, and included patients scheduled for elective total knee arthroplasty. Patients were divided into two groups based on the clinician's preference: group P received propofol infusion, and group D received dexmedetomidine. All patients underwent spinal anesthesia. The primary outcome was the comparison of iCEB and iCEBc values between the two groups. Secondary outcomes included comparisons of QT, QTc, QTd, and Tp-e values.</p><p><strong>Results: </strong>A total of 74 participants were enrolled, and 70 were included in the final analysis (35 per group). No significant differences were found in demographic data, local anesthetic dose, spinal interventions, sensory block level, or bispectral index values (p > 0.05). QTc increased in both groups after spinal anesthesia; however, group P exhibited significantly higher values at t1 and t15 compared with group D (p = 0.004 and p = 0.046, respectively). iCEBc returned to baseline at t10 in group D and t45 in group P. A significant iCEBc increase from t0 to t1 was observed in group P but not in group D.</p><p><strong>Conclusion: </strong>Compared with propofol, dexmedetomidine sedation under spinal anesthesia was associated with differences in ECG-derived indices related to repolarization duration, homogeneity, repolarization-depolarization balance, and transmural distribution. These findings should be interpreted within the context of the study's observational design and the use of ECG-derived markers rather than clinical arrhythmic endpoints.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"479-488"},"PeriodicalIF":1.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transversus abdominis and erector spinae plane blocks on postoperative pain control and postpartum depression after cesarean section: a randomized prospective study.","authors":"Hilal Biradli, Feyza Çalişir, Alev Özer","doi":"10.55730/1300-0144.6155","DOIUrl":"10.55730/1300-0144.6155","url":null,"abstract":"<p><strong>Background/aim: </strong>Effective postoperative pain management after cesarean section is essential for maternal recovery. Poor pain control can lead to complications, including postpartum depression. This study aimed to compare the postoperative analgesic efficacy of erector spinae plane (ESP) and transversus abdominis plane (TAP) blocks following cesarean section, with a particular focus on their potential impact on postpartum depression.</p><p><strong>Materials and methods: </strong>Sixty patients were randomly assigned to receive either an ESP block (Group E, n = 30) or a TAP block (Group T, n = 30) after cesarean section. Pain severity was assessed using a visual analog scale (VAS), and the need for rescue analgesics and patient satisfaction were recorded. Postpartum depression was evaluated using the Edinburgh Postpartum Depression Scale (EPDS) at 4-6 weeks postpartum.</p><p><strong>Results: </strong>There was no significant difference between the groups in analgesic duration (Group E: 15 h, Group T: 14 h, p = 0.314). Group E showed a significantly lower need for rescue analgesics (0 vs. 1, p = 0.049). The VAS score at the first hour was lower in Group E (2 vs. 3, p = 0.032), but no differences were observed at subsequent time points. Postpartum depression rates were not statistically significant.</p><p><strong>Conclusion: </strong>With the ESP block, no significant difference was observed compared to the TAP block in terms of total analgesic duration, opioid consumption, postpartum depression, or patient satisfaction, except for the postoperative 1-h VAS pain score. This suggests that the ESP block does not provide clear superiority over the TAP block.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"218-228"},"PeriodicalIF":1.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of novel renal biomarkers in predicting the prognosis of patients with chronic kidney disease: a prospective cohort study.","authors":"Raghavan Padmanabhan, Kaviya Manoharan, Melina Sahay, Pooja Bhujangarao, Luxitaa Goenka, Solai Priya, Kumarasamy Subramaniyan, Damal Kandadai Sriram, Melvin George","doi":"10.55730/1300-0144.6179","DOIUrl":"10.55730/1300-0144.6179","url":null,"abstract":"<p><strong>Background/aim: </strong>Several biomarkers have been assessed for the diagnosis of chronic kidney disease (CKD). However, limited data are available regarding their ability to predict mortality in CKD. The aim of this study was to assess the ability of lipocalin-2, receptor for advanced glycation end products (RAGE), tissue inhibitor of metalloproteinase 1 (TIMP-1), osteopontin, and trefoil factor 3 (TFF-3) in predicting the prognosis of patients with CKD.</p><p><strong>Materials and methods: </strong>We included patients with CKD as defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m² of either sex who were above the age of 18 years. Patients with a history of acute-on-chronic kidney disease were excluded. The novel markers of interest were estimated from patients' plasma samples using the multiplex enzyme-linked immunosorbent assay. These patients were followed for 1 year to assess mortality.</p><p><strong>Results: </strong>The median (with interquartile range) plasma concentrations of lipocalin-2, RAGE, TIMP-1, osteopontin, and TFF-3 were 56.9 (44.72-64.18) ng/mL, 7.1 (4.92-9.56) ng/mL, 46.44 (33.52-47.56) ng/mL, 60.2 (98.9-167.61) ng/mL, and 4.87 (8.03-15.65) ng/mL, respectively. A combined receiver operating characteristic curve was plotted to determine the ability of the novel renal biomarkers to predict mortality in patients with CKD. The cutoff values for lipocalin-2 and RAGE for predicting mortality were 62.48 ng/mL with sensitivity and specificity of 86% and 78% (area under the curve: 0.814; p = 0.007) and 8.5 ng/mL with sensitivity and specificity of 71% and 72% (area under the curve: 0.738; p = 0.04), respectively.</p><p><strong>Conclusion: </strong>Biomarkers including lipocalin-2 and RAGE were assessed in this study and were found to have good predictive value for mortality outcomes in CKD. Future studies should establish the relationship between these novel renal biomarkers and the progression of CKD.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"454-463"},"PeriodicalIF":1.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical analysis of skeletal open bite treatment methods: a comparative finite element study.","authors":"Ömer Faruk Sari, Muhammed Hilmi Büyükçavuş","doi":"10.55730/1300-0144.6191","DOIUrl":"10.55730/1300-0144.6191","url":null,"abstract":"<p><strong>Background/aim: </strong>The biomechanical effects of zygomatic anchorage plates, vertical chin-caps, and occipital headgear on dentofacial structures in patients with skeletal anterior open bite malocclusion were compared using three-dimensional finite element analysis.</p><p><strong>Materials and methods: </strong>Three-dimensional finite element models were constructed based on computed tomography data obtained from a patient with skeletal anterior open bite. Simulation models representing zygomatic anchorage-supported intrusion, vertical chin-cap, and occipital headgear were generated under fixed orthodontic conditions. In each scenario, a unilateral force of 200 g (1.96 N) was applied along clinically relevant force vectors. Stress distributions in craniofacial bones, sutural structures, teeth, roots, and temporomandibular joint components, as well as displacement patterns of the teeth and roots, were evaluated. Von Mises stress was used to assess craniofacial and dental structures, whereas minimum principal stress was used to evaluate sutural regions.</p><p><strong>Results: </strong>The highest von Mises stress within craniofacial structures was observed in the posterior maxilla in the zygomatic anchorage plate scenario, followed by the vertical chin-cap and occipital headgear scenarios. Across all models, compressive stresses in sutural structures were predominantly concentrated in the zygomaticomaxillary suture, with the greatest magnitude observed in the zygomatic anchorage model. Dental and root stress analyses revealed peak von Mises stress at the mesiobuccal root of the maxillary first molar, particularly in the zygomatic anchorage scenario. The greatest tooth and root displacements along the vertical axis, indicative of intrusion, were also observed in this model. Condylar stress was primarily localized in the superior region of the condyle, with higher peak values observed in the vertical chin-cap simulation.</p><p><strong>Conclusion: </strong>Within the limitations of finite element analysis, zygomatic anchorage-supported intrusion demonstrated greater predicted posterior maxillary intrusion and higher localized stress concentrations than vertical chin-cap and occipital headgear approaches. These findings indicate distinct biomechanical profiles among the appliances, which should be considered when selecting treatment strategies for skeletal anterior open bite.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"585-596"},"PeriodicalIF":1.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum phosphoproteome alterations associated with cardiac troponin I levels in acute myocardial infarction.","authors":"Merve Öztuğ, Meltem Aşicioğlu, Konca Altinkaynak, Evren Kilinç","doi":"10.55730/1300-0144.6194","DOIUrl":"10.55730/1300-0144.6194","url":null,"abstract":"<p><strong>Background/aim: </strong>Acute myocardial infarction (AMI) triggers systemic biochemical responses, including dynamic changes in the phosphorylation status of circulating proteins. However, the phosphoproteomic profile of serum in the context of AMI remains insufficiently characterized. This study aimed to investigate serum phosphoproteomic alterations associated with AMI and to explore potential correlations with markers of cardiac injury.</p><p><strong>Materials and methods: </strong>A comparative phosphoproteomic analysis was performed on serum samples obtained from eight patients with AMI and pooled healthy control samples. High-abundance serum proteins were depleted, and phosphopeptides were enriched using TiO₂ phosphopeptide enrichment kit. Samples were analyzed by liquid chromatography-tandem mass spectrometry using a Q Exactive HF-X Orbitrap mass spectrometer. Data were searched against the Homo sapiens database using Sequest HT with a 1% false discovery rate and were quantified by label-free quantification using Proteome Discoverer version 2.4.</p><p><strong>Results: </strong>A total of 46 phosphoproteins were confidently identified, revealing distinct phosphorylation profiles between AMI and control samples. Increased phosphorylation levels were observed for solute carrier family 12 member 5, apolipoprotein L1, the low-molecular-weight isoform of kininogen-1, and osteopontin in AMI serum. Conversely, phosphorylated inter-alpha-trypsin inhibitor heavy chain H2, antithrombin III, histidine-rich glycoprotein, peroxiredoxin-4, GTPase ERas, and the 26S proteasome non-ATPase regulatory subunit 1 were reduced or undetectable. A strong negative correlation was found between apolipoprotein L1 phosphorylation and cardiac troponin I concentrations (r = -0.91; p = 0.0016).</p><p><strong>Conclusion: </strong>These findings demonstrate that serum phosphoproteomics can provide valuable insights into the molecular events associated with AMI. The inverse relationship between apolipoprotein L1 phosphorylation and cardiac troponin I levels suggests that phosphoproteomic profiling may aid in understanding myocardial injury mechanisms.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"613-623"},"PeriodicalIF":1.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty status and pain, balance, and quality of life in patients with lumbar spinal stenosis.","authors":"Musa Güneş, Aydın Sinan Apaydin","doi":"10.55730/1300-0144.6158","DOIUrl":"10.55730/1300-0144.6158","url":null,"abstract":"<p><strong>Background/aim: </strong>Frailty is a clinical syndrome that affects individuals physically and psychosocially. However, the association between lumbar spinal stenosis (LSS) and frailty remains unclear. This study aimed to compare pain, balance, disability, fear of falling, and quality of life between patients with LSS with and without frailty.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 43 frail and 48 nonfrail patients with LSS according to the frailty criteria of Fried et al. Pain intensity (numeric rating scale [NRS]), static balance (single leg stance test [SLST]), dynamic balance (Timed Up and Go test [TUG]), disability (Oswestry Disability Index [ODI]), fear of falling (Falls Efficacy Scale-International [FES-I]), and quality of life (Short form-36 [SF-36]) were assessed.</p><p><strong>Results: </strong>Frailty was observed in 47.3% of patients, and baseline characteristics were similar between the groups (p > 0.05). NRS scores for low back and leg pain, ODI and FES-I scores, and TUG test durations were significantly higher in frail patients with LSS than in nonfrail patients (p < 0.05). SLST durations and SF-36 subscale scores were significantly lower in frail patients with LSS (p < 0.05). TUG duration (p = 0.001, OR = 1.482), physical activity level (p = 0.007, OR = 0.999), and the SF-36 vitality subscale (p = 0.031, OR = 0.968) were significantly associated with frailty in the logistic regression model (p < 0.001).</p><p><strong>Conclusion: </strong>Frail patients with LSS experience greater pain intensity, balance disorders, disability, fear of falling, and poorer quality of life. Moreover, reduced mobility, lower physical activity levels, and decreased vitality are associated with a higher likelihood of frailty in patients with LSS. Therefore, early assessment of frailty in patients with LSS and the implementation of personalized rehabilitation approaches may help mitigate its negative impact.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"246-255"},"PeriodicalIF":1.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of sexual health literacy and cyberchondria levels in women with vaginismus.","authors":"Gonca Türker Ergün, Cemal Ünlü, Ayşe Kuyulu Akman, Elçin Işlek Seçen, Raziye Toksöz","doi":"10.55730/1300-0144.6156","DOIUrl":"10.55730/1300-0144.6156","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to compare sexual health literacy and cyberchondria levels between women who had been diagnosed with vaginismus and those who had not.</p><p><strong>Materials and methods: </strong>The research was conducted as a prospective cohort study including 60 women over the age of 18 who were married and unable to engage in sexual intercourse due to primary vaginismus and 60 sexually active married women without vaginismus. Data collection tools included a patient information form, the Cyberchondria Severity Scale (CSS-12-TR), and the Sexual Health Literacy Scale (SHLS).</p><p><strong>Results: </strong>The median age of the women diagnosed with vaginismus was 27 (21-54) years, while the median age of the women without a vaginismus diagnosis was 30 (20-57) years. The majority of women diagnosed with vaginismus were not employed and had married for love. No significant difference was found between the groups in terms of the total SHLS score. Women with vaginismus showed lower levels of cyberchondria. Most participants were university graduates and sexual health literacy levels were found to be high.</p><p><strong>Conclusion: </strong>Cyberchondria levels in women diagnosed with vaginismus may be low because confronting their condition is challenging. However, it can be inferred that women with vaginismus who seek help from healthcare institutions have high levels of problem-solving skills.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"229-236"},"PeriodicalIF":1.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-assisted neuropharmacology: reshaping drug discovery and translational strategies for neurological diseases.","authors":"Priyanka Rathee, Sunidhi Lohan, Sarita Khatkar, Neelam Malik, Esra Küpeli Akkol, Renu Sehrawat, Pooja Rathee, Anurag Khatkar","doi":"10.55730/1300-0144.6176","DOIUrl":"10.55730/1300-0144.6176","url":null,"abstract":"<p><p>The rapid expansion of data-driven technologies, particularly machine learning (ML) and artificial intelligence (AI), has substantially influenced biomedical research and drug discovery. In neuropharmacology, the availability of large-scale genomic, proteomic, chemical, and clinical datasets has stimulated the adoption of AI-based approaches to address persistent challenges in neurological drug development, including high attrition rates and the scarcity of disease-modifying therapies. Unlike prior reviews that broadly discuss AI applications in drug discovery or neurology, this narrative review focuses specifically on neuropharmacology, with an emphasis on translational relevance, disease-oriented examples, and real-world constraints. We critically examine the application of AI and ML across key stages of the neuropharmacological drug discovery pipeline, including target identification, drug-target interaction prediction, lead optimization, toxicity assessment, and early-stage clinical translation. Particular attention is given to concrete case studies in neurodegenerative and neurological disorders, illustrating where AI has meaningfully enhanced discovery efficiency and where its anticipated \"revolutionary\" impact has not yet been realized. In parallel, we analyze the biological, technical, and regulatory barriers that limit the clinical success of AI-driven strategies, including data bias, limited model interpretability, incomplete understanding of brain biology, and translational bottlenecks. By integrating case-based evidence with a critical analytical perspective, this review delineates both the opportunities and limitations of AI in neuropharmacology. We argue that AI is most effective when deployed as a complementary tool alongside mechanistic neuroscience and clinical expertise, rather than as a standalone solution. As AI methodologies continue to mature, their careful, transparent, and ethically governed integration into neuropharmacological research may advance precision medicine and help bridge persistent gaps in the treatment of neurological disorders.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"405-425"},"PeriodicalIF":1.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and outcomes of childhood interstitial lung disease: a tertiary center experience.","authors":"Ayyüce Ünlü, Şule Selin Akyan Soydaş, Satı Özkan Tabakçi, Işıl Bilgiç, Meltem Kürtül Çakar, Gamze Akca Dinç, Hande Yetişgin, Çelebi Yildirim, Gökçen Dilşa Tuğcu, Dilber Ademhan Tural, Sanem Eryilmaz Polat, Güzin Cinel","doi":"10.55730/1300-0144.6153","DOIUrl":"10.55730/1300-0144.6153","url":null,"abstract":"<p><strong>Background/aim: </strong>Childhood interstitial lung diseases (chILD) constitute a rare and clinically complex group of disorders. This study aimed to characterize the clinical, radiological, and genetic features, as well as the outcomes, of chILD in a Turkish cohort classified according to the chILD-EU framework.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed the medical records of 84 pediatric patients diagnosed with chILD between 2017 and 2024 at a tertiary referral center in Türkiye. Patients were categorized according to the chILD-EU classification. Clinical variables, imaging findings, genetic analyses, pulmonary function test results, and Fan severity scores were systematically assessed. Logistic regression analysis was performed to identify independent predictors of clinical instability.</p><p><strong>Results: </strong>The median age at diagnosis was 6.0 years (IQR: 1.1-12.9). Surfactant dysfunction disorders (A4) and immune- or environmental-related diseases (B2) were the most frequently identified subtypes. Hypoxia was observed in 36 of 84 patients (42.8%) and emerged as the strongest independent predictor of clinical instability (OR: 8.5; 95% CI: 2.2-33.0; p = 0.002). Pathogenic or likely pathogenic variants were identified in 18 of 84 patients (21.4%); among variant-positive cases, <i>ABCA3</i> was the most frequently affected gene (3 of 18; 16.7%). Chest computed tomography was available in 82 of 84 patients, with ground-glass opacities being the most common finding, observed in 51 of 82 patients (62.2%). A decrease of at least one point in the Fan severity score was observed in 42 of 84 patients (p < 0.001). Mortality was 12 of 84 patients (14.3%) after a median follow-up of 3.2 years (range: 1.2-4).</p><p><strong>Conclusion: </strong>This study presents one of the largest single-center pediatric chILD cohorts reported from Türkiye. It highlights the prognostic relevance of baseline hypoxia and underscores the importance of comprehensive radiological and genetic assessment in the management of chILD.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"195-207"},"PeriodicalIF":1.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of adenosine A_2A receptor agonist and antagonist on ovarian ischemia/reperfusion injury in rats.","authors":"Azad Mammadov, Abdullah Tuncay Demiryürek, Ahmet Saracaloğlu, Cahit Demirkiran, İsmail Tuncer Değim, Ömer Eronat, Şeniz Demiryürek","doi":"10.55730/1300-0144.6170","DOIUrl":"10.55730/1300-0144.6170","url":null,"abstract":"<p><strong>Background/aim: </strong>To determine the effects of an A_2A receptor agonist regadenoson, an A_2A receptor antagonist istradefylline, and istradefylline nanosuspension on ovarian ischemia/reperfusion (I/R) injury in rats.</p><p><strong>Materials and methods: </strong>A total of 80 female rats were divided into 10 groups: sham, ovarian I/R, blank nanosuspension + ovarian I/R, regadenoson (3 μg/kg) + ovarian I/R, regadenoson (30 μg/kg) + ovarian I/R, istradefylline (0.3 mg/kg) + ovarian I/R, istradefylline (3 mg/kg) + ovarian I/R, istradefylline-loaded nanosuspension (3 mg/kg) + ovarian I/R, istradefylline (3 mg/kg) + regadenoson (30 μg/kg) + ovarian I/R, and istradefylline-loaded nanosuspension (3 mg/kg) + regadenoson (30 μg/kg) + ovarian I/R. ELISA, chemiluminescence, and spectrophotometric analyses were performed on blood and ovarian tissue samples. Histopathological changes were analyzed using hematoxylin and eosin staining, and a scoring system was applied to assess ovarian tissue damage.</p><p><strong>Results: </strong>Serum malondialdehyde levels were augmented in the I/R and blank nanosuspension + I/R groups. Although tissue superoxide dismutase levels were decreased with I/R, these levels were increased with regadenoson (3 μg/kg), istradefylline (0.3-3 mg/kg), and istradefylline nanosuspension (3 mg/kg). While there was augmentation in the serum and tissue 3-nitrotyrosine levels in the I/R group, a marked decrease was identified with regadenoson (30 μg/kg, p < 0.05). Native thiol levels were decreased in the I/R group, and this decrease was prevented by regadenoson. Serum disulfide levels were increased in the I/R group, and this increase was suppressed by regadenoson.</p><p><strong>Conclusion: </strong>These data showed that adenosine A_2A receptors may contribute to the ovarian I/R injury and regadenoson can produce protective effects.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"364-376"},"PeriodicalIF":1.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}