Effects of lumbar stabilization exercises on serum biomarker levels and clinical outcomes in lumbar disc herniation: a subgroup analysis of a randomized controlled trial.
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引用次数: 0
Abstract
Background/aim: The aim of our study was to investigate the effectiveness of lumbar stabilization exercises on serum biomarker levels and clinical outcomes in lumbar disc herniation (LDH) patients with and without neurological deficit.
Materials and methods: 40 patients with neurological deficits (WND) and 34 patients without neurological deficits (WOND) diagnosed with LDH were included in this study. The patients' WND and WOND were randomized into stabilization exercises (SE) and general exercises (GE) groups. Stabilization exercises or general exercises were applied for six weeks. Serum levels of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-4, beta-endorphin (BE), anandamide (AEA), and 2-arachidonoylglycerol (2-AG) were measured using the enzyme-linked immunosorbent assay. All patients filled out the Visual Analog Scale, Oswestry Disability Index, Beck Depression Inventory, and Beck Anxiety Inventory.
Results: In patients WND and WOND, SE did not show any statistically significant difference in relation to TNF-α, IL-1β, IL-6, IL-4, BE, AEA, and 2-AG (p > 0.05). There were no statistically significant differences between the SE and GE groups in pain intensity and disability outcomes in patients WND (p > 0.05). SE group showed greater reductions in depression and anxiety scores compared to the GE group (p < 0.05). In patients WOND, there were no differences in pain, disability, or depression results between the SE and GE groups (p>0.05), whereas the decrease in anxiety score was greater in the SE group (p < 0.05).
Conclusion: Our results demonstrate that no effect of lumbar stabilization exercise is seen on circulating levels of TNF-α, IL-1β, IL-6, IL-4, BE, AEA, and 2-AG. Further exercise trials are needed to investigate what type, duration, and intensity of exercise is relevant for biomarkers that may play a role in the immune process.
期刊介绍：
Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical details of a given medical subspeciality may not be evaluated for publication.
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