Turkish Journal of Medical Sciences最新文献

{"title":"New index for distinguishing between critical illness myopathy and neuromyopathy: CMAP amplitude/duration index.","authors":"Handan Uzunçakmak Uyanik, Fatma Gökçem Yildiz, Çağrı Mesut Temuçin","doi":"10.55730/1300-0144.5949","DOIUrl":"10.55730/1300-0144.5949","url":null,"abstract":"<p><strong>Background/aim: </strong>Critical illness-associated weakness is a common neuromuscular syndrome that may manifest as critical illness myopathy (CIM), critical illness polyneuropathy (CIP), or an overlapping syndrome known as critical illness polyneuromyopathy (CIPM). Distinguishing between these subtypes can be challenging due to technical issues, patient-related factors such as insufficient cooperation with needle electromyography (EMG) or edema, and the need for sophisticated, time-consuming electrophysiological methods and invasive procedures such as biopsy. This study aimed to contribute to the electrophysiological distinction between CIM and CIPM.</p><p><strong>Materials and methods: </strong>A new index was designed based on distal compound muscle action potential (CMAP) amplitude and negative peak duration values. Comparative and receiver operating characteristic curve analyses were performed on the parameters of patients with CIM and CIPM, as well as between patient groups and controls.</p><p><strong>Results: </strong>The median and ulnar CMAP index cut-off values for distinguishing between CIM and CIPM were determined to be 0.35 and 0.51, respectively. Values below these cut-off points support a diagnosis of CIPM while higher values indicate CIM. The best parameter for distinguishing both CIM and CIPM patients from healthy controls was the peroneal CMAP index, with a cut-off value of 0.45.</p><p><strong>Conclusion: </strong>The CMAP index can be easily calculated from CMAP values obtained during routine nerve conduction studies. This index may serve as a practical and guiding method for differentiating between CIM and CIPM, contributing to the electrophysiological diagnosis of critically ill patients, and particularly those with unreliable sensory nerve action potentials and needle EMG examinations.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"112-120"},"PeriodicalIF":1.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does CD47 expression have prognostic significance in classical Hodgkin lymphoma?","authors":"Aydan Kiliçarslan, Gülnaz Kurt Çevik, Mehmet Doğan, Ayşegül Aksoy Altinboğa, Funda Ceran, Gülşah Efecik, Mine Bakanay Öztürk","doi":"10.55730/1300-0144.5958","DOIUrl":"10.55730/1300-0144.5958","url":null,"abstract":"<p><strong>Background/aim: </strong>Hodgkin lymphoma (HL) is highly treatable, but new chemotherapy agents are needed for patients with progression or recurrence. CD47 regulates antiphagocytic activity by signaling through the signal regulatory protein alpha (SIRPα) pathway on macrophages. This study aimed to assess the expression of CD47 in HL cases and explore its relationship with Epstein-Barr virus (EBV) status and the International Prognostic Index (IPI).</p><p><strong>Materials and methods: </strong>One hundred twenty patients diagnosed with classical HL, characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells, and for whom IPI scores were available were included. Their demographic data and EBV status were retrieved from hospital records. CD47 immunohistochemical expression in HRS cells was evaluated based on its prevalence and intensity. The product of these two values was used to calculate the CD47 expression score.</p><p><strong>Results: </strong>Of the 120 patients, 76 (63.33%) were male and 44 (36.66%) were female, with an average age of 38.77 years. EBV ISH test results were available for 93 patients, of which 48 (51.61%) were positive. CD47 expression was 67% on average, and patients were categorized based on CD47 expression scores of ≤6 and >6 and IPI scores of ≤2 and >2. No significant relationship was found between CD47 expression score and age (p: 0.990), sex (p: 0.086), EBV status (p: 0.374), or IPI score (p: 0.805). However, higher IPI scores were significantly associated with increased EBV positivity (p: 0.041).</p><p><strong>Conclusion: </strong>CD47 was widely expressed, but no significant relationship with clinical parameters was observed. Further studies are required to validate its role as a biomarker.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"203-208"},"PeriodicalIF":1.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between uncoupling protein 1 (UCP1) levels and psoriasis.","authors":"Fikret Akyürek, Fatma Tuncez Akyürek, Fatma Şengül Bağ","doi":"10.55730/1300-0144.5960","DOIUrl":"10.55730/1300-0144.5960","url":null,"abstract":"<p><strong>Background/aim: </strong>Psoriasis is a common chronic autoimmune skin disease. Comorbidities increase the mortality risk of the disease. The aim of this study was to investigate the changes in uncoupling protein 1 (UCP1) level in psoriasis patients and evaluate its possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity Index), dyslipidemia, inflammation, and cardiovascular risk.</p><p><strong>Materials and methods: </strong>This study included 30 psoriasis patients and 30 healthy individuals as a control group. Serum UCP1 was measured using an ELISA test kit. The laboratory results of psoriasis patients and healthy controls were compared.</p><p><strong>Results: </strong>UCP1 level was a significant candidate marker for the prediction of psoriatic disease (AUC: 0.708, 95% CI: 0.577-0.819, p = 0.002) with sensitivity of 66.67%, specificity of 76.67%, negative predictive value of 69.7%, and positive predictive value of 74.1%. Simple logistic regression analysis showed that an individual with a UCP1 value below 7.561 had a 73% lower probability (OR: 0.27, 95% CI: 0.08-0.94, p = 0.039) of developing psoriasis than an individual with a UCP1 value above 7.561. Among the biochemical parameters, the high-sensitivity C-reactive protein and triglyceride levels of the patients were significantly higher compared to those of the healthy controls while their high-density lipoprotein levels were lower.</p><p><strong>Conclusion: </strong>According to the sensitivity (66.67%) and specificity (76.67%) of UCP1, it may be a valuable candidate marker in the diagnosis of psoriasis patients in symptomatic and asymptomatic phases. Further work is needed to substantiate these findings.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"215-222"},"PeriodicalIF":1.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic mutations and prognostic indicators in differentiated thyroid cancer: a molecular perspective.","authors":"Halim Özçevik, Müge Öner Tamam, Gündüzalp Buğrahan Babacan, Selma Şengiz Erhan, Merve Nur Acar Tayyar, Biray Ertürk","doi":"10.55730/1300-0144.5944","DOIUrl":"10.55730/1300-0144.5944","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim of this study was to investigate the relationship between the presence of the BRAF, HRAS, NRAS, and KRAS gene mutations and the development of dedifferentiation (iodine-refractory disease) and extrathyroidal disease in patients with differentiated thyroid carcinoma (DTC).</p><p><strong>Materials and methods: </strong>The patient group included 77 adults classified as intermediate or high-risk according to the American Thyroid Association's 2015 guidelines who underwent total thyroidectomy followed by radioiodine I-131 (RAI) therapy between June 2014 and December 2022. Clinical data were collected via the hospital information system, including the number of surgeries and RAI treatments and the levels of thyroglobulin (Tg), anti-thyroglobulin, and thyroid-stimulating hormone. The histopathological subtypes of DTC were reevaluated, and mutation analyses of the BRAF, KRAS, NRAS, and HRAS genes were performed using real-time polymerase chain reaction (PCR). Statistical analyses were conducted using Medcalc software, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Of the 77 patients, most had classical papillary thyroid carcinoma, while others represented various subtypes. No mutations were found in BRAF K601E/V600_K601, KRAS G12x-G13D, or NRAS G12-G13; however, NRAS Q61x was found in one patient, HRAS Q61x in 12, and BRAFV600E/Ec in 36. A significant relationship was observed between HRAS Q61x mutation and disease response, alongside a significant association between gene mutations and iodine-refractory disease development (p = 0.0004). A ROC curve analysis indicated a 49.2 ng/mL threshold for Tg with 75% sensitivity and 94.1% specificity.</p><p><strong>Conclusion: </strong>The findings suggest that the HRAS Q61x gene mutation is significantly associated with iodine-resistant disease. It may serve as a prognostic biomarker in early-stage thyroid cancer and aid in disease monitoring in metastatic patients.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"72-81"},"PeriodicalIF":1.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac surgery dilemmas: evaluating outcomes of sternotomy versus thoracotomy.","authors":"Muhammet Fethi Sağlam, Emrah Uğuz, Kemal Eşref Erdoğan, Hüseyin Ünsal Erçelik, Murat Yücel, Mete Hidiroğlu, Erol Şener","doi":"10.55730/1300-0144.5992","DOIUrl":"https://doi.org/10.55730/1300-0144.5992","url":null,"abstract":"<p><strong>Background/aim: </strong>This retrospective study aimed to compare the clinical outcomes, including reoperation rates, mortality, and valve size measurements, in patients undergoing sternotomy and thoracotomy for cardiac surgery, particularly focusing on tricuspid valve replacements. The study sought to highlight differences in surgical approaches and their impact on patient outcomes.</p><p><strong>Materials and methods: </strong>A total of 107 patients were included, with 82 undergoing sternotomy and 25 undergoing thoracotomy. Preoperative right ventricular function parameters (mean pulmonary artery pressure, tissue Doppler imaging, and tricuspid annular plane systolic excursion), valve sizes, and other clinical data were recorded. Statistical analyses were performed to assess differences in outcomes between the two surgical groups.</p><p><strong>Results: </strong>Reoperation rates were significantly higher in the sternotomy group than in the thoracotomy group. Additionally, there were notable differences in valve sizes between the groups, with larger valves being used in sternotomy cases. However, mortality rates did not differ significantly between the groups.</p><p><strong>Conclusion: </strong>This study suggests that while sternotomy may lead to higher reoperation rates, the two surgical approaches yield comparable mortality outcomes. Further prospective studies are needed to fully understand the long-term implications of these findings.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"482-487"},"PeriodicalIF":1.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new formula for predicting the actual volume of parathyroid adenoma in patients with primary hyperparathyroidism.","authors":"İbrahim Kilinç, Mustafa Oruç, Serap Ulusoy, Ali Coşkun, Mehmet Kiliç","doi":"10.55730/1300-0144.5945","DOIUrl":"10.55730/1300-0144.5945","url":null,"abstract":"<p><strong>Background/aim: </strong>Knowing adenoma volume in patients with primary hyperparathyroidism is useful for surgeons during parathyroidectomy. The primary aim of our study was to identify the most accurate method for calculating adenoma volume. Our secondary aim was to determine the relationship between adenoma volume and preoperative biochemical parameters (parathyroid hormone [PTH] and calcium levels).</p><p><strong>Material and methods: </strong>The medical histories of 75 patients who underwent surgery for a single parathyroid adenoma were prospectively collected. After excision, the adenomas were placed in water-filled syringes, and their actual volume was determined according to the amount of water displaced. The radiological volume of the adenomas was calculated using the ellipsoid body formula according to the ultrasonographic dimensions. The PTH and calcium levels of the patients were retrieved from the patients' hospital records.</p><p><strong>Results: </strong>The calculated radiological volumes correlated with the actual adenoma volumes, but there were significant differences between the two measurements. A new formula was developed based on actual volumes and radiological volumes. A positive correlation was found between the adenoma volumes and the preoperative PTH and calcium levels.</p><p><strong>Conclusion: </strong>Adenoma volume calculated using a mathematical formula based on ultrasound measurements does not accurately reflect the actual volume. Higher preoperative calcium and PTH levels are associated with larger adenoma size.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"82-86"},"PeriodicalIF":1.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of bacteremia caused by <i>Ralstonia insidiosa</i> isolated from a contaminated blood gas syringe.","authors":"Elif Ayça Şahin, Özge Özgen Top, Pınar Aysert Yildiz, Elif Seren Tanriverdi, Hasan Selçuk Özger, Barış Otlu, Özlem Güzel Tunçcan, Murat Dizbay, Ayşe Kalkanci, Kayhan Çağlar","doi":"10.55730/1300-0144.5967","DOIUrl":"10.55730/1300-0144.5967","url":null,"abstract":"<p><strong>Background/aim: </strong><i>Ralstonia</i> species are opportunistic, waterborne microorganisms known for their ability to survive and proliferate in a wide range of water-based environments. They can contaminate solutions used for patient care and cause hospital outbreaks due to contaminated solutions. The aim of this study was to investigate the source and clonal relationship of <i>Ralstonia insidiosa</i> bacteremia detected in 28 patients between August and December 2021, as part of an unusual outbreak.</p><p><strong>Materials and methods: </strong>Active prospective surveillance studies were conducted, and environmental samples, including saline, antiseptic, and antibiotic solutions, injectors, arterial blood gas syringes, tap water, and hand soap, were collected from wards to determine the source of the outbreak. An arbitrary-primed polymerase chain reaction (AP-PCR) genotyping method was used to determine the clonal relationship between the isolates.</p><p><strong>Results: </strong>All the samples were cultured, and <i>R. insidiosa</i> was isolated from arterial blood gas syringes with the same location and time-based identifier (LOT number). All the arterial blood gas syringes were recalled from the hospital departments and sent back to the manufacturer. The outbreak was reported to the national health authorities. Clonal analysis between isolates from the patients and the blood gas syringes was performed using AP-PCR. It was observed that the <i>R. insidiosa</i> isolates were monoclonal and identical.</p><p><strong>Conclusion: </strong>It was concluded that these contaminated arterial blood gas syringes caused the <i>R. insidiosa</i> bacteremia, especially in immunocompromised patients.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"265-270"},"PeriodicalIF":1.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of TURP, HoLEP, and RFA for nonneurogenic LUTS in men.","authors":"Turgay Ebiloğlu, Özgür Çinar, Selçuk Sarikaya, Adem Emrah Coğuplugil, Bahadır Topuz, Cengiz Kara, Selahattin Bedir","doi":"10.55730/1300-0144.5979","DOIUrl":"https://doi.org/10.55730/1300-0144.5979","url":null,"abstract":"<p><strong>Background/aim: </strong>The effect of transurethral resection of the prostate (TURP) for nonneurogenic male lower urinary tract symptoms (LUTS) is well known. However, recent advancements have come into use, so studies have been done to compare these new techniques to the gold standard TURP technique. The aim of this study was to compare the results of TURP, holmium laser enucleation of the prostate (HoLEP), and radiofrequency ablation (RFA) in men.</p><p><strong>Materials and methods: </strong>The patients who had the TURP procedure were defined as group 1 (G1), those who had HoLEP were in group 2 (G2), and those who had RFA were in group 3 (G3). Preoperative and postoperative results were compared, with postoperative checks done at 1, 12, 24, and 36 months.</p><p><strong>Results: </strong>There were 41, 40, and 40 patients in G1, G2, and G3, respectively. The mean ages for G1, G2, and G3 were 68.21 ± 8.19, 65.44 ± 10.48, and 77.32 ± 10.58, respectively. The decrease in international prostate symptom score (IPSS) was similar in G1 and G2 for all follow-up periods, but the decrease for G3 was smaller. The quality of life improvement can be summarized as G1 > G2 > G3 at the 36-month follow-up. Scores on the overactive bladder questionnaire (OAB-V8) decreased at the 1-month follow-up for G1 and G2, but then started to increase again over time. Scores on the international index of erectile function (IIEF-5) improved in a continuous fashion up to the 36^th postoperative month for G1. The incontinence rate was highest in G2 for all time periods despite a decrease after the first postoperative month. The incontinence rate was the lowest for G3 across all time periods.</p><p><strong>Conclusions: </strong>The TURP and HoLEP procedures yielded equal improvement in IPSS, however HoLEP had a higher incontinence rate. RFA did not yield much improvement in IPSS, however it seems suitable for older patients with the lowest incontinence rates. None of the techniques provided an improvement in terms of the OAB-V8.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"360-367"},"PeriodicalIF":1.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ivermectin on nerve regeneration following sciatic injury in mice: the consequences of dietary high fructose.","authors":"Ezgi Deniz Arikan, Barışcan Çimen, Ayşe Ece Gezen Yilmaz, Elif Akaydin, Berkay Alpay, Deniz Ekin Erbaş, Erblina Nikshiqi, Sevda F Müftüoğlu, Yıldırım Sara","doi":"10.55730/1300-0144.5971","DOIUrl":"10.55730/1300-0144.5971","url":null,"abstract":"<p><strong>Background/aim: </strong>Peripheral nerve injuries (PNIs) are debilitating disorders affecting predominantly the younger generation, often leading to significant disabilities. Current treatment strategies are inadequate for addressing the complex nature of these injuries. Peripheral nerve healing and functional recovery are crucial components of both pathophysiology and therapeutic approaches. High fructose corn syrup (HFCS) is a sweetener frequently used in several beverages and foods. It is associated with several metabolic disturbances including insulin resistance and may impair nerve healing. This study investigated the therapeutic role of ivermectin on nerve regeneration following sciatic nerve injury and evaluated motor and sensorial functions together with histopathological evaluation. Additionally, we aimed to compare nerve healing between animals that consume HFCS and those that do not.</p><p><strong>Materials and methods: </strong>Forty-eight male Swiss albino mice were randomly divided into six groups, with three consuming HFCS-42 (11% v/v) and the other three regular tap water for 8 weeks. On day 28, sciatic nerve injury (SNI) was caused in all groups. Ivermectin (1 mg/kg) or gabapentin (30 mg/kg) treatments were administered to selected groups. Body weight, blood glucose, motor function (rotarod, open field test), and thermal-mechanical sensorial functions were assessed weekly. Finally, insulin levels were measured and histopathological samples were taken.</p><p><strong>Results: </strong>Eight weeks of HFCS consumption impaired mechanical and thermal sensory functions and resulted in histopathologically poor nerve repair. Ivermectin resulted in improved sensorial and faster motor function recovery in the HFCS groups. Elevated plasma insulin levels/HOMA-IR values were diminished by ivermectin in the HFCS groups. In the ivermectin non-HFCS group, histopathology revealed accelerated healing and higher scores in total. Ivermectin also ameliorated mechanical sensation loss after SNI along with cold sensation.</p><p><strong>Conclusion: </strong>Ivermectin accelerated sensorial and motor nerve recovery, resulting in faster nerve healing alongside improved insulin resistance, suggesting it might serve as a potential foundation for developing a new treatment for nerve regeneration after injury.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"299-312"},"PeriodicalIF":1.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the density of degenerated neurons in the carotid body and changes in blood pH.","authors":"Hakan Kina, Aydın Sinan Apaydin","doi":"10.55730/1300-0144.5961","DOIUrl":"10.55730/1300-0144.5961","url":null,"abstract":"<p><strong>Background and aim: </strong>The carotid artery is the main artery supplying blood to the brain. Carotid bodies (CB), located at the bifurcation of the carotid artery, regulate blood pH. This study aimed to assess the changes in CB-related pH levels following degeneration induced by ligation of both common carotid arteries (CCA).</p><p><strong>Materials and methods: </strong>We included 23 adult male New Zealand rabbits in the study. The animals were divided into three groups: a control group (n = 5), a sham group (saline injection, n = 5), and a study group subjected to bilateral CCA ligation (n = 13). pH levels and cardiac rhythms were monitored before, during, and after the procedure at two-day intervals over three weeks. Additionally, we quantified both healthy and degenerated neuron densities in the CB.</p><p><strong>Results: </strong>Initial pH levels were as follows: control group (7.42 ± 0.039), sham (7.39 ± 0.059), and study group (7.35 ± 0 .12). Prior to euthanasia, pH levels were the following: control (7.40 ± 0.029), sham (7.42 ± 0.041), and study (7.39 ± 0.12). The density of degenerated neurons in the CB was as follows: control (11 ± 4/mm³), sham (394 ± 74/mm³), and study (1363 ± 347/mm³). Statistical analysis showed the following significant differences: control vs. sham (p < 0.001), sham vs. study (p < 0.0005), and control vs. study (p < 0.000001).</p><p><strong>Conclusions: </strong>Increased degenerated neuron density in CB leads to reduced blood pH following CCA ligation due to acute ischemia of CB. Timely pH normalization occurs as vertebrobasilar reverse blood flow supplies CB, reversing neurodegeneration and normalizing pH.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"223-230"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}