Turkish Journal of Medical Sciences最新文献

{"title":"Prevalence of gout in the Sincan district of Ankara, Türkiye: a primary care-based cross-sectional study.","authors":"Rıza Can Kardaş, Yasemin Ünsal, Derya Yildirim, Hakan Tüzün, Mustafa Necmi Ilhan, Hamit Küçük, Abdurrahman Tufan, M Akif Öztürk","doi":"10.55730/1300-0144.6134","DOIUrl":"https://doi.org/10.55730/1300-0144.6134","url":null,"abstract":"<p><strong>Background/aim: </strong>Gout, the most prevalent form of inflammatory arthritis, has shown a global increase in prevalence; however, data from Türkiye remain scarce, inconsistent, and largely confined to western regions. This study aimed to estimate the prevalence of gout among adults in the Sincan district of Ankara, Türkiye, and to provide updated data from a previously understudied region.</p><p><strong>Materials and methods: </strong>This cross-sectional, community-based study employed a multistage design. Adults aged ≥18 years who presented to selected family health centers in Sincan between February and June 2023 were screened using a structured questionnaire. Individuals with suspected gout underwent comprehensive clinical evaluation, including medical history, physical examination, and relevant laboratory testing, conducted by rheumatologists. Gout was classified according to the 2015 ACR/EULAR criteria, with a score of ≥8 required for classification.</p><p><strong>Results: </strong>Of the 517 individuals approached, 515 provided consent, and data from 513 participants were included in the final analysis. Screening identified 26 individuals with suspected gout, of whom 24 completed evaluation, resulting in the confirmation of seven gout cases (five men and two women). The overall estimated prevalence of gout was 1.36% (95% CI: 0.55%-2.81%). Prevalence was higher in men (2.18%; 95% CI: 0.71%-5.01%) than in women (0.70%; 95% CI: 0.09%-2.52%) although this difference was not statistically significant due to the small sample size, and prevalence increased with age.</p><p><strong>Conclusion: </strong>These findings provide updated epidemiological data, indicating a higher prevalence than previously reported in western Türkiye, while remaining within the lower range of global estimates. These data underscore the need to enhance gout awareness and to develop effective management strategies within the Turkish population.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"23-31"},"PeriodicalIF":1.0,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of fall history on instability, disability, and anxiety in patients with chronic neck pain.","authors":"Bülent Bozyiğit, Emre Söylemez, Aydın Sinan Apaydin","doi":"10.55730/1300-0144.6149","DOIUrl":"https://doi.org/10.55730/1300-0144.6149","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to investigate the impact of fall history on postural stability, disability, and anxiety in individuals with chronic neck pain (CNP). It was hypothesized that patients with a history of falls would exhibit greater postural instability, perceived disability, and anxiety levels compared with those without a fall history and healthy controls.</p><p><strong>Materials and methods: </strong>A total of 62 participants were included: 16 CNP patients with a history of falling (Group Ia), 21 CNP patients without falls (Group Ib), and 25 healthy controls. Assessments included the Neck Disability Index (NDI), Beck Anxiety Inventory (BAI), and Visual Analog Scale (VAS) for instability, and static postural stability was measured using a force platform under four sensory conditions.</p><p><strong>Results: </strong>Group Ia demonstrated significantly higher NDI, BAI, and VAS scores than Group Ib and controls (p < 0.05). Postural stability was significantly worse in Group Ia under eyes-closed conditions on both firm and foam surfaces (p < 0.05). Group Ib showed balance deficits only on the foam surface with eyes closed. No significant differences were found under eyes-open conditions (p > 0.05).</p><p><strong>Conclusion: </strong>Fall history in patients with chronic neck pain is associated with greater balance impairments and increased anxiety, suggesting that a simple self-reported fall history may serve as a low-cost indicator of disrupted postural control. These findings may provide a practical guide for early screening of fall risk in clinical settings and highlight the importance of implementing preventive strategies for individuals with chronic neck pain.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"162-168"},"PeriodicalIF":1.0,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiologies of chronic cough in children: a two-year experience from a tertiary pediatric pulmonology center.","authors":"Yasin Maruf Ergen, Nagehan Emiralioğlu, Ebru Yalçin, Deniz Doğru, Uğur Özçelik, Nural Kiper","doi":"10.55730/1300-0144.6151","DOIUrl":"https://doi.org/10.55730/1300-0144.6151","url":null,"abstract":"<p><strong>Background/aim: </strong>Chronic cough is a common yet diagnostically challenging symptom in pediatric pulmonology. This study aimed to evaluate the etiologies of chronic cough in children referred to a tertiary center and to analyze the relationship between specific cough characteristics and final diagnoses.</p><p><strong>Materials and methods: </strong>This retrospective study evaluated patients presenting with chronic cough (duration >4 weeks) at a tertiary pediatric pulmonology center. Demographic data, cough characteristics (wet vs. dry), and diagnostic findings were analyzed.</p><p><strong>Results: </strong>A total of 62 patients were included. A specific etiology was identified in 95.1% of the patients. Asthma and reactive airway disease were the most common diagnoses (45.2%), predominantly associated with dry cough. Notably, we observed an unexpectedly high prevalence of primary ciliary dyskinesia (PCD) (19.4%) and cystic fibrosis (CF) (6.5%), particularly in the wet cough group. This distribution differs significantly from primary care studies, reflecting the selected, refractory nature of patients referred to our tertiary center. Protracted bacterial bronchitis (PBB) was identified in only 3.2% of cases.</p><p><strong>Conclusion: </strong>While asthma remains the leading cause of dry cough, structural lung diseases such as PCD and CF are major etiologies in children presenting with chronic wet cough in tertiary settings. The high rate of these serious conditions underscores the need for early and detailed investigation in patients unresponsive to standard therapies, rather than repeated empirical treatments for presumed PBB.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"176-183"},"PeriodicalIF":1.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided microwave ablation for the treatment of abdominal wall scar endometriosis.","authors":"Saffet Öztürk, Umut Asfuroğlu, Esin Kurtuluş Öztürk, Sadık Ahmet Uyanik, Gülcan Kocaoğlu, İsmail Burak Gültekin, Hüseyin Levent Keskin","doi":"10.55730/1300-0144.6145","DOIUrl":"https://doi.org/10.55730/1300-0144.6145","url":null,"abstract":"<p><strong>Background/aim: </strong>To evaluate the efficacy of ultrasound (US)-guided microwave ablation (MWA) in treating abdominal wall endometriosis (AWE) lesions located at the cesarean scar and to assess the early clinical outcomes of this minimally invasive procedure.</p><p><strong>Materials and methods: </strong>A total of 18 patients diagnosed with AWE based on characteristic clinical and US findings were included in this retrospective study. Preprocedural visual analog scale (VAS) scores, ultrasonographic features, and lesion volumes were recorded. The procedure was performed under both general and local anesthesia to ensure patient comfort and procedural accuracy. Hydrodissection was performed before ablation to minimize the risk of thermal injury. Using US guidance, an MWA antenna was inserted into the AWE lesion, and ablation was performed with the moving-shot technique until the lesion became indistinct as microbubbles formed. Postprocedural VAS scores and lesion volumes were evaluated at 1, 3, and 6 months.</p><p><strong>Results: </strong>After MWA treatment, the median VAS score decreased from 8 (range: 8-10) to 0 (range: 0-1) at 1 month (p < 0.001). The mean volume of AWE lesions was 3.75 ± 2.42 cm³ before the procedure, 3.33 ± 2.1 cm³ at 1 month, 1.89 ± 1.18 cm³ at 3 months, and 0.75 ± 0.6 cm³ at 6 months, showing a significant reduction (p < 0.001). The longest axis and lesion volume progressively decreased during follow-up, with the most pronounced reduction observed at 6 months. Additionally, the volumetric reduction rate reached 79.6% at 6 months (p < 0.001). A minor infection occurred at the procedure site in one patient (5.6%) and was successfully treated with antibiotics.</p><p><strong>Conclusion: </strong>US-guided MWA significantly reduced cyclic pain (median VAS 8-10 to 0-1) and lesion volume at 6 months, with only minor complications observed. Larger, multicenter studies with extended follow-up are warranted to confirm the durability of these outcomes.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"128-136"},"PeriodicalIF":1.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levothyroxine poisoning in children: a multicenter study from Türkiye.","authors":"Kübra Şen Küçük, Şule Demir, Reyhan Deveci Sevim, Fatma Akgül, Gülşen Yalçin, Öznur Eser, Alkan Bal, Elif Ergin, Sercan Öztürk, Ahmet Anik","doi":"10.55730/1300-0144.6152","DOIUrl":"https://doi.org/10.55730/1300-0144.6152","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to investigate the clinical features, laboratory findings, treatment approaches, and follow-up strategies employed in the management of pediatric patients with levothyroxine poisoning.</p><p><strong>Materials and methods: </strong>This multicenter retrospective study included patients aged ≤18 years who presented with acute, single-episode levothyroxine ingestion to the pediatric emergency departments of six tertiary care centers between 2010 and 2023. Clinical data, laboratory findings, symptom onset and severity, and treatment modalities were extracted from medical records. Thyroid function tests (TFTs) were interpreted according to the age-specific reference ranges of each center. Treatment decisions, including gastric decontamination and pharmacologic therapy, were evaluated based on documented clinical indications.</p><p><strong>Results: </strong>A total of 45 patients were included in the study. The median age was 3.83 years (interquartile range [IQR]: 2.2-6.1). Levothyroxine ingestion was accidental in 80% (n = 36) of cases and intentional (suicidal) in 20% (n = 9). The median ages for accidental and suicidal ingestions were 3.0 years (IQR: 2.0-4.2) and 15.0 years (IQR: 13.7-16.9), respectively (p < 0.001). The median total ingested levothyroxine dose was 500 μg (IQR: 212.5-1112.5). Symptoms were reported in 33.3% (n = 15) of patients, with tachycardia being the most common (100%, n = 15), followed by hypertension (26.7%, n = 4) and agitation (20.0%, n = 3). The median levothyroxine dose among symptomatic patients was 1100 μg (IQR: 450-2250), significantly higher than that of asymptomatic patients 312.5 μg (IQR: 187.5-750) (p = 0.003). TFTs were abnormal in 51.1% (n = 23) of patients. Treatment was initiated in 55.6% (n = 25) of patients; activated charcoal was administered to 51.1% (n = 23), and gastric lavage to 26.7% (n = 12). Among the three patients with moderate symptoms, one received propranolol, methimazole, and corticosteroids, whereas the other two were treated with propranolol alone. An asymptomatic patient with markedly abnormal TFTs received corticosteroids. No fatal outcomes were reported.</p><p><strong>Conclusion: </strong>Levothyroxine poisoning in children is generally asymptomatic. When symptoms do occur, they are typically mild to moderate in severity, and the overall prognosis is favorable.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"184-194"},"PeriodicalIF":1.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of colonization with multidrug-resistant microorganisms and the incidence of attributable infections in patients undergoing hematopoietic stem cell transplantation.","authors":"Burcu Çalişkan Demirkiran, Gülşen Iskender, İpek Mumcuoğlu, Duygu Mert, Sinan Dal, Tuba Dal, Semra Tunçbilek, Mustafa Ertek, Fevzi Altuntaş","doi":"10.55730/1300-0144.6148","DOIUrl":"https://doi.org/10.55730/1300-0144.6148","url":null,"abstract":"<p><strong>Background/aim: </strong>The global rise in multidrug-resistant organisms (MDROs) has led to an increased incidence of MDRO infections following hematopoietic stem cell transplantation (HSCT), particularly during the preengraftment period. The objective of this study was to evaluate the relationship between pretransplant colonization by MDROs or carbapenem-resistant <i>Enterobacterales</i> (CRE) and the occurrence of infections caused by phenotypically similar microorganisms during the preengraftment period, as well as to assess the clinical outcomes of patients colonized with MDROs prior to transplantation.</p><p><strong>Materials and methods: </strong>This prospective cohort study included patients diagnosed with hematological malignancies who underwent HSCT at the bone marrow transplant unit of Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital between 01 May 2023 and 30 July 2024. Weekly surveillance cultures were obtained at admission and thereafter, including axillary, inguinal, and perianal swabs for MDRO/CRE detection and stool samples for vancomycin-resistant <i>Enterococcus</i> (VRE) colonization. The effect of MDRO colonization on the development of infections caused by phenotypically similar MDRO pathogens during the preengraftment period was analyzed.</p><p><strong>Results: </strong>A total of 118 patients were included in the study. The infection rate with CRE pathogens in patients colonized at least once and in those without CRE colonization was 23.3% and 1.3%, respectively (p = 0.004). The incidences of sepsis (p = 0.003), septic shock (p = 0.01), intensive care unit transfer (p = 0.006), and 28-day mortality (p < 0.001) were significantly higher among patients colonized at admission.</p><p><strong>Conclusion: </strong>Early detection of CRE colonization through surveillance culture screening may facilitate timely initiation of appropriate antibiotic therapy for CRE infections during the early preengraftment period, potentially improving clinical outcomes and survival.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"152-161"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring gender differences in the impact of sleep and fatigue on disease severity in rheumatoid arthritis: a moderated mediation model.","authors":"Musa Salmanoğlu, Habip Yilmaz","doi":"10.55730/1300-0144.6113","DOIUrl":"10.55730/1300-0144.6113","url":null,"abstract":"<p><strong>Background/aim: </strong>Rheumatoid arthritis (RA) is often accompanied by fatigue and sleep disturbances, which aggravate disease severity. Gender differences in these interrelationships remain insufficiently understood. This study aimed to examine whether fatigue mediates the association between sleep quality and disease severity in RA, and whether these pathways differ by gender.</p><p><strong>Materials and methods: </strong>A single-center study was conducted with 68 RA patients (55.9% female). Disease severity was assessed using the Routine Assessment of Patient Index Data-3, fatigue using the Bristol Rheumatology Fatigue Multidimensional Questionnaire, and sleep quality using the Pittsburgh Sleep Quality Index (PSQI).</p><p><strong>Results: </strong>Fatigue significantly mediated the relationship between poor sleep quality and disease severity (indirect effect β = 0.209, p = 0.003). While gender significantly predicted fatigue (β = 0.297, p = 0.005) and females reported higher fatigue and disease severity, gender did not significantly moderate the mediation pathway (PSQI × gender interaction β = 0.019, p = 0.856). The direct effect of sleep quality on disease severity was not significant (β = 0.047, p = 0.663), supporting a full mediation model. Menopausal status was not significantly related to symptom variation among women with RA.</p><p><strong>Conclusion: </strong>Fatigue is a key mechanism connecting poor sleep to greater disease severity in RA. The female participants reported greater symptom burden, underscoring the importance of fatigue-focused, gender-sensitive management strategies.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 6","pages":"1552-1560"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and impact of workplace violence in community pharmacies: a mixed-methods study.","authors":"Hilal Ilbars, Berna Terzioğlu Bebitoğlu, Seyhan Hidiroğlu, Fatma Burcu Doğanç, Yağız Varol","doi":"10.55730/1300-0144.6167","DOIUrl":"https://doi.org/10.55730/1300-0144.6167","url":null,"abstract":"<p><strong>Background/aim: </strong>Pharmacists and pharmacy technicians employed in community pharmacies face a considerable risk of workplace violence, which can negatively influence their job satisfaction, productivity, and mental well-being. This study examined the prevalence and consequences of workplace violence in community pharmacies in Ankara through a mixed-methods design integrating cross-sectional survey data with qualitative insights.</p><p><strong>Materials and methods: </strong>The target population included pharmacists and pharmacy technicians. We examined demographic factors, psychological outcomes, and the nature of violent incidents. Data were obtained from a random sample of 355 community pharmacies using a 39-item survey and the depression anxiety stress scales (DASS-21), complemented by qualitative interviews with 12 pharmacists.</p><p><strong>Results: </strong>A total of 242 participants took part in the study: 174 pharmacists (71.9%; median age 46.0 years) and 68 pharmacy technicians (28.1%; median age 35.0 years). Overall, 63.2% reported at least one violent incident (58.0% of pharmacists; 76.5% of pharmacy technicians). Verbal violence emerged as the most prevalent form, with pharmacy technicians reporting significantly higher exposure than pharmacists. Perpetrators were most often patients or their relatives, while broader societal violence and deficiencies within the health system were frequently cited as contributing factors. Many participants refrained from taking legal action, attributing this to professional burnout and the perception of violence as an inherent aspect of their occupation. Findings from the DASS-21 revealed higher anxiety scores among pharmacy technicians compared to pharmacists. Among pharmacists, exposure to workplace violence was paradoxically associated with lower stress and depression scores, a pattern not observed among technicians.</p><p><strong>Conclusion: </strong>Workplace violence in community pharmacies is prevalent-particularly verbal abuse-and disproportionately impacts pharmacy technicians. Addressing this issue necessitates enhanced training, institutional support, and strengthened security measures, alongside extending white code legal protections to community pharmacies to improve safety and service quality.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"333-343"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of miR-34a with metastatic progression through the FoxO3a-SIRT1 regulatory axis in breast cancer.","authors":"Banu Şahin, İlker Batuhan Bural, Hüseyin Özcan, Sendegül Yildirim, Gamze Tanriöver, Şükran Burçak Yoldaş","doi":"10.55730/1300-0144.6166","DOIUrl":"https://doi.org/10.55730/1300-0144.6166","url":null,"abstract":"<p><strong>Background/aim: </strong>Breast cancer represents the foremost cause of cancer-related mortality among women worldwide and is characterized by a markedly high metastatic potential, contributing substantially to its clinical severity and poor prognosis. This study aimed to evaluate the interrelationship among silent information regulator (SIRT1), Forkhead box O3a (FoxO3a), and microRNA-34a (miR-34a), the latter of which promotes apoptosis by suppressing the proliferation, migration, and invasion of breast cancer cells. Specifically, we investigated the tumor microenvironment associated with metastatic progression of malignant primary tumors, the influence of nonmetastatic (benign) tumors, and the potential roles of these proteins in both primary tumor development and metastasis.</p><p><strong>Materials and methods: </strong>In this study, metastatic 4TLM and nonmetastatic 67NR breast cancer cell lines were used. These cell lines were orthotopically injected into the mammary fat pads of 8-10-week-old female Bagg Albino laboratory-bred strain c (BALB/c) mice. Mice were sacrificed 28 days postinjection, and primary tumors, lungs, and liver tissues were collected for analysis. Expression levels of SIRT1, FoxO3a, and miR-34a were evaluated using immunohistochemistry, Western blotting, and RT-PCR.</p><p><strong>Results: </strong>Expression levels of SIRT1 and FoxO3a were significantly higher in metastatic 4TLM tumors compared to the nonmetastatic 67NR group. Conversely, miR-34a expression was markedly higher in nonmetastatic tumors, whereas its level was reduced in metastatic tissues (p < 0.05). In metastatic tissues, SIRT1 expression remained elevated, whereas FoxO3a and miR-34a levels were significantly reduced (p < 0.05).</p><p><strong>Conclusion: </strong>SIRT1 may act as either a tumor suppressor or a tumor promoter, depending on cellular context, signaling pathways, and its specific molecular targets across cancer types. The elevated expression of SIRT1 in 67NR primary tumors suggests a tumor-suppressive role in nonmetastatic settings. However, the increased SIRT1 expression observed in metastatic regions indicates its potential role as a tumor promoter and modulator of the tumor microenvironment, possibly through FoxO3a and miR-34a signaling, thereby enhancing cellular proliferation and invasion.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"326-332"},"PeriodicalIF":1.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine disruptors and pregnancy.","authors":"Betül Yiğit Yalçin, Gamze Bilik Oyman, Ayşe Kubat Üzüm","doi":"10.55730/1300-0144.6123","DOIUrl":"10.55730/1300-0144.6123","url":null,"abstract":"<p><strong>Background/aim: </strong>Sensitivity to endocrine disruptors is higher in early life. Endocrine disruptor chemicals can be passed from pregnant women to their babies through the placenta or breast milk during lactation, leading to long-term and potentially permanent adverse effects.</p><p><strong>Materials and methods: </strong>This review evaluates the effects of endocrine-disrupting chemicals (EDCs) on pregnancy by summarizing findings from experimental and observational studies. Exposure routes, reproductive outcomes, fetal development implications, and potential preventive strategies are analyzed.</p><p><strong>Results: </strong>Exposure to EDCs during pregnancy has been linked to various complications, including infertility, implantation defects, premature birth, spontaneous abortions, gestational hypertension, and gestational diabetes. Intrauterine exposure to these chemicals may lead to metabolic disorders, congenital anomalies, low birth weight, and delayed physical and mental development in offspring depending on the level and timing of exposure.</p><p><strong>Conclusion: </strong>Due to the significant impact of endocrine disruptors on maternal and fetal health, it is critical to implement protective measures to reduce exposure during pregnancy and lactation. Increased awareness and preventive strategies can help mitigate adverse effects.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 7","pages":"1625-1634"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}