Turkish Journal of Medical Sciences最新文献

{"title":"Letter to the editor regarding \"Kılıçarslan A, Kurt Çevik G, Doğan M, Aksoy Altınboğa A, Ceran F, et al. Does CD47 expression have prognostic significance in classical Hodgkin lymphoma? Turkish Journal of Medical Sciences: 2025; 55 (1): 22\".","authors":"Burcu Baba, Ayşegül Akbay","doi":"10.55730/1300-0144.6056","DOIUrl":"10.55730/1300-0144.6056","url":null,"abstract":"","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1035-1036"},"PeriodicalIF":1.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicolegal evaluation of pediatric patients with injection neuropathy.","authors":"Hızır Asliyüksek, Caner Beşkoç, Ömer Faruk Şimşeker, Nihan Hande Akçakaya, Adem Karbuz","doi":"10.55730/1300-0144.6021","DOIUrl":"10.55730/1300-0144.6021","url":null,"abstract":"<p><strong>Background/aim: </strong>Injection neuropathy (IN) is a rare but preventable form of iatrogenic nerve injury, particularly affecting the sciatic nerve when intramuscular injections are administered incorrectly. While IN is uncommon in high-income countries, it remains a significant public health issue in Türkiye, especially in pediatric populations. The aim of this study is to evaluate pediatric IN cases referred to the Council of Forensic Medicine and highlight medicolegal aspects to inform clinical and legal preventive strategies.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 67 pediatric cases (age range: 1-17 years; mean age: 10.5 years; 57 boys, 10 girls) referred to the Council of Forensic Medicine between January 01/01/2015 and January 01/01/2023, due to suspected injection-related sciatic neuropathy. Demographic data, clinical findings, suspected drugs, injection sites, and medicolegal conclusions were reviewed using descriptive statistics.</p><p><strong>Results: </strong>Sciatic nerve involvement was confirmed in 64 cases. The most frequently implicated drug was diclofenac sodium (n = 38), followed by sulbactam-ampicillin and clindamycin. In 59 cases, complications were identified; 2 cases were classified as malpractice due to incorrect site or technique. Six cases could not be evaluated due to insufficient medical documentation.</p><p><strong>Conclusion: </strong>Intramuscular injections, especially in pediatric patients, should not be considered routine procedures. Given the potential for severe complications, oral alternatives should be prioritized. When unavoidable, injections must be performed by qualified professionals considering patient age, muscle mass, and anatomical safety. This study underscores the medicolegal importance of accurate technique and documentation to prevent lifelong disability and litigation.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"727-732"},"PeriodicalIF":1.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for long-term outcomes of unilateral atrophic kidneys in adult patients: a single-center retrospective cohort study.","authors":"Zülal Istemihan, Ahmet Burak Dirim, Ali Rıza Uçar, Ceren Bağriaçik, Gamze Kemeç, Şafak Mirioğlu, Seda Şafak, Vafa Suleymanova, Özgür Akın Oto, Ayşe Serra Artan, Alaattin Yildiz, Aydın Türkmen, Halil Yazici","doi":"10.55730/1300-0144.6016","DOIUrl":"10.55730/1300-0144.6016","url":null,"abstract":"<p><strong>Background/aim: </strong>Unilateral atrophic kidney (UAK) could be related to many etiologies that can cause chronic kidney disease in adults. There is limited data on the long-term outcome of adults with UAK in the literature.</p><p><strong>Materials and methods: </strong>This study included 199 adult patients with UAK. The etiology, baseline clinical/laboratory, and radiological findings were evaluated. Composite primary outcomes (CPO) (chronic kidney disease stage 5 or doubling of serum creatinine) and secondary outcomes (new-onset proteinuria (>0.5 g/day or g/g) or >50% increase in proteinuria level according to baseline, mortality, and nephrectomy requirement during follow-up) were evaluated in 166 patients with at least 3 months of follow-up.</p><p><strong>Results: </strong>Of 199 patients, 57.3% were female. The mean age at presentation was 44.4 years. Right and left kidney atrophy rates were 51.8% and 48.2%, respectively. Among the known etiologies, the most common was chronic pyelonephritis (17.1%, n = 34). Of 166 patients, 19 had a CPO. Patients with CPO had higher rates of hypertension (p = 0.033), proteinuria (p < 0.001), and renal artery stenosis. Baseline systolic blood pressure (p = 0.004) and serum creatinine (p < 0.001) were higher, and baseline eGFR (p < 0.001) and serum albumin (p = 0.001) were lower in these patients than in patients without CPO. Multivariate logistic regression analysis showed that baseline creatinine (p < 0.001), serum albumin (p = 0.034), and renal artery stenosis (p = 0.015) were independent risk factors for CPO.</p><p><strong>Conclusion: </strong>Higher baseline serum creatinine and lower serum albumin levels were associated with poor renal prognosis in adult patients with UAK. Also, UAK due to renal artery stenosis might be associated with worse outcomes than UAK related to other etiologies.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"687-695"},"PeriodicalIF":1.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA-target gene network analysis in siblings with cystic fibrosis and phenotypic variability.","authors":"Ayberk Mustafaoğlu, Senem Noyan, Yeliz Z Akkaya Ulum, Bala Gür Dedeoğlu, Nagehan Emiralioğlu, Uğur Özçelik, Ebru Yalçin, Deniz Doğru, Nural Kiper, Didem Dayangaç Erden","doi":"10.55730/1300-0144.6054","DOIUrl":"10.55730/1300-0144.6054","url":null,"abstract":"<p><strong>Background/aim: </strong>Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene. CF is characterized by respiratory tract infections, pancreatic insufficiency, meconium ileus, intestinal obstruction, and male infertility. A genotype to phenotype correlation is difficult to establish because of the heterogeneity of disease severity. Even patients with the same <i>CFTR</i> mutation can have varying clinical severities. In recent years, studies have explored the role of microRNA (miRNA) expression in the regulation of respiratory diseases. However, no research has been conducted to date on miRNAs in siblings with the same <i>CFTR</i> mutation.</p><p><strong>Materials and methods: </strong>Nasal cells of CF siblings from two families with discordant phenotype (n = 2 per family) were collected, and differentially expressed miRNAs were identified using miRNA arrays. Differentially expressed miRNAs and their target genes were determined using several bioinformatic databases and tools.</p><p><strong>Results: </strong>miR-449c-5p, miR-92b-3p, miR-34c-3p, miR-34c-5p, miR-6732-5p, and miR-4793-3p were differentially expressed in patients with severe disease compared to mild. <i>CXCL1</i>, <i>CXCL2</i>, <i>DUSP1</i>, <i>GCLC</i>, <i>ICAM1</i>, <i>KIT</i>, <i>PRKAA2</i>, and <i>PTGS2</i> genes were identified as the target genes of candidate miRNAs (miR-34c-3p, miR-92b-3p, miR-449c-5p, miR-4793-3p). miRNA-mRNA interaction network analysis was performed and strong interaction was shown between miR-449c-5p target genes (<i>CXCL1</i>, <i>CXCL2</i>, <i>PTGS2</i>, <i>ICAM1</i>). <i>CXCL1</i> expression decreased 5.28-fold in patients with severe disease compared to those with mild (p = 0.01).</p><p><strong>Conclusion: </strong>Our results highlight the importance of miR-449c-5p interaction with <i>CXCL1</i> and other target genes related to inflammation. Further studies should focus on the functional analysis of miR-449c-5p.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"1014-1023"},"PeriodicalIF":1.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of ultrasonography-guided periforaminal oxygen-ozone therapy in chronic low back pain.","authors":"Esra Ülgen Kiratlioğlu, Kutay Tezel, Eda Gürçay","doi":"10.55730/1300-0144.6015","DOIUrl":"10.55730/1300-0144.6015","url":null,"abstract":"<p><strong>Background/aim: </strong>Treatment of chronic low back pain (LBP) includes various minimally invasive image-guided interventional techniques. The aim of this study, which was planned based on the idea that periforaminal oxygen-ozone (O2-O3) gas application with ultrasonography (USG) could be an alternative treatment option, was to compare the therapeutic efficacy of USG-guided periforaminal ozone infiltration (PFOI) or transforaminal epidural steroid injection (TFESI) in patients with chronic radicular LBP on pain, disability, and quality of life (QoL).</p><p><strong>Materials and methods: </strong>A total of 50 patients were randomly divided into 2 groups of 25 patients each underwent PFOI by USG or TFESI via fluoroscopy. Pain intensity was assessed with visual analogue score (VAS), disability with Oswestry disability index (ODI), and QoL with short form-36 (SF-36), before treatment, at the 2nd week, 1st month, and 2nd month, after treatment.</p><p><strong>Results: </strong>Intra-group comparisons showed significant improvements in LBP VAS, radicular pain VAS, and ODI after treatment for both groups. The reduction in LBP VAS was found to be higher in the PFOI group at week 2 (p = 0.010) and month 1 (p = 0.037), and the improvement in ODI scores was significantly better in the PFOI group at week 2 (p = 0.017) compared to the TFESI group.</p><p><strong>Conclusion: </strong>Our findings have shown that PFOI and TFESI have positive effects on chronic radicular LBP, disability, and QoL parameters. Since ultrasound-guided O2-O3 injections were found to be more effective than epidural steroid injections, particularly in the early period, it was suggested that O2-O3 therapy may be considered in the preoperative treatment algorithm of patients with chronic radicular LBP.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"676-686"},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the predictors of malignancy in inflammatory bowel disease?","authors":"Zülal Istemihan, Bilger Çavuş, Ali Emre Bardak, Ayşe Merve Kirkoğlu, Cansu Kiziltaş, Rüveyda Silay, İbrahim Volkan Şenkal, Ziya Imanov, Kenan Nuriyev, Aynure Rüstemzade, Sezen Genç, Mine Güllüoğlu, Aslı Çifcibaşi Örmeci, Kadir Demir, Fatih Beşişik, Sabahattin Kaymakoğlu, Filiz Akyüz","doi":"10.55730/1300-0144.6036","DOIUrl":"10.55730/1300-0144.6036","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aims to investigate the prevalence of malignancy in patients with inflammatory bowel disease (IBD) followed up in a tertiary reference center.</p><p><strong>Materials and methods: </strong>IBD patients with at least 6 months of follow-up from the gastroenterology clinic between 2000 and 2022 were evaluated retrospectively in a tertiary center. Patient information was obtained from the patient registration system.</p><p><strong>Results: </strong>There were 697 patients in the study, 320 (45.9%) of these were female. The mean age of the patients at IBD diagnosis was 33.4 ± 13.1 years. The mean follow-up time was 93.1 ± 64.8 (median 84, IQR (25-75) (36-144)) months. IBD types were as; 315 (45.2%) had ulcerative colitis, and 382 (54.8%) had Crohn's disease. Before the diagnosis of IBD, 10 patients (1.4%) had a history of malignancy. The prevalence of malignancy after the diagnosis of IBD was 13 (1.9%). There was a relationship between malignancy and older age, higher BMI, and female sex in survival analysis (p < 0.05). There was no correlation with disease type and malignancy (p = 0.820). When the patients who developed malignancy in IBD were compared in terms of the immunomodulators and biological agents used by the patients who did not develop malignancy, there was no statistical difference between the two groups (p > 0.05).</p><p><strong>Conclusion: </strong>Older age, higher BMI, and female sex were found to be at risk for the development of malignancy in IBD, although no relationship was found with the use of immunomodulators, biological agents, or disease type.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"846-854"},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different local anesthetic volumes in pericapsular nerve group block for hip fracture patients.","authors":"Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jülide Ergil, Erbil Aydin","doi":"10.55730/1300-0144.6038","DOIUrl":"10.55730/1300-0144.6038","url":null,"abstract":"<p><strong>Background/aim: </strong>The pericapsular nerve group (PENG) block is an effective method for pain management in patients with hip fractures. In our study, we compared three different local anesthetic volumes of the PENG block in patients who underwent surgery for hip fracture.</p><p><strong>Materials and methods: </strong>Patients who underwent surgery with spinal anesthesia for intertrochanteric femur fractures (60 patients) were divided into three groups based on the volume of local anesthetic administered: Group 1 (20 mL), Group 2 (30 mL), and Group 3 (40 mL). Postoperative patient-controlled analgesia was initiated. Postoperative tramadol consumption, rest and movement pain scores, and the duration of motor block were monitored.</p><p><strong>Results: </strong>We found that Group 2 (118 ± 35.48 mg) and Group 3 (115 ± 42.98 mg) had reduced tramadol consumption compared to Group 1 (151 ± 31.43 mg) (p < 0.05). However, Group 3 (161 ± 18.6 min) had a longer duration of motor block (time to reach a Bromage score of 0) compared to Group 1 (132.25 ± 13.71 min) and Group 2 (143.5 ± 19.54 min) (p < 0.05).</p><p><strong>Conclusion: </strong>We found that the 30 mL and 40 mL volumes in the PENG block resulted in lower tramadol consumption compared to the 20 mL volume. We believe that the 30 mL volume is the most appropriate option among the three volumes, as it provides similar analgesic efficacy to the 40 mL volume but causes less motor block.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"860-867"},"PeriodicalIF":1.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of critically ill patients following earthquake disasters.","authors":"Esat Kıvanç Kaya, Burçin Halaçli, Mehmet Yildirim, Arzu Topeli","doi":"10.55730/1300-0144.6033","DOIUrl":"10.55730/1300-0144.6033","url":null,"abstract":"<p><p>The devastating earthquakes that struck southeastern Türkiye on February 6, 2023, underscored the profound social and healthcare challenges of large-scale natural disasters. These events highlighted the need for healthcare professionals to be well-prepared and equipped with the expertise to manage such crises effectively. Earthquake-induced trauma presents a wide array of medical and surgical complications, frequently requiring urgent hospitalization and specialized management for critically ill patients. However, the limited availability of comprehensive data and evidence-based guidelines complicates optimal care delivery in these scenarios. This review outlines current recommendations for the multidisciplinary management of critically ill patients with earthquake-related trauma. It underscores the significance of promptly identifying and addressing acute complications, including crush syndrome, acute kidney injury, infections, and sepsis. Key strategies such as individualized fluid and electrolyte management, nutritional interventions, and rigorous infection control measures are discussed. Additionally, this review highlights the critical roles of physiotherapy and psychological support in the rehabilitation process, as well as the importance of long-term follow-up for survivors at risk of postintensive care syndrome and posttraumatic stress disorder. To enhance future disaster response and patient outcomes, the review calls for strengthened collaboration, preparedness, and research efforts. This comprehensive examination provides a framework for managing critically ill patients hospitalized due to earthquake-related trauma, offering valuable insights for healthcare providers across multiple disciplines.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"813-825"},"PeriodicalIF":1.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish translation, validity, and reliability of the European organization for research and treatment of cancer quality of life-high dose chemotherapy29 in patients undergone hematopoietic stem cell transplantation.","authors":"Vesile Yildiz Kabak, Sevilay Karahan, Elifcan Aladağ Karakulak, Tülin Düger, Songül Atasavun Uysal, Fulya Ipek Erdem, Hakan Göker","doi":"10.55730/1300-0144.6001","DOIUrl":"10.55730/1300-0144.6001","url":null,"abstract":"<p><strong>Background/aim: </strong>Our aim was to investigate psychometric properties of the Turkish version of the European organization for research and treatment of cancer quality of life-high dose chemotherapy29 (EORTC QLQ-HDC29) in patients treated with hematopoietic stem cell transplantation (HSCT).</p><p><strong>Materials and methods: </strong>Patients between the ages of 18 and 65 years and undergone HSCT were included. The European organization for research and treatment of cancer quality of life questionnaire-cancer30 the Eastern cooperative oncology group performance score, and the functional assessment of cancer therapy-bone marrow transplant were used to determine convergent validity. Reliability was assessed through the calculation of Cronbach's alpha and intra-class correlation coefficient (ICC) values.</p><p><strong>Results: </strong>Totally 151 patients were included. The convergent validity analysis between the EORTC QLQ-HDC29 and the other variables revealed significant, low to strong correlations (p < 0.05). The test-retest reliability of the questionnaire was excellent (ICC values ranged from 0.886 to 1.000). The internal consistency values were acceptable except for the \"Worries/Anxiety\" and \"Inpatient Issues\" scales (ranged from 0.175 to 0.985).</p><p><strong>Conclusion: </strong>The reliability and validity of Turkish version of the EORTC QLQ-HDC29 was feasible and acceptable in patients treated with HSCT. Further research is required to ascertain the psychometric properties of the EORTC QLQ-HD29.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"540-546"},"PeriodicalIF":1.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term efficacy and safety of nondamaging retinal laser therapy for retinitis pigmentosa-associated cystoid macular edema.","authors":"Seda Çevik Kaya, Mehmet Çitirik, Mevlüt Yilmaz, Eyüpcan Şensoy","doi":"10.55730/1300-0144.6012","DOIUrl":"10.55730/1300-0144.6012","url":null,"abstract":"<p><strong>Background/aim: </strong>To evaluate the short-term efficacy and safety of nondamaging retinal laser therapy (NRT) for retinitis pigmentosa-associated cystoid macular edema (RP-CME) and analyze anatomical and functional outcomes.</p><p><strong>Materials and methods: </strong>A retrospective case series of 40 eyes from 30 patients with RP-CME was conducted. The patients underwent NRT using a PASCAL laser system with endpoint management (EpM) software. Central macular thickness (CMT) and best-corrected visual acuity (BCVA) were assessed at baseline and 2 months posttreatment. Long-term follow-up data, including recurrence rates were also reviewed.</p><p><strong>Results: </strong>At the 2-month follow-up, NRT significantly reduced mean CMT by 79.7 μm (p < 0.001) and improved BCVA by 0.10 LogMAR (p < 0.001). Complete resolution of CME was observed in 30% of the eyes, while 52.5% experienced recurrence within 6 months. Unilateral cases exhibited greater CMT reductions than bilateral cases (p < 0.05). No retinal damage from the laser was observed. The long-term sustainability of these effects remains unclear, and repeated treatments have not yet been assessed.</p><p><strong>Conclusion: </strong>NRT is a safe and effective short-term treatment for RP-CME, achieving significant anatomical and functional improvements without evidence of retinal damage. However, the high recurrence rate and absence of long-term data warrant further investigation. Future studies should explore repeated treatments, genetic subtypes, and correlations with the ellipsoid zone integrity.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 3","pages":"652-657"},"PeriodicalIF":1.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}