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Metabolically activated energetic materials mediate cellular anabolism for bone regeneration. 新陈代谢激活的能量材料介导细胞合成代谢，促进骨再生。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-04 DOI: 10.1016/j.tibtech.2024.08.002
Jian Li, Xu Zhang, Zi-Xin Peng, Jian-Hai Chen, Jian-Hui Liang, Li-Qing Ke, Dan Huang, Wen-Xiang Cheng, Sien Lin, Gang Li, Rui Hou, Wen-Zhao Zhong, Zheng-Jie Lin, Ling Qin, Guo-Qiang Chen, Peng Zhang
{"title":"Metabolically activated energetic materials mediate cellular anabolism for bone regeneration.","authors":"Jian Li, Xu Zhang, Zi-Xin Peng, Jian-Hai Chen, Jian-Hui Liang, Li-Qing Ke, Dan Huang, Wen-Xiang Cheng, Sien Lin, Gang Li, Rui Hou, Wen-Zhao Zhong, Zheng-Jie Lin, Ling Qin, Guo-Qiang Chen, Peng Zhang","doi":"10.1016/j.tibtech.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.08.002","url":null,"abstract":"<p><p>The understanding of cellular energy metabolism activation by engineered scaffolds remains limited, posing challenges for therapeutic applications in tissue regeneration. This study presents biosynthesized poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and its major degradation product, 3-hydroxybutyrate (3HB), as endogenous bioenergetic fuels that augment cellular anabolism, thereby facilitating the progression of human bone marrow-derived mesenchymal stem cells (hBMSCs) towards osteoblastogenesis. Our research demonstrated that 3HB markedly boosts in vitro ATP production, elevating mitochondrial membrane potential and capillary-like tube formation. Additionally, it raises citrate levels in the tricarboxylic acid (TCA) cycle, facilitating the synthesis of citrate-containing apatite during hBMSCs osteogenesis. Furthermore, 3HB administration significantly increased bone mass in rats with osteoporosis induced by ovariectomy. The findings also showed that P(3HB-co-4HB) scaffold substantially enhances long-term vascularized bone regeneration in rat cranial defect models. These findings reveal a previously unknown role of 3HB in promoting osteogenesis of hBMSCs and highlight the metabolic activation of P(3HB-co-4HB) scaffold for bone regeneration.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering therapeutical extracellular vesicles for clinical translation. 细胞外治疗囊泡工程化，促进临床转化。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-02 DOI: 10.1016/j.tibtech.2024.08.007
Yifan Ma, Shiyan Dong, Adam J Grippin, Lesheng Teng, Andrew S Lee, Betty Y S Kim, Wen Jiang
{"title":"Engineering therapeutical extracellular vesicles for clinical translation.","authors":"Yifan Ma, Shiyan Dong, Adam J Grippin, Lesheng Teng, Andrew S Lee, Betty Y S Kim, Wen Jiang","doi":"10.1016/j.tibtech.2024.08.007","DOIUrl":"10.1016/j.tibtech.2024.08.007","url":null,"abstract":"<p><p>Cell-based therapies are revolutionizing medicine by replacing or modifying dysfunctional cells with healthy cells or engineered derivatives, offering disease reversal and cure. One promising approach is using cell-derived extracellular vesicles (EVs), which offer therapeutic benefits similar to cell transplants without the biosafety risks. Although EV applications face challenges like limited production, inadequate therapeutic loading, and poor targeting efficiency, recent advances in bioengineering have enhanced their effectiveness. Herein, we summarize technological breakthroughs in EV bioengineering over the past 5 years, highlighting their improved therapeutic functionalities and potential clinical prospects. We also discuss biomanufacturing processes, regulation, and safety considerations for bioengineered EV therapies, emphasizing the significance of establishing robust frameworks to ensure translation capability, safety, and therapeutic effectiveness for successful clinical adoption.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticipatory regulation for pandemic responses: are we there yet? 大流行病应对的预期监管：我们到了吗？
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-03-27 DOI: 10.1016/j.tibtech.2024.02.016
Maria Giuliana Oyola-Lozada, Lisette Pregelj, Anna Jenkins, Evan Siegel, Trent Munro, Damian Hine
{"title":"Anticipatory regulation for pandemic responses: are we there yet?","authors":"Maria Giuliana Oyola-Lozada, Lisette Pregelj, Anna Jenkins, Evan Siegel, Trent Munro, Damian Hine","doi":"10.1016/j.tibtech.2024.02.016","DOIUrl":"10.1016/j.tibtech.2024.02.016","url":null,"abstract":"<p><p>Can drug and vaccine regulatory agencies leverage their experience during the coronavirus disease 2019 (COVID-19) pandemic to advance from reactive regulation to adaptive regulation and beyond to anticipatory regulation to prevent or curb future pandemics?</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual staining for histology by deep learning. 通过深度学习实现组织学虚拟染色。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-03-13 DOI: 10.1016/j.tibtech.2024.02.009
Leena Latonen, Sonja Koivukoski, Umair Khan, Pekka Ruusuvuori
{"title":"Virtual staining for histology by deep learning.","authors":"Leena Latonen, Sonja Koivukoski, Umair Khan, Pekka Ruusuvuori","doi":"10.1016/j.tibtech.2024.02.009","DOIUrl":"10.1016/j.tibtech.2024.02.009","url":null,"abstract":"<p><p>In pathology and biomedical research, histology is the cornerstone method for tissue analysis. Currently, the histological workflow consumes plenty of chemicals, water, and time for staining procedures. Deep learning is now enabling digital replacement of parts of the histological staining procedure. In virtual staining, histological stains are created by training neural networks to produce stained images from an unstained tissue image, or through transferring information from one stain to another. These technical innovations provide more sustainable, rapid, and cost-effective alternatives to traditional histological pipelines, but their development is in an early phase and requires rigorous validation. In this review we cover the basic concepts of virtual staining for histology and provide future insights into the utilization of artificial intelligence (AI)-enabled virtual histology.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel natural nanosyringes: solving biologics delivery at the cellular level. 新型天然纳米环：解决细胞水平的生物制剂输送问题。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1016/j.tibtech.2024.06.003
Joseph R J Healey
{"title":"Novel natural nanosyringes: solving biologics delivery at the cellular level.","authors":"Joseph R J Healey","doi":"10.1016/j.tibtech.2024.06.003","DOIUrl":"10.1016/j.tibtech.2024.06.003","url":null,"abstract":"","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging biotechnological applications of anaerobic ammonium oxidation. 厌氧氨氧化的新兴生物技术应用。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-03-21 DOI: 10.1016/j.tibtech.2024.02.013
Dario Rangel Shaw, Julian Tobon Gonzalez, Carlos Bibiano Guadarrama, Pascal E Saikaly
{"title":"Emerging biotechnological applications of anaerobic ammonium oxidation.","authors":"Dario Rangel Shaw, Julian Tobon Gonzalez, Carlos Bibiano Guadarrama, Pascal E Saikaly","doi":"10.1016/j.tibtech.2024.02.013","DOIUrl":"10.1016/j.tibtech.2024.02.013","url":null,"abstract":"<p><p>Anaerobic ammonium oxidation (anammox) is an energy-efficient method for nitrogen removal that opens the possibility for energy-neutral wastewater treatment. Research on anammox over the past decade has primarily focused on its implementation in domestic wastewater treatment. However, emerging studies are now expanding its use to novel biotechnological applications and wastewater treatment processes. This review highlights recent advances in the anammox field that aim to overcome conventional bottlenecks, and explores novel and niche-specific applications of the anammox process. Despite the promising results and potential of these advances, challenges persist for their real-world implementation. This underscores the need for a transition from laboratory achievements to practical, scalable solutions for wastewater treatment which mark the next crucial phase in the evolution of anammox research.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peroxisome-based metabolic engineering for biomanufacturing and agriculture. 基于过氧化物酶体的生物制造和农业代谢工程。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-02-28 DOI: 10.1016/j.tibtech.2024.02.005
Shuyan Song, Cuifang Ye, Yijun Jin, Huaxin Dai, Jianping Hu, Jiazhang Lian, Ronghui Pan
{"title":"Peroxisome-based metabolic engineering for biomanufacturing and agriculture.","authors":"Shuyan Song, Cuifang Ye, Yijun Jin, Huaxin Dai, Jianping Hu, Jiazhang Lian, Ronghui Pan","doi":"10.1016/j.tibtech.2024.02.005","DOIUrl":"10.1016/j.tibtech.2024.02.005","url":null,"abstract":"<p><p>Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the palatability of cultivated meat. 提高养殖肉类的适口性。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-03-26 DOI: 10.1016/j.tibtech.2024.02.014
Ella G Lambert, Christopher J O'Keeffe, Alexander O Ward, Tim A Anderson, Queenie Yip, Peter L H Newman
{"title":"Enhancing the palatability of cultivated meat.","authors":"Ella G Lambert, Christopher J O'Keeffe, Alexander O Ward, Tim A Anderson, Queenie Yip, Peter L H Newman","doi":"10.1016/j.tibtech.2024.02.014","DOIUrl":"10.1016/j.tibtech.2024.02.014","url":null,"abstract":"<p><p>Cultivated meat (CM) has transitioned from a futuristic concept to a present reality, with select products approved for consumption and sale in Singapore, Israel, and the USA. This evolution has emphasized scalable, cost-effective, and sustainable production, as well as navigation of regulatory pathways. As CM develops, a crucial challenge lies in delivering products that are highly appealing to consumers. Central to this will be refining CM palatability, a term encompassing food's taste, aroma, texture, tenderness, juiciness, and color. We explore the scientific and engineering approaches to producing palatable CM, including cell-line selection, cell differentiation, and post-processing techniques. This includes a discussion of the structural and compositional properties of meat that are intrinsically coupled to palatability.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring the economic efficiency of laboratory automation in biotechnology. 衡量生物技术实验室自动化的经济效益。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-02-23 DOI: 10.1016/j.tibtech.2024.02.001
Han Min Woo, Jay Keasling
{"title":"Measuring the economic efficiency of laboratory automation in biotechnology.","authors":"Han Min Woo, Jay Keasling","doi":"10.1016/j.tibtech.2024.02.001","DOIUrl":"10.1016/j.tibtech.2024.02.001","url":null,"abstract":"<p><p>Laboratory automation with robot-assisted processes enhances synthetic biology, but its economic impact on projects is uncertain. We have proposed an experiment price index (EPI) for a quantitative comparison of factors in time, cost, and sample numbers, helping measure the efficiency of laboratory automation in synthetic biology and biomolecular engineering.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driving towards digital biomanufacturing by CHO genome-scale models. 通过 CHO 基因组尺度模型推动数字化生物制造。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI: 10.1016/j.tibtech.2024.03.001
Seo-Young Park, Dong-Hyuk Choi, Jinsung Song, Meiyappan Lakshmanan, Anne Richelle, Seongkyu Yoon, Cleo Kontoravdi, Nathan E Lewis, Dong-Yup Lee
{"title":"Driving towards digital biomanufacturing by CHO genome-scale models.","authors":"Seo-Young Park, Dong-Hyuk Choi, Jinsung Song, Meiyappan Lakshmanan, Anne Richelle, Seongkyu Yoon, Cleo Kontoravdi, Nathan E Lewis, Dong-Yup Lee","doi":"10.1016/j.tibtech.2024.03.001","DOIUrl":"10.1016/j.tibtech.2024.03.001","url":null,"abstract":"<p><p>Genome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing integrative models that account for different cellular processes and data for future applications. With supportive collaborative efforts by the research community, we envisage that CHO-GEMs will be crucial for the increasingly digitized and dynamically controlled bioprocessing pipelines, especially because they can be successfully deployed in conjunction with artificial intelligence (AI) and systems engineering algorithms.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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