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Risk-appropriate, science-based innovation regulations are important.
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 DOI: 10.1016/j.tibtech.2024.11.004
Karinne Ludlow, Jose Falck-Zepeda, Stuart J Smyth
{"title":"Risk-appropriate, science-based innovation regulations are important.","authors":"Karinne Ludlow, Jose Falck-Zepeda, Stuart J Smyth","doi":"10.1016/j.tibtech.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.11.004","url":null,"abstract":"<p><p>Inappropriate and often politicized regulations in many countries have limited the global benefits of agricultural biotechnology. The Cartagena Protocol on Biosafety (CPB) has proven to be one of the biggest barriers to biotechnological innovations, especially for food-insecure countries. The global movement of international agreements, such as the CPB, Convention on Biological Diversity, and Global Biodiversity Framework, contribute to the erosion of evidence-based regulation, enabling the development and spread of precaution-based regulatory frameworks. Despite 50 years of accumulated knowledge about the safety of genetic modification technology application since the Asilomar Conference, regulatory requirements are increasing, slowing innovation rates. This article discusses the importance of risk-appropriate regulation for innovation efficiency to avoid precaution-based regulation stifling innovation.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":"43 3","pages":"502-510"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein nanocarrier-enabled plant genetic engineering systems. 蛋白质纳米载体植物基因工程系统。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2024-09-13 DOI: 10.1016/j.tibtech.2024.08.009
Temoor Ahmed, Muhammad Noman, Yetong Qi, Jason C White, Xingjiang Qi
{"title":"Protein nanocarrier-enabled plant genetic engineering systems.","authors":"Temoor Ahmed, Muhammad Noman, Yetong Qi, Jason C White, Xingjiang Qi","doi":"10.1016/j.tibtech.2024.08.009","DOIUrl":"10.1016/j.tibtech.2024.08.009","url":null,"abstract":"<p><p>Genetic engineering can enhance crop yields by developing climate-resilient crop varieties. Nanobiotechnology plays a crucial role in precision delivery of genetic materials, nutrients, and stress-responsive agents into plant cells. This forum highlights recent advances in biodegradable protein-based nanocarrier systems for plant genome editing to transform agricultural practices.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"498-501"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant DNA: unlocking untapped microbial potential for innovation in crop agriculture.
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 DOI: 10.1016/j.tibtech.2025.01.001
Aranksha Thakor, Trevor C Charles
{"title":"Recombinant DNA: unlocking untapped microbial potential for innovation in crop agriculture.","authors":"Aranksha Thakor, Trevor C Charles","doi":"10.1016/j.tibtech.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.tibtech.2025.01.001","url":null,"abstract":"<p><p>The Asilomar Conference on Recombinant DNA, held in 1975, established guidelines for recombinant DNA (rDNA) research and laid the foundation for biotechnology regulations. While rDNA has driven significant advancements in pharmaceutical and crop biotechnology, the commercialization of plant-beneficial microbials developed using rDNA has lagged behind. This disparity may be attributed to a cumbersome regulatory framework shaped by the perception that rDNA products pose biosafety risks. To unlock the full potential of rDNA technology in addressing global challenges, regulatory reform for rDNA-derived microbial products for crop plants that reduce reliance on chemical fertilizers and pesticides is essential. Streamlining these barriers will enable greater societal benefits from microbial solutions in agriculture and beyond.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":"43 3","pages":"533-539"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing carbon to life via one-carbon metabolism. 通过一碳新陈代谢让碳焕发生机。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2024-09-20 DOI: 10.1016/j.tibtech.2024.08.014
Samantha O'Keeffe, Lilly Garcia, Yi Chen, Richard C Law, Chong Liu, Junyoung O Park
{"title":"Bringing carbon to life via one-carbon metabolism.","authors":"Samantha O'Keeffe, Lilly Garcia, Yi Chen, Richard C Law, Chong Liu, Junyoung O Park","doi":"10.1016/j.tibtech.2024.08.014","DOIUrl":"10.1016/j.tibtech.2024.08.014","url":null,"abstract":"<p><p>One-carbon (C1) compounds found in greenhouse gases and industrial waste streams are underutilized carbon and energy sources. While various biological and chemical means exist for converting C1 substrates into multicarbon products, major challenges of C1 conversion lie in creating net value. Here, we review metabolic strategies to utilize carbon across oxidation states. Complications arise in biochemical C1-utilization approaches because of the need for cellular energy currency ATP. ATP supports cell maintenance and proliferation and drives thermodynamically challenging reactions by coupling them with ATP hydrolysis. Powering metabolism through substrate cofeeding and energy transduction from light and electricity improves ATP availability, relieves metabolic bottlenecks, and upcycles carbon. We present a bioenergetic, engineering, and technoeconomic outlook for bringing elements to life.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"572-585"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human health and genetic technology. 人类健康与基因技术。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 DOI: 10.1016/j.tibtech.2024.12.006
Hans-Georg Dederer
{"title":"Human health and genetic technology.","authors":"Hans-Georg Dederer","doi":"10.1016/j.tibtech.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.12.006","url":null,"abstract":"<p><p>The 1975 Asilomar conference contributed to the misperception that recombinant DNA (rDNA) technology is inherently risky to human health and the environment. It thus paved the way toward process-based regulation of genetically modified organisms (GMOs), such as in the EU. Initially, this regulatory approach obstructed technological uses of rDNA related to human health. However, regulators gradually softened the rules applicable to laboratories or industrial facilities. This encouraged R&D and production of pharmaceuticals derived from GMOs. Nevertheless, administering pharmaceuticals containing GMOs to patients may still be confronted with burdensome process-based GMO law on the deliberate release of GMOs into the environment. On the other hand, pharmaceutical law may need to be updated regarding, for example, novel gene therapies or xenotransplantation.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":"43 3","pages":"522-532"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioengineered yeast for preventing age-related diseases. 用于预防老年疾病的生物工程酵母。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2024-10-01 DOI: 10.1016/j.tibtech.2024.08.011
Olga Sofianovich, Kate Willis-Urena, Yueming Dong, Codruta Ignea
{"title":"Bioengineered yeast for preventing age-related diseases.","authors":"Olga Sofianovich, Kate Willis-Urena, Yueming Dong, Codruta Ignea","doi":"10.1016/j.tibtech.2024.08.011","DOIUrl":"10.1016/j.tibtech.2024.08.011","url":null,"abstract":"<p><p>The aging process entails a multifaceted decline in the capacity to restore homeostasis in response to stress. A prevalent characteristic of many age-related diseases is the presence of low-grade chronic inflammation, a risk factor contributing significantly to morbidity and mortality in the elderly population. Specific lifestyle interventions, such as regular physical activity, targeted diet, and supplementation, can delay the accumulation of chronic age-associated conditions by mitigating inflammation processes. Bioengineered yeast-producing compounds with distinctive bioactivities, including anti-inflammatory properties, have the potential to provide rich dietary alternatives for the prevention of age-related diseases. This review highlights recent achievements in engineering effective yeast platforms, namely Saccharomyces cerevisiae and Yarrowia lipolytica, that hold promise in retarding the onset of aging and age-related ailments.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"586-600"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation and biotechnology: 50 years after Asilomar.
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 DOI: 10.1016/j.tibtech.2025.02.001
Stuart J Smyth, Matthew J Pavlovich
{"title":"Innovation and biotechnology: 50 years after Asilomar.","authors":"Stuart J Smyth, Matthew J Pavlovich","doi":"10.1016/j.tibtech.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.tibtech.2025.02.001","url":null,"abstract":"","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":"43 3","pages":"489-490"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing synthetic microbial communities with the capacity to upcycle fermentation byproducts to increase production yields. 设计具有发酵副产品上行循环能力的合成微生物群落，以提高产量。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1016/j.tibtech.2024.10.015
Razieh Rafieenia, Cinzia Klemm, Piotr Hapeta, Jing Fu, María Gallego García, Rodrigo Ledesma-Amaro
{"title":"Designing synthetic microbial communities with the capacity to upcycle fermentation byproducts to increase production yields.","authors":"Razieh Rafieenia, Cinzia Klemm, Piotr Hapeta, Jing Fu, María Gallego García, Rodrigo Ledesma-Amaro","doi":"10.1016/j.tibtech.2024.10.015","DOIUrl":"10.1016/j.tibtech.2024.10.015","url":null,"abstract":"<p><p>Microbial cell factories, which convert feedstocks into a product of value, have the potential to help transition toward a bio-based economy with more sustainable ways to produce food, fuels, chemicals, and materials. One common challenge found in most bioconversions is the co-production, together with the product of interest, of undesirable byproducts or overflow metabolites. Here, we designed a strategy based on synthetic microbial communities to address this issue and increase overall production yields. To achieve our goal, we created a Yarrowia lipolytica co-culture comprising a wild-type (WT) strain that consumes glucose to make biomass and citric acid (CA), and an 'upcycler' strain, which consumes the CA produced by the WT strain. The co-culture produced up to two times more β-carotene compared with the WT monoculture using either minimal medium or hydrolysate. The proposed strategy has the potential to be applied to other bioprocesses and organisms.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"601-619"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Absolute quantification of cell-free DNA for prenatal genetics and oncology. 无细胞DNA的绝对定量用于产前遗传学和肿瘤学。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI: 10.1016/j.tibtech.2024.12.003
David S Tsao
{"title":"Absolute quantification of cell-free DNA for prenatal genetics and oncology.","authors":"David S Tsao","doi":"10.1016/j.tibtech.2024.12.003","DOIUrl":"10.1016/j.tibtech.2024.12.003","url":null,"abstract":"","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"732-733"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetogenesis to ethanologenesis: facilitating NADH oxidation via reductive acetate uptake. 丙酮生成到乙醇生成：通过还原乙酸摄取促进NADH氧化。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI: 10.1016/j.tibtech.2024.11.008
Soyoung Oh, Jiyeong Jeong, Byeonghyeok Park, Byeongchan Kang, Ji-Yeon Kim, Sehoon Park, Dong-Hun Lee, Seunghyeon Jung, Mungyu Lee, Wonjung Lee, Muhammad Yasin, Junhyeok Seo, Zee-Yong Park, Kyung-Hoon Shin, Volker Müller, In-Geol Choi, In Seop Chang
{"title":"Acetogenesis to ethanologenesis: facilitating NADH oxidation via reductive acetate uptake.","authors":"Soyoung Oh, Jiyeong Jeong, Byeonghyeok Park, Byeongchan Kang, Ji-Yeon Kim, Sehoon Park, Dong-Hun Lee, Seunghyeon Jung, Mungyu Lee, Wonjung Lee, Muhammad Yasin, Junhyeok Seo, Zee-Yong Park, Kyung-Hoon Shin, Volker Müller, In-Geol Choi, In Seop Chang","doi":"10.1016/j.tibtech.2024.11.008","DOIUrl":"10.1016/j.tibtech.2024.11.008","url":null,"abstract":"<p><p>(Homo)acetogens, including Clostridium spp., represent an enigma in metabolic flexibility and diversity. Eubacterium callanderi KIST612 is an acetogen that produces n-butyrate with carbon monoxide (CO) as the carbon and energy source; however, the production route is unknown. Here, we report that its distinctive butyrate formation links to reductive acetate uptake, suggesting that acetate (the end-product) is reuptake, leading to a physiological advantage through NADH oxidation. Thus, we introduced an ethanol production pathway from acetyl-CoA as a competitive pathway for butyrate production. Consequently, the metabolic pathway in our mutants switched from acetogenesis to 'ethanologenesis', eliminating butyrate production and the uptake of previously produced acetate. The metabolic shifts occurred toward greater NADH oxidation, facilitating CO oxidation and productivity, which is a survival mechanism at the thermodynamic edge. This metabolic shift to a single product holds potential to revolutionize product separation strategies in synthetic gas (syngas)-based biorefineries.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"696-714"},"PeriodicalIF":14.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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