{"title":"Engineering biological curvatures.","authors":"Jiaxing Gong, Kejie Lu, Ying Qian, Yu Shrike Zhang, Mengfei Yu","doi":"10.1016/j.tibtech.2025.02.013","DOIUrl":null,"url":null,"abstract":"<p><p>The curvatures within the human body have essential functions, but their fabrication remains relatively unexplored. We re-emphasize the importance of curvatures in native biological tissues, present technologies to fabricate biomimetic curvatures, and discuss the challenges of integrating curvatures into biomanufacturing. Finally, we recommend how to incorporate curvatures into engineered tissues.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2025.02.013","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The curvatures within the human body have essential functions, but their fabrication remains relatively unexplored. We re-emphasize the importance of curvatures in native biological tissues, present technologies to fabricate biomimetic curvatures, and discuss the challenges of integrating curvatures into biomanufacturing. Finally, we recommend how to incorporate curvatures into engineered tissues.
期刊介绍:
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).