设计新一代氧气生成支架，促进骨再生。

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-09-28 DOI:10.1016/j.tibtech.2024.09.006

Jingtong Zhao, Naboneeta Sarkar, Yunke Ren, Arvind P Pathak, Warren L Grayson

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引用次数: 0

摘要

在骨骼的发育、平衡和愈合过程中，充足的氧气供应至关重要。氧气生成支架（OGS）在促进骨再生方面具有巨大潜力。然而，由于体内氧气输送和信号传导的复杂性，要量身定制 OGS 的设计以精确满足这一生物学要求极具挑战性。我们回顾了 OGS 的最新进展，分析了持续存在的工程和转化障碍。我们还讨论了计算和机器学习（ML）模型在促进新型成像数据与生物读数和先进生物制造技术整合方面的潜力。通过阐明如何利用尖端技术应对当前的挑战，我们为从传统 OGS 过渡到下一代 OGS 以改善患者的骨再生提供了真知灼见。

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Engineering next-generation oxygen-generating scaffolds to enhance bone regeneration.

In bone, an adequate oxygen (O₂) supply is crucial during development, homeostasis, and healing. Oxygen-generating scaffolds (OGS) have demonstrated significant potential to enhance bone regeneration. However, the complexity of O₂ delivery and signaling in vivo makes it challenging to tailor the design of OGS to precisely meet this biological requirement. We review recent advances in OGS and analyze persisting engineering and translational hurdles. We also discuss the potential of computational and machine learning (ML) models to facilitate the integration of novel imaging data with biological readouts and advanced biomanufacturing technologies. By elucidating how to tackle current challenges using cutting-edge technologies, we provide insights for transitioning from traditional to next-generation OGS to improve bone regeneration in patients.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).