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The transcription factor NFAT5 limits infection-induced type I interferon responses 转录因子NFAT5限制了感染诱导的I型干扰素反应
The Tokushima journal of experimental medicine Pub Date : 2019-12-05 DOI: 10.1084/jem.20190449
Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez
{"title":"The transcription factor NFAT5 limits infection-induced type I interferon responses","authors":"Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez","doi":"10.1084/jem.20190449","DOIUrl":"https://doi.org/10.1084/jem.20190449","url":null,"abstract":"Huerga Encabo et al. show that NFAT5, previously characterized as a pro-inflammatory transcription factor, limits the IFN-I response to control antiviral defenses and preserve HSC quiescence. NFAT5 represses IFN-I and ISG expression through an evolutionarily conserved DNA element that prevents IRF3 recruitment to the IFNB1 enhanceosome.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75244893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2 巨噬细胞中IL-10信号的丢失限制了前列腺素E2驱动的细菌杀伤
The Tokushima journal of experimental medicine Pub Date : 2019-12-05 DOI: 10.1084/jem.20180649
S. Mukhopadhyay, E. Heinz, I. Porreca, K. Alasoo, Amy T. Y. Yeung, Huei-Ting Yang, T. Schwerd, J. Forbester, C. Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, M. Capitani, L. Jostins-Dean, D. Thomas, S. Travis, Daniel J. Gaffney, W. Skarnes, N. Thomson, H. Uhlig, G. Dougan, F. Powrie
{"title":"Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2","authors":"S. Mukhopadhyay, E. Heinz, I. Porreca, K. Alasoo, Amy T. Y. Yeung, Huei-Ting Yang, T. Schwerd, J. Forbester, C. Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, M. Capitani, L. Jostins-Dean, D. Thomas, S. Travis, Daniel J. Gaffney, W. Skarnes, N. Thomson, H. Uhlig, G. Dougan, F. Powrie","doi":"10.1084/jem.20180649","DOIUrl":"https://doi.org/10.1084/jem.20180649","url":null,"abstract":"Cytokines and lipid mediators are key regulators of inflammation; but how they are mechanistically linked is poorly understood. Here, Mukhopadhyay et al. show a novel regulation between cytokine IL-10 and lipid mediator PGE2 that functionally connects them to intestinal inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75864918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis lncrna编码的多肽ASRPS抑制三阴性乳腺癌血管生成
The Tokushima journal of experimental medicine Pub Date : 2019-12-05 DOI: 10.1084/jem.20190950
Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Sheng-hua Zhang, Rui Wu, Zheng Zhang, Kexin Wang, Jiachun Lu, Yifeng Zhou
{"title":"LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis","authors":"Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Sheng-hua Zhang, Rui Wu, Zheng Zhang, Kexin Wang, Jiachun Lu, Yifeng Zhou","doi":"10.1084/jem.20190950","DOIUrl":"https://doi.org/10.1084/jem.20190950","url":null,"abstract":"In this study, Wang et al. demonstrate that lncRNA-encoded polypeptide ASRPS is down-regulated in TNBC. ASRPS regulates angiogenesis and may serve as a novel prognostic marker and therapeutic target for TNBC.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76093885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 122
Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge 针对DIII侧脊的公共抗体谱系对寨卡病毒和登革热病毒的差异中和机制
The Tokushima journal of experimental medicine Pub Date : 2019-11-22 DOI: 10.1084/jem.20191792
Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel S. Nargi, Z. Deng, J. Errico, C. Nelson, Kimberly A. Dowd, T. Pierson, J. Crowe, M. Diamond, D. Fremont
{"title":"Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge","authors":"Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel S. Nargi, Z. Deng, J. Errico, C. Nelson, Kimberly A. Dowd, T. Pierson, J. Crowe, M. Diamond, D. Fremont","doi":"10.1084/jem.20191792","DOIUrl":"https://doi.org/10.1084/jem.20191792","url":null,"abstract":"Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90464412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation CFIm25的下调通过选择性聚腺苷化放大皮肤纤维化
The Tokushima journal of experimental medicine Pub Date : 2019-11-22 DOI: 10.1084/jem.20181384
Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi
{"title":"Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation","authors":"Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi","doi":"10.1084/jem.20181384","DOIUrl":"https://doi.org/10.1084/jem.20181384","url":null,"abstract":"This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79412982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine 单细胞转录组分析揭示了人类肠道不同的营养吸收功能
The Tokushima journal of experimental medicine Pub Date : 2019-11-21 DOI: 10.1084/jem.20191130
Yalong Wang, Wanlu Song, Jilian Wang, Ting Wang, X. Xiong, Zhen Qi, W. Fu, Xuerui Yang, Ye-Guang Chen
{"title":"Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine","authors":"Yalong Wang, Wanlu Song, Jilian Wang, Ting Wang, X. Xiong, Zhen Qi, W. Fu, Xuerui Yang, Ye-Guang Chen","doi":"10.1084/jem.20191130","DOIUrl":"https://doi.org/10.1084/jem.20191130","url":null,"abstract":"Single-cell transcriptome analysis of epithelial cells from human ileum, colon, and rectum reveals different nutrient-absorption preferences in the small and large intestine, providing a rich resource for further characterization of human intestine cell constitution and functions.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75590863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 196
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection B细胞足以启动对疟原虫感染的显性CD4+ Tfh反应
The Tokushima journal of experimental medicine Pub Date : 2019-11-20 DOI: 10.1084/jem.20190849
E. N. Arroyo, M. Pepper
{"title":"B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection","authors":"E. N. Arroyo, M. Pepper","doi":"10.1084/jem.20190849","DOIUrl":"https://doi.org/10.1084/jem.20190849","url":null,"abstract":"Arroyo and Pepper demonstrate that interactions with B cells, not dendritic cells, are required for the priming of the CD4+ T cell response during Plasmodium infection. This results in a Tfh-biased response as reported by others in both mice and humans.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77332465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils 更正:细胞质内PCNA与p47phox相互作用并控制中性粒细胞中NADPH氧化酶NOX2的激活
The Tokushima journal of experimental medicine Pub Date : 2019-11-15 DOI: 10.1084/jem.2018037111082019c
Delphine Ohayon, Alessia De Chiara, P. My-Chan Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat
{"title":"Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils","authors":"Delphine Ohayon, Alessia De Chiara, P. My-Chan Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat","doi":"10.1084/jem.2018037111082019c","DOIUrl":"https://doi.org/10.1084/jem.2018037111082019c","url":null,"abstract":"2900 https://doi.org/10.1084/jem.20180371 J. Exp. Med. 2019 Vol. 216 No. 12 2900 Rockefeller University Press Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils Delphine Ohayon, Alessia De Chiara, Pham My-Chan Dang, Nathalie Th ieblemont, Simon Chatfi eld, Viviana Marzaioli, Sabrina Sofi a Burgener, Julie Mocek, Céline Candalh, Coralie Pintard, Pascale Tacnet-Delorme, Gilles Renault, Isabelle Lagoutte, Maryline Favier, Francine Walker, Margarita Hurtado-Nedelec, Dominique Desplancq, Etienne Weiss, Charaf Benarafa, Dominique Housset, Jean-Claude Marie, Philippe Frachet, Jamel El-Benna, and Véronique Witko-Sarsat","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"23 1","pages":"2900 - 2900"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78211753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of interleukin-17 in tumor development and progression 白细胞介素-17在肿瘤发生发展中的作用
The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI: 10.1084/jem.20190297
Junjie Zhao, Xing Chen, T. Herjan, Xiaoxia Li
{"title":"The role of interleukin-17 in tumor development and progression","authors":"Junjie Zhao, Xing Chen, T. Herjan, Xiaoxia Li","doi":"10.1084/jem.20190297","DOIUrl":"https://doi.org/10.1084/jem.20190297","url":null,"abstract":"This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85312447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 116
Targeting the interleukin-17 immune axis for cancer immunotherapy 靶向白细胞介素-17免疫轴的癌症免疫治疗
The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI: 10.1084/jem.20190456
G. Vitiello, G. Miller
{"title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","authors":"G. Vitiello, G. Miller","doi":"10.1084/jem.20190456","DOIUrl":"https://doi.org/10.1084/jem.20190456","url":null,"abstract":"IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 82
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