Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier
{"title":"CXCR6调节组织驻留记忆CD8 T细胞向气道的定位","authors":"Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier","doi":"10.1084/jem.20181308","DOIUrl":null,"url":null,"abstract":"Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1999 1","pages":"2748 - 2762"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"191","resultStr":"{\"title\":\"CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways\",\"authors\":\"Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier\",\"doi\":\"10.1084/jem.20181308\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"1999 1\",\"pages\":\"2748 - 2762\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"191\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20181308\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20181308","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways
Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.
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