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The Tokushima journal of experimental medicine最新文献

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Targeting the interleukin-17 immune axis for cancer immunotherapy 靶向白细胞介素-17免疫轴的癌症免疫治疗
The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI: 10.1084/jem.20190456
G. Vitiello, G. Miller
{"title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","authors":"G. Vitiello, G. Miller","doi":"10.1084/jem.20190456","DOIUrl":"https://doi.org/10.1084/jem.20190456","url":null,"abstract":"IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 82
Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment 白介素-17细胞因子:银屑病的效应因子和靶点——认识和治疗的突破
The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI: 10.1084/jem.20191397
I. Prinz, I. Sandrock, U. Mrowietz
{"title":"Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment","authors":"I. Prinz, I. Sandrock, U. Mrowietz","doi":"10.1084/jem.20191397","DOIUrl":"https://doi.org/10.1084/jem.20191397","url":null,"abstract":"This review summarizes the steps from basic research on IL-17 family cytokines to understanding their role in psoriasis pathogenesis to the approval of a number of monoclonal antibodies targeting IL-17 pathways as first line treatment of psoriasis and psoriatic arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81608228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective 靶向白介素-17治疗慢性炎性疾病的临床研究
The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI: 10.1084/jem.20191123
P. Zwicky, S. Unger, B. Becher
{"title":"Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective","authors":"P. Zwicky, S. Unger, B. Becher","doi":"10.1084/jem.20191123","DOIUrl":"https://doi.org/10.1084/jem.20191123","url":null,"abstract":"Although many chronic inflammatory diseases share the feature of elevated IL-17 production, therapeutic targeting of IL-17 has vastly different clinical outcomes. Here the authors summarize the recent progress in understanding the protective and pathogenic role of the IL-23/IL-17 axis in preclinical models and human inflammatory diseases.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"217 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86986746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress 甲羟戊酸代谢依赖蛋白香叶酰化调节胸腺细胞的分泌
The Tokushima journal of experimental medicine Pub Date : 2019-11-13 DOI: 10.1084/jem.20190969
Xingrong Du, H. Zeng, Shaofeng Liu, C. Guy, Yogesh Dhungana, G. Neale, M. Bergo, H. Chi
{"title":"Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress","authors":"Xingrong Du, H. Zeng, Shaofeng Liu, C. Guy, Yogesh Dhungana, G. Neale, M. Bergo, H. Chi","doi":"10.1084/jem.20190969","DOIUrl":"https://doi.org/10.1084/jem.20190969","url":null,"abstract":"Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Du et al. describe unexpected roles of mevalonate metabolism–fueled protein geranylgeranylation, but not farnesylation, in driving thymocyte egress through modulating Cdc42 and Pak activities.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87255288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells 酪氨酸激酶抑制剂伊马替尼通过消耗效应调节性T细胞增强肿瘤免疫
The Tokushima journal of experimental medicine Pub Date : 2019-11-08 DOI: 10.1084/jem.20191009
A. Tanaka, H. Nishikawa, Shinsuke Noguchi, D. Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, D. Ha, Naoya Shigeta, T. Kitawaki, Y. Maeda, Takuro Saito, Yoshinori Shinohara, Y. Kameoka, K. Iwaisako, F. Monma, K. Ohishi, J. Karbach, E. Jäger, K. Sawada, N. Katayama, N. Takahashi, S. Sakaguchi
{"title":"Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells","authors":"A. Tanaka, H. Nishikawa, Shinsuke Noguchi, D. Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, D. Ha, Naoya Shigeta, T. Kitawaki, Y. Maeda, Takuro Saito, Yoshinori Shinohara, Y. Kameoka, K. Iwaisako, F. Monma, K. Ohishi, J. Karbach, E. Jäger, K. Sawada, N. Katayama, N. Takahashi, S. Sakaguchi","doi":"10.1084/jem.20191009","DOIUrl":"https://doi.org/10.1084/jem.20191009","url":null,"abstract":"As a novel type of anticancer reagent, imatinib inhibits not only BCR-ABL oncogenic protein but also LCK in T cells as an off-target, being able to selectively deplete mature T reg cells and thereby evoke effective immune responses to various cancers.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79815893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
ILC2s are the predominant source of intestinal ILC-derived IL-10 ILC2s是肠道IL-10来源的主要来源
The Tokushima journal of experimental medicine Pub Date : 2019-11-07 DOI: 10.1084/jem.20191520
Jennifer K. Bando, S. Gilfillan, B. Di Luccia, J. L. Fachi, Cristiane Sécca, M. Cella, M. Colonna
{"title":"ILC2s are the predominant source of intestinal ILC-derived IL-10","authors":"Jennifer K. Bando, S. Gilfillan, B. Di Luccia, J. L. Fachi, Cristiane Sécca, M. Cella, M. Colonna","doi":"10.1084/jem.20191520","DOIUrl":"https://doi.org/10.1084/jem.20191520","url":null,"abstract":"This study shows that the regulatory innate lymphoid cell (ILCreg), a recently described IL-10–producing innate lymphocyte, is not present in mice bred in four different facilities. Instead, group 2 ILCs provide an inducible source of IL-10 in the intestine.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73830756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 78
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis 去泛素酶BAP1的谷氨酰化控制造血干细胞的自我更新和造血
The Tokushima journal of experimental medicine Pub Date : 2019-11-07 DOI: 10.1084/jem.20190974
Zhen Xiong, P. Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, B. Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Z. Fan
{"title":"Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis","authors":"Zhen Xiong, P. Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, B. Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Z. Fan","doi":"10.1084/jem.20190974","DOIUrl":"https://doi.org/10.1084/jem.20190974","url":null,"abstract":"Xiong et al. show that CCP3 performs deglutamylation of BAP1 to stabilize BAP1, which eliminates H2AK119Ub from Hoxa1 promoter and initiates Hoxa1 expression, leading to enhanced HSC self-renewal.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86640986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis 内皮细胞Cdk5缺陷通过CXCL1/ cxcr2介导的反应性星形胶质细胞形成导致自发性癫痫的发生
The Tokushima journal of experimental medicine Pub Date : 2019-11-07 DOI: 10.1084/jem.20180992
Xiuxiu Liu, Lin Yang, Ling-Xiao Shao, Yang He, Gang Wu, Y. Bao, Nan-nan Lu, Dong-Mei Gong, Yangyang Lu, Tian-Tian Cui, Ninghe Sun, Dan-yang Chen, W. Shi, K. Fukunaga, Hong-Shan Chen, Zhong Chen, Feng Han, Ying-Mei Lu
{"title":"Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis","authors":"Xiuxiu Liu, Lin Yang, Ling-Xiao Shao, Yang He, Gang Wu, Y. Bao, Nan-nan Lu, Dong-Mei Gong, Yangyang Lu, Tian-Tian Cui, Ninghe Sun, Dan-yang Chen, W. Shi, K. Fukunaga, Hong-Shan Chen, Zhong Chen, Feng Han, Ying-Mei Lu","doi":"10.1084/jem.20180992","DOIUrl":"https://doi.org/10.1084/jem.20180992","url":null,"abstract":"Liu et al. reveal a key mechanism that mediating the transition from cerebrovascular damage to epilepsy. They identify the endothelial cyclin-dependent kinase 5 (CDK5) regulates astrocytic glutamate reuptake and increased glutamate synaptic function through CXCL1/CXCR2-mediated astrogliosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78339048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. 抗crf抗体抑制HPA轴并逆转应激诱导的表型。
The Tokushima journal of experimental medicine Pub Date : 2019-11-04 Epub Date: 2019-08-29 DOI: 10.1084/jem.20190430
Hunter S Futch, Karen N McFarland, Brenda D Moore, M Zino Kuhn, Benoit I Giasson, Thomas B Ladd, Karen A Scott, Melanie R Shapiro, Rachel L Nosacka, Marshall S Goodwin, Yong Ran, Pedro E Cruz, Daniel H Ryu, Cara L Croft, Yona Levites, Christopher Janus, Paramita Chakrabarty, Andrew R Judge, Todd M Brusko, Annette D de Kloet, Eric G Krause, Todd E Golde
{"title":"An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.","authors":"Hunter S Futch, Karen N McFarland, Brenda D Moore, M Zino Kuhn, Benoit I Giasson, Thomas B Ladd, Karen A Scott, Melanie R Shapiro, Rachel L Nosacka, Marshall S Goodwin, Yong Ran, Pedro E Cruz, Daniel H Ryu, Cara L Croft, Yona Levites, Christopher Janus, Paramita Chakrabarty, Andrew R Judge, Todd M Brusko, Annette D de Kloet, Eric G Krause, Todd E Golde","doi":"10.1084/jem.20190430","DOIUrl":"10.1084/jem.20190430","url":null,"abstract":"<p><p>Hypothalamic-pituitary-adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis. CTRND05 induces skeletal muscle hypertrophy and increases lean body mass, effects not previously reported with small-molecule HPA-targeting pharmacologic agents. Multiorgan transcriptomics demonstrates broad HPA axis target engagement through altering levels of known HPA-responsive transcripts such as Fkbp5 and Myostatin and reveals novel HPA-responsive pathways such as the Apelin-Apelin receptor system. These studies demonstrate the therapeutic potential of CTRND05 as a suppressor of the HPA axis and serve as an exemplar of a potentially broader approach to target neuropeptides with immunotherapies, as both pharmacologic tools and novel therapeutics.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"43 1","pages":"2479-2491"},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78956950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging. 生发中心反应过程中B细胞播散模式的全器官显像。
The Tokushima journal of experimental medicine Pub Date : 2019-11-04 Epub Date: 2019-09-06 DOI: 10.1084/jem.20190789
Liat Stoler-Barak, Adi Biram, Natalia Davidzohn, Yoseph Addadi, Ofra Golani, Ziv Shulman
{"title":"B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging.","authors":"Liat Stoler-Barak, Adi Biram, Natalia Davidzohn, Yoseph Addadi, Ofra Golani, Ziv Shulman","doi":"10.1084/jem.20190789","DOIUrl":"10.1084/jem.20190789","url":null,"abstract":"<p><p>Germinal centers (GCs) are sites wherein B cells proliferate and mutate their immunoglobulins in the dark zone (DZ), followed by affinity-based selection in the light zone (LZ). Here, we mapped the location of single B cells in the context of intact lymph nodes (LNs) throughout the GC response, and examined the role of BCR affinity in dictating their position. Imaging of entire GC structures and proximal single cells by light-sheet fluorescence microscopy revealed that individual B cells that previously expressed AID are located within the LN cortex, in an area close to the GC LZ. Using in situ photoactivation, we demonstrated that B cells migrate from the LZ toward the GC outskirts, while DZ B cells are confined to the GC. B cells expressing very-low-affinity BCRs formed GCs but were unable to efficiently disperse within the follicles. Our findings reveal that BCR affinity regulates B cell positioning during the GC response.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"90 1","pages":"2515-2530"},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79401777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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