The Tokushima journal of experimental medicine最新文献_第6页

WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation 结合wdr82的长链非编码RNA lncEry控制小鼠红细胞的分化和成熟

The Tokushima journal of experimental medicine Pub Date : 2021-07-13 DOI: 10.1101/2021.07.13.452142

Shangda Yang, Guohuan Sun, Peng Wu, Cong Chen, Yijin Kuang, Ling Liu, Zhaofeng Zheng, Yi-Di He, Quan Gu, Ting Lu, Caiying Zhu, Fengjiao Wang, Fanglin Gou, Zining Yang, Xiangnan Zhao, Shiru Yuan, Liu Yang, Shihong Lu, Yapu Li, Xue Lv, F. Dong, Yanni Ma, Jia Yu, L. Ng, Lihong Shi, Jing Liu, Lei Shi, T. Cheng, Hui Cheng

{"title":"WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation","authors":"Shangda Yang, Guohuan Sun, Peng Wu, Cong Chen, Yijin Kuang, Ling Liu, Zhaofeng Zheng, Yi-Di He, Quan Gu, Ting Lu, Caiying Zhu, Fengjiao Wang, Fanglin Gou, Zining Yang, Xiangnan Zhao, Shiru Yuan, Liu Yang, Shihong Lu, Yapu Li, Xue Lv, F. Dong, Yanni Ma, Jia Yu, L. Ng, Lihong Shi, Jing Liu, Lei Shi, T. Cheng, Hui Cheng","doi":"10.1101/2021.07.13.452142","DOIUrl":"https://doi.org/10.1101/2021.07.13.452142","url":null,"abstract":"Hematopoietic differentiation is controlled by both genetic and epigenetic regulators. Long non-coding RNAs (lncRNAs) have been demonstrated to be important for normal hematopoiesis, but their function in erythropoiesis needs to be further explored. We profiled the transcriptomes of 16 murine hematopoietic cell populations by deep RNA-sequencing and identified a novel lncRNA, Gm15915, that was highly expressed in erythroid-related progenitors and erythrocytes. For this reason, we named it lncEry. We also identified a novel lncEry isoform, which was also the principal transcript that has not been reported before. LncEry depletion impaired erythropoiesis, indicating the important role of the lncRNA in regulating erythroid differentiation and maturation. Mechanistically, we found that lncEry interacted with WD repeat-containing protein 82 (WDR82) to promote the transcription of Klf1 and globin genes and thus control the early and late stages of erythropoiesis, respectively. These findings identified lncEry as an important player in the transcriptional regulation of erythropoiesis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76378910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme 分子结构决定脑传递转铁蛋白受体靶向溶酶体酶

The Tokushima journal of experimental medicine Pub Date : 2021-05-22 DOI: 10.1084/jem.20211057

A. Arguello, Cathal S. Mahon, M. E. Calvert, D. Chan, J. Dugas, Michelle E Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A Damo, Joseph Duque, Meng Fang, T. Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, J. Ullman, Junhua Wang, M. Dennis, D. Diaz, K. Gunasekaran, K. Henne, Joseph W. Lewcock, P. Sanchez, M. Troyer, Jeffrey M Harris, K. Scearce-Levie, L. Shan, R. Watts, R. Thorne, Anastasia G. Henry, Mihalis S. Kariolis

{"title":"Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme","authors":"A. Arguello, Cathal S. Mahon, M. E. Calvert, D. Chan, J. Dugas, Michelle E Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A Damo, Joseph Duque, Meng Fang, T. Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, J. Ullman, Junhua Wang, M. Dennis, D. Diaz, K. Gunasekaran, K. Henne, Joseph W. Lewcock, P. Sanchez, M. Troyer, Jeffrey M Harris, K. Scearce-Levie, L. Shan, R. Watts, R. Thorne, Anastasia G. Henry, Mihalis S. Kariolis","doi":"10.1084/jem.20211057","DOIUrl":"https://doi.org/10.1084/jem.20211057","url":null,"abstract":"Delivery of biotherapeutics across the blood-brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytosis across the BBB. Here, we characterized the pharmacological behavior of two distinct TfR-targeted platforms fused to iduronate 2-sulfatase (IDS), a lysosomal enzyme deficient in mucopolysaccharidosis type II (MPS II), and compared the relative brain exposures and functional activities of both approaches in mouse models. IDS fused to a moderate-affinity, monovalent TfR binding enzyme transport vehicle (ETV:IDS) resulted in widespread brain exposure, internalization by parenchymal cells, and significant substrate reduction in the CNS of an MPS II mouse model. In contrast, IDS fused to a standard high-affinity bivalent antibody (IgG:IDS) resulted in lower brain uptake, limited biodistribution beyond brain endothelial cells, and reduced brain substrate reduction. These results highlight important features likely to impact the clinical development of TfR-targeting platforms in MPS II and potentially other CNS diseases. Summary Brain delivery, biodistribution and pharmacodynamics of a lysosomal enzyme fused to a moderate-affinity transferrin receptor-directed blood-brain barrier enzyme transport vehicle are superior to a traditional high-affinity anti-TfR monoclonal antibody fusion.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82308808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Immune checkpoint inhibitors 免疫检查点抑制剂

The Tokushima journal of experimental medicine Pub Date : 2021-02-16 DOI: 10.1007/s40278-017-37902-z

G. Kroemer, L. Zitvogel

引用次数: 0

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets. RORα 示踪小鼠肺单细胞分析揭示了 ILC 祖细胞和效应 ILC2 亚群。

The Tokushima journal of experimental medicine Pub Date : 2020-03-02 DOI: 10.1084/jem.20182293

Maryam Ghaedi, Zi Yi Shen, Mona Orangi, Itziar Martinez-Gonzalez, Lisa Wei, Xiaoxiao Lu, Arundhoti Das, Alireza Heravi-Moussavi, Marco A Marra, Avinash Bhandoola, Fumio Takei

{"title":"Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.","authors":"Maryam Ghaedi, Zi Yi Shen, Mona Orangi, Itziar Martinez-Gonzalez, Lisa Wei, Xiaoxiao Lu, Arundhoti Das, Alireza Heravi-Moussavi, Marco A Marra, Avinash Bhandoola, Fumio Takei","doi":"10.1084/jem.20182293","DOIUrl":"10.1084/jem.20182293","url":null,"abstract":"Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue repair. ILC2 development is dependent on the transcription factor retinoic acid receptor-related orphan receptor (RORα), which is also expressed in common ILC progenitors. To elucidate the developmental pathways of lung ILC2s, we generated RORα lineage tracer mice and performed single-cell RNA sequencing, flow cytometry, and functional analyses. In adult mouse lungs, we found an IL-18Rα+ST2- population different from conventional IL-18Rα-ST2+ ILC2s. The former was GATA-3intTcf7EGFP+Kit+, produced few cytokines, and differentiated into multiple ILC lineages in vivo and in vitro. In neonatal mouse lungs, three ILC populations were identified, namely an ILC progenitor population similar to that in adult lungs and two distinct effector ILC2 subsets that differentially produced type 2 cytokines and amphiregulin. Lung ILC progenitors might actively contribute to ILC-poiesis in neonatal and inflamed adult lungs. In addition, neonatal lung ILC2s include distinct proinflammatory and tissue-repairing subsets.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88649387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A super enhancer controls expression and chromatin architecture within the MHC class II locus. 一个超级增强子控制着 MHC II 类基因座内的表达和染色质结构。

The Tokushima journal of experimental medicine Pub Date : 2020-02-03 DOI: 10.1084/jem.20190668

Parimal Majumder, Joshua T Lee, Andrew R Rahmberg, Gaurav Kumar, Tian Mi, Christopher D Scharer, Jeremy M Boss

{"title":"A super enhancer controls expression and chromatin architecture within the MHC class II locus.","authors":"Parimal Majumder, Joshua T Lee, Andrew R Rahmberg, Gaurav Kumar, Tian Mi, Christopher D Scharer, Jeremy M Boss","doi":"10.1084/jem.20190668","DOIUrl":"10.1084/jem.20190668","url":null,"abstract":"Super enhancers (SEs) play critical roles in cell type-specific gene regulation. The mechanisms by which such elements work are largely unknown. Two SEs termed DR/DQ-SE and XL9-SE are situated within the human MHC class II locus between the HLA-DRB1 and HLA-DQA1 genes and are highly enriched for disease-causing SNPs. To test the function of these elements, we used CRISPR/Cas9 to generate a series of mutants that deleted the SE. Deletion of DR/DQ-SE resulted in reduced expression of HLA-DRB1 and HLA-DQA1 genes. The SEs were found to interact with each other and the promoters of HLA-DRB1 and HLA-DQA1. DR/DQ-SE also interacted with neighboring CTCF binding sites. Importantly, deletion of DR/DQ-SE reduced the local chromatin interactions, implying that it functions as the organizer for the local three-dimensional architecture. These data provide direct mechanisms by which an MHC-II SE contributes to expression of the locus and suggest how variation in these SEs may contribute to human disease and altered immunity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1084/jem.20190668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81288251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses. HIV Env 疫苗诱导的 B 细胞反应的广泛传播和群内成熟。

The Tokushima journal of experimental medicine Pub Date : 2020-02-03 DOI: 10.1084/jem.20191155

Ganesh E Phad, Pradeepa Pushparaj, Karen Tran, Viktoriya Dubrovskaya, Monika Àdori, Paola Martinez-Murillo, Néstor Vázquez Bernat, Suruchi Singh, Gilman Dionne, Sijy O'Dell, Komal Bhullar, Sanjana Narang, Chiara Sorini, Eduardo J Villablanca, Christopher Sundling, Benjamin Murrell, John R Mascola, Lawrence Shapiro, Marie Pancera, Marcel Martin, Martin Corcoran, Richard T Wyatt, Gunilla B Karlsson Hedestam

{"title":"Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.","authors":"Ganesh E Phad, Pradeepa Pushparaj, Karen Tran, Viktoriya Dubrovskaya, Monika Àdori, Paola Martinez-Murillo, Néstor Vázquez Bernat, Suruchi Singh, Gilman Dionne, Sijy O'Dell, Komal Bhullar, Sanjana Narang, Chiara Sorini, Eduardo J Villablanca, Christopher Sundling, Benjamin Murrell, John R Mascola, Lawrence Shapiro, Marie Pancera, Marcel Martin, Martin Corcoran, Richard T Wyatt, Gunilla B Karlsson Hedestam","doi":"10.1084/jem.20191155","DOIUrl":"10.1084/jem.20191155","url":null,"abstract":"Well-ordered HIV-1 envelope glycoprotein (Env) trimers are prioritized for clinical evaluation, and there is a need for an improved understanding about how elicited B cell responses evolve following immunization. To accomplish this, we prime-boosted rhesus macaques with clade C NFL trimers and identified 180 unique Ab lineages from ∼1,000 single-sorted Env-specific memory B cells. We traced all lineages in high-throughput heavy chain (HC) repertoire (Rep-seq) data generated from multiple immune compartments and time points and expressed several as monoclonal Abs (mAbs). Our results revealed broad dissemination and high levels of somatic hypermutation (SHM) of most lineages, including tier 2 virus neutralizing lineages, following boosting. SHM was highest in the Ab complementarity determining regions (CDRs) but also surprisingly high in the framework regions (FRs), especially FR3. Our results demonstrate the capacity of the immune system to affinity-mature large numbers of Env-specific B cell lineages simultaneously, supporting the use of regimens consisting of repeated boosts to improve each Ab, even those belonging to less expanded lineages.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79968267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer. 源自核心 1 的粘蛋白型 O-糖基化可预防自发性胃炎和胃癌。

The Tokushima journal of experimental medicine Pub Date : 2020-01-06 DOI: 10.1084/jem.20182325

Fei Liu, Jianxin Fu, Kirk Bergstrom, Xindi Shan, J Michael McDaniel, Samuel McGee, Xia Bai, Weichang Chen, Lijun Xia

{"title":"Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer.","authors":"Fei Liu, Jianxin Fu, Kirk Bergstrom, Xindi Shan, J Michael McDaniel, Samuel McGee, Xia Bai, Weichang Chen, Lijun Xia","doi":"10.1084/jem.20182325","DOIUrl":"10.1084/jem.20182325","url":null,"abstract":"Core 1-derived mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear role. To address this, we generated mice lacking gastric epithelial O-glycans (GEC C1galt1-/-). GEC C1galt1-/- mice exhibited spontaneous gastritis that progressed to adenocarcinoma with ∼80% penetrance by 1 yr. GEC C1galt1-/- gastric epithelium exhibited defective expression of a major mucus forming O-glycoprotein Muc5AC relative to WT controls, which was associated with impaired gastric acid homeostasis. Inflammation and tumorigenesis in GEC C1galt1-/- stomach were concurrent with activation of caspases 1 and 11 (Casp1/11)-dependent inflammasome. GEC C1galt1-/- mice genetically lacking Casp1/11 had reduced gastritis and gastric cancer progression. Notably, expression of Tn antigen, a truncated form of O-glycan, and CASP1 activation was associated with tumor progression in gastric cancer patients. These results reveal a critical role of O-glycosylation in gastric homeostasis and the protection of the gastric mucosa from Casp1-mediated gastric inflammation and cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84775138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective cancer invasion forms an integrin-dependent radioresistant niche. 癌症的集体侵袭形成了依赖于整合素的抗放射生态位。

The Tokushima journal of experimental medicine Pub Date : 2020-01-06 DOI: 10.1084/jem.20181184

Anna Haeger, Stephanie Alexander, Manon Vullings, Fabian M P Kaiser, Cornelia Veelken, Uta Flucke, Gudrun E Koehl, Markus Hirschberg, Michael Flentje, Robert M Hoffman, Edward K Geissler, Stephan Kissler, Peter Friedl

{"title":"Collective cancer invasion forms an integrin-dependent radioresistant niche.","authors":"Anna Haeger, Stephanie Alexander, Manon Vullings, Fabian M P Kaiser, Cornelia Veelken, Uta Flucke, Gudrun E Koehl, Markus Hirschberg, Michael Flentje, Robert M Hoffman, Edward K Geissler, Stephan Kissler, Peter Friedl","doi":"10.1084/jem.20181184","DOIUrl":"10.1084/jem.20181184","url":null,"abstract":"Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy of orthotopic sarcoma and melanoma xenografts. We demonstrate that these tumors invade collectively and that, specifically, cells within the invasion zone acquire increased resistance to radiotherapy, rapidly normalize DNA damage, and preferentially survive. Using a candidate-based approach to identify effectors of invasion-associated resistance, we targeted β1 and αVβ3/β5 integrins, essential extracellular matrix receptors in mesenchymal tumors, which mediate cancer progression and resistance. Combining radiotherapy with β1 or αV integrin monotargeting in invading tumors led to relapse and metastasis in 40-60% of the cohort, in line with recently failed clinical trials individually targeting integrins. However, when combined, anti-β1/αV integrin dual targeting achieved relapse-free radiosensitization and prevented metastatic escape. Collectively, invading cancer cells thus withstand radiotherapy and DNA damage by β1/αVβ3/β5 integrin cross-talk, but efficient radiosensitization can be achieved by multiple integrin targeting.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87244572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection. 冈比亚按蚊mosGILT的破坏会影响卵巢发育和疟原虫感染。

The Tokushima journal of experimental medicine Pub Date : 2020-01-06 DOI: 10.1084/jem.20190682

Jing Yang, Tyler R Schleicher, Yuemei Dong, Hyun Bong Park, Jiangfeng Lan, Peter Cresswell, Jason Crawford, George Dimopoulos, Erol Fikrig

{"title":"Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection.","authors":"Jing Yang, Tyler R Schleicher, Yuemei Dong, Hyun Bong Park, Jiangfeng Lan, Peter Cresswell, Jason Crawford, George Dimopoulos, Erol Fikrig","doi":"10.1084/jem.20190682","DOIUrl":"10.1084/jem.20190682","url":null,"abstract":"Plasmodium infection in Anopheles is influenced by mosquito-derived factors. We previously showed that a protein in saliva from infected Anopheles, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT), inhibits the ability of sporozoites to traverse cells and readily establish infection of the vertebrate host. To determine whether mosGILT influences Plasmodium within the mosquito, we generated Anopheles gambiae mosquitoes carrying mosaic mutations in the mosGILT gene using CRISPR/CRISPR associated protein 9 (Cas9). Here, we show that female mosaic mosGILT mutant mosquitoes display defects in ovarian development and refractoriness to Plasmodium. Following infection by either Plasmodium berghei or Plasmodium falciparum, mutant mosquitoes have significantly reduced oocyst numbers as a result of increased thioester-containing protein 1 (TEP1)-dependent parasite killing. Expression of vitellogenin (Vg), the major yolk protein that can reduce the parasite-killing efficiency of TEP1, is severely impaired in mutant mosquitoes. MosGILT is a mosquito factor that is essential for ovarian development and indirectly protects both human and rodent Plasmodium species from mosquito immunity.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83111607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The transcription factor NFAT5 limits infection-induced type I interferon responses 转录因子NFAT5限制了感染诱导的I型干扰素反应

The Tokushima journal of experimental medicine Pub Date : 2019-12-05 DOI: 10.1084/jem.20190449

Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez

引用次数: 14