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Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance 营养mTORC1信号支持调节性T细胞控制免疫耐受
The Tokushima journal of experimental medicine Pub Date : 2019-10-24 DOI: 10.1084/jem.20190848
Mytrang H Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, A. Efeyan, D. Sabatini, Ming O. Li
{"title":"Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance","authors":"Mytrang H Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, A. Efeyan, D. Sabatini, Ming O. Li","doi":"10.1084/jem.20190848","DOIUrl":"https://doi.org/10.1084/jem.20190848","url":null,"abstract":"Rag GTPase–dependent nutrient mTORC1 signaling plays a critical role in control of T reg cell suppression of autoimmunity and tumor immunity. These findings establish nutrients as a novel class of signaling molecule.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77414617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation 组蛋白甲基转移酶Nsd2是滤泡辅助性T细胞分化所必需的
The Tokushima journal of experimental medicine Pub Date : 2019-10-21 DOI: 10.1084/jem.20190832
Xuehui Long, Le Zhang, Yang Zhang, Min Min, Bichun Lin, Jingjing Chen, Xiaojie Ma, Sulan Zhai, Zhenming Cai, Yingxia Liu, Yanlai Lu, N. Che, W. Tan, J. Qin, Xiaoming Wang
{"title":"Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation","authors":"Xuehui Long, Le Zhang, Yang Zhang, Min Min, Bichun Lin, Jingjing Chen, Xiaojie Ma, Sulan Zhai, Zhenming Cai, Yingxia Liu, Yanlai Lu, N. Che, W. Tan, J. Qin, Xiaoming Wang","doi":"10.1084/jem.20190832","DOIUrl":"https://doi.org/10.1084/jem.20190832","url":null,"abstract":"Regulation of Bcl6 expression during follicular helper T cell differentiation remains incompletely understood. Here, Long et al. show that T cell activation induces H3K36me2 methyltransferase Nsd2, in a CD28- and ICOS-dependent manner, to promote Bcl6 expression and Tfh differentiation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86711120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Creatine uptake regulates CD8 T cell antitumor immunity 肌酸摄取调节CD8 T细胞抗肿瘤免疫
The Tokushima journal of experimental medicine Pub Date : 2019-10-18 DOI: 10.1084/jem.20182044
S. Di Biase, Xiaoya Ma, Xi Wang, Jiaji Yu, Yu-Chen Wang, Drake J. Smith, Yang Zhou, Zhe Li, Y. J. Kim, N. Clarke, Angela To, Lili Yang
{"title":"Creatine uptake regulates CD8 T cell antitumor immunity","authors":"S. Di Biase, Xiaoya Ma, Xi Wang, Jiaji Yu, Yu-Chen Wang, Drake J. Smith, Yang Zhou, Zhe Li, Y. J. Kim, N. Clarke, Angela To, Lili Yang","doi":"10.1084/jem.20182044","DOIUrl":"https://doi.org/10.1084/jem.20182044","url":null,"abstract":"Di Biase et al. show for the first time that creatine acts as a “molecular battery” conserving bioenergy to power CD8 T cell activities; that creatine uptake is critical in supporting antitumor T cell immunity; and that creatine supplementation holds promise for improving cancer immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90754139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
GM-CSF in inflammation 炎症中的GM-CSF
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20190945
J. Hamilton
{"title":"GM-CSF in inflammation","authors":"J. Hamilton","doi":"10.1084/jem.20190945","DOIUrl":"https://doi.org/10.1084/jem.20190945","url":null,"abstract":"GM-CSF is a potential therapeutic target in inflammation and autoimmunity. This study reviews the literature on the biology of GM-CSF, in particular that describing the research leading to clinical trials targeting GM-CSF and its receptor in numerous inflammatory/autoimmune conditions, such as rheumatoid arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78590807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 152
Inflammasome signaling and regulation of interleukin-1 family cytokines 炎性小体的信号传导和白细胞介素-1家族细胞因子的调控
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20190314
A. Chan, K. Schroder
{"title":"Inflammasome signaling and regulation of interleukin-1 family cytokines","authors":"A. Chan, K. Schroder","doi":"10.1084/jem.20190314","DOIUrl":"https://doi.org/10.1084/jem.20190314","url":null,"abstract":"Specific IL-1 family cytokines are initially expressed as inactive, cytosolic pro-forms. Chan and Schroder review inflammasome signaling and cell death decisions, mechanisms underpinning IL-1α, IL-1β, IL-18, and IL-37 maturation and release, and the functions of these cytokines in protective and pathological inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75935520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 204
Effects of interleukin-2 in immunostimulation and immunosuppression 白细胞介素-2在免疫刺激和免疫抑制中的作用
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20191247
Jonathan G. Pol, Pamela Caudana, J. Paillet, E. Piaggio, G. Kroemer
{"title":"Effects of interleukin-2 in immunostimulation and immunosuppression","authors":"Jonathan G. Pol, Pamela Caudana, J. Paillet, E. Piaggio, G. Kroemer","doi":"10.1084/jem.20191247","DOIUrl":"https://doi.org/10.1084/jem.20191247","url":null,"abstract":"Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects. Particularly, low-dose IL-2 and some recombinant derivatives are being evaluated to enhance/inhibit immune responses for therapeutic purposes.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84059956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 90
Biology and therapeutic potential of interleukin-10 白细胞介素-10的生物学和治疗潜力
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20190418
M. Saraiva, P. Vieira, A. O’Garra
{"title":"Biology and therapeutic potential of interleukin-10","authors":"M. Saraiva, P. Vieira, A. O’Garra","doi":"10.1084/jem.20190418","DOIUrl":"https://doi.org/10.1084/jem.20190418","url":null,"abstract":"The authors review the molecular mechanisms regulating IL-10 production and response and describe classic and novel functions of IL-10 in immune and non-immune cells. They further discuss the therapeutic potential of IL-10 in different diseases and the outstanding questions underlying an effective application of IL-10 in clinical settings.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85909960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 367
Pathogenic T cell cytokines in multiple sclerosis 多发性硬化症中的致病性T细胞因子
The Tokushima journal of experimental medicine Pub Date : 2019-10-14 DOI: 10.1084/jem.20190460
Catriona A Wagner, Pamela J. Roqué, J. Goverman
{"title":"Pathogenic T cell cytokines in multiple sclerosis","authors":"Catriona A Wagner, Pamela J. Roqué, J. Goverman","doi":"10.1084/jem.20190460","DOIUrl":"https://doi.org/10.1084/jem.20190460","url":null,"abstract":"This review summarizes our current understanding of how specific cytokines produced by pathogenic CD4 T cells contribute to central nervous system autoimmune disease. Data obtained from animal models and patients with multiple sclerosis are discussed.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77265513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis 纯合子SFTPA1突变驱动特发性肺纤维化患者II型肺泡上皮细胞坏死
The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI: 10.1084/jem.20182351
Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo
{"title":"A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis","authors":"Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo","doi":"10.1084/jem.20182351","DOIUrl":"https://doi.org/10.1084/jem.20182351","url":null,"abstract":"We identify a homozygous mutation in SFTPA1 in patients with idiopathic pulmonary fibrosis (IPF). The mutation causes increased necroptosis of type II alveolar epithelial cells through the IRE1α–JNK axis, which highlights the necroptosis pathway as a therapeutic target for IPF.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80602377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 真菌菌群的调节是由几丁质结合受体FIBCD1调控的
The Tokushima journal of experimental medicine Pub Date : 2019-10-10 DOI: 10.1084/jem.20182244
J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis
{"title":"Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1","authors":"J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis","doi":"10.1084/jem.20182244","DOIUrl":"https://doi.org/10.1084/jem.20182244","url":null,"abstract":"In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90540898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
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