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The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function Nlrp6炎性小体不是结肠内黏液层形成或功能所必需的
The Tokushima journal of experimental medicine Pub Date : 2019-08-16 DOI: 10.1084/jem.20190679
Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough
{"title":"The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function","authors":"Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough","doi":"10.1084/jem.20190679","DOIUrl":"https://doi.org/10.1084/jem.20190679","url":null,"abstract":"It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"10 26 1","pages":"2602 - 2618"},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90197733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection. 浆细胞样树突状细胞在自身免疫和慢性病毒感染中的致病作用。
The Tokushima journal of experimental medicine Pub Date : 2019-08-16 DOI: 10.1084/jem.20181359
F. Barrat, L. Su
{"title":"A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection.","authors":"F. Barrat, L. Su","doi":"10.1084/jem.20181359","DOIUrl":"https://doi.org/10.1084/jem.20181359","url":null,"abstract":"Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83754105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells IL-1β调节宿主可提高过继转移T细胞的抗肿瘤功能
The Tokushima journal of experimental medicine Pub Date : 2019-08-12 DOI: 10.1084/jem.20181218
Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo
{"title":"Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells","authors":"Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo","doi":"10.1084/jem.20181218","DOIUrl":"https://doi.org/10.1084/jem.20181218","url":null,"abstract":"Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"40 1","pages":"2619 - 2634"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79587697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 48
Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis 内皮细胞IQGAP1通过引导LBRC到渗出部位来调节白细胞的转运
The Tokushima journal of experimental medicine Pub Date : 2019-08-08 DOI: 10.1084/jem.20190008
D. Sullivan, P. Dalal, F. Jaulin, D. Sacks, G. Kreitzer, W. Muller
{"title":"Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis","authors":"D. Sullivan, P. Dalal, F. Jaulin, D. Sacks, G. Kreitzer, W. Muller","doi":"10.1084/jem.20190008","DOIUrl":"https://doi.org/10.1084/jem.20190008","url":null,"abstract":"The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruption of diapedesis in two models of inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"131 1","pages":"2582 - 2601"},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79193292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity 中枢神经系统损伤后皮质脊髓回路重构依赖于神经元活动
The Tokushima journal of experimental medicine Pub Date : 2019-08-07 DOI: 10.1084/jem.20181406
P. Bradley, Carmen K. Denecke, Almir Aljović, Anja Schmalz, M. Kerschensteiner, F. Bareyre
{"title":"Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity","authors":"P. Bradley, Carmen K. Denecke, Almir Aljović, Anja Schmalz, M. Kerschensteiner, F. Bareyre","doi":"10.1084/jem.20181406","DOIUrl":"https://doi.org/10.1084/jem.20181406","url":null,"abstract":"This study investigates the principles of target selection during the remodeling of neuronal circuits following spinal cord injury. It demonstrates that remodeling axons select their postsynaptic partners in an activity-dependent competitive process that is critical for functional recovery after injury.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":"2503 - 2514"},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83005088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3 纠正:KLRG1和NKp46区分人类CD117+CRTH2−ILCs亚群偏向于ILC2或ILC3
The Tokushima journal of experimental medicine Pub Date : 2019-08-06 DOI: 10.1084/jem.2019049007302019c
M. Nagasawa, B. Heesters, C. Kradolfer, L. Krabbendam, Itziar Martinez-Gonzalez, Marjolein J. W. de Bruijn, K. Golebski, R. Hendriks, R. Stadhouders, H. Spits, S. Bal
{"title":"Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3","authors":"M. Nagasawa, B. Heesters, C. Kradolfer, L. Krabbendam, Itziar Martinez-Gonzalez, Marjolein J. W. de Bruijn, K. Golebski, R. Hendriks, R. Stadhouders, H. Spits, S. Bal","doi":"10.1084/jem.2019049007302019c","DOIUrl":"https://doi.org/10.1084/jem.2019049007302019c","url":null,"abstract":"2221 https://doi.org/10.1084/jem.20190490 J. Exp. Med. 2019 Vol. 216 No. 9 2221 Rockefeller University Press Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3 Maho Nagasawa, Balthasar A. Heesters, Chantal M.A. Kradolfer, Lisette Krabbendam, Itziar Martinez-Gonzalez, Marjolein J.W. de Bruijn, Korneliusz Golebski, Rudi W. Hendriks, Ralph Stadhouders, Hergen Spits, and Suzanne M. Bal","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":"2221 - 2222"},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89735165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Endothelial life discontinues without Erk. 没有 Erk，内皮细胞的生命就会中断。
The Tokushima journal of experimental medicine Pub Date : 2019-08-05 Epub Date: 2019-07-18 DOI: 10.1084/jem.20191048
Yihai Cao
{"title":"Endothelial life discontinues without Erk.","authors":"Yihai Cao","doi":"10.1084/jem.20191048","DOIUrl":"10.1084/jem.20191048","url":null,"abstract":"<p><p>The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In this issue of <i>JEM</i>, Ricard et al. (https://doi.org/10.1084/jem.20182151) discover essential roles of ERK1/2 in maintaining endothelial homeostasis and its deletion-related serious defects in multiple tissues and organs.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"216 1","pages":"1730-1732"},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78595876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD97 is a critical regulator of acute myeloid leukemia stem cell function CD97是急性髓系白血病干细胞功能的关键调节因子
The Tokushima journal of experimental medicine Pub Date : 2019-08-01 DOI: 10.1084/jem.20190598
G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park
{"title":"CD97 is a critical regulator of acute myeloid leukemia stem cell function","authors":"G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park","doi":"10.1084/jem.20190598","DOIUrl":"https://doi.org/10.1084/jem.20190598","url":null,"abstract":"Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"19 1","pages":"2362 - 2377"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72723344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer 在结肠炎相关结直肠癌的小鼠模型中，肠道微生物群的编辑减少了致癌作用
The Tokushima journal of experimental medicine Pub Date : 2019-07-29 DOI: 10.1084/jem.20181939
Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter
{"title":"Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer","authors":"Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter","doi":"10.1084/jem.20181939","DOIUrl":"https://doi.org/10.1084/jem.20181939","url":null,"abstract":"Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"17 1","pages":"2378 - 2393"},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90466619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 76
Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes 利用抗独特型检测和激活HIV广泛中和抗体前体B细胞
The Tokushima journal of experimental medicine Pub Date : 2019-07-25 DOI: 10.1084/jem.20190164
T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor
{"title":"Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes","authors":"T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor","doi":"10.1084/jem.20190164","DOIUrl":"https://doi.org/10.1084/jem.20190164","url":null,"abstract":"An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"97 1","pages":"2331 - 2347"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76668928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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