Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough
{"title":"The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function","authors":"Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough","doi":"10.1084/jem.20190679","DOIUrl":null,"url":null,"abstract":"It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"10 26 1","pages":"2602 - 2618"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"69","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190679","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 69
Abstract
It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
