Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis

Abstract

The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruption of diapedesis in two models of inflammation.