浆细胞样树突状细胞在自身免疫和慢性病毒感染中的致病作用。

F. Barrat, L. Su
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引用次数: 37

摘要

随着浆细胞样树突状细胞(pDCs)的发现以及它们在TLR7和TLR9刺激下产生I型ifn (IFN-I)的非凡能力的发现,人们假设它们的主要功能是参与抗病毒反应。越来越多的证据表明,在慢性病毒感染和癌症的情况下,pDCs和/或ifn - 1也可能在许多炎症和自身免疫性疾病中发挥有害作用。这些细胞是否应该作为患者的靶点,以及它们的生物学特性与IFN-I的产生有多大关系,这些都尚不清楚,本文将对此进行讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection.
Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.
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