G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park
{"title":"CD97 is a critical regulator of acute myeloid leukemia stem cell function","authors":"G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park","doi":"10.1084/jem.20190598","DOIUrl":null,"url":null,"abstract":"Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"19 1","pages":"2362 - 2377"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"27","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190598","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 27
Abstract
Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
