Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, P. Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, B. Ye, Yong Tian, Z. Fan
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引用次数: 11
摘要
Liu等人的研究表明，yeat4通过识别H3K27ac修饰，将Dot1l-RNA Pol II复合物招募到Lmo4启动子上，启动α4β7+ CLPs中的Lmo4转录，从而导致ILC谱系承诺。
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription
Liu et al. show that Yeats4 recruits the Dot1l–RNA Pol II complex onto the Lmo4 promoter by recognizing H3K27ac modification to initiate Lmo4 transcription in α4β7+ CLPs, leading to ILC lineage commitment.
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