Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo
{"title":"IL-1β调节宿主可提高过继转移T细胞的抗肿瘤功能","authors":"Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo","doi":"10.1084/jem.20181218","DOIUrl":null,"url":null,"abstract":"Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"40 1","pages":"2619 - 2634"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"48","resultStr":"{\"title\":\"Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells\",\"authors\":\"Ping-Hsien Lee, Tori N. Yamamoto, Devikala Gurusamy, M. Sukumar, Zhiya Yu, J. Hu‐Li, T. Kawabe, Arunakumar Gangaplara, R. Kishton, A. Henning, S. Vodnala, R. Germain, W. Paul, N. Restifo\",\"doi\":\"10.1084/jem.20181218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"40 1\",\"pages\":\"2619 - 2634\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"48\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20181218\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20181218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells
Lee et al. reveal that administration of IL-1β can alter the host environment to augment the magnitude and functionality of CD8+ T cells, thereby improving the efficacy of adoptively transferred tumor-reactive T cells in treating large, established tumors in mice.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
