Xingrong Du, H. Zeng, Shaofeng Liu, C. Guy, Yogesh Dhungana, G. Neale, M. Bergo, H. Chi
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Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress
Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Du et al. describe unexpected roles of mevalonate metabolism–fueled protein geranylgeranylation, but not farnesylation, in driving thymocyte egress through modulating Cdc42 and Pak activities.
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