Dehong Yan, Jing-Horng Wang, Honghong Sun, Aliyeh Zamani, Hongling Zhang, Weihong Chen, A. Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen, X. Wan
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TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis
In this study, Yan et al. demonstrate that TIPE2, which is induced by tumor-derived ROS, promotes the functional polarization of protumoral myeloid-derived suppressor cells (MDSCs) during tumorigenesis by specifying the expression of MDSC signature genes such as Cebpb.
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