CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier
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引用次数: 191

Abstract

Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.
CXCR6调节组织驻留记忆CD8 T细胞向气道的定位
肺TRM细胞存在于间质和气道中,但调节其定位到这些不同部位的因素尚不清楚。这项工作表明,CXCR6/CXCL16轴控制TRM细胞向肺不同腔室的分配,并维持气道TRM细胞池。
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