转录因子NFAT5限制了感染诱导的I型干扰素反应

The Tokushima journal of experimental medicine Pub Date : 2019-12-05 DOI:10.1084/jem.20190449

Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez

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引用次数: 14

摘要

Huerga Encabo等人表明，NFAT5，以前被认为是一种促炎转录因子，限制IFN-I的反应来控制抗病毒防御并保持HSC静止。NFAT5通过一个进化上保守的DNA元件抑制IFN-I和ISG的表达，该元件阻止IRF3招募到IFNB1增强体。

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The transcription factor NFAT5 limits infection-induced type I interferon responses

Huerga Encabo et al. show that NFAT5, previously characterized as a pro-inflammatory transcription factor, limits the IFN-I response to control antiviral defenses and preserve HSC quiescence. NFAT5 represses IFN-I and ISG expression through an evolutionarily conserved DNA element that prevents IRF3 recruitment to the IFNB1 enhanceosome.

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The Tokushima journal of experimental medicine

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