针对DIII侧脊的公共抗体谱系对寨卡病毒和登革热病毒的差异中和机制

The Tokushima journal of experimental medicine Pub Date : 2019-11-22 DOI:10.1084/jem.20191792

Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel S. Nargi, Z. Deng, J. Errico, C. Nelson, Kimberly A. Dowd, T. Pierson, J. Crowe, M. Diamond, D. Fremont

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引用次数: 26

摘要

对寨卡病毒人抗体反应的评估已经确定了能够交叉中和黄病毒的常见种系衍生单克隆抗体。Zhao等人提供了一个详细的机制，了解如何通过具有代表性的单克隆抗体以菌株特异性的方式预防黄病毒感染。

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Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge

Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.

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The Tokushima journal of experimental medicine

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