Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi
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Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation
This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.
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