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The Tokushima journal of experimental medicine最新文献

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EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model EP3增强小鼠肝纤维化模型中NK细胞对肝星状细胞的粘附和细胞毒性
The Tokushima journal of experimental medicine Pub Date : 2022-04-14 DOI: 10.1084/jem.20212414
Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen
{"title":"EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model","authors":"Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, H. Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, M. Lazarus, Lu Zhou, Bangmao Wang, Yingjia Yu, Yujun Shen","doi":"10.1084/jem.20212414","DOIUrl":"https://doi.org/10.1084/jem.20212414","url":null,"abstract":"Tao et al. describe that activation of E-prostanoid 3 receptor (EP3) ameliorates injury-induced liver fibrosis through promoting NK cell adhesion and killing of activated hepatic stellate cells in mice, indicating that EP3 may serve as a potential therapeutic target for liver fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73013768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Toward an understanding of allogeneic conflict in pregnancy and transplantation 对妊娠和移植中同种异体冲突的理解
The Tokushima journal of experimental medicine Pub Date : 2022-04-13 DOI: 10.1084/jem.20211493
Samarth S Durgam, M. Alegre, A. Chong
{"title":"Toward an understanding of allogeneic conflict in pregnancy and transplantation","authors":"Samarth S Durgam, M. Alegre, A. Chong","doi":"10.1084/jem.20211493","DOIUrl":"https://doi.org/10.1084/jem.20211493","url":null,"abstract":"Discussion on the divergent immunological effects of pregnancy on T cell and humoral immunity, how prior pregnancy impacts responses upon alloantigen re-encounter in the context of solid organ transplantation, and potential strategies for controlling pregnancy-dependent allosensitization.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76374254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Calcium burns beige 钙烧米色
The Tokushima journal of experimental medicine Pub Date : 2022-04-12 DOI: 10.1084/jem.20220382
Jakub Bunk, L. Kazak
{"title":"Calcium burns beige","authors":"Jakub Bunk, L. Kazak","doi":"10.1084/jem.20220382","DOIUrl":"https://doi.org/10.1084/jem.20220382","url":null,"abstract":"In this issue of Journal of Experimental Medicine, Yin et al. (2022) discover that loss of FNIP1 is associated with browning of white adipose tissue, which they propose is driven by decreased calcium uptake into the ER.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74720451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics FNIP1通过塑造细胞内钙动力学调节小鼠脂肪细胞褐变和全身葡萄糖稳态
The Tokushima journal of experimental medicine Pub Date : 2022-04-12 DOI: 10.1084/jem.20212491
Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan
{"title":"FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics","authors":"Yujing Yin, Dengqiu Xu, Yan Mao, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Z. Gan","doi":"10.1084/jem.20212491","DOIUrl":"https://doi.org/10.1084/jem.20212491","url":null,"abstract":"Metabolically beneficial beige adipocytes offer tremendous potential to treat obesity and metabolic diseases. Yin et al. show that FNIP1 acts as a negative regulator of beige adipocyte thermogenesis to control systemic glucose homeostasis through modulating the ER Ca2+-ATPase SERCA.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76288431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria. 肝脏巨噬细胞对胶囊的功能脆弱性决定了血液传播细菌的毒性。
The Tokushima journal of experimental medicine Pub Date : 2022-04-04 Epub Date: 2022-03-08 DOI: 10.1084/jem.20212032
Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing-Ren Zhang
{"title":"Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria.","authors":"Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing-Ren Zhang","doi":"10.1084/jem.20212032","DOIUrl":"10.1084/jem.20212032","url":null,"abstract":"<p><p>Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the capsules enhance bacterial virulence under in vivo infection conditions. Here we show that the capsules primarily target the liver to enhance bacterial survival at the onset of blood-borne infections. In a mouse sepsis model, the capsules enabled human pathogens Streptococcus pneumoniae and Escherichia coli to circumvent the recognition of liver-resident macrophage Kupffer cells (KCs) in a capsular serotype-dependent manner. In contrast to effective capture of acapsular bacteria by KCs, the encapsulated bacteria are partially (low-virulence types) or completely (high-virulence types) \"untouchable\" for KCs. We finally identified the asialoglycoprotein receptor (ASGR) as the first known capsule receptor on KCs to recognize the low-virulence serotype-7F and -14 pneumococcal capsules. Our data identify the molecular interplay between the capsules and KCs as a master controller of the fate and virulence of encapsulated bacteria, and suggest that the interplay is targetable for therapeutic control of septic infections.</p>","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82396657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions Ly49E将肝脏ILC1s分离为胚胎源性和出生后的不同功能亚群
The Tokushima journal of experimental medicine Pub Date : 2022-03-29 DOI: 10.1084/jem.20211805
Yawen Chen, Xianwei Wang, Xiaolei Hao, Bin Li, Wanyin Tao, Shu Zhu, K. Qu, Haiming Wei, R. Sun, Hui Peng, Z. Tian
{"title":"Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions","authors":"Yawen Chen, Xianwei Wang, Xiaolei Hao, Bin Li, Wanyin Tao, Shu Zhu, K. Qu, Haiming Wei, R. Sun, Hui Peng, Z. Tian","doi":"10.1084/jem.20211805","DOIUrl":"https://doi.org/10.1084/jem.20211805","url":null,"abstract":"Chen et al. uncovered the transcriptional, developmental, and functional heterogeneity of ILC1s and demonstrated the dynamic changes that occur in ILC1 subsets from different origins during ontogeny, which correspond to their different functional roles, facilitating adaptation to age-related immune demands.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86345734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine 小胶质细胞对小鼠成年神经元突触的修剪依赖于磷脂酰丝氨酸
The Tokushima journal of experimental medicine Pub Date : 2022-03-17 DOI: 10.1084/jem.20202304
Chihiro Kurematsu, Masato Sawada, M. Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, M. Matsumoto, Hisashi Oishi, H. Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, T. Q. Thai, S. Kohsaka, N. Ohno, M. Yamada, Masato Asai, M. Sokabe, J. Nabekura, K. Asano, Masato Tanaka, K. Sawamoto
{"title":"Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine","authors":"Chihiro Kurematsu, Masato Sawada, M. Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, M. Matsumoto, Hisashi Oishi, H. Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, T. Q. Thai, S. Kohsaka, N. Ohno, M. Yamada, Masato Asai, M. Sokabe, J. Nabekura, K. Asano, Masato Tanaka, K. Sawamoto","doi":"10.1084/jem.20202304","DOIUrl":"https://doi.org/10.1084/jem.20202304","url":null,"abstract":"Mechanisms for synaptic pruning of adult-born neurons remain unknown. In this study, Kurematsu et al. demonstrate that phosphatidylserine is involved in microglial spine pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88354777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Allo-reactive tissue-resident T cells causing damage: An inside job 同种异体反应性组织驻留T细胞造成损伤:内部工作
The Tokushima journal of experimental medicine Pub Date : 2022-03-14 DOI: 10.1084/jem.20220121
R. V. van Lier, P. Hombrink
{"title":"Allo-reactive tissue-resident T cells causing damage: An inside job","authors":"R. V. van Lier, P. Hombrink","doi":"10.1084/jem.20220121","DOIUrl":"https://doi.org/10.1084/jem.20220121","url":null,"abstract":"Using single-cell RNA and TCR sequencing, Snyder et al. show that during acute cellular rejection there is an allograft-specific clonal expansion of cytotoxic recipient-derived tissue resident memory T cells that are reprogrammed but persist despite high-dose glucocorticoid therapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78150230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen PERK对造血祖细胞进行重编程，以指导脾脏中促进肿瘤的骨髓生成
The Tokushima journal of experimental medicine Pub Date : 2022-03-10 DOI: 10.1084/jem.20211498
Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi‐Mei Zhuang, Tiebang Kang, Limin Zheng
{"title":"PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen","authors":"Mingyu Liu, Chong Wu, Shufeng Luo, Qiaomin Hua, Hai-Tian Chen, Yulan Weng, Junyu Xu, Huiling Lin, Lu Wang, Jinheng Li, Lan Zhu, Zhenhong Guo, Shi‐Mei Zhuang, Tiebang Kang, Limin Zheng","doi":"10.1084/jem.20211498","DOIUrl":"https://doi.org/10.1084/jem.20211498","url":null,"abstract":"Liu et al. demonstrate that the PERK-triggered HSPC preconditioning in the spleen is essential for their myeloid descendant cells to become immune suppressors in response to subsequent tumor microenvironmental stimulation. A spleen-targeted PERK blockade could be an effective strategy of immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73964867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Iron out KRAS-driven cancer 消除kras驱动的癌症
The Tokushima journal of experimental medicine Pub Date : 2022-03-09 DOI: 10.1084/jem.20212166
G. Lei, B. Gan
{"title":"Iron out KRAS-driven cancer","authors":"G. Lei, B. Gan","doi":"10.1084/jem.20212166","DOIUrl":"https://doi.org/10.1084/jem.20212166","url":null,"abstract":"Jiang et al. leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90370491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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