M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid
{"title":"B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2","authors":"M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid","doi":"10.1084/jem.20190860","DOIUrl":null,"url":null,"abstract":"This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"37","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190860","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 37
Abstract
This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.
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