T. Bigley, Liping Yang, L. Kang, J. Saenz, F. Victorino, W. Yokoyama
{"title":"小鼠玫瑰病毒感染破坏胸腺中枢耐受诱导自身免疫性胃炎","authors":"T. Bigley, Liping Yang, L. Kang, J. Saenz, F. Victorino, W. Yokoyama","doi":"10.1084/jem.20211403","DOIUrl":null,"url":null,"abstract":"Bigley et al. show that neonatal murine roseolovirus infection disrupts central tolerance. Autoimmunity arises later, in the absence of ongoing infection. This study provides evidence for a new mechanism by which viruses induce autoimmunity at a time remote from initial infection.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis\",\"authors\":\"T. Bigley, Liping Yang, L. Kang, J. Saenz, F. Victorino, W. Yokoyama\",\"doi\":\"10.1084/jem.20211403\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bigley et al. show that neonatal murine roseolovirus infection disrupts central tolerance. Autoimmunity arises later, in the absence of ongoing infection. This study provides evidence for a new mechanism by which viruses induce autoimmunity at a time remote from initial infection.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-02-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20211403\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20211403","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis
Bigley et al. show that neonatal murine roseolovirus infection disrupts central tolerance. Autoimmunity arises later, in the absence of ongoing infection. This study provides evidence for a new mechanism by which viruses induce autoimmunity at a time remote from initial infection.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
