B细胞对乳糜泻自身抗原转谷氨酰胺酶2的耐受性和抗体产生

The Tokushima journal of experimental medicine Pub Date : 2019-11-14 DOI:10.1084/jem.20190860

M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid

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引用次数: 37

摘要

本研究揭示了在乳糜泻中形成转谷氨酰胺酶2 (TG2)自身抗体的机制。作者发现自身反应性tg2特异性B细胞没有缺失或沉默，抗tg2自身抗体的产生是由T细胞帮助控制的。

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B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.

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The Tokushima journal of experimental medicine

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