The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

{"title":"Mortality and hospitalization among older caregivers: Results from the Atherosclerosis Risk in Communities Study","authors":"Shoshana H Ballew, Emmanuel E Garcia Morales, Wuyang Zhang, Martha Abshire Saylor, Danielle S Powell, James R Pike, Anna Kucharska-Newton, Nancy L Schoenborn, Silvia Koton, Erin E Kent, David L Roth, Josef Coresh, Jennifer L Wolff, Nicholas Reed, Katherine A Ornstein","doi":"10.1093/gerona/glaf182","DOIUrl":"https://doi.org/10.1093/gerona/glaf182","url":null,"abstract":"Background Few studies have comprehensively examined health outcomes among older caregivers. We aimed to describe older caregivers and characterize risks for mortality and hospitalization compared to non-caregivers. Methods Caregiving status and characteristics were determined for Atherosclerosis Risk in Communities (ARIC) Study participants via a one-time telephone assessment in 2015. All-cause mortality was identified from active surveillance, state records, and linkage to the National Death Index through December 31, 2021. Hospitalizations were identified from active cohort surveillance. Cox proportional hazard models assessed risks of mortality and hospitalization. Results Among 5,239 ARIC participants [mean age: 75.4 (SD 5.1) years; female: 60.0%; Black: 18.9%], 427 (8.2%) reported caregiving. Caregivers were generally female and younger as compared to non-caregivers. Most caregivers provided care for their spouse (55.0%) and 28.3% reported spending >40 hours/week on caregiving activities. Caregivers had modestly better cognitive scores but were similar to non-caregivers in the number of comorbidities and self-rated health. During a mean 5.4 (SD 1.3) years of follow-up, caregivers had a lower risk of mortality than non-caregivers (18.7% vs. 23.8%), although not statistically significant in fully adjusted time-to-event models (hazard ratio [HR]=0.84; 95%CI:0.67-1.06). Caregivers and non-caregivers had similar risk of hospitalization (63.5% vs. 64.9%; HR = 1.00; 95%CI:0.89-1.14). Conclusions Older caregivers provide substantial care while facing their own health challenges. Despite similar baseline comorbidity burdens as non-caregivers, caregivers had a lower risk of all-cause mortality over the 6 years of follow-up. Future studies should examine the potential protective factors of caregiving in older age to inform caregiver support initiatives for older adults providing care.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Lifestyle Mitigates the Adverse Association of Particulate Matter with Cognitive Function: A 10-year Longitudinal Analysis of Older Adults in China","authors":"Qi Zhao, Qiushi Feng, Saima Hilal, Wei Jie Seow","doi":"10.1093/gerona/glaf171","DOIUrl":"https://doi.org/10.1093/gerona/glaf171","url":null,"abstract":"Background Both air pollution and lifestyle are associated with cognitive function, with air pollution being detrimental and positive lifestyles being beneficial. The extent to which a favorable lifestyle can mitigate the harmful effects of air pollution on cognitive function in later life warrants further investigation. Methods 7,651 individuals aged 65 years and above from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were followed up between 2008 and 2018. Cognitive function was measured at each wave using the Mini-Mental State Examination (MMSE). Particulate matter (PM1, PM2.5, and PM10) concentrations were assessed using satellite-based spatiotemporal models. A favorable lifestyle was determined based on four lifestyle factors: never drinking, never smoking, regular exercise, and a healthy diet. Linear mixed-effects models were employed to estimate the association between PM and cognitive function as well as potential mitigation by lifestyle. Results Overall, there were significant associations between PM and cognitive function, with MMSE scores decreasing by 0.47 points (95% confidence interval (CI): -0.62, -0.33), 0.66 points (95% CI: -0.83, -0.49), and 0.62 points (95% CI: -0.78, -0.46) per IQR increase in PM1, PM2.5, and PM10, respectively. A favorable lifestyle was beneficial for cognitive function. Moreover, the adverse association between PM exposure and cognitive function was significantly attenuated by a favorable lifestyle (p-interaction = 0.007, 0.013, 0.037 for PM1, PM2.5, and PM10, respectively). Conclusions A favorable lifestyle may mitigate the adverse association between PM exposure and cognitive function. Lifestyle interventions could be beneficial in counteracting the neurological impacts of ambient air pollution.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying Oral Panoramic Radiography to Health Screening of the Aging Population: Cross-sectional and Longitudinal Associations between Adverse Oral Conditions and Intrinsic Capacity Deficiency.","authors":"Han Jiang,Li Cheng,Tingjuan He,Chenchen Zhang,Birong Dong,He Cai,Tao Hu","doi":"10.1093/gerona/glaf180","DOIUrl":"https://doi.org/10.1093/gerona/glaf180","url":null,"abstract":"BACKGROUNDIntrinsic capacity (IC) and oral health are crucial for healthy aging and are linked to future adverse health outcomes. Panoramic radiography provides comprehensive oral assessments and may have broader applications in health screening. However, the cross-sectional and longitudinal relationships between adverse oral conditions detected through panoramic radiographs and deficient IC remain insufficiently explored. Therefore, this study aimed to investigate these associations and explore the feasibility of panoramic radiography in primary health screening.METHODSData from the West China Health and Aging Trend study (2021-2024) were used. Adverse oral conditions (caries, residual roots, periodontitis, tooth loss, and functional impairments) were assessed by manual radiograph reading. IC levels were measured at each visit, encompassing locomotor, cognitive, psychological, vitality, and sensory functions. Cross-sectional analysis used logistic regression, and longitudinal analysis incorporated follow-up data via generalized estimating equations.RESULTSCross-sectional analysis showed that residual roots (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.09-4.78), severe periodontitis (2.17, 1.00-4.68), missing teeth (2.57, 1.23-5.38), and >16 functional tooth loss (2.65, 1.15-6.09) were linked to deficient IC (n = 235). Longitudinal analysis confirmed associations of residual roots (-0.21, -0.42-0.00) and >16 functional tooth loss (-0.38, -0.73 to -0.02) with IC decline.CONCLUSIONSAdverse oral conditions were proved to have detrimental impact on IC among middle-aged and older adults, highlighting the potential of panoramic radiography as a valuable tool for early health screening in aging populations, as it may promote healthy aging and help mitigate health disparities.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Survival and Pneumonia Risk in Advanced Dementia Patients on Nasogastric Tube Feeding versus Careful Hand Feeding.","authors":"Jacqueline K Yuen,Rachelle Bernacki,Felix H W Chan,Tuen-Ching Chan,David T Y Chow,Yat-Fung Shea,Betty L H Ng,Karen M K Chan,Xue Li,Qi-Man Shi,James K H Luk","doi":"10.1093/gerona/glaf165","DOIUrl":"https://doi.org/10.1093/gerona/glaf165","url":null,"abstract":"BACKGROUNDNasogastric tube feeding is commonly used for enteral nutrition in individuals with advanced dementia with feeding difficulties, but its impact on survival and pneumonia risk compared to careful hand feeding remains controversial. This study aimed to compare one-year survival and pneumonia risk in individuals with advanced dementia initiated on nasogastric tube feeding versus those receiving careful hand feeding.METHODSA prospective propensity score-matched cohort study was conducted. Participants included individuals aged ≥60 years with advanced dementia and feeding problems admitted to two geriatric hospitals between September 2020 and September 2022. Propensity-score matched cohorts were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression models.RESULTSAmong 283 participants (mean age 89.8 years, 62.2% female, 73.5% residential care home residents), 184 (65.0%) were received careful hand feeding and 99 (35.0%) nasogastric tube feeding. A matched subsample of 176 participants (116 careful hand feeding, 60 nasogastric tube feeding) was analyzed. One-year adjusted survival did not differ significantly between the nasogastric tube feeding and careful hand feeding groups (AHR= 0.85, 95% CI, 0.59-1.23, P =.38). However, the nasogastric tube feeding group had a significantly higher one-year adjusted pneumonia risk compared to the careful hand feeding group (AHR 1.60, 95% CI, 1.06-2.42, P =.03).CONCLUSIONSIndividuals with advanced dementia initiated on nasogastric tube feeding do not have meaningfully improved survival and have a higher risk of pneumonia compared to those receiving careful hand feeding. These findings can guide clinicians and families when considering feeding tube placement for individuals with advanced dementia.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"739 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Longitudinal Association Between Intrinsic Capacity and Functional Ability in Older Adults: Comparing Findings from the Cross-Lagged Panel Model and the Random-Intercept Cross-Lagged Panel Model","authors":"Yilin Cheng, Shuqin Xiao, Yurun Cai, Liwei Jing, Weiyao Li, Xue Liu","doi":"10.1093/gerona/glaf172","DOIUrl":"https://doi.org/10.1093/gerona/glaf172","url":null,"abstract":"Background Intrinsic Capacity (IC) is a multidimensional construct defined by the World Health Organization (WHO). Although IC has been established as a significant predictor of functional decline in older adults, emerging evidence suggests that functional impairment may, in turn, accelerate the degradation of IC, indicating a potential bidirectional relationship. Therefore, this study aims to systematically examine the potential bidirectional relationship between IC and functional ability. Methods This study analyzed longitudinal data from 2,233 adults aged 60 and above from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015). Cross-lagged panel models (CLPM) and random-intercept cross-lagged panel models (RI-CLPM) were used to examine bidirectional associations between IC and functional ability. IC (0-100) was assessed across five domains: locomotion, cognition, psychological well-being, vitality, and sensory function. Functional ability was measured using scores for basic (BADL: 0-18) and instrumental (IADL: 0-15) activities of daily living at three time points. Models were adjusted for sociodemographic, health, and behavioral factors. Results Compared to CLPM, RI-CLPM better captured the dynamic trajectory of functional status in older adults. IC decline significantly predicted BADL deterioration (β = 0.089-0.109, p < 0.05), but BADL changes did not significantly affect IC. A bidirectional relationship existed between IC and IADL, with IC’s effect on IADL (β = 0.206-0.236, p < 0.001) being stronger than the reverse (β = 0.093-0.100, p < 0.001). Conclusions This study employed CLPM and RI-CLPM to investigate the dynamic relationship between IC and functional ability. These results offer new directions for developing interventions to promote healthy aging.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.","authors":"Guillaume Provost,Kamaryn Tanner,Véronique Legault,Luigi Ferrucci,Stefania Bandinelli,Linda P Fried,Daniel W Belsky,Benoit Laurent,Alan A Cohen","doi":"10.1093/gerona/glaf179","DOIUrl":"https://doi.org/10.1093/gerona/glaf179","url":null,"abstract":"Aging is the leading risk factor for most chronic disease. However, disease risk varies substantially between individuals of the same age. Biological aging measures attempt to quantify this difference using biomarkers; such measures have amassed substantial evidence as reliable correlates of morbidity and mortality. Although many have been developed throughout the years, there is no clear consensus as to which one is the best, if any. This study evaluates four methods for measuring biological aging: Klemera and Doubal's method for biological age (KDM BA), phenotypic age (PA), homeostatic dysregulation (DM), and Pace of Aging (Pace). Using five cohort studies from four different countries (InCHIANTI from Italy, WHAS I and II from the US, NuAge from Canada, and the UK Biobank), we assessed the relationship of these metrics with six health outcomes. The metrics were calculated using a consistent set of biomarkers to facilitate comparison. The biological aging measures correlated only weakly with each other (r > 0.5 for six of 21 correlations). The meta-analyses performed on the results from each dataset revealed that all biological age measures were significantly associated with at least one health outcome; however, no single metric consistently outperformed the others, with strength of association strikingly similar across metrics. This study is the first to combine an international multi-cohort analysis using a consistent set of biomarkers across biological age metrics. While there are no net winners or losers, effect sizes are heterogeneous across cohorts, highlighting the importance of replicating findings in different contexts and with different metrics.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of macronutrient intake patterns with accelerated biological ageing and life expectancy: Evidence from a population-based study in the UK Biobank","authors":"Peng Wang, Yiming Wang, Ping Xiang, Binyu Bai, Biao Xie, Dan Shi","doi":"10.1093/gerona/glaf175","DOIUrl":"https://doi.org/10.1093/gerona/glaf175","url":null,"abstract":"BACKGROUND The associations of macronutrient intake with accelerated biological aging and life expectancy remain unclear. METHODS In total, 56,555 participants in the UK Biobank were included. Macronutrient intake patterns, including overall low-carbohydrate-diet (LCD), low-fat-diet (LFD), low-protein-diet (LPD), low-animal-protein diet (LAPD), low-vegetable-protein diet (LVPD), low-animal-fat diet (LAFD), low-vegetable-fat diet (LVFD), and healthful plant-based diet index (hPDI), were assessed via the Oxford WebQ. Klemera-Doubal-Method Biological Age acceleration (KDM-BA Accel) and PhenoAge acceleration (PhenoAge Accel) were computed to assess accelerated biological aging. Multivariable generalized linear regressions were conducted to estimate the β and 95% confidence intervals (CI). Life expectancy was assessed by proportional hazards survival analysis. RESULTS We observed consistent significant associations of overall LCD and LFD, but not LPD, with biological aging. However, overall macronutrient intake patterns were not related to life expectancy. Compared with the lowest tertile, adherence to the LLQCD, LAPD, LAFD and hPDI in the highest tertile were associated with decreases of -0.901 (95% CI: -1.025, -0.778), -0.762 (-0.888, -0.637), -0.996 (-1.121, -0.870), and -0.113 (-0.127, -0.099) KDM-BA-Accel years, and -0.847 (-0.933, -0.761), -0.497 (-0.585, -0.409), -0.950 (-1.038, -0.863), and -0.221 (-0.241, -0.200) PhenoAge-Accel years, as well as additional gains of 1.666 (1.039, 2.294), 1.538 (0.912, 2.164), 1.381 (0.757, 2.006), and 2.650 (2.007, 3.292) life years, respectively. Conversely, LHQCD, LVPD, and LVFD were associated with accelerated biological aging and shorten life expectancy. CONCLUSIONS This study demonstrates that the quality of macronutrient intake patterns may be more important than overall patterns in influencing biological aging and life expectancy.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.","authors":"Golam Rabbani,Sheikh M Alif,Zhen Zhou,Joanne Ryan,Nazmul Karim","doi":"10.1093/gerona/glaf174","DOIUrl":"https://doi.org/10.1093/gerona/glaf174","url":null,"abstract":"BACKGROUNDSerum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function.METHODSFive electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardised mean difference (SMD) was calculated and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates.RESULTSTen prospective cohort and sixteen cross-sectional studies were eligible for inclusion, but only a subset of these studies was included in each meta-analysis. Pooled estimates from cross-sectional studies showed that higher SUA levels were significantly associated with better global cognition (n = 6, SMD = 2.27, 95%CI:1.18-3.35), and learning and memory (n = 4, SMD = 1.49, 95%CI:1.12-1.87). Sensitivity analysis, excluding the study conducted on amyotrophic lateral sclerosis (ALS) patients, resulted in better performance estimates for executive function (n = 4, SMD = 0.51, 95%CI:0.47-0.55) and language (n = 2, SMD = 0.75, 95%CI:0.71-0.79). The pooled result from two prospective cohort studies found a positive relationship between SUA levels and attention (SMD = 0.22, 95%CI:0.07-0.36). SUA levels were associated with executive function and learning and memory in males, and with language in females.CONCLUSIONSHigher SUA levels were associated with better global cognitive performance executive function, learning and memory, attention and language. These findings highlight low SUA levels as a potential useful biomarker for cognitive decline.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging as a Key Determinant of Glymphatic System Function in older adults.","authors":"Feiyue Yin,Bang Zeng,Lisha Nie,Shuang Ding,Dan Luo,Peng Zeng,Binglan Li,Zhuowei Shi,Yongmei Li,Tianyou Luo","doi":"10.1093/gerona/glaf176","DOIUrl":"https://doi.org/10.1093/gerona/glaf176","url":null,"abstract":"BACKGROUNDThe glymphatic system is a crucial pathway for the clearance of metabolic waste in the central nervous system. However, the risk factors of glymphatic system such as age, gender, metabolic factors, cardiovascular disease and lifestyle are not fully investigated. We examined the association between risk factors and glymphatic system to identify the key factors that influence glymphatic system in older adults.METHODSA total of 228 community-dwelling participants aged 40-82 years were assessed with 3T MRI. MRI measures, including perivascular space (PVS) volume fraction (PVSVF), free water (FW), and diffusion tensor image analysis along the perivascular space (DTI-ALPS) were calculated. The participants were divided into three subgroups by age including 40-54 years (n = 88), 55-64 years (n = 83), and ≥65 years group (n = 34). The association between age and glymphatic system was analyzed using linear regression model.RESULTSIn total, 205 participants aged from 40 to 82 years were analyzed. FW in white matter (β = 0.308, p = 0.020) and DTI-ALPS (β=-0.356, p = 0.001) were associated with age significantly. In subgroup, FW in white matter (β = 0.732, p < 0.001) positively correlated with age in ≥ 65 years group. DTI-ALPS negatively correlated with age in ≥ 65 years group (β=-0.532, p = 0.001) after including fractional anisotropy (FA) and mean diffusivity (MD) of interest region as covariates.DISCUSSIONAging was found to be a key factor influencing the function of the glymphatic system especially in the participants during older age (≥ 65 years), suggesting the potential importance of the sixth decade for early preservation methods of the glymphatic system.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase.","authors":"Kevin M Thyne,Raechel Camones,Adam B Salmon","doi":"10.1093/gerona/glaf177","DOIUrl":"https://doi.org/10.1093/gerona/glaf177","url":null,"abstract":"Methionine restriction (MR) has many effects on different molecular and physiological systems and pathways associated with aging. However, these outcomes have often been ambiguous across studies, suggesting context of outcomes, including tissue type or donor sex, may have significant impact. We have previously shown that methionine sulfoxide reductase A (MsrA) may have discrete roles on aging physiology under methionine restriction. Here we investigated the effect of MR on putative molecular hallmarks of aging, including mitochondrial function and regulation of the intracellular signal hydrogen sulfide, across tissues and in males and females. We found that females tended to have greater changes to mitochondrial oxygen consumption than males with MR, while the effects of MsrA were context dependent. Mitochondrial hydrogen peroxide production was decreased by MR in hepatic mitochondria from females and only slightly higher with loss of MsrA in both sexes. In contrast, mitochondrial peroxide production was increased in the kidney with MR regardless of sex or MsrA status. Hydrogen sulfide production capacity was increased only in the liver by MR independent of MsrA, though expression of regulators of hydrogen sulfide generation were changed in a tissue-dependent manner that was not altered by MsrA status. Expression of methionine sulfoxide reductases were also impacted by MR showing changes in expression in a tissue and sex dependent manner. These results suggest a complex interaction between tissue, sex, diet, and MsrA status.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}