The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

{"title":"Association of cumulative blood pressure with progression of depressive symptoms and functional impairment among adults aged 50 years or older: 10-year follow-up of two longitudinal cohorts","authors":"Wenya Zhang, Jie Liang, Chenglong Li, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng","doi":"10.1093/gerona/glaf080","DOIUrl":"https://doi.org/10.1093/gerona/glaf080","url":null,"abstract":"Background The association of cumulative blood pressure (BP) with progression rate of depressive symptoms and functional impairment remained largely unknown, and this study aims to explore whether higher cumulative BP is associated with a faster rate of aggravation of depressive symptoms and functional impairment. Methods This longitudinal cohort study adopted data from the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). Cumulative BP was calculated as area under the curve using BP measurements from 3 visits (wave 0, 2 and 4) in ELSA and 2 visits (wave 8 and 10) in HRS. Depressive symptoms were evaluated in a biennial frequency via Center for Epidemiological Studies Depression (CES-D) scale, while functional status was measured every two years using adapted versions of Katz Activities of Daily Living (ADL) scale and Lawton Instrumental Activities of Daily Living (IADL) scale. Results A total of 3500 and 6036 participants from ELSA and HRS were included. Elevated cumulative pulse pressure (PP) was significantly associated with accelerated aggravation of depressive symptoms (P < 0.001 for both). Elevated cumulative systolic BP and PP were significantly associated with accelerated decline of ADL function (P < 0.001 for both) and IADL function (P < 0.001 for both). However, elevated cumulative diastolic BP was associated with decelerated decline of IADL function (P = 0.031 in ELSA and P < 0.001 in HRS). Conclusions Elevated cumulative BP was associated with accelerated aggravation of depressive symptoms and functional impairment, suggesting that controlling systolic BP and PP while maintaining adequate diastolic BP is of paramount importance for adults to achieve health longevity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Dementia, Depression, and Other Mental Disorders on Reoperation and Mortality among Hip Fracture Patients: A Nationwide Danish Cohort Study.","authors":"Simon Storgaard Jensen,Per Hviid Gundtoft,Jan-Erik Gjertsen,Alma B Pedersen","doi":"10.1093/gerona/glaf074","DOIUrl":"https://doi.org/10.1093/gerona/glaf074","url":null,"abstract":"BACKGROUNDDespite the rising global burden of mental disorders, their impact on complication risk following hip fracture surgery remains unclear. We examined reoperation and mortality risks after hip fracture surgery, investigating patients with and without moderate to severe mental disorders.METHODSUsing a nationwide cohort design, we identified patients undergoing hip fracture surgery from the Danish Multidisciplinary Hip Fracture Register. Mental disorders (including organic disorders (dementia), substance use, schizophrenia, mood disorders, and neurotic disorders) and reoperations were determined using diagnosis and procedure codes in the Danish National Patient Registry. We estimated reoperation and mortality risk with adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs), comparing each mental disorder to no mental disorder while accounting for death as a competing risk.RESULTSAmong 110,625 hip fracture patients from 2004 to 2021, 15,254 (14%) had a mental disorder. The 30-day aHRs for reoperation ranged from 1.05 (CI: 0.9-1.2) for dementia to 1.67 (CI: 1.3-2.1) for substance use. The 365-day aHRs for reoperation ranged from 0.92 (CI: 0.9-1.0) for dementia to 1.37 (CI: 1.2-1.5) for neurotic disorders. Patients with mental disorders had an increased aHR for mortality at both 30-day and 365-day follow-up compared to patients without mental disorders, with the most pronounced risk observed among patients with dementia.CONCLUSIONThe risk of reoperation and mortality following hip fracture surgery was significantly higher in patients with moderate to severe mental disorders compared to those without. These findings emphasise the need for targeted prevention strategies to reduce reoperation risk and mortality.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain resting-state functional connectivity mediates the age-associated decline in physical activity engagement.","authors":"Meishan Ai,Emma M Tinney,Goretti España-Irla,Charles H Hillman,Arthur F Kramer,Timothy P Morris","doi":"10.1093/gerona/glaf075","DOIUrl":"https://doi.org/10.1093/gerona/glaf075","url":null,"abstract":"BACKGROUNDPhysical activity (PA) engagement declines with age in late adulthood. Therefore, understanding factors underlying PA engagement is needed for PA promotion in older adults. Executive function is a potential key neurocognitive resource that supports PA engagement. The current study aims to provide neurobiological evidence for this hypothesis by examining the role of the executive function networks in PA engagement.METHODSResting-state functional Magnetic Resonance Imaging (MRI) data and self-reported PA engagement were obtained from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) (age range 18-81). The frontoparietal network (FPN) and salience network (SN) were chosen as networks of interest.RESULTSWe found that PA engagement began to decline at the age of 49 via piecewise regression. Meanwhile, functional connectivity within FPN connecting posterior cingulate, parietal area, and precuneus, and functional connectivity within SN connecting right temporo-parieto-occipital area, anterior and middle cingulate, and bilateral fronto-operculum and insula were associated with PA. The PA-associated functional connectivity within SN mediated the age-related decline of PA engagement, which was not observed for the FPN.CONCLUSIONSPA engagement begins to decrease in middle-age, while functional connectivity between key regions related to inhibitory control and behavior regulation is a potential neural mechanism underlying this age-related decline. These findings provide neurobiological evidence for the hypothesis that aspects of executive function support PA engagement. Moreover, it also identifies potential neural targets for future PA promotion interventions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to minimize fall-related injuries in older adults at risk of falls: the Falling Safely Training (FAST) study.","authors":"Tobia Zanotto,Lingjun Chen,James R Fang,Abbas Tabatabaei,Jianghua He,Shelley B Bhattacharya,Neil B Alexander,Jacob J Sosnoff","doi":"10.1093/gerona/glaf076","DOIUrl":"https://doi.org/10.1093/gerona/glaf076","url":null,"abstract":"BACKGROUNDFalls are the leading cause of accidental injury among older adults. Current fall prevention programs are useful but do not target the key variable for injury (i.e., impact force). An approach, which has shown promise in robust older adults, is to teach safe-falling strategies to reduce impact forces. In this single-blinded, pilot randomized controlled trial, we explored the feasibility and preliminary efficacy of a safe-falling program.METHODSTwenty-four older adults at risk of injurious falls were randomly assigned either to Falling Safely Training (FAST), a standardized progressive training of safe-falling strategies, or an active control group consisting of evidence-based balance training. Participants underwent a series of experimentally induced falls at baseline, after the 4-week intervention, and three months after the intervention. Hip and head acceleration (proxies of impact force) and the number of head impacts experienced during the falls were collected.RESULTSNo adverse events were reported, and eleven of 12 FAST participants completed the intervention. The FAST group had a greater reduction in the number of fall-related head impacts following the intervention (odds ratio = 0.10, 95% CI: 0.02, 0.61, p=0.012). This improvement coincided with a significant reduction in head acceleration in the FAST group compared to control (between-group mean difference = -9.54 m/sec2, p=0.028). Hip acceleration decreased significantly in both groups (p's˂0.001).CONCLUSIONTeaching older adults at risk of falls safe-falling strategies is safe and feasible and has the potential to minimize fall-related head impacts and reduce fall morbidity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submaximal eccentric training during immobilization does not prevent serial sarcomere loss or impairments in mechanical function in old or young rats","authors":"Avery Hinks, Ethan Vlemmix, Geoffrey A Power","doi":"10.1093/gerona/glaf082","DOIUrl":"https://doi.org/10.1093/gerona/glaf082","url":null,"abstract":"The age-related loss of muscle mass is partly driven by a reduction in serial sarcomere number (SSN), and further SSN loss occurs during immobilization. SSN is associated with optimal force and power production and muscle passive tension, thus immobilization-induced SSN loss is especially a concern for older individuals who are often subjected to forced muscle disuse with illness and injury. We previously showed that submaximal eccentric resistance training increased SSN and improved muscle function in old rats. The present study investigated whether this training could prevent the losses of SSN and function when performed intermittently during immobilization. 10 old (32 months) and 10 young (8 months) rats underwent unilateral casting of the plantar flexors in a shortened position for 2 weeks. Thrice weekly, casts were removed for isokinetic eccentric resistance training. Pre- and post-training we assessed in-vivo maximum isometric torque at ankle angles corresponding to stretched and neutral muscle lengths, the passive torque-angle relationship, and isotonic power. The soleus and medial gastrocnemius were harvested for SSN measurements, with the untrained leg as a control. In old and young rats, muscles of the casted leg had smaller muscle wet weights (20-40%), physiological cross-sectional area (16-20%), and SSN (7-29%) than the control leg. Furthermore, maximum isometric torque (37-46%) and isotonic power (≈70%) decreased, and passive torque increased (+≈400%) from pre- to post-training for both age groups. Thus, irrespective of age, submaximal eccentric resistance training 3 days/week was ineffective for preventing the losses of muscle contractile tissue and mechanical function during casting.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incongruence between Self-report and Performance-based Measure of Balance in Community-Dwelling Adults.","authors":"Shweta Kapur,Kwame S Sakyi,Joshua L Haworth,Prateek Lohia,Daniel J Goble","doi":"10.1093/gerona/glaf069","DOIUrl":"https://doi.org/10.1093/gerona/glaf069","url":null,"abstract":"BACKGROUNDMost population-based studies and clinical fall-risk screenings depend on self-reported balance information. This study investigated the congruency between self-reported balance information and performance-based balance measure (Romberg Test of Standing Balance on Firm and Compliant Support Surfaces, RTSBFCSS). It also explored predictors of congruency between these balance measures.METHODSDesign: Secondary analysis of cross-sectional National Health and Nutrition Examination Survey cycles 2001-2004 (latest data cycles with variables of interest). Participants: Nationally representative sample of 4939 adults (≥40 years). Procedures: The proportion of individuals who underestimated (self-reported no balance problem but failed RTSBFCSS) or overestimated (self-reported having a balance problem but passed RTSBFCSS) their balance problem was calculated. Predictors of congruency among balance measures were explored using multivariable regression.RESULTSThe study included 4,939 adults (mean-age 56.0 years (0.3 SE), 51.2% females). Of all participants, 36.9% had evidence of balance problems on RTSBFCSS. About 70% of those with performance-based balance deficits reported no balance problems on the self-reported question. About 35.8% (95%CI:33.7%-38.1%) were incongruent among balance measures. Specifically, 25.8% (95%CI:23.9%-27.8%) under-estimated their balance issues, and 10.1% (95%CI:8.8%-11.5%) over-estimated their balance problems. Males had 4% reduction in odds of congruency among balance measures with every one-year increase in age compared to 3% reduction in the same for females (aOR=0.96; 95%CI:0.95-0.96; p-value<0.001 males; aOR=0.97; 95%CI:0.96-0.98; p-value<0.001 females).CONCLUSIONSAbout 7 in 10 adults with performance-based balance deficits were unaware of their condition. Sole reliance on self-reported information for balance screening may be inadequate. Results can help identify populations more likely to have discrepancies between balance measures.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Plasma p-tau231，p-tau181 and p-tau217 are associated with Postoperative Delirium: a prospective study.","authors":"Li Xue Wu,Jia Bao Su,Guang Ling Li,Meng Zhuang,Hai Jian Sun,Ji Ru Zhang","doi":"10.1093/gerona/glaf058","DOIUrl":"https://doi.org/10.1093/gerona/glaf058","url":null,"abstract":"BACKGROUNDThe pathophysiology of delirium remains incompletely understood. The relationship between preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau proteins and postoperative delirium needs further validation. We aimed to verify whether these markers can identify and predict the occurrence and severity of postoperative delirium.METHODS172 older adults undergoing laparoscopic surgery were selected from a tertiary comprehensive hospital. All patients received intravenous anesthesia. Preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau proteins were measured using enzyme-linked immunosorbent assay. The occurrence and severity of postoperative delirium were respectively assessed using the 3D-CAM and DRS-R-98 scales.RESULTSOf 172 patients (mean age: 72±6 years, 34.9% female), 20 (12%) experienced postoperative delirium. Patients who developed postoperative delirium had higher preoperative plasma concentrations of p-tau181, p-tau231, p-tau217, and T-tau than those without. After adjusting for age, ASA, and education, preoperative concentrations of p-tau181 (OR 1.05, 95% CI: 1.03-1.08), p-tau217 (OR 1.02, 95% CI: 1.01-1.04), p-tau231 (OR 1.09, 95% CI: 1.04-1.14), and T-tau (OR 1.01, 95% CI: 1.00-1.02) were independently associated with postoperative delirium(P＜0.001). Preoperative plasma p-tau231 showed the highest diagnostic performance with an AUC of 0.966, surpassing p-tau181 (0.869), p-tau217 (0.775), and T-tau (0.750). P-tau231 also demonstrated the highest sensitivity (0.900) and specificity (0.967) for predicting postoperative delirium, compared to p-tau181, p-tau217, and T-tau.CONCLUSIONPreoperative plasma concentrations of p-tau181, p-tau231, and p-tau217 can effectively predict the occurrence and severity of postoperative delirium in older adult undergoing laparoscopic surgery, with p-tau231 demonstrating higher predictive value.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular-derived Circulating Cell-Free DNA Fragments are Associated with Frailty and Increased Cardiovascular Events in Older Adults.","authors":"Lolita S Nidadavolu,David W Sosnowski,Nikita Sivakumar,Alessandra Merino Gomez,Yuqiong Wu,Thomas Laskow,Taylor Bopp,Nicholas Milcik,Anne Le,Cissy Zhang,Pratik Khare,Andrea Zammit,Francine Grodstein,Jeremy D Walston,David A Bennett,Rasika A Mathias,Jude M Phillip,Brion S Maher,Esther S Oh,Peter M Abadir","doi":"10.1093/gerona/glaf081","DOIUrl":"https://doi.org/10.1093/gerona/glaf081","url":null,"abstract":"Increased cellular damage in aging tissues releases circulating cell-free genomic DNA (ccf-gDNA) into the bloodstream, and these fragments are associated with a higher risk of frailty and dementia. We hypothesized that identifying the tissue of origin for ccf-gDNA using methylation signatures can distinguish subgroups of participants with distinct clinical outcomes, biological aging rates, and energy use. Serum ccf-gDNA from 181 participants in the Religious Orders Study or Rush Memory and Aging Project (ROS-MAP) was assessed for DNA methylation at one timepoint using the Illumina Methylation EPIC array. Clinical outcomes six years after ccf-gDNA measurement were determined for the following: frailty, cognitive test scores, and cardiovascular disease. Hierarchical clustering identified major clusters based on the predominance of ccf-gDNA source: Cardiovascular, Erythrocyte Progenitor, and Immune Cell. Participants with cardiovascular-enriched ccf-gDNA (CV ccf-gDNA) had higher rates of myocardial infarction (39%) at the last study visit compared to other subgroups (immune ccf-gDNA 21%, erythrocyte ccf-gDNA 23%), and similar findings were observed for congestive heart disease and stroke. There were no significant associations between cognitive test scores and ccf-gDNA subgroups. Individuals with CV ccf-gDNA demonstrated 3.1 times higher odds of being frail compared to the other groups and showed increased epigenetic age acceleration for the fragments compared to the other subgroups, indicating that this group was enriched with ccf-gDNA originating from older cells. The CV ccf-gDNA subgroup exhibited dysregulation of glycine and serine metabolism and pathways integral to cardiovascular health, endothelial function, and inflammation. We demonstrate that ccf-gDNA methylation patterns can detect high-turnover tissues and identify older adults at higher risk of frailty and cardiovascular disease.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe cognitive decline in long-term care is related to gut microbiome production of metabolites involved in neurotransmission, immunomodulation, and autophagy","authors":"Andrew P Shoubridge, Lucy Carpenter, Erin Flynn, Lito E Papanicolas, Josephine Collins, David Gordon, David J Lynn, Craig Whitehead, Lex E X Leong, Monica Cations, David P De Souza, Vinod K Narayana, Jocelyn M Choo, Steve L Wesselingh, Maria Crotty, Maria C Inacio, Kerry Ivey, Steven L Taylor, Geraint B Rogers","doi":"10.1093/gerona/glaf053","DOIUrl":"https://doi.org/10.1093/gerona/glaf053","url":null,"abstract":"Ageing-associated cognitive decline affects more than half of those in long-term residential aged care. Emerging evidence suggests that gut microbiome-host interactions influence the effects of modifiable risk factors. We investigated the relationship between gut microbiome characteristics and severity of cognitive impairment CI in 159 residents of long-term aged care. Severe CI was associated with a significantly increased abundance of proinflammatory bacterial species, including Methanobrevibacter smithii and Alistipes finegoldii, and decreased relative abundance of beneficial bacterial clades. Severe CI was associated with increased microbial capacity for methanogenesis, and reduced capacity for synthesis of short-chain fatty acids, neurotransmitters glutamate and gamma-aminobutyric acid, and amino acids required for neuro-protective lysosomal activity. These relationships were independent of age, sex, antibiotic exposure, and diet. Our findings implicate multiple gut microbiome-brain pathways in ageing-associated cognitive decline, including inflammation, neurotransmission, and autophagy, and highlight the potential to predict and prevent cognitive decline through microbiome-targeted strategies.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer Acknowledgement - 2024","authors":"","doi":"10.1093/gerona/glaf012","DOIUrl":"https://doi.org/10.1093/gerona/glaf012","url":null,"abstract":"Scientific progress depends on the generosity of reviewers who assist editors by sharing their time and expertise in the peer review process. Lewis Lipsitz, Editor-in-Chief of The Medical Sciences Section of the Journal of Gerontology Series A, on behalf of the editorial leadership team, wishes to thank the following individuals for their assistance in reviewing manuscripts during 2024.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}