The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献_第4页

Oral microbiome and Frailty: Insights from NHANES 2009-2012 and Mendelian Randomization Analysis. 口腔微生物组与脆弱性：来自NHANES 2009-2012和孟德尔随机化分析的见解。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-19 DOI: 10.1093/gerona/glag079

Ting Xu,Xichenhui Qiu,Qiqi Hang,Xiang Qi,Haokun Mei,Jiajie Guo,Yaguang Zheng,Minghui Ji,Qin Xu,Bei Wu

{"title":"Oral microbiome and Frailty: Insights from NHANES 2009-2012 and Mendelian Randomization Analysis.","authors":"Ting Xu,Xichenhui Qiu,Qiqi Hang,Xiang Qi,Haokun Mei,Jiajie Guo,Yaguang Zheng,Minghui Ji,Qin Xu,Bei Wu","doi":"10.1093/gerona/glag079","DOIUrl":"https://doi.org/10.1093/gerona/glag079","url":null,"abstract":"BACKGROUNDFrailty is associated with increased risks of disability, hospitalization, and mortality. Emerging evidence suggests that the oral microbiome may influence frailty development, but population-based evidence is limited and causal relationships remain unclear. This study explored the link between oral bacteria and frailty, using genetic analysis to investigate causality.METHODSWe analyzed data from 2,696 adults aged ≥50 years in NHANES 2009-2012. Oral microbiome diversity was assessed using 16S rRNA gene sequencing. Frailty was measured using a 36-item Frailty Index. Survey-weighted linear regression and restricted cubic spline models examined associations between four α-diversity indices and frailty. β-diversity was quantified using Bray-Curtis dissimilarities and compared by frailty status using PERMANOVA. Bidirectional two-sample Mendelian randomization (MR) using GWAS data assessed causal relationships between taxa and frailty.RESULTSLower α-diversity across all four indices were associated with higher frailty scores (P < 0.050). β-diversity differed by frailty (P = 0.001). MR analyses indicated that in saliva, Campylobacter_A, Saccharimonadaceae, and TM7x were protective, whereas Gemella was associated with increased frailty risk. In tongue samples, Saccharimonadaceae was a risk factor, while Fusobacterium, TM7x, and Solobacterium showed protective effects.CONCLUSIONSOral microbiome diversity is inversely associated with frailty in U.S. adults, and MR analyses identify specific oral taxa potentially involved in frailty development. These findings provide population-level evidence and genetic support for the oral microbiome as a potential modifiable target to promote healthy aging.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep survival modelling to predict future cognitive impairment in unimpaired adults. 深度生存模型用于预测未受损成人未来的认知障碍。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-17 DOI: 10.1093/gerona/glag076

Phoebe Imms,Haoqing Wang,Samayan Bhattacharya,Nikhil N Chaudhari,Owen M Vega,Jorge A Solis Galvan,Siyu Chen,Ruixi Li,Andrei Irimia

{"title":"Deep survival modelling to predict future cognitive impairment in unimpaired adults.","authors":"Phoebe Imms,Haoqing Wang,Samayan Bhattacharya,Nikhil N Chaudhari,Owen M Vega,Jorge A Solis Galvan,Siyu Chen,Ruixi Li,Andrei Irimia","doi":"10.1093/gerona/glag076","DOIUrl":"https://doi.org/10.1093/gerona/glag076","url":null,"abstract":"BACKGROUNDPredicting Alzheimer's disease (AD)-related cognitive impairment (CI) among cognitively normal (CN) adults enables meaningful disease modification through early intervention and enrichment of clinical trials.METHODSA deep survival model is trained to predict CI conversion risk in 1,415 CN adults from the National Alzheimer's Coordinating Center. Converters' (N = 212) and non-converters' (N = 1,203) baseline clinical measures and magnetic resonance images are used to estimate their conversion probability up to 22 years after baseline observation.RESULTSAfter 20-fold cross-validation, the model predicts conversion probability with a c-index of 0.88, and classification accuracy of 75% and AUC ROC of 0.89, outperforming previous machine learning models.CONCLUSIONSThis is one of few studies on the important challenge of predicting future CI among unimpaired subjects. Deep survival modelling can improve the identification of preclinical AD and suggests that uncertainty in AD risk estimation is due to potentially modifiable lifestyle factors.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECSIT facilitates exercise-induced amelioration of skeletal muscle atrophy by maintaining mitochondrial quality control in Middle-aged mice. ECSIT通过维持中年小鼠线粒体质量控制，促进运动诱导的骨骼肌萎缩的改善。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-15 DOI: 10.1093/gerona/glag065

Jingcheng Fan,Xin Wen,Xuemei Duan,Xue Zhang,Tan Zhang

{"title":"ECSIT facilitates exercise-induced amelioration of skeletal muscle atrophy by maintaining mitochondrial quality control in Middle-aged mice.","authors":"Jingcheng Fan,Xin Wen,Xuemei Duan,Xue Zhang,Tan Zhang","doi":"10.1093/gerona/glag065","DOIUrl":"https://doi.org/10.1093/gerona/glag065","url":null,"abstract":"Although exercise is well-established in alleviating aging-associated skeletal muscle atrophy, the underlying mechanism is not fully understood. Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) has been shown to be a crucial adaptor for inflammation and mitochondrial function, however, little is known about the action of ECSIT in skeletal muscle atrophy. Firstly, the young and middle-aged mice were performed with exercise training, skeletal muscle atrophy, mitochondrial quality control, and mitochondrial complex in skeletal muscle were detected. Then, we analyzed the Gene Expression Omnibus (GEO) database and performed in vivo experiments to determine the effect of exercise on ECSIT expression. Furthermore, ECSIT was knockdown in myoblasts to examine its effects on muscle atrophy, mitochondrial quality control and mitochondrial complex. Compared with young mice, middle-aged mice exhibited significant reductions in relative weights of skeletal muscles, grip strength, hang time, and exhaustion exercise performance, while exercise restored these deficits dramatically. Consistently, exercise promoted protein synthesis and inhibited protein degradation in the gastrocnemius of middle-aged mice. Therefore, exercise significantly mitigated skeletal muscle atrophy in middle-aged mice. Concomitantly, exercise alleviated the impaired mitophagy in the gastrocnemius of middle-aged mice. ECSIT expression was elevated in the gastrocnemius of middle-aged mice but was reversed by exercise intervention. Mechanistically, ECSIT knockdown impaired myoblast differentiation, mitochondrial complex and mitochondrial quality control in myoblasts. Collectively, this study reveals, for the first time, that ECSIT is important for myogenesis by maintaining mitochondrial quality control, thereby facilitating exercise-induced amelioration of skeletal muscle atrophy during aging.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary One‑Carbon Nutrients and Genetic Risk in Parkinson's Disease: A Prospective Cohort Study. 饮食中一碳营养素与帕金森病遗传风险：一项前瞻性队列研究

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-14 DOI: 10.1093/gerona/glag048

Junliang Tao,Yongsheng Wang,Xuedan Xia,Yafang Li,Xinxin Deng,Faqiang Zhang,Jiayi Huang,Cui Liang,Qiangsheng He,Ye Zhu,Kehu Yang,Jinqiu Yuan,Di Wang,Xiuxia Li

{"title":"Dietary One‑Carbon Nutrients and Genetic Risk in Parkinson's Disease: A Prospective Cohort Study.","authors":"Junliang Tao,Yongsheng Wang,Xuedan Xia,Yafang Li,Xinxin Deng,Faqiang Zhang,Jiayi Huang,Cui Liang,Qiangsheng He,Ye Zhu,Kehu Yang,Jinqiu Yuan,Di Wang,Xiuxia Li","doi":"10.1093/gerona/glag048","DOIUrl":"https://doi.org/10.1093/gerona/glag048","url":null,"abstract":"BACKGROUNDSeveral studies have investigated the effects of dietary one-carbon metabolism (OCM) nutrients, such as methionine, folate, vitamin B6, and vitamin B12, on Parkinson's disease (PD). However, current evidence remains insufficient to definitively establish a link between OCM intake, PD incidence, and genetic risk.METHODSAmong 202171 individuals aged 37-73 in the UK Biobank, we assessed dietary OCM nutrient intake via repeated 24‑hour recalls, determined PD incidence via validated ICD‑10 codes, and quantified genetic risk with polygenic risk scores. Employing Cox proportional hazards models supplemented by sensitivity analyses, we evaluated the associations and potential interactions among OCM nutrient intake, genetic risk, and PD incidence.RESULTSOver a median 12.27-year follow-up of 202171 participants, 1037 incident PD cases occurred. In multivariable-adjusted Cox models, compared with participants in the lowest quartile, those in the highest quartile of methionine, vitamin B6, folate, and vitamin B12 had a lower risk of PD [HR (95% CI)=0.83 (0.69-1.00), 0.75 (0.62-0.90), 0.71 (0.59-0.85), and 0.79 (0.65-0.94)]. Genetically-stratified analyses showed folate inversely associated with PD risk in the low-risk group [HR  (95% CI)= 0.65 (0.48-0.88)] (P for interaction = 0.48); vitamin B12 linked to lower risk in the high-risk group [HR (95% CI)= 0.78 (0.63-0.99)] (P for interaction = 0.83); and vitamin B6 inversely associated across both strata [high-risk HR (95% CI)= 0.77 (0.62-0.97); low-risk HR (95% CI) = 0.59 (0.44-0.80)](P for interaction = 0.08).CONCLUSIONSHigher OCM nutrient intake might be inversely associated with PD risk. However, evidence regarding the independent contributions of dietary and genetic factors remains inconclusive.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a two-step shared parameter model for dementia imputation in the Cardiovascular Health Study Cohort. 在心血管健康研究队列中痴呆归因的两步共享参数模型的开发和验证。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-14 DOI: 10.1093/gerona/glag072

Katie M Lynch,Erin E Bennett,Chelsea Liu,Emma K Stapp,Deborah A Levine,M Maria Glymour,Scott C Zimmerman,Michael E Griswold,Michelle C Odden,Oscar L Lopez,Melinda C Power

{"title":"Development and validation of a two-step shared parameter model for dementia imputation in the Cardiovascular Health Study Cohort.","authors":"Katie M Lynch,Erin E Bennett,Chelsea Liu,Emma K Stapp,Deborah A Levine,M Maria Glymour,Scott C Zimmerman,Michael E Griswold,Michelle C Odden,Oscar L Lopez,Melinda C Power","doi":"10.1093/gerona/glag072","DOIUrl":"https://doi.org/10.1093/gerona/glag072","url":null,"abstract":"BACKGROUNDLarge-scale dementia ascertainment for research remains challenging. We demonstrate a method to impute dementia status and onset time using data from the Cardiovascular Health Study (CHS).METHODSWe used a linear mixed effects model to estimate individual cognitive trajectories and included the estimates as covariates in an accelerated failure time model used to impute time to incident dementia in the CHS Cognition Study, a sub-study with dementia ascertainment. We calibrated the model in a 60% random sample (n = 2,000) of eligible participants with CHS Cognition Study dementia classifications and validated the final model in the remaining 40% sample (n = 1,334). We then imputed dementia onset time and dementia status during follow-up in the full CHS sample, including those without (n = 1,415) CHS Cognition Study dementia classifications.RESULTSIn the validation sample, relative to the CHS Cognition Study dementia classifications used as the \"reference standard\", specificity (98.5%), positive predictive value (81.9%), negative predictive value (92.0%) and accuracy (91.3%) were high, while sensitivity was modest (43.8%), with mean imputed onset time +/-1.5 years of classified. Performance varied by participant characteristics. Ultimately, 227 (16.0%) of participants without CHS Cognition Study classifications, and 472 (9.9%) of all CHS participants were classified as having dementia according to this approach.CONCLUSIONThe shared parameter approach can be implemented in samples with existing cognitive data and a validation sample with reference-standard dementia adjudication. We found high overall accuracy and higher specificity than sensitivity, similar to reported performance metrics for algorithmic approaches requiring linkage to administrative data.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Age Acceleration and Mortality Among Persons with Poorly Controlled HIV. 艾滋病毒控制不良者的表观遗传年龄加速和死亡率。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-13 DOI: 10.1093/gerona/glag071

David W Sosnowski,Chang Shu,Hsing-Yu Hsu,Yutong Jiang,Annie Kathuria,Damani A Piggott,Shruti H Mehta,Gregory D Kirk,Brion S Maher,Jing Sun

{"title":"Epigenetic Age Acceleration and Mortality Among Persons with Poorly Controlled HIV.","authors":"David W Sosnowski,Chang Shu,Hsing-Yu Hsu,Yutong Jiang,Annie Kathuria,Damani A Piggott,Shruti H Mehta,Gregory D Kirk,Brion S Maher,Jing Sun","doi":"10.1093/gerona/glag071","DOIUrl":"https://doi.org/10.1093/gerona/glag071","url":null,"abstract":"We sought to assess the relationship between HIV infection and disease severity with epigenetic age and to examine the combined association of epigenetic age acceleration and HIV infection with mortality. Participants were drawn from the ALIVE study, a community-based cohort of persons who inject drugs (PWID) in Baltimore, USA. DNA from buffy coat samples was bisulfite-treated and assayed using the Illumina MethylationEPIC BeadChip. Repeated assessment of epigenetic age was indexed using PhenoAge, Horvath age, Hannum age, GrimAge, and DunedinPACE of aging. Annual linkage to the National Death Index-Plus provided mortality data. Linear mixed-effects regressions compared epigenetic age acceleration trajectories. Cox models estimated hazard ratios for all-cause mortality by epigenetic age and HIV status, adjusting for demographics, risk behaviors, cell compositions, and ancestry principal components. Among 396 participants (127 with HIV [PWH]) and 3,862 person-years of follow-up, the median baseline age was 48.5 years; 89% were Black and 69% male. PWH showed greater epigenetic age acceleration than people without HIV (PWoH), especially those with detectable viremia, low CD4 counts, and low CD4: CD8 ratios. Both HIV and epigenetic age acceleration were independently associated with all-cause mortality. Compared to PWoH without PhenoAge acceleration, PhenoAge acceleration with or without HIV was associated with 3.28 (95% CI: 2.06, 5.02) and 2.12 (95% CI: 1.32, 3.41) times higher mortality hazard, respectively. HIV infection, uncontrolled viremia, and poor immune recovery are linked to epigenetic age acceleration, contributing to mortality risk among PWID, underscoring the need to address molecular aging to mitigate mortality in this population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of biological aging markers for mortality risk stratification in community-dwelling older adults: Insights from the Mr. OS & Ms. OS (Hong Kong) cohort. 生物衰老标志物在社区老年人死亡风险分层中的应用：来自Mr. OS和Ms. OS（香港）队列的见解。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-13 DOI: 10.1093/gerona/glag073

Yafei Wu,Ting Zhang,Shuyi Li,Jason Leung,Timothy Kwok

{"title":"Utility of biological aging markers for mortality risk stratification in community-dwelling older adults: Insights from the Mr. OS & Ms. OS (Hong Kong) cohort.","authors":"Yafei Wu,Ting Zhang,Shuyi Li,Jason Leung,Timothy Kwok","doi":"10.1093/gerona/glag073","DOIUrl":"https://doi.org/10.1093/gerona/glag073","url":null,"abstract":"BACKGROUNDStudies regarding the integration of various biological aging (BA) markers and their predictive values for long-term mortality risk remain limited, particularly in Asian older adults. We evaluated the associations of multiple BA markers with overall and cause-specific mortality over a 20-year period.METHODSData on 4000 older adults (mean age: 72.5 years) were obtained from the Mr. OS and Ms. OS cohort. BA was assessed by the frailty phenotype, clinical deficit-based frailty index (FI), biochemical-enhanced FI (eGFR, homocysteine, hsCRP, 25(OH)-D), and leukocyte telomere length. Mortality was ascertained by the Hong Kong Death Registry. Hazard ratios (HRs) were assessed using Cox and Fine-Gray models and predictive accuracy with Harrell's c-index.RESULTSOver a median follow-up of 18.25 years, 2446 deaths occurred (CVD: 511, cancer: 644). For overall mortality, the HRs (95%CI) of pre-frail and frail groups were 1.24 (1.13-1.35) and 1.66 (1.39-1.98) compared to the fit. Each standard deviation (SD) increase in the clinical or biochemical-enhanced FI was associated with 22% or 23% increased risk of overall mortality (P < 0.001). Longer telomere length reduced overall mortality risk (HR per SD: 0.93, 95%CI: 0.88-0.99). All BA markers except telomere length were significantly associated with CVD mortality. While all BA markers were not significantly associated with cancer mortality. Frailty-related markers showed added predictive values for both overall and cause-specific mortality, while telomere length was specifically predictive for CVD mortality (C-index improvements: 0.32%-7.90%).CONCLUSIONSBiological aging is associated with overall and CVD-cause mortality in older Chinese and may support risk stratification and personalized interventions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Observational Data to Investigate Cognitive Outcomes of Obstructive Sleep Apnea Treatment: A Scoping Review 使用观察性数据调查阻塞性睡眠呼吸暂停治疗的认知结果：一项范围综述

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-12 DOI: 10.1093/gerona/glag078

Christopher N Kaufmann, Kevin H Yang, Chien-Yu (Irene) Tseng, Ginger Chang, Halima Amjad, Jennifer S Albrecht, Adam P Spira, Alden L Gross, Emerson M Wickwire, Atul Malhotra

{"title":"Using Observational Data to Investigate Cognitive Outcomes of Obstructive Sleep Apnea Treatment: A Scoping Review","authors":"Christopher N Kaufmann, Kevin H Yang, Chien-Yu (Irene) Tseng, Ginger Chang, Halima Amjad, Jennifer S Albrecht, Adam P Spira, Alden L Gross, Emerson M Wickwire, Atul Malhotra","doi":"10.1093/gerona/glag078","DOIUrl":"https://doi.org/10.1093/gerona/glag078","url":null,"abstract":"Background Prior research indicates a connection between obstructive sleep apnea (OSA) and cognitive deficits, prompting interest in whether OSA treatment can prevent or slow cognitive decline. Past clinical trials on OSA treatment and cognitive impairment have shown inconsistent results. However, observational data might help by examining more diverse populations and larger sample sizes, increasing the ability to detect subtle effects. Therefore, we reviewed literature to characterize studies evaluating cognitive outcomes from OSA treatment using observational study data. Methods We conducted a scoping review of studies retrieved on PubMed and Embase. Studies were screened by title/abstract, and then full text, for inclusion. We extracted data characterizing data source, study design, population, sample size, follow-up time, treatments assessed, cognitive outcome variables, and key associations. Results Of 3,655 unique articles obtained from PubMed and Embase, 13 met eligibility criteria. All were retrospective cohort studies. Ten studies evaluated positive airway pressure (PAP) therapies, one examined uvulopalatopharyngoplasty, and two evaluated any type of OSA treatment. No studies evaluated mandibular advancement devices. Cognitive outcomes assessed included dementia diagnosis (8 studies), and changes in cognitive performance (5 studies). Results from studies for most part found OSA treatment was associated with better cognitive outcomes, although effects varied in magnitude and statistical significance based on the data source, outcomes, and sample size. Conclusions Observational data has the potential to help evaluate cognitive outcomes from OSA treatment, but more studies are needed, especially for OSA therapies beyond PAP alone.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging’s Intervention Testing Program Data 通过解决聚类和筑巢效应来提高动物衰老研究的统计严谨性：以国家衰老干预测试计划数据为例

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-11 DOI: 10.1093/gerona/glag074

Erik S Parker, Lilian Golzarri-Arroyo, Stephanie Dickinson, Beate Henschel, Luis-Enrique Becerra-Garcia, Thirupathi R Mokalla, Olivia C Robertson, Deependra K Thapa, Colby J Vorland, David B Allison

{"title":"Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging’s Intervention Testing Program Data","authors":"Erik S Parker, Lilian Golzarri-Arroyo, Stephanie Dickinson, Beate Henschel, Luis-Enrique Becerra-Garcia, Thirupathi R Mokalla, Olivia C Robertson, Deependra K Thapa, Colby J Vorland, David B Allison","doi":"10.1093/gerona/glag074","DOIUrl":"https://doi.org/10.1093/gerona/glag074","url":null,"abstract":"Clustering effects, such as those introduced by housing animals in shared cages, are often overlooked in preclinical lifespan studies, despite their potential to underestimate variance estimates and inflate Type I error rates, leading to misleading conclusions. This methodological oversight reduces statistical rigor and may undermine the reliability of findings. To address this gap, the current study examines the impact of accounting for a clustering and nesting effect on lifespan analyses by comparing the results of statistical models which both account for and ignore this effect. Using 2019 data from the Interventions Testing Program (ITP), a large-scale initiative evaluating the effects of compounds on lifespan in UM-HET3 mice as a case study, we illustrate how different modeling approaches influence statistical estimates and conclusions. The clustering and nesting effect was addressed using linear mixed-effects and Cox frailty models, both of which explicitly account for cage-level dependencies and the nesting of cages within treatment. Comparisons were made between unadjusted lifespan analyses and those incorporating the clustering and nesting adjustment. The results of this case study indicate that properly adjusting for a clustering and nesting effect can change the conclusions drawn from statistical significance tests as compared to unadjusted model approaches, and so it remains best practice to properly account for clustering and nesting to reduce the potential for inflated Type I error rates. These findings highlight the importance of accounting for clustering and nesting in preclinical research to ensure valid and robust statistical inference.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of the FOXO3 Gene in Cardiometabolic Disease in the CHAMP Cohort FOXO3基因在CHAMP队列心脏代谢疾病中的保护作用

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-11 DOI: 10.1093/gerona/glag063

Lovina Abdi, Glen Lockwood, Jarrod J Kennedy, David Le Couteur, David J Handelsman, Vasi Naganathan, Fiona Blyth, Louise M Waite, Victoria Cogger, Bradley Willcox, Richard Allsopp

{"title":"Protective Effect of the FOXO3 Gene in Cardiometabolic Disease in the CHAMP Cohort","authors":"Lovina Abdi, Glen Lockwood, Jarrod J Kennedy, David Le Couteur, David J Handelsman, Vasi Naganathan, Fiona Blyth, Louise M Waite, Victoria Cogger, Bradley Willcox, Richard Allsopp","doi":"10.1093/gerona/glag063","DOIUrl":"https://doi.org/10.1093/gerona/glag063","url":null,"abstract":"Recent findings from the Honolulu Heart Program cohort in Hawaii suggest a longevity-associated variant of FOXO3 may provide resilience against cardiometabolic diseases (CMD), such as hypertension, diabetes, and angina. The present study utilizes data from the Concord Health and Ageing in Men Project (CHAMP) cohort in Australia to further investigate the impact of the longevity associated FOXO3 variant on CMD and longevity. Specifically, the protective ‘G’ allele of rs2802292 was examined for potential protective effects against mortality in individuals with hypertension, diabetes or angina (p-value: 0.01). While no significant impact on mortality was observed in individuals with hypertension or diabetes, a reduced risk of mortality was observed for G allele carriers with angina. These findings are consistent with prior research linking longevity-associated FOXO3 variants to increased lifespan in individuals with heart disease and provide further evidence of its importance as a genetic factor influencing CMD risk. The protective effects against heart disease may arise from FOXO3’s ability to enhance cellular resilience against oxidative stress and regulating metabolic pathways crucial for cardiovascular function. Additional studies are needed to fully understand the mechanisms behind FOXO3’s influence on CMD, in particular heart disease, and to explore its potential for therapeutic development. This research highlights the relevance of genetic factors, specifically FOXO3, in CMD prevention and longevity in the elderly.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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