The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献_第4页

Rethinking the relationship between ambulatory activity and falls in long-term care: Risk versus reward. 重新思考长期护理中走动活动与跌倒之间的关系：风险与回报。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-09-08 DOI: 10.1093/gerona/glaf197

Ríona Mc Ardle,Lynne Taylor,Silvia Del Din,Lynn Rochester,Ngaire Kerse,Jochen Klenk

{"title":"Rethinking the relationship between ambulatory activity and falls in long-term care: Risk versus reward.","authors":"Ríona Mc Ardle,Lynne Taylor,Silvia Del Din,Lynn Rochester,Ngaire Kerse,Jochen Klenk","doi":"10.1093/gerona/glaf197","DOIUrl":"https://doi.org/10.1093/gerona/glaf197","url":null,"abstract":"BACKGROUNDAmbulatory older residents in long-term care(LTC) have the highest risk of falling. However, the relationship between ambulatory activity (steps per day) and fall risk in LTC is unclear. This study examined whether baseline daily step count, functional capacity and cognitive function predicted falls in LTC residents, and whether functional capacity modified the relationship between step count and fall risk.METHODS276 LTC residents from New Zealand-based Staying UpRight randomised controlled trial were included (age: 84 ± 7 years;61% female). Baseline daily step count was derived from a lumbar-based accelerometer (3,589 ± 2,379steps). Falls rates were calculated from facilities' falls reports (6 ± 18falls). Residents were categorised as Moderate (n = 71) or Low functional capacity (n = 205) based on Short Physical Performance Battery scores. The Montreal Cognitive Assessment assessed cognition (15 ± 6). Quasipoisson generalised linear models explored associations between steps, cognition and functional capacity with falls rates, including interactions between capacity and steps. Relative risk of falling and fall-related injuries were estimated between activity levels.RESULTSKey results showed a significant interaction (p = 0.036) indicating that only the Moderate functional capacity group had a positive association between steps and falls rates. The Moderate group had a ∼23-24% and ∼6% higher relative risk of falls and fall-related injuries respectively with higher activity, while the Low group showed a lower risk of falls (∼2.7-3.9%) and falls-related injuries (2-4%). Cognitive function was not associated with falls.CONCLUSIONSFindings suggest that higher exposure to ambulatory activity is related to greater falls risk but not falls-related injuries only among residents with moderate functional capacity. This stratification should be considered when shaping falls prevention policies.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel information theoretic approach reveals loss of effective biomolecular communication in aging muscle cells. 一种新的信息理论方法揭示了衰老肌肉细胞中有效的生物分子通讯的丧失。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-09-08 DOI: 10.1093/gerona/glaf195

Sruthi Sivakumar,Ryan William LeFebre,Giulia Menichetti,Hirotaka Iijima,Andrew Mugler,Fabrisia Ambrosio

{"title":"A novel information theoretic approach reveals loss of effective biomolecular communication in aging muscle cells.","authors":"Sruthi Sivakumar,Ryan William LeFebre,Giulia Menichetti,Hirotaka Iijima,Andrew Mugler,Fabrisia Ambrosio","doi":"10.1093/gerona/glaf195","DOIUrl":"https://doi.org/10.1093/gerona/glaf195","url":null,"abstract":"Maintenance of organismal function requires tightly regulated biomolecular communication. However, with aging, communication deteriorates, thereby disrupting effective information flow. Using information theory applied to skeletal muscle single cell RNA-seq data from young, middle-aged, and aged animals, we quantified the loss of communication efficiency over time. We considered communication channels between transcription factors (TF; 'input message') and corresponding target genes (TG; 'output message'). Mutual information (MI), defined as the information effectively transmitted between TFs and TGs, declined with age. This decline was attributed to escalating biological noise and loss of precision with which TFs regulate TGs (ie, channel capacity). When we ranked TF:TG pairs by MI, pairs associated with fatty acid oxidation displayed the greatest loss of communication with aging, while the system preserved communication between pairs related to RNA synthesis. These data suggest ineffective communication with aging against a backdrop of resource reallocation to support essential cellular functions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living in Historically Redlined Neighborhoods and Biological Aging among Older Adults 生活在历史上的红线社区和老年人的生物老化

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-09-02 DOI: 10.1093/gerona/glaf190

Calley E Fisk, Katrina M Walsemann, Chelsey Jones, Eileen Crimmins, Jennifer A Ailshire

{"title":"Living in Historically Redlined Neighborhoods and Biological Aging among Older Adults","authors":"Calley E Fisk, Katrina M Walsemann, Chelsey Jones, Eileen Crimmins, Jennifer A Ailshire","doi":"10.1093/gerona/glaf190","DOIUrl":"https://doi.org/10.1093/gerona/glaf190","url":null,"abstract":"Living in historically redlined neighborhoods has deleterious effects on aging-related health outcomes, yet little is known about how historical redlining affects the physiological aging process and the role of current neighborhood socioeconomic status (SES) on this relationship. This study determined if living in historically redlined neighborhoods was associated with biological age and if this association was mediated by neighborhood-level socioeconomic status. We linked the Health and Retirement Study 2016 Venous Blood Study (HRS-VBS) to redlining scores from the Historic Redlining Indicator data and census tract level data from the 2014-2018 American Community Survey 5-year estimates (N = 6,466 respondents). Multivariable linear regression models were used to assess differences in biological age among older residents of historically redlined neighborhoods graded “Best/Desirable”, “Declining”, and “Hazardous”. Mediation analyses using the khb method were used to assess whether measures of neighborhood affluence and disadvantage explained differences in biological age by historical redlining grade. Older residents of “Declining” or “Hazardous” neighborhoods were about 2.5 and 1.7 years older biologically than residents of “Best/Desirable” neighborhoods. Neighborhood SES mediated this relationship, with affluence explaining approximately 20% and disadvantage explaining about 8% (“Declining”) and 25% (“Hazardous”) of the association between historical redlining and biological age. Our study highlights the importance of evaluating measures of physiological functioning and current neighborhood conditions to clarify existing health disparities among residents of historically redlined neighborhoods.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between perceived fatigability, intrinsic capacity and physical activity: network analysis in a British birth cohort study 感知疲劳、内在能力和身体活动之间的相互作用：英国出生队列研究的网络分析

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-09-02 DOI: 10.1093/gerona/glaf192

Kaisa Koivunen, Lotta Palmberg, Gabriela Lunansky, Almar Kok, Nancy W Glynn, Rachel Cooper

{"title":"The interplay between perceived fatigability, intrinsic capacity and physical activity: network analysis in a British birth cohort study","authors":"Kaisa Koivunen, Lotta Palmberg, Gabriela Lunansky, Almar Kok, Nancy W Glynn, Rachel Cooper","doi":"10.1093/gerona/glaf192","DOIUrl":"https://doi.org/10.1093/gerona/glaf192","url":null,"abstract":"Background Fatigability—an individual’s susceptibility to fatigue when performing standardized activities—may arise from diminished functional reserves and contribute to reduced physical activity levels, potentially reinforcing the disablement process. In this study, we used network analysis to examine the associations among physical and mental fatigability, different domains of intrinsic capacity (IC), and physical activity (PA). Additionally, we investigated whether fatigability mediates the association between IC and PA. Methods We ran analyses of cross-sectional data on participants from the MRC National Survey of Health and Development at age 68-69 years (n = 1537). Physical and mental fatigability were assessed using the Pittsburgh Fatigability Scale and PA was self-reported. We quantified five IC domains: vitality, locomotion, cognition, psychology, and sensory, using performance-based and self-reported measurements. Networks were estimated based on Mixed Graphical Models stratified by sex. Results In both sexes, greater physical and mental fatigability were consistently associated with lower scores in two IC domains (psychology and locomotion) and PA. The network structure showed that physical fatigability mediated the relation between locomotion and psychology domains and PA. The same applied to mental fatigability, but to a lesser extent and only in women. Conclusions Perceived physical fatigability is a potentially important factor on the pathway between lower physical and mental resources and activity behavior in older adults. Future work is needed to study the temporality of these associations.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Provocative testing in community dwelling older adults: a path to identify physical resilience 在社区居住的老年人中进行挑衅性测试：确定身体恢复能力的途径

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-09-01 DOI: 10.1093/gerona/glaf186

Kenneth Ladd Seldeen, Saurav Saha, Zhuo Tang, Angela Van Sciver, Cedric Lee Treadway, Owen Paul Treanor, Nikhil Satchidanand, Bruce Robert Troen

{"title":"Provocative testing in community dwelling older adults: a path to identify physical resilience","authors":"Kenneth Ladd Seldeen, Saurav Saha, Zhuo Tang, Angela Van Sciver, Cedric Lee Treadway, Owen Paul Treanor, Nikhil Satchidanand, Bruce Robert Troen","doi":"10.1093/gerona/glaf186","DOIUrl":"https://doi.org/10.1093/gerona/glaf186","url":null,"abstract":"Background Resilience is the capacity of an organism to both resist and recover from stressors, and its decline can be an early indicator of susceptibility that precedes frailty, disability, and death. This study explores the use of provocative tests—time-based responses to non-harmful challenges—as potential indicators of resilience. Methods Provocative tests were performed in 50 community-dwelling adults (24 men, 26 women), aged 23–82 years and included cognitive challenges, strength and heart rate recovery after exercise, cold exposure, blood occlusion, and resistance to balance perturbations. Results Age was associated with declines in recovery from cold-water hand immersion (r2 = 0.18, p = 0.002) and upper-arm blood occlusion (r2 = 0.11, p = 0.023). Susceptibility to balance perturbations also increased with age (r2 = 0.10, p = 0.025). Notably, heart rate and strength recovery post-exercise did not correlate with age, although older participants walked shorter distances (r2 = 0.54, p &lt; 0.0001) and curled less weight (r2 = 0.17, p = 0.0003). Cognitive performance in the Stroop Color and Word test was unaffected by exercise but did show age-related declines (r2 = 0.53, p &lt; 0.0001). A composite resilience score derived from the measures inversely associated with age (r2 = 0.17, p = 0.0027). Additionally, responses to cold-water immersion and blood occlusion correlated in older adults (r2 = 0.31, p = 0.002, N = 18), suggesting interrelated physiological responses. Conclusions These findings support provocative testing to identify early signs of declining resilience and guide interventions targeting age-related vulnerability.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomic clocks to predict phenotypic age in mice 多组时钟预测小鼠表型年龄

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-28 DOI: 10.1093/gerona/glaf188

Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, Isaac Bishof, Anderson Butler, Karolina Chwalek, David S Vogel, Alice E Kane, David A Sinclair

{"title":"Multiomic clocks to predict phenotypic age in mice","authors":"Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, Isaac Bishof, Anderson Butler, Karolina Chwalek, David S Vogel, Alice E Kane, David A Sinclair","doi":"10.1093/gerona/glaf188","DOIUrl":"https://doi.org/10.1093/gerona/glaf188","url":null,"abstract":"Biological age refers to a person’s overall health in aging, as distinct from their chronological age. Diverse measures of biological age, referred to as “clocks”, have been developed in recent years and enable risk assessments, and an estimation of the efficacy of longevity interventions in animals and humans. While most clocks are trained to predict chronological age, clocks have been developed to predict more complex composite biological age outcomes, at least in humans. These composite outcomes can be made up of a combination of phenotypic data, chronological age, and disease or mortality risk. Here, we develop the first such composite biological age measure for mice: the mouse phenotypic age model (Mouse PhenoAge). This outcome is based on frailty measures, complete blood counts, and mortality risk in a longitudinally assessed cohort of male and female C57BL/6 mice. We then develop clocks to predict Mouse PhenoAge, based on multi-omic models using metabolomic and DNA methylation data. Our models accurately predict Mouse PhenoAge, and residuals of the models are associated with remaining lifespan, even for mice of the same chronological age. These methods offer novel ways to accurately predict mortality in laboratory mice thus reducing the need for lengthy and costly survival studies.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rimonabant treatment partly attenuates skeletal muscle loss following immobilization in young and in old, sarcopenic male mice 利莫那班治疗部分减轻了年轻和年老肌肉减少的雄性小鼠固定后的骨骼肌损失

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-28 DOI: 10.1093/gerona/glaf189

Sebastiaan Dalle, Kaat Vanderbeke, Moniek Schouten, Monique Ramaekers, Michel Abou-Samra, Domiziana Costamagna, Katrien Koppo

{"title":"Rimonabant treatment partly attenuates skeletal muscle loss following immobilization in young and in old, sarcopenic male mice","authors":"Sebastiaan Dalle, Kaat Vanderbeke, Moniek Schouten, Monique Ramaekers, Michel Abou-Samra, Domiziana Costamagna, Katrien Koppo","doi":"10.1093/gerona/glaf189","DOIUrl":"https://doi.org/10.1093/gerona/glaf189","url":null,"abstract":"Muscle tissue is important for locomotion and metabolic health. Muscle disuse (e.g. post-operative) occurs more often in older adults, and results in rapid muscle wasting. Currently, there is no effective treatment to combat immobilization-induced atrophy, which is why novel therapeutic strategies are needed. Antagonism of cannabinoid receptor 1 (CB1) can stimulate muscle protein synthesis, thereby protecting against glucocorticosteroid-induced atrophy. However, its therapeutic potential against (age-related) immobilization-induced atrophy remains unknown. Therefore, we investigated the effect of CB1 antagonism on muscle responses following immobilization in young and old, sarcopenic male mice. One hind limb of young and old male C57BL/6 mice was immobilized for five days, during which they were treated with the CB1 antagonist Rimonabant (10 mg/kg/d) or vehicle. Hereafter, mice were euthanized and muscles were collected. Endocannabinoid, anabolic and catabolic markers were analyzed in the gastrocnemius muscle via western blotting. Rimonabant attenuated immobilization-induced gastrocnemius muscle mass loss in both ages (-7.9% vs. vehicle: -11.2%; p = 0.0027). Immobilization increased expression of the anabolic regulators (p-S6rp, p-4E-BP1), and of the catabolic markers (LC3b-II/I, MAFbx), which remained unaffected by Rimonabant treatment. Surprisingly, Rimonabant amplified the immobilization-induced decrease in muscle protein synthesis (-45.8% vs. vehicle: -27%; p = 0.0180), to a larger extent in young vs. old mice (p = 0.0005). Immobilization decreased the expression of the enzyme NAPE-PLD, responsible for synthesis of the endocannabinoid anandamide, whereas its degrading enzyme FAAH was higher expressed. More research is needed to unravel the mechanisms underlying the muscle sparing effect of Rimonabant, and anandamide’s role in muscle degeneration.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals 建立一个跨学科的劳动力在地球科学：调整观点和教育目标

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-24 DOI: 10.1093/gerona/glaf090

Iman M Al-Naggar, Crystal G Quinn, Sara C LaHue, Sarah R Ocañas, Matthew Yousefzadeh, Chester Kozikowski, Heather McAbee-Sevick, Kenneth G Campellone, Sean Curran, Jamie N Justice, Miranda E Orr, Christine Thatcher, Sara Espinoza, John C Newman, Robert J Pignolo, George A Kuchel

引用次数: 0

Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank 全基因组Cox回归分析确定了134个新的残疾发展风险位点：加拿大老龄化和英国生物银行的纵向研究

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-22 DOI: 10.1093/gerona/glaf185

Huiping Zheng, Tao Sun, Xiaojun Wang

{"title":"Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank","authors":"Huiping Zheng, Tao Sun, Xiaojun Wang","doi":"10.1093/gerona/glaf185","DOIUrl":"https://doi.org/10.1093/gerona/glaf185","url":null,"abstract":"Background Disability significantly affects the well-being of older adults and imposes substantial personal and social burdens. Although genetic effects play a role in disability, large-scale genome-wide association studies (GWAS) of disability development remain scarce. Methods We performed the first Cox proportional hazards GWAS on disability development on 8,421 individuals aged 65 and older from the Canadian Longitudinal Study on Aging (CLSA). Disability was defined as the inability to perform daily activities, as measured by the Activities of Daily Living (ADL) scale. A polygenic hazard score (PHS) was developed and incorporated into the predictive model, along with demographic and environmental factors. Results The study observed a 16.28% incidence of disability over a mean follow-up duration of 4.64 years (SD = 1.95). The COX-GWAS identified six genome-wide significant variants (p &lt; 5E-08) and 134 independent SNPs with suggestive significance level (p &lt; 1E−05). Replication in the UK Biobank confirmed that rs589819, rs56294014, and rs143714258 remained nominally significant and exhibited consistent effect directions. Post-GWAS analyses, including transcriptome-wide association studies TWAS, gene set, and tissue enrichment analyses, revealed genetic pathways related to inflammation regulation, neurogenesis, and metabolic processes. Incorporating PHS with demographic and environmental factors improves the prediction performance in both CLSA and UKB. Conclusion This study is among the first genome-wide Cox regression analyses to uncover novel genetic loci and biological pathways involved in disability development in older adults. These findings provide a foundation for predictive modeling and targeted prevention strategies.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than step counts — slow walking speed, little running and few long walks predict cardiovascular mortality: a Walk Watch UK Biobank Study 步行观察英国生物银行的一项研究表明，缓慢的步行速度、很少的跑步和很少的长时间步行可以预测心血管疾病的死亡率

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-08-21 DOI: 10.1093/gerona/glaf184

Beatriz Herrero Pinilla, Serena Hong, Matthew A Brodie, Stephen R Lord, Lloyd L Y Chan

{"title":"More than step counts — slow walking speed, little running and few long walks predict cardiovascular mortality: a Walk Watch UK Biobank Study","authors":"Beatriz Herrero Pinilla, Serena Hong, Matthew A Brodie, Stephen R Lord, Lloyd L Y Chan","doi":"10.1093/gerona/glaf184","DOIUrl":"https://doi.org/10.1093/gerona/glaf184","url":null,"abstract":"Background Low daily step counts have traditionally been associated with cardiovascular death risk, suggesting other objective real-world gait measures may be complementary or better predictors. This study examined the relationship between real-world walking speed, quality, and walking bout distributions, measured using a wrist-worn device, and cardiovascular death in a large cohort of older people. Methods Participants aged 60to78 years from the UK Biobank who wore a wrist-worn device were included in this population-based observational cohort study. Gait data were analysed using Watch Walk methods. Cardiovascular death, defined as death within ten years of follow-up due to heart disease, stroke, or vascular conditions, was tracked using National Health Service databases. Minimally adjusted and multivariable Cox proportional-hazard models assessed the relationship between digital gait biomarkers and cardiovascular death. Results Among 38,766 participants, 485(1.3%) had cardiovascular deaths during follow-up. In minimally adjusted models, maximal walking speed, running duration, step count, longest walk duration, and the proportion of short walks were associated with cardiovascular death. In multivariable models adjusted for age, sex and smoking status, slower maximal walking speed, reduced daily running duration, and a higher proportion of short walks remained independent predictors. This model had a C-statistic of 0.75, comparable to traditional risk scores including SCORE2 and the Framingham Risk Score (both 0.74). Conclusions Walking speed, running duration, and the proportion of longer walks are key real-world walking characteristics to consider when assessing cardiovascular death risk. Predictive models with these measures demonstrate good accuracy, suggesting a non-invasive option for early risk assessment.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0