The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia through Mendelian Randomization and Single-cell RNA Sequencing.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-23 DOI: 10.1093/gerona/glaf073

Yichuan Wang,Liang Zhou,Jiahao Liu,Qing Zhou,Wei Xiong,Long Wang

{"title":"Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia through Mendelian Randomization and Single-cell RNA Sequencing.","authors":"Yichuan Wang,Liang Zhou,Jiahao Liu,Qing Zhou,Wei Xiong,Long Wang","doi":"10.1093/gerona/glaf073","DOIUrl":"https://doi.org/10.1093/gerona/glaf073","url":null,"abstract":"BACKGROUNDBenign prostatic hyperplasia (BPH) is a widely observed disorder in older men, with substantial evidence indicating that cellular senescence serves a pivotal function in its progression. This investigation seeks to pinpoint cellular senescence-related genes causally connected with BPH and to examine their expression and regulatory networks across distinct prostate cells.METHODSUsing exposure data from the eQTLGen database and outcome data from both FinnGen Consortium and UKB database, Mendelian randomization (MR) was utilized to determine cell senescence genes that are causally linked to BPH. These associations were further validated through co-localization analysis. Expression patterns of these genes in different prostate cells were assessed via single-cell RNA sequencing (scRNA-seq), and changes along pseudotime were tracked. Regulatory networks were evaluated using SCENIC to identify key transcription factors involved.RESULTSSix cell senescence genes causally linked to BPH were identified through MR. ATM, ATRAID, MAP2K1, and TP53 were identified as protective factors, whereas ITPR1 and SENP7 were associated with increased risk. Co-localization analysis suggested that ATM and TP53 are likely to share the same variant implicated in BPH. MAP2K1 expression demonstrated a steady decline along inferred pseudotime across fibroblasts, macrophages, T cells, and epithelial cells, while the remaining five genes exhibited an opposite trend. ATF3, EGR1, and FOS were pinpointed as the core transcription factors regulating these genes.CONCLUSIONSThese observations emphasize consistent expression patterns among different prostate cell types and suggest a highly interconnected regulatory network that underpins BPH pathology, thereby providing fresh perspectives on the molecular mechanisms underlying the disease.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of epigenetic markers of ageing with prevalent and incident type 2 diabetes.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-21 DOI: 10.1093/gerona/glaf085

Danmeng Lily Li,Allison M Hodge,Melissa C Southey,Graham G Giles,Pierre-Antoine Dugué

{"title":"Association of epigenetic markers of ageing with prevalent and incident type 2 diabetes.","authors":"Danmeng Lily Li,Allison M Hodge,Melissa C Southey,Graham G Giles,Pierre-Antoine Dugué","doi":"10.1093/gerona/glaf085","DOIUrl":"https://doi.org/10.1093/gerona/glaf085","url":null,"abstract":"BACKGROUNDType 2 diabetes (T2D) is characterised by elevated levels of metabolic and inflammatory markers but less is known about other molecular alterations that occur with ageing. We aimed to assess the associations of DNA methylation-based measures of ageing (epigenetic ageing) with prevalent and incident T2D in a large sample of middle-aged and older Australians.METHODSWe used data from 5403 participants in the Melbourne Collaborative Cohort Study (mean age=59 years). Five blood-based epigenetic ageing measures: PCPhenoAge, PCGrimAge, DNAmFitAge, bAge, and DunedinPACE were calculated. T2D status was assessed at baseline (1990-1994, Ncases=180) and two waves of follow-up (1995-1998, Ncases=134; 2003-2007, Ncases=244). Modified Poisson regression models were used to estimate risk ratios (RRs) for the associations of epigenetic age with prevalent and incident T2D.RESULTSA standard deviation increase in epigenetic age was associated with 1.11-fold (PCPhenoAge, 95%CI: 0.98-1.26) to 1.33-fold (bAge, 95%CI: 1.12-1.57) higher prevalence of T2D at baseline. Prospectively, DunedinPACE showed the strongest association with incident T2D at follow-up 2 (RR=1.22, 95%CI: 1.07-1.38). These estimates were slightly attenuated but consistent in sensitivity analyses reclassifying participants who reported being T2D-free but had high glucose concentrations (>7mmol/L for fasting glucose, >11.1mmol/L for non-fasting glucose). No evidence of increased epigenetic age was found for participants with pre-T2D (>5.6mmol/L for fasting glucose, >7.8mmol/L for non-fasting glucose). The positive associations between epigenetic age and fasting glucose levels appeared stronger in participants with T2D.CONCLUSIONSIn middle-aged and older Australians, epigenetic age, in particular as assessed by bAge and DunedinPACE, was positively associated with prevalent and incident T2D. Our findings may have implications for understanding of the aetiology and management of T2D.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal dynamics of intrinsic brain activity in older women with subclinical depression.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-18 DOI: 10.1093/gerona/glaf084

Jing Jiang,Lei Li,Xueling Suo,Taolin Chen,Stefania Ferraro,Jin Gao,Dongmei Wu,Song Wang

{"title":"Temporal dynamics of intrinsic brain activity in older women with subclinical depression.","authors":"Jing Jiang,Lei Li,Xueling Suo,Taolin Chen,Stefania Ferraro,Jin Gao,Dongmei Wu,Song Wang","doi":"10.1093/gerona/glaf084","DOIUrl":"https://doi.org/10.1093/gerona/glaf084","url":null,"abstract":"Subclinical depression is common in older adults, especially in females, and may correlate with a higher likelihood of health events and poor prognosis. However, the underlying neurobiology remains unclear. This study, employing resting-state functional magnetic resonance imaging (rs-fMRI), identified alterations in temporal dynamics of intrinsic brain activity in older women with subthreshold depression (OWSD) and their potential relationships to depressive symptoms. The sliding window approach was applied to evaluate the temporal variations of the rs-fMRI indices, including the amplitude of low-frequency fluctuation (ALFF), the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) in 50 OWSD and 52 healthy older women controls (HOWC). We then calculated the dynamic voxel-wise concordance index of the rs-fMRI indices. The correlational analyses were used to assess the correlations between the dynamic indices and depressive symptoms. We found that OWSD showed a significant increase in dynamic ALFF (dALFF) in the left dorsolateral prefrontal cortex (DLPFC) relative to HOWC. With respect to regional brain function integration, OWSD showed a significantly lower dynamic voxel-wise concordance index in the right parietal lobe, mainly including the precuneus and superior parietal lobule extending to the postcentral gyrus. The regional dALFF and dynamic concordance index alterations were correlated with depressive symptoms. In conclusion, OWSD showed depression-correlated alterations in temporal variability of intrinsic brain activity, along with regional deficits in brain function integration. The findings reinforce our understanding of subthreshold depression psychopathology in older women.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and meta-analysis highlights a link between aerobic fitness and telomere maintenance

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-18 DOI: 10.1093/gerona/glaf068

Clodagh Ryall, Joshua Denham

{"title":"A systematic review and meta-analysis highlights a link between aerobic fitness and telomere maintenance","authors":"Clodagh Ryall, Joshua Denham","doi":"10.1093/gerona/glaf068","DOIUrl":"https://doi.org/10.1093/gerona/glaf068","url":null,"abstract":"Cardiorespiratory fitness declines with ageing and is a major risk factor of cardiometabolic diseases and early death. Although the benefits of regular exercise are well established, whether maximal oxygen uptake (V̇O2max) is associated with biological ageing remains unclear. Given that telomere shortening is a hallmark of ageing, the purpose of this systematic review and meta-analysis was to determine the association between V̇O2max and telomere length. Articles were retrieved from PubMed, Scopus, and ScienceDirect and deemed eligible if they: 1) involved human participants with relatively low and high V̇O2max values objectively assessed by pulmonary analysis; 2) quantified telomere length using an established technique; and 3) were peer-reviewed journal articles written in English. Relative to individuals with below average V̇O2max based on age- and sex-adjusted norms, fit participants with relative V̇O2max values in the 70th percentile or higher possessed longer telomeres (SMD [95%CI]: 0.36 [0.14–0.59], p=0.002). A similar difference was observed between individuals with below average V̇O2max and those above the 90th percentile (0.28 [0.03–0.53], p=0.03). However, no statistically significant telomere length differences were observed between individuals in the 70th to 90th percentile compared to those above the 90th (-0.08 [-0.40–0.24], p=0.62). The findings provide evidence linking metabolism to telomere biology. They encourage individuals to regularly engage in endurance exercise to attenuate telomere attrition and promote healthy biological ageing. Importantly, the results suggest that extensive endurance training may not be required to protect the telomeres, rather moderate amounts of training may be sufficient to reach more achievable V̇O2max targets.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying causal brain structures, genes and proteins for osteoarthritis: A large-scale genetic correlation study based on brain imaging-derived phenotypes, transcriptomes, and proteomes

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-18 DOI: 10.1093/gerona/glaf083

Chao Wang, Zhi Liu, Yong Zhu, Zhe Ruan, Haitao Long, Zhangyuan Lin, Ruibo Zhao, Wenfeng Xiao, Yusheng Li, Shushan Zhao

{"title":"Identifying causal brain structures, genes and proteins for osteoarthritis: A large-scale genetic correlation study based on brain imaging-derived phenotypes, transcriptomes, and proteomes","authors":"Chao Wang, Zhi Liu, Yong Zhu, Zhe Ruan, Haitao Long, Zhangyuan Lin, Ruibo Zhao, Wenfeng Xiao, Yusheng Li, Shushan Zhao","doi":"10.1093/gerona/glaf083","DOIUrl":"https://doi.org/10.1093/gerona/glaf083","url":null,"abstract":"Background Recent epidemiological studies have linked the central nervous system (CNS) to osteoarthritis (OA), suggesting that targeting the CNS could offer new therapeutic strategies. This study aimed to validate the correlation between brain structures and OA risk, and to identify key causal genes by integrating brain transcriptomic and proteomic data with OA genome-wide association studies (GWAS). Methods We analyzed OA summary statistics from 826,690 participants. Using linkage disequilibrium score regression (LDSC) and Mendelian randomization (MR), we explored the genetic relationships between brain structures and OA. A transcriptome-wide association study (TWAS) was conducted with 5,138 brain transcriptomes. Additionally, a proteome-wide association study (PWAS) combined GWAS data with 152 human brain proteomes. Single-cell RNA-Seq eQTL data helped identify causal genes in brain cells linked to OA. Results LDSC and MR indicated brain structures, such as the putamen and amygdala, are strongly associated with OA. Seven genes were linked to knee OA and four to hip OA (FDR &lt; 0.05). Proteins associated with knee, hip, and thumb OA were also identified. scRNA analysis revealed CPNE1 in excitatory neurons and EMILIN2 in oligodendrocyte progenitor cells as causally linked to knee OA. Conclusions This study enhances our understanding of the brain-joint axis in OA genetics, potentially informing new treatment strategies and therapeutic targets.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of vitamin D3 supplementation on the incidence of diagnosed dementia among healthy older adults – the Finnish Vitamin D Trial

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-17 DOI: 10.1093/gerona/glaf077

Eija Lönnroos, Maija Ylilauri, Christel Lamberg-Allardt, Jo Ann E Manson, Tarja Nurmi, Matti Uusitupa, Ari Voutilainen, Sari Hantunen, Tomi-Pekka Tuomainen, Jyrki K Virtanen

{"title":"The effect of vitamin D3 supplementation on the incidence of diagnosed dementia among healthy older adults – the Finnish Vitamin D Trial","authors":"Eija Lönnroos, Maija Ylilauri, Christel Lamberg-Allardt, Jo Ann E Manson, Tarja Nurmi, Matti Uusitupa, Ari Voutilainen, Sari Hantunen, Tomi-Pekka Tuomainen, Jyrki K Virtanen","doi":"10.1093/gerona/glaf077","DOIUrl":"https://doi.org/10.1093/gerona/glaf077","url":null,"abstract":"Background Some short-term vitamin D supplementation trials suggest benefits on cognitive performance, but apart from observational studies, there is little evidence whether long-term vitamin D supplementation can prevent development of dementia. We investigated whether vitamin D3 supplementation could affect the incidence of diagnosed dementia in a generally healthy population. Methods The study included 2492 participants from the Finnish Vitamin D Trial, free of diagnosed dementia at baseline. They were randomized to placebo, 1600 IU/day or 3200 IU/day of vitamin D3 arm for up to 5 years. Incident diagnoses of dementia were obtained from the national care registries. Results The mean age of the participants at baseline was 68.2 y and 42.8% were female. During the mean follow-up of 4.2 y, 18 participants in the placebo arm, 14 participants in the 1600 IU/day arm (compared to placebo, hazard ratio [HR]=0.77, 95% confidence interval [CI] 0.38-1.55) and 13 participants in the 3200 IU/day arm (HR=0.72, 95% CI 0.35-1.48) were diagnosed with dementia. Of the diagnoses, 29 were Alzheimer’s disease, without statistically significant differences in the event rates between the three arms. Age, sex, or body mass index did not modify the effects. In the subgroup of 550 participants, the mean baseline serum 25-hydroxyvitamin D concentration was 74.8 nmol/L. After 12 months, the mean concentrations were 73.0, 99.7 and 120.4 nmol/L, in the placebo, 1600 IU/day and 3200 IU/day arms, respectively. Conclusions Five-year, medium-dose or high-dose vitamin D3 supplementation did not affect the dementia incidence in this largely vitamin D sufficient older population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of cumulative blood pressure with progression of depressive symptoms and functional impairment among adults aged 50 years or older: 10-year follow-up of two longitudinal cohorts

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-17 DOI: 10.1093/gerona/glaf080

Wenya Zhang, Jie Liang, Chenglong Li, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng

{"title":"Association of cumulative blood pressure with progression of depressive symptoms and functional impairment among adults aged 50 years or older: 10-year follow-up of two longitudinal cohorts","authors":"Wenya Zhang, Jie Liang, Chenglong Li, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng","doi":"10.1093/gerona/glaf080","DOIUrl":"https://doi.org/10.1093/gerona/glaf080","url":null,"abstract":"Background The association of cumulative blood pressure (BP) with progression rate of depressive symptoms and functional impairment remained largely unknown, and this study aims to explore whether higher cumulative BP is associated with a faster rate of aggravation of depressive symptoms and functional impairment. Methods This longitudinal cohort study adopted data from the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). Cumulative BP was calculated as area under the curve using BP measurements from 3 visits (wave 0, 2 and 4) in ELSA and 2 visits (wave 8 and 10) in HRS. Depressive symptoms were evaluated in a biennial frequency via Center for Epidemiological Studies Depression (CES-D) scale, while functional status was measured every two years using adapted versions of Katz Activities of Daily Living (ADL) scale and Lawton Instrumental Activities of Daily Living (IADL) scale. Results A total of 3500 and 6036 participants from ELSA and HRS were included. Elevated cumulative pulse pressure (PP) was significantly associated with accelerated aggravation of depressive symptoms (P &lt; 0.001 for both). Elevated cumulative systolic BP and PP were significantly associated with accelerated decline of ADL function (P &lt; 0.001 for both) and IADL function (P &lt; 0.001 for both). However, elevated cumulative diastolic BP was associated with decelerated decline of IADL function (P = 0.031 in ELSA and P &lt; 0.001 in HRS). Conclusions Elevated cumulative BP was associated with accelerated aggravation of depressive symptoms and functional impairment, suggesting that controlling systolic BP and PP while maintaining adequate diastolic BP is of paramount importance for adults to achieve health longevity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Dementia, Depression, and Other Mental Disorders on Reoperation and Mortality among Hip Fracture Patients: A Nationwide Danish Cohort Study.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-17 DOI: 10.1093/gerona/glaf074

Simon Storgaard Jensen,Per Hviid Gundtoft,Jan-Erik Gjertsen,Alma B Pedersen

{"title":"Impact of Dementia, Depression, and Other Mental Disorders on Reoperation and Mortality among Hip Fracture Patients: A Nationwide Danish Cohort Study.","authors":"Simon Storgaard Jensen,Per Hviid Gundtoft,Jan-Erik Gjertsen,Alma B Pedersen","doi":"10.1093/gerona/glaf074","DOIUrl":"https://doi.org/10.1093/gerona/glaf074","url":null,"abstract":"BACKGROUNDDespite the rising global burden of mental disorders, their impact on complication risk following hip fracture surgery remains unclear. We examined reoperation and mortality risks after hip fracture surgery, investigating patients with and without moderate to severe mental disorders.METHODSUsing a nationwide cohort design, we identified patients undergoing hip fracture surgery from the Danish Multidisciplinary Hip Fracture Register. Mental disorders (including organic disorders (dementia), substance use, schizophrenia, mood disorders, and neurotic disorders) and reoperations were determined using diagnosis and procedure codes in the Danish National Patient Registry. We estimated reoperation and mortality risk with adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs), comparing each mental disorder to no mental disorder while accounting for death as a competing risk.RESULTSAmong 110,625 hip fracture patients from 2004 to 2021, 15,254 (14%) had a mental disorder. The 30-day aHRs for reoperation ranged from 1.05 (CI: 0.9-1.2) for dementia to 1.67 (CI: 1.3-2.1) for substance use. The 365-day aHRs for reoperation ranged from 0.92 (CI: 0.9-1.0) for dementia to 1.37 (CI: 1.2-1.5) for neurotic disorders. Patients with mental disorders had an increased aHR for mortality at both 30-day and 365-day follow-up compared to patients without mental disorders, with the most pronounced risk observed among patients with dementia.CONCLUSIONThe risk of reoperation and mortality following hip fracture surgery was significantly higher in patients with moderate to severe mental disorders compared to those without. These findings emphasise the need for targeted prevention strategies to reduce reoperation risk and mortality.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain resting-state functional connectivity mediates the age-associated decline in physical activity engagement.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-17 DOI: 10.1093/gerona/glaf075

Meishan Ai,Emma M Tinney,Goretti España-Irla,Charles H Hillman,Arthur F Kramer,Timothy P Morris

{"title":"Brain resting-state functional connectivity mediates the age-associated decline in physical activity engagement.","authors":"Meishan Ai,Emma M Tinney,Goretti España-Irla,Charles H Hillman,Arthur F Kramer,Timothy P Morris","doi":"10.1093/gerona/glaf075","DOIUrl":"https://doi.org/10.1093/gerona/glaf075","url":null,"abstract":"BACKGROUNDPhysical activity (PA) engagement declines with age in late adulthood. Therefore, understanding factors underlying PA engagement is needed for PA promotion in older adults. Executive function is a potential key neurocognitive resource that supports PA engagement. The current study aims to provide neurobiological evidence for this hypothesis by examining the role of the executive function networks in PA engagement.METHODSResting-state functional Magnetic Resonance Imaging (MRI) data and self-reported PA engagement were obtained from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) (age range 18-81). The frontoparietal network (FPN) and salience network (SN) were chosen as networks of interest.RESULTSWe found that PA engagement began to decline at the age of 49 via piecewise regression. Meanwhile, functional connectivity within FPN connecting posterior cingulate, parietal area, and precuneus, and functional connectivity within SN connecting right temporo-parieto-occipital area, anterior and middle cingulate, and bilateral fronto-operculum and insula were associated with PA. The PA-associated functional connectivity within SN mediated the age-related decline of PA engagement, which was not observed for the FPN.CONCLUSIONSPA engagement begins to decrease in middle-age, while functional connectivity between key regions related to inhibitory control and behavior regulation is a potential neural mechanism underlying this age-related decline. These findings provide neurobiological evidence for the hypothesis that aspects of executive function support PA engagement. Moreover, it also identifies potential neural targets for future PA promotion interventions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to minimize fall-related injuries in older adults at risk of falls: the Falling Safely Training (FAST) study.

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-04-17 DOI: 10.1093/gerona/glaf076

Tobia Zanotto,Lingjun Chen,James R Fang,Abbas Tabatabaei,Jianghua He,Shelley B Bhattacharya,Neil B Alexander,Jacob J Sosnoff

{"title":"Strategies to minimize fall-related injuries in older adults at risk of falls: the Falling Safely Training (FAST) study.","authors":"Tobia Zanotto,Lingjun Chen,James R Fang,Abbas Tabatabaei,Jianghua He,Shelley B Bhattacharya,Neil B Alexander,Jacob J Sosnoff","doi":"10.1093/gerona/glaf076","DOIUrl":"https://doi.org/10.1093/gerona/glaf076","url":null,"abstract":"BACKGROUNDFalls are the leading cause of accidental injury among older adults. Current fall prevention programs are useful but do not target the key variable for injury (i.e., impact force). An approach, which has shown promise in robust older adults, is to teach safe-falling strategies to reduce impact forces. In this single-blinded, pilot randomized controlled trial, we explored the feasibility and preliminary efficacy of a safe-falling program.METHODSTwenty-four older adults at risk of injurious falls were randomly assigned either to Falling Safely Training (FAST), a standardized progressive training of safe-falling strategies, or an active control group consisting of evidence-based balance training. Participants underwent a series of experimentally induced falls at baseline, after the 4-week intervention, and three months after the intervention. Hip and head acceleration (proxies of impact force) and the number of head impacts experienced during the falls were collected.RESULTSNo adverse events were reported, and eleven of 12 FAST participants completed the intervention. The FAST group had a greater reduction in the number of fall-related head impacts following the intervention (odds ratio = 0.10, 95% CI: 0.02, 0.61, p=0.012). This improvement coincided with a significant reduction in head acceleration in the FAST group compared to control (between-group mean difference = -9.54 m/sec2, p=0.028). Hip acceleration decreased significantly in both groups (p's˂0.001).CONCLUSIONTeaching older adults at risk of falls safe-falling strategies is safe and feasible and has the potential to minimize fall-related head impacts and reduce fall morbidity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0