The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

{"title":"Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women’s Health Across the Nation (SWAN)","authors":"Elizabeth A Jackson, Carrie A Karvonen-Gutierrez, Maria M Brooks, Elsa Strotmeyer, Brittney S Lange-Maia, Daniel H Solomon, Michelle M Hood, Carol A Derby","doi":"10.1093/gerona/glag058","DOIUrl":"https://doi.org/10.1093/gerona/glag058","url":null,"abstract":"Background Metabolic syndrome is associated with frailty in older adults, with few data among midlife women. We examined metabolic syndrome (MetSyn), including duration, for associations with the development of prefrailty and frailty. Methods The Study of Women’s Health Across the Nation is a multiethnic, longitudinal cohort study of women aged 42-52 years at the time of enrollment (1996-1997). MetSyn was measured longitudinally, using ATP III criteria, starting at baseline. Pre-frailty and frailty were measured at two later visits (2012/13 and 2015/16) using Fried criteria. Associations of pre-frailty and frailty with prevalent MetSyn, the cumulative number of prior visits with MetSyn, and individual MetSyn criteria were examined using multivariable models. Results A total of 1,769 women were included (mean age 59.7 years, standard deviation [SD] 3.3). The adjusted odds ratios (aOR) for having pre-frailty or frailty in women with MetSyn compared to those without were 2.77 (95% confidence interval [CI], 2.19-3.50) and 8.73 (95% CI, 5.89-12.95), respectively. Each additional visit a woman met criteria for MetSyn was associated with a higher odds of pre-frailty and frailty (aOR 1.20; 95% CI: 1.14-1.26, and aOR 1.41; 95% CI: 1.33-1.50, respectively). Individual MetSyn criteria were also associated with the risk of frailty. Conclusion Among women in this multiethnic cohort, MetSyn was common during midlife and strongly associated with future development of pre-frailty and frailty while women were in their early sixties. Measurement of MetSyn during midlife can help identify women at high risk for developing frailty early in the aging process.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"268 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Health in Aging Male and Female Mice: Does Cardiac Function Dictate Frailty or Physical Resilience?","authors":"Grecia Garcia Marquez, George E Taffet, Katarzyna A Cieslik","doi":"10.1093/gerona/glag075","DOIUrl":"https://doi.org/10.1093/gerona/glag075","url":null,"abstract":"As the global population over age 65 is projected to triple by 2050, understanding the physiological mechanisms of aging and the role of sex as a biological variable (SABV) is critical. Research conducted on old mice demonstrates that age-related cardiac dysfunction is differentially linked to markers of frailty and resilience in a sex-dependent manner. We assessed post-anesthesia recovery time, wire hanging test, and a deficit accumulation-based frailty index as markers of whole-body frailty and resilience, and correlated these variables with cardiac parameters obtained by echocardiography and Doppler imaging in 25–26-month-old mice. The results demonstrated significant heterogeneity across all functional parameters in both groups. Male and female aging profiles are distinct: in males, higher frailty scores are primarily associated with cardiac hypertrophy and increased body surface area (BSA). In contrast, female mice exhibit a more complex relationship in which hyperdynamic cardiac markers (such as increased aortic peak velocity) correlate with prolonged recovery from systemic stressors like anesthesia. Crucially, the three primary functional assessments used—the frailty index, anesthesia recovery time, and the wire hanging test—did not strongly correlate with each other, indicating that they measure interrelated yet distinct aspects of biological vulnerability and physiological reserve. These findings underscore the necessity of sex-disaggregated data and multi-metric assessments in geroscience to develop effective, personalized strategies for extending healthspan.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor.","authors":"Morten Tange Kristensen,Ina Trolle Andersen,Bjarke Viberg,Alma Becic Pedersen","doi":"10.1093/gerona/glag025","DOIUrl":"https://doi.org/10.1093/gerona/glag025","url":null,"abstract":"","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent IQ and Risk of Dementia: A 67-Year Prospective Study.","authors":"Yannick Stephan,Angelina R Sutin,Martina Luchetti,Selin Karakose,Antonio Terracciano","doi":"10.1093/gerona/glag069","DOIUrl":"https://doi.org/10.1093/gerona/glag069","url":null,"abstract":"BACKGROUNDEarly-life IQ is a consistent predictor of overall late life health, but its association with the risk of dementia is inconclusive. The present study examined the association between IQ in adolescence and the risk of all-cause dementia in older adulthood.METHODSParticipants (N = 3,498) from the Wisconsin Longitudinal Study completed measures of IQ and demographic factors at about age 18 (1957) and were screened for dementia at about age 81 (2019-2024). Education and history of diabetes, hypertension, and smoking were tested as potential mediators.RESULTSAt the 67 years follow-up assessment, 378 participants (11%) had dementia. Higher IQ at 18 was associated with a lower risk of all-cause dementia (Odds ratio [OR] per one-SD increase in IQ = 0.78; 95% confidence interval [95% CI]= 0.69-0.88) at age 81. The association was similar when adolescent IQ was considered as a categorical variable that contrasted the top versus bottom quartiles (OR = 0.59; 95% CI = 0.43-0.81, p<.01). The association persisted controlling for demographic factors, was partially accounted for by the potential mediators (education, clinical and behavioral covariates), and was not moderated by sex or childhood socioeconomic status.CONCLUSIONSAdolescent IQ is an early life factor associated with a lower risk of dementia in older adulthood. This research highlights the importance of a life-course perspective on brain health.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Frailty, Self-Rated Health, and All-Cause Mortality: Implications for Understanding Resilience in Aging.","authors":"Vishaldeep Kaur Sekhon,Roshni Wani,Chenkai Wu,Nadia M Chu,Qian-Li Xue","doi":"10.1093/gerona/glag067","DOIUrl":"https://doi.org/10.1093/gerona/glag067","url":null,"abstract":"Frailty and poor self-rated health (SRH) as potential indicators of reduced resilience are associated with all-cause mortality. However, it is lesser known whether these associations are independent of each other, physical disability or disease burden, and whether SRH remains predictive of mortality among frail older adults. We leveraged the National Health and Aging Trends Study of U.S. Medicare beneficiaries, followed annually from 2011 to 2019. Baseline assessments included physical frailty and SRH (excellent/very good, good, or fair/poor). Cox models examined associations with all-cause mortality, adjusting for demographic characteristics and comorbidities. Sensitivity analyses excluded participants with probable or possible dementia at baseline. Of the 7,425 participants at baseline, 14% were physically frail, and 25% reported fair/poor SRH. Although frailty was positively correlated with fair/poor SRH, 12% of frail participants reported excellent/very good health, and 6.6% of those with fair/poor SRH were non-frail. Over a median follow-up of 4.3 years, 29% died. Compared to non-frail participants, pre-frailty and frailty were associated with 1.4- and 2.0-fold increased hazard of mortality, respectively, after adjusting for SRH (p < 0.001); reporting good and fair/poor SRH was associated with 29% and 59% higher hazard of mortality compared to excellent/very good SRH, respectively, after adjusting for frailty (p < 0.001). Fair/poor SRH was associated with higher mortality among the frail. Sensitivity analyses yielded similar results. Physical frailty and SRH, while related, capture distinct aspects of health. Each independently and jointly predicts mortality, with SRH retaining prognostic value in frail individuals. Incorporating both measures may improve risk stratification and guide tailored interventions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand grip strength and loss of independence in indigenous and non-Indigenous New Zealand octogenarians-the LiLACS NZ cohort study.","authors":"Simon A Moyes,Vanessa Selak,Lindsay D Plank,Joanna Hikaka,Ruth Teh,Ngaire Kerse","doi":"10.1093/gerona/glag066","DOIUrl":"https://doi.org/10.1093/gerona/glag066","url":null,"abstract":"BACKGROUNDThe number of people losing their independence is increasing as the population ages. Sarcopenia, low muscle strength and mass, and hand grip strength (HGS) are known to predict reduced independence in people in their seventies. This paper investigates these relationships in New Zealand octogenarians, including Indigenous Māori.METHODSThis study used data from Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ), which recruited 421 Māori and 516 non-Māori in 2010-2011. The Nottingham Extended Activities of Daily Living (NEADL) scale measured independence. Participants were classified by ethnicity (Māori or non-Māori) and sex into high, medium or low independence trajectory groups based on their six annual NEADL scores using group-based trajectory modelling. The associations between HGS or probable sarcopenia (a binary measure of HGS) and independence trajectory group (high, medium, low) were tested separately by ethnicity and sex in multinomial logistic regression models.RESULTSHand grip strength was inversely associated with low (versus medium) independence trajectory among Māori women, non-Māori women and non-Māori men, adjusting for age, comorbidities and cognition (adjusted odds ratio, aOR, 0.84 (95% CI 0.72, 0.97), 0.86 (0.77, 0.96) and 0.90 (0.81, 0.99), respectively). Similar associations were seen for probable sarcopenia and independence trajectory among those three groups, but the effects did not reach statistical significance.CONCLUSIONSHand grip strength could be a valuable screening tool to assess independence trajectory in octogenarians, but further study is needed to clarify the effects of indigeneity and sex in this population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighted Vest Use or Resistance Exercise to Offset Muscle Loss in Older Adults: Secondary Findings from the INVEST in Bone Health RCT","authors":"S Delanie Lynch, Marjorie Howard, Daniel P Beavers, Ashley A Weaver, Leon Lenchik, Ryan Barnard, Peggy M Cawthon, Jessica Bon, Kristen M Beavers","doi":"10.1093/gerona/glag062","DOIUrl":"https://doi.org/10.1093/gerona/glag062","url":null,"abstract":"Background The INVEST in Bone Health Trial examined the effects of weight loss (WL), WL plus resistance training (WL+RT), or WL plus weighted vest use (WL+VEST) on musculoskeletal health. This secondary analysis evaluated changes in muscle area and density using computed tomography (CT) and lean and fat mass using dual-energy X-ray absorptiometry (DXA). Methods 150 participants (50/group) were randomized to 12-months of WL, WL+RT, or WL+VEST, undergoing CT and DXA scans at baseline, six- and 12-months. DXA measured lean and fat mass, while CT assessed muscle and intermuscular adipose tissue (IMAT) cross-sectional area (CSA) and density. Mixed linear models evaluated changes and treatment effects, and partial Pearson’s correlations examined relationships between weight change and CT/DXA outcomes. Results Participants (66.4±4.6 years,75% female,69% white) were living with overweight (14.7%) or obesity (85.3%). All groups achieved similar and significant weight loss (∼10%). At 12-months, WL+RT increased mid-thigh muscle CSA (0.5%, p &amp;lt; 0.05), improved muscle density (3.7–5.9%, p &amp;lt; 0.03), and reduced IMAT (20–22%, p &amp;lt; 0.05) and fat masses (22-26.8%, all p &amp;lt; 0.061). At the trunk, WL+VEST showed a trend toward muscle preservation and improved density (4.2%, p = 0.08) compared to WL, but had minimal impact on other measures. Differences between WL+VEST and WL were insignificant (all p &amp;gt; 0.05), but group comparisons showed improvements for WL+RT. Weight loss correlated with increased muscle density (r &amp;lt; 0, p &amp;lt; 0.001) but reduced muscle CSA and IMAT (r &amp;gt; 0, p &amp;lt; 0.001), indicating improved quality but reduced quantity. Conclusion Our findings underscore the significance of weight loss-associated muscle loss, highlighting progressive RT as a minimally effective preservation strategy.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of National Partnership to Improve Dementia Care on Antipsychotic Use Duration for Dementia Residents in Nursing Homes","authors":"Theresa I Shireman, Corinne Roma, Andrew R Zullo, Antoinette B Coe, Lori A Daiello, Christopher J Liu, Derrick Lo, Julie P W Bynum, Lauren B Gerlach","doi":"10.1093/gerona/glag060","DOIUrl":"https://doi.org/10.1093/gerona/glag060","url":null,"abstract":"Background Federal policies have successfully targeted the prevalence of antipsychotic (AP) exposure in NHs, but the duration of treatment among nursing home (NH) residents has not been reported. We evaluated AP duration and discontinuation within six months in residents with dementia. Methods Retrospective cohort study of long-stay NH residents with dementia who newly initiated an AP medication. We evaluated changes in AP duration and discontinuation within six months relative to two federal initiatives: National Partnership to Improve Dementia Care (2012) and inclusion of AP use measures in the NH Star Ratings (2015). We accounted for resident and facility characteristics in a competing-risks analysis establishing the relationship between the two policy periods and AP outcomes. Results There were 43,668 new episodes of AP initiation among 38,275 residents. The duration of treatment within six months declined from 125.9 days in the pre-Partnership period to 120.5 days and 120.6 days in the post-Partnership and post-Five Star periods, respectively. Those who initiated APs after the Partnership (adjusted hazard ratio (AHR) = 1.17; confidence interval, 1.10-1.24) and after the Five Star Rating change (aHR = 1.19; 95% CI, 1.07-1.32) policy periods were more likely to stop the medication within 6 months as compared to those who initiated during the prior period. Conclusions Federal policies designed to reduce AP prescribing in NH residents with dementia had a nominal impact on treatment duration within the first six months, with more than half continuing treatment beyond 6 months.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sleep habits on life expectancy free of cardiovascular disease in the Chinese population: a prospective cohort study","authors":"Qiufen Sun, Jingcen Hu, Canqing Yu, Dianjianyi Sun, Pei Pei BsC, Ling Yang, Yiping Chen Dphil, Huaidong Du, Xiaofang Zhang, Dan Schmidt, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, , Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Liming Li, Jun Lv, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Yuting Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Yiping Chen, Zhengming Chen, Jonathan Clarke, Robert Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Dan Schmidt, Becky Stevens, Iain Turnbull, Robin Walters, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Qingdao C D C, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Licang C D C, Dan Hu, Xiaoyan Zheng, Yujie Wang, Heilongjiang Provincial CDC, Wei Sun, Shichun Yan, , Nangang C D C, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Hainan Provincial CDC, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Tingting Ou, Meilan C D C, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Jiangsu Provincial CDC, Yan Xu, Jinyi Zhou, Ran Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Suzhou C D C, Yan Lu, Yujie Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, Guangxi Provincial CDC, Ge Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Liuzhou C D C, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Sichuan Provincial CDC, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Pengzhou C D C, Mingqiang Yuan, Ling Wang, Xiaofang Chen, Zhaodong Wang, Qiang Sun, Yang Lin, Gansu Provincial CDC, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Maiji C D C, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Henan Provincial CDC, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, Li Gao, Shaofang Li, Tianfang Xing, Wei Tang, Huixian C D C, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Zhejiang Provincial CDC, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Tongxiang C D C, Hao Xu, Yuan Cao, Kaixu Xie, Lingli Chen, Xiaomei Tu, Junlong Pan, Hunan Provincial CDC, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Yin, Xian Xie, Jing Wang, Liuyang C D C, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Chan Qu, li Deng, Qili Jiang, Yanling Chen","doi":"10.1093/gerona/glaf284","DOIUrl":"https://doi.org/10.1093/gerona/glaf284","url":null,"abstract":"Background Abnormal sleep duration and poor sleep quality have been associated with increased risks of cardiovascular disease (CVD) incidence and mortality. However, little is known about how these sleep problems affect total life expectancy (LE) and LE free of CVD and its subtypes. Methods We included 483,384 adults from the China Kadoorie Biobank (CKB) who were free of heart disease, stroke, cancer, major depressive disorder, and generalized anxiety disorder at baseline. Sleep duration was categorized as &amp;lt; 6 h/d, 6-9 h/d, and &amp;gt;9 h/d. Three sleep disturbance symptoms were considered: self-reported difficulties initiating and maintaining sleep, early morning awakening, and daytime dysfunction. Participants with at least one of the three symptoms were considered to have a sleep disturbance. We estimated sex-specific LE with and without CVD at age 40 by using multistate Markov models, with separate models specified for total CVD, ischemic heart disease (IHD), ischemic stroke (IS), and hemorrhagic stroke (HS) as the disease state. Results During a median follow-up of 12.1 years, we documented 135,429 incident CVD events, including 46,479 IHD events, 47,562 IS events, and 10,844 HS events. Overall, there were 48,372 deaths. Compared to other sleep problems, longer sleep duration (&amp;gt;9 h/d) had the greatest impact on total LE and LE free of CVD and its subtypes, with the impact on total LE greater than that of disease-free LE. In men, the reduction in total LE and LE without CVD (95% confidence intervals) at age 40 associated with longer sleep duration was 2.11 (-2.50, -1.71) and 1.29 (-1.68, -0.98) years, respectively. The corresponding values for women were 1.37 (-1.81, -0.98) and 0.43 (-0.75, -0.07) years. In contrast, sleep disturbance had a stronger impact on disease-free LE than on total LE, thereby reducing the proportion of life spent in a healthy state. Compared with participants without sleep disturbance, the total LE at age 40 was 0.46 (-0.77, -0.15) and 0.22 (-0.47, 0.06) years lower in men and women with sleep disturbance, respectively, and the LE without CVD was 0.99 (-1.23, -0.73) and 1.05 (-1.27, -0.85) years lower. Conclusions In this Chinese population, abnormal sleep duration, especially long sleep, and sleep disturbance were linked with lower total LE and LE free of CVD. This study confirmed the importance of good sleep habits in health management for both those without and with CVD.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder","authors":"Sumiran Kasturi, Arnold M Salazar, Cara Hardy, Ron Korstanje, Indira U Mysorekar","doi":"10.1093/gerona/glag059","DOIUrl":"https://doi.org/10.1093/gerona/glag059","url":null,"abstract":"Lower urinary tract dysfunction (LUTD) increases with age and disproportionately affects women, yet the molecular mechanisms underlying this sex bias remain poorly defined. The aging bladder plays a central role in this decline, and our previous work identified increased cellular senescence, oxidative stress, and activation of the PERK arm of the unfolded protein response (UPR) as key features of bladder aging. In this study, conducted as part of the NIH Common Fund SenNet program to investigate cellular senescence in mice, we explored the therapeutic potential of a senolytic drug combination of Dasatinib and Quercetin (D&amp;Q) in male and female aged (25-month-old) bladders from genetically diverse Diversity Outbred mice. We first assessed sex differences in aged bladders (&amp;gt;20 months of age), then evaluated whether D&amp;Q treatment could improve bladder health by modulating ER stress. We identified significant baseline sex differences in UPR and ER-associated degradation (ERAD) proteins, with higher expression of PERK pathway ER stress components in females and more efficient ERAD and autophagy flux in males. While D&amp;Q did not broadly alter ER stress or autophagy markers, it selectively increased ERAD markers in females. D&amp;Q also enhanced uroplakin expression and urothelial thickness in aged females, suggesting potential benefit to urothelial integrity. These findings suggest a potential sex-specific regulatory mechanism within the UPR pathway that may contribute to the increased vulnerability of aged females to bladder dysfunction.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"417 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147287401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}