运动认知危险综合征和高c反应蛋白血清水平与重大神经认知障碍事件的关联:来自魁北克NuAge队列的结果

Olivier Beauchet, Kevin Galéry, Pierrette Gaudreau, Gilles Allali
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引用次数: 0

摘要

运动认知风险综合征(MCR)和c反应蛋白(CRP)血清水平分别与发生重大神经认知障碍的风险增加相关。本研究旨在比较有MCR和无MCR的老年人血清CRP水平,并探讨MCR、CRP血清水平及其与重大神经认知障碍的相关性。915人参加了一项以老年人为基础的观察性队列研究,随访设计为3年。在基线时收集MCR和CRP血清水平。在年度随访时,使用修正的最小精神状态(≤79/100)和简化的工具活动日常生活量表(<4/4)评分值测量事件性重大神经认知障碍。基线评估时MCR的患病率为3.7%。主要神经认知障碍的总发生率为3.0%。单独MCR(风险比(HR)=28.09, 95%可信区间(CI=[7.00;112.72], P≤0.001)和血清CRP水平高的MCR (HR=6.33, 95% CI[1.45;27.62], P=0.014)与严重神经认知障碍的发生显著相关。MCR是预测老年人主要神经认知障碍的重要危险因素,而血清CRP水平则不是。此外,血清CRP水平降低了MCR对主要神经认知障碍的预测强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of motoric cognitive risk syndrome and high C-reactive protein serum levels with incident major neurocognitive disorder: Results from the Quebec NuAge cohort
Both motoric cognitive risk syndrome (MCR) and C-reactive protein (CRP) serum levels have been separately associated with increased risk of incident major neurocognitive disorder. The study aims to compare the CRP serum levels of older adults with and without MCR, and to examine the associations of MCR, CRP serum levels and their combination with incident major neurocognitive disorder. 915 individuals participating in an older adults population-based observational cohort study with a 3-year follow-up design, were selected. MCR and CRP serum levels were collected at baseline. Incident major neurocognitive disorder was measured at annual follow-up visits using the modified mini-mental state (≤79/100) and simplified instrumental activity daily living scale (&lt;4/4) score values. The prevalence of MCR at baseline assessment was 3.7%. The overall incidence of major neurocognitive disorder was 3.0%. MCR alone (Hazard Ratio (HR)=28.09 with 95% Confidence Interval (CI=[7.00;112.72] and P≤0.001) and MCR with a high CRP serum level (HR=6.33, with 95% CI[1.45;27.62] and P=0.014) were significantly associated with incident major neurocognitive disorder. MCR is a significant risk factor for predicting major neurocognitive disorder in older adults, while serum CRP levels are not. In addition, serum CRP levels reduce the predictive strength of MCR for major neurocognitive disorder.
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