The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

{"title":"Phenoage and Phenoageaccel Do Not Outperform Chronological Age in Predicting Physical Performance Decline or Mortality in Community-Dwelling Older Adults","authors":"Maria Serena Iuorio, Antonio De Vincentis, Diana Lelli, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi, Claudio Pedone","doi":"10.1093/gerona/glaf285","DOIUrl":"https://doi.org/10.1093/gerona/glaf285","url":null,"abstract":"Background Chronological age inadequately captures inter-individual variability in aging-related functional decline. Biological age metrics such as PhenoAge and PhenoAgeAccel, based on clinical biomarkers, have shown associations with frailty and mortality in clinical populations, but their utility in predicting physical performance decline in community-dwelling older adults remains uncertain. Methods We used data from 979 participants aged ≥65 years in the InCHIANTI study, with complete baseline biomarker and physical performance data. Associations of standardized (z-scores) chronological age, PhenoAge, and PhenoAgeAccel with longitudinal changes in physical function (rescaled SPPB) and 10-year all-cause mortality were analyzed using linear mixed and Cox models respectively. A secondary analysis in 504 participants with normal baseline physical performance (SPPB ≥10) assessed the predictive value of each rescaled metric for the onset of compromised function (SPPB ≤9) at 6 years. Model performance was evaluated using AIC and AUC. Results All three metrics showed statistically significant positive associations with physical function decline and mortality. Chronological age showed the strongest associations with rSPPB decline (β = -0.41, AIC = 3793) and mortality (HR = 2.78). PhenoAge (β = -0. 32, AIC 4338, HR = 2.57) and PhenoAgeAccel (β = -0.14, AIC 4642, HR = 1.71) showed weaker effects. Chronological age also outperformed PhenoAge and PhenoAgeAccel in predicting SPPB decline (AUC = 0.71 vs. 0.69 and 0.55, respectively). Conclusion While PhenoAge and PhenoAgeAccel are associated with adverse functional outcomes, they do not add predictive value over chronological age in a general older population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the Population-Level Impact of Insomnia on Dementia Among Older Adults in the United States","authors":"Yuqian Lin, Fei Wu, Yuhan Wu, Wanru Liu, Goodarz Danaei, Ruijia Chen","doi":"10.1093/gerona/glaf289","DOIUrl":"https://doi.org/10.1093/gerona/glaf289","url":null,"abstract":"Background Insomnia has been identified as a plausible modifiable risk factor for dementia. Quantifying its population-level impact may inform strategies to reduce dementia risk among older adults in the United States. Methods We used data from the 2022 National Health and Aging Trends Study (NHATS) to classify insomnia as sleep-onset insomnia, sleep-maintenance insomnia, or both, and to identify probable dementia using established algorithms. We obtained relative risks from a published meta-analysis. Using these relative risks and NHATS prevalence estimates, we estimated the population attributable fraction (PAF) of dementia cases attributable to insomnia overall and stratified by age and sex. Results Among 5,899 participants (44.7% aged ≥ 80 years; 57.9% females; 77.9% non-Hispanic White), 28.7% (95% CI: 26.9%, 30.5%) reported insomnia symptoms and 6.6% (95% CI: 5.9%, 7.3%) had probable dementia. The estimated PAF of probable dementia due to any insomnia was 12.5% (95% CI: 1.0%, 25.0%), and it was slightly higher among females (13.1%, 95% CI: 1.0%, 26.1%) than males (11.6%, 95% CI: 0.9%, 23.3%). The highest PAF was observed in the 65–69 age group (14.4%, 95% CI: 1.1%, 27.8%) among females and in the 70–74 age group (12.8%, 95% CI: 0.9%, 25.8%) among males. An estimated 449,069 (95% CI: 35,049, 923,082) dementia cases in 2022 could have been prevented if insomnia were eliminated. Conclusions Approximately 13% of dementia cases, almost half a million cases, among U.S. older adults may be attributable to insomnia. Addressing insomnia could be a promising target for dementia prevention efforts in aging populations.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional and Longitudinal Associations between Testosterone and Cognitive Performance in Older People: Results of the Berlin Aging Study II (BASE-II)","authors":"Vivien Bahr, Hannah Schmid, Valentin Max Vetter, Dominik Spira, Johanna Drewelies, Vera Regitz-Zagrosek, Denis Gerstorf, Sandra Düzel, Knut Mai, Ilja Demuth","doi":"10.1093/gerona/glaf286","DOIUrl":"https://doi.org/10.1093/gerona/glaf286","url":null,"abstract":"Background Age-related declines in gonadal and cognitive function are commonly observed, but their relationship is still not completely understood. Methods 615 men and 607 women from the Berlin Aging Study II aged ≥60 years were analyzed at baseline, of which 308 men and 297 women were re-assessed on average 7.2 years later. Total testosterone (TT) was measured, and free testosterone estimated using the Vermeulen (FTV), Sartorius (FTS), and Free Androgen Index (FAI) equations. Cognitive performance was assessed using the Digit Symbol Substitution Test (DSST) and latent factor scores established from the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Plus test battery representing four cognitive domains (verbal memory, visuo-construction, executive functions and processing speed, verbal fluency). Associations between testosterone measures and cognitive function were analyzed using linear regression. Results Cross-sectional analyses showed negative associations in women between visuo-construction and TT (β=-0.215, p = 0.010) and FTS (β=-0.013, p = 0.03) as well as between verbal fluency and TT (β=-0.189, p = 0.006), FAI (β=-0.062, p = 0.03), FTS (β=-0.013, p = 0.008) and FTV (β=-0.012, p = 0.01). In men, FAI was positively associated with DSST performance (β = 0.103, p = 0.003). Longitudinally, higher FAI and FTV at baseline were associated with a less steep decline in DSST performance in men (β = 0.066, and β = 0.007, all p = 0.03). In women, declines in FAI and DSST scores were positively associated (β = 1.794, p = 0.03). Conclusions Our findings suggest sex-specific associations between testosterone levels and cognitive function in older adults. Higher testosterone levels were predominantly associated with better DSST performance in men, but with poorer visuo-construction and verbal fluency in women.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sixth Annual Symposium of the Midwest Aging Consortium","authors":"Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K Mccrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K Lebrasseur, Marissa J Schafer","doi":"10.1093/gerona/glaf280","DOIUrl":"https://doi.org/10.1093/gerona/glaf280","url":null,"abstract":"Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its inception in 2019, the Midwest Aging Consortium (MAC) has provided an engaging platform for aging researchers in the United States’ Midwest to connect, collaborate, and exchange ideas. The Sixth Annual Research Symposium of the MAC held at the Mayo Clinic in Rochester, Minnesota in April 2025 highlighted the continued impact of the MAC in bringing together aging researchers, including many trainees and early career investigators, into a collaborative environment. This record-setting event featured interdisciplinary research on key aging mechanisms, including lipid metabolism, mitochondrial dysfunction, stress response, cellular senescence, and immune adaptations across organ systems. New therapeutic concepts and clinical trial approaches were presented. Cutting-edge methodologies including single-cell and spatial transcriptomics, metabolomics, and organoid cultures, to dissect aging process in tissue-specific and systemic contexts also were presented. Overall, the MAC symposium underscored the translational potential of geroscience and reinforced the MAC’s mission to accelerate aging research through regional collaborations and innovation.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cumulative deficit frailty with brain age and Alzheimer's disease-related brain structure starting in late middle age.","authors":"Jack F V Hunt,Erik J Buchholz,Carol E Franz,Chandra A Reynolds,Matthew S Panizzon,McKenna E Williams,Tyler R Bell,Rongxiang Tang,Donald J Hagler,Nathan Gillespie,Jeremy A Elman,Michael C Neale,Stephen Dorros,Anders M Dale,William S Kremen,Christine Fennema-Notestine, ","doi":"10.1093/gerona/glaf283","DOIUrl":"https://doi.org/10.1093/gerona/glaf283","url":null,"abstract":"BACKGROUNDCumulative deficit frailty (CDF) is a syndrome characterized by the accumulation of negative physical, functional and psychosocial insults. Accumulation of CDF and changes in brain structure both occur during the transition to older age and are associated with the development of Alzheimer's disease (AD) and related dementias. However, how these phenomena are temporally related to each other during the aging process is not well understood.METHODSWe examined bidirectional relationships between CDF and brain structure using structural MRI-based brain-predicted age difference and an AD brain signature. Longitudinal MRI and questionnaire-based data were collected from men in the Vietnam Era Twin Study of Aging at three study waves (average ages 56, 62 and 68).RESULTSBest-fitting longitudinal random intercepts cross-lagged panel models support the strong overall association between CDF and brain structural integrity with significant covariance between random intercepts for CDF and brain-predicted age difference (r = 0.36, p < 0.001) and between CDF and AD brain signature (r=-0.16, p = 0.005) after controlling for chronological age, smoking, race/ethnicity and education. Significant bidirectional negative cross-lagged associations suggested attenuation over time of the association between CDF and non-specific brain aging (β's=-0.33 to -0.23, p < =0.012) but not between CDF and AD brain signature.CONCLUSIONSCDF was associated with age-related brain structure via strong time-invariant common variance as well as weaker across-time factors. By contrast, the association between CDF and AD-related brain structure was via moderate common variance and was not temporally dynamic. Together, this suggests that CDF is differentially associated with age-related and AD-related brain changes and may be a clinically relevant risk factor for pathological brain aging.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease.","authors":"Jessica E Rast,Andrea L Rosso,Bryan D James,Jack F G Underwood,Jacob Bergstedt,Viktor H Ahlqvist,Jakob Grove,Fang Fang,Neal D Goldstein,Giacomo Vivanti,Stephen Z Levine,Anna Nordström,Diana Schendel,Kristen Lyall,Peter Nordström,Marcel Ballin,Jean Stafford,Adam C Naj,Brian K Lee, ","doi":"10.1093/gerona/glaf281","DOIUrl":"https://doi.org/10.1093/gerona/glaf281","url":null,"abstract":"BACKGROUNDNeurodevelopmental conditions (NDC), including attention deficit/hyperactivity disorder (ADHD) and autism, are associated with increased rates of neurodegenerative diseases, including Alzheimer's disease and related dementias (ADRD) and Parkinson's disease. Such associations are unstudied in diverse populations and while controlling for a range of important covariates. The purpose of this study was to examine the association of ADRD and Parkinson's disease with NDCs in a diverse sample of adults.METHODSThis case-control study used data from the U.S. All of Us Research Program 2018-2023 from approximately 600,000 adults in the U.S. We matched on ADRD and Parkinson's disease status in order to examine the association of these conditions with NDCs.RESULTSNDC was more prevalent in ADRD cases than in non-ADRD controls (7.8% versus 2.4%) and among Parkinson's disease cases than non-Parkinson's disease controls (4.5% versus 1.8%). After adjustment for sex, age, education level, body mass index, cardiometabolic conditions, and psychiatric conditions, individuals with ADRD had significantly higher odds of having an NDC compared with controls (adjusted odds ratio, 2.68; 95% CI, 2.40-2.99). Similarly, Parkinson's disease cases had 2.09 times the odds of having an NDC as non-Parkinson's disease controls (95% CI 1.66, 2.59) in adjusted models.CONCLUSIONSAs the population of individuals with NDCs ages, and more older adults find themselves in the care of clinicians with experetise in ADRD and Parkinson's disease, it is imperative to understand the support needs of this population, and to provide targets for reducing ADRD prevalence in younger or middle adulthood.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"369 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain prevalence and pain management at the end of life: Regional and urban-rural differences from a national-representative survey of chinese older adults","authors":"Yaolin Pei, Xiang Qi, Zexi Zhou, Yifan Lou, Jing Wang, Yang Li, Bei Wu","doi":"10.1093/gerona/glaf282","DOIUrl":"https://doi.org/10.1093/gerona/glaf282","url":null,"abstract":"Background Effective pain management is essential for enhancing quality of life at the end of life. However, challenges persist globally, particularly in China, where palliative care remains underdeveloped. This study investigates pain prevalence and the associations between pain severity, place of death, and the quality of pain management among older adults in China, with a focus on regional and urban-rural disparities. Methods We used data from the 2014, 2016, 2018, and 2020 waves of the China Longitudinal Aging Social Survey. The final sample included 1,525 older adults who deceased during the study period. We conducted OLS regression analyses to examine the regional and rural-urban disparities in the associations between pain severity, place of death, and the quality of pain management. Results Severe pain at the end of life was reported for 42.6% of decedents. Severe pain and hospital death were associated with better quality of pain management. The association between hospital death and pain management quality was stronger in the Eastern region than in the Middle and Western regions. The associations between severe pain symptoms, place of death, and pain management quality were stronger in urban areas than in rural areas. The urban-rural disparities in pain management quality were stronger in the Eastern region than in the Middle and Western regions. Conclusions The regional and urban-rural disparities in end-of-life pain management in China highlight the urgent need to strengthen palliative care capacity in under-resourced and rural areas through equitable expansion of home- and community-based services and integrated medical insurance reforms.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICEBERG emergency room screening tool for early adverse outcome prediction in older patients admitted to acute care: a multi-center study.","authors":"Heike A Bischoff-Ferrari,Dai-Hua Tsai,Melanie Kistler-Fischbacher,E John Orav,Patricia Lanz,Katharina Geiling,Cathrine Klaghofer,Patrick Sidler,Uenal Can,Romano Steiner,Markus Minder,Bettina von Rickenbach,Ali Yildirim-Aman,Heinz Bruppacher,Michael Dietrich,Andreas Egli,Michael Gagesch,Gregor Freystaetter","doi":"10.1093/gerona/glaf270","DOIUrl":"https://doi.org/10.1093/gerona/glaf270","url":null,"abstract":"BACKGROUNDThe ICEBERG tool was initially validated in two small pilot studies to address the lack of a comprehensive geriatric screening tool in emergency settings. The present study builds on the second pilot study and extends it to a larger, multicentre sample.METHODSWe report results from a large ICBERG tool validation study across three emergency rooms (ERs) including 1,664 patients aged 70 years and older. The tool targets 9 domains and is administered by ER physicians or specialized nurses. To assess criterion validity-the extent to which ICEBERG scores are associated with relevant clinical outcomes-we compared patients who scored below versus above the median (< 10; ≥10) ICEBERG score for six key clinical outcomes: length of stay in acute care, nursing care in minutes, one-on-one nursing care, in-hospital mortality, discharge to nursing home, and re-admission within 30 days. Negative binomial regression was used for the outcomes length of stay and nursing care in minutes. Logistic regression was used for the other outcomes. All analyses were adjusted for age and sex.RESULTSPatients with ICEBERG scores of 10 or higher had significantly longer stays in acute care (8.9 vs. 6.6 days), required more nursing care (56.4 vs. 32.8 hours), had higher odds of one-on-one nursing care (Odds Ratio, OR = 2.85), in-hospital mortality (OR = 1.89), discharge to a nursing home (OR = 3.20) or being readmitted within 30 days (OR = 1.81).CONCLUSIONSBased on our findings the ICEBERG tool identifies older patients with a geriatric risk profile at ER on all key clinical outcomes tested.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Symptoms, Sleep Duration and Risk of Falls in Older Adult Women: Findings from the Study of Women's Health Across the Nation.","authors":"Jillian S Baker,Michelle M Hood,Leslie M Swanson,Christopher E Kline,Kelly R Ylitalo,Jane A Cauley,Robin R Green,Carrie A Karvonen-Gutierrez","doi":"10.1093/gerona/glaf249","DOIUrl":"https://doi.org/10.1093/gerona/glaf249","url":null,"abstract":"BACKGROUNDAs the leading cause of injury and injury-related death for older adults in the United States, falls can be consequential for function and mortality but are preventable. Sleep may be a modifiable risk factor for falls.METHODSData from 1,795 female participants of the multi-ethnic and community-based cohort Study of Women's Health Across the Nation (SWAN) were analyzed to examine whether frequent insomnia symptoms and shorter sleep duration are associated with an increased risk of falls or a greater number of falls. Sleep variables were measured at Visit 12 (2010-2011, analytic baseline). Insomnia symptoms were assessed through self-reported frequency of restless sleep, trouble falling asleep, and waking early and being unable to fall asleep again. Sleep duration was self-reported hours of sleep, dichotomized as fewer than <6 hours/night and ≥6 hours/night. At Visit 15 (2015-2016, analytic follow-up), participants reported the number of falls in the year prior. Log-binomial and multinomial logistic regression models were adjusted for demographic and socioeconomic factors and health conditions.RESULTSWomen who reported frequent (5+ times/week) trouble falling asleep and frequent waking in the middle of the night at baseline had a 30% increased risk (aRR = 1.30, 95% CI = 1.04, 1.62) and 24% increased risk (aRR = 1.24, 95% CI = 1.03, 1.49), respectively, of having fallen in the year prior at follow-up.Frequent trouble falling asleep and short sleep duration (<6 hours) were both associated with higher odds of falling three or more times vs. once or never prior to follow-up (aOR = 2.42, 95% CI = 1.26, 4.63; aOR = 1.77, 95% CI = 1.08, 2.93), respectively.CONCLUSIONSMultiple indicators of poor sleep, including trouble falling asleep, frequent waking, and short sleep duration, were associated with an increased risk of falling and odds of higher fall burden in older adult women. Promoting adequate, high-quality sleep may be an essential component in fall prevention.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-fat diet exacerbates skeletal muscle mass loss via Nrf2/Prdx6 pathway in sarcopenic obesity mice.","authors":"Danni Wang,Xinyue Zheng,Yang Zhu,Wen Zhang,Sujuan Liu,Yanmei Niu","doi":"10.1093/gerona/glaf271","DOIUrl":"https://doi.org/10.1093/gerona/glaf271","url":null,"abstract":"Sarcopenic obesity (SO), a dual condition characterized by the coexistence of sarcopenia and obesity, elevates the risk of metabolic disorders, disability, and mortality to magnitudes exceeding the combined risks of both conditions individually, demonstrating a \"super-additive impairment\" effect on health. Therefore, this study aims to investigate the mechanisms underlying the pathogenesis and progression of SO. We utilized natural aging mice fed high-fat diets (HFD) to simulate the progression of muscle mass decline observed in geriatric populations and high-calorie diets prevalent in modern societies, creating an SO animal model with exceptional clinical relevance. Our study demonstrates that HFD exacerbates age-related reductions in muscle mass, accompanied by decreased physical performance and increased lipid accumulation. Importantly, HFD-induced lipid infiltration emerges as a significant contributor to the further decline in skeletal muscle mass in SO mice, and the Nrf2/Prdx6 pathway is a mechanism regulating this factor. Aerobic exercise, a safe and reliable means for older adults, is particularly effective for fat loss and muscle maintenance. In our study, aerobic exercise effectively alleviated the detrimental effects of HFD on muscle health in aging mice. Mechanistic studies revealed that Nrf2 and Prdx6 protein expression was significantly suppressed in vivo by HFD and in vitro following palmitic acid (PA) exposure. Conversely, overexpression of Nrf2 and Prdx6 in vitro was able to mimic the protective effects of aerobic exercise. Our results indicate that the Nrf2/Prdx6 pathway plays a crucial role in counteracting muscle mass loss induced by HFD and may underlie beneficial effects of aerobic exercise on skeletal muscle.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}