Age-Related Cognitive Decline and Dementia: Interface of Microbiome-Immune-Neuronal Interactions

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2025-03-04 DOI:10.1093/gerona/glaf038

Santosh Kumar Prajapati, Shalini Jain, Hariom Yadav

{"title":"Age-Related Cognitive Decline and Dementia: Interface of Microbiome-Immune-Neuronal Interactions","authors":"Santosh Kumar Prajapati, Shalini Jain, Hariom Yadav","doi":"10.1093/gerona/glaf038","DOIUrl":null,"url":null,"abstract":"The microbiome plays a critical role in both promoting human health and contributing to diseases. Multiple emerging evidence shows that it contributes to aging and cognitive decline; however, the mechanisms are not fully understood. Changes in the microbiome and immune system occur with age, and immune functions are one of the key mechanisms linking the microbiome to the brain. Disrupted immunological balance may lead to neuroinflammation and blood-brain barrier dysfunction, contributing to cognitive decline. However, comprehensive knowledge regarding the types of microbiome and immune interactions influencing neuronal and cognitive health in aging remains largely unknown. This review presents evidence about the types of microbiome alterations associated with healthy versus unhealthy aging and how they interact with immune cells linked to neuronal and cognitive functions. It also explores whether and how microbiome modulators like probiotics, prebiotics, and postbiotics can be potential interventions to help preserve cognitive function in older adults.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"104 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/gerona/glaf038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The microbiome plays a critical role in both promoting human health and contributing to diseases. Multiple emerging evidence shows that it contributes to aging and cognitive decline; however, the mechanisms are not fully understood. Changes in the microbiome and immune system occur with age, and immune functions are one of the key mechanisms linking the microbiome to the brain. Disrupted immunological balance may lead to neuroinflammation and blood-brain barrier dysfunction, contributing to cognitive decline. However, comprehensive knowledge regarding the types of microbiome and immune interactions influencing neuronal and cognitive health in aging remains largely unknown. This review presents evidence about the types of microbiome alterations associated with healthy versus unhealthy aging and how they interact with immune cells linked to neuronal and cognitive functions. It also explores whether and how microbiome modulators like probiotics, prebiotics, and postbiotics can be potential interventions to help preserve cognitive function in older adults.

查看原文本刊更多论文

与年龄相关的认知衰退和痴呆：微生物组-免疫-神经元相互作用的界面

微生物组在促进人类健康和导致疾病方面发挥着关键作用。多项新证据表明，它会导致衰老和认知能力下降；然而，其机制尚不完全清楚。随着年龄的增长，微生物组和免疫系统会发生变化，而免疫功能是将微生物组与大脑联系起来的关键机制之一。免疫平衡被破坏可能导致神经炎症和血脑屏障功能障碍，从而导致认知能力下降。然而，关于微生物组的类型和免疫相互作用在衰老过程中影响神经元和认知健康的全面知识在很大程度上仍然未知。这篇综述提供了与健康和不健康衰老相关的微生物组改变类型的证据，以及它们如何与与神经元和认知功能相关的免疫细胞相互作用。它还探讨了微生物组调节剂如益生菌、益生元和后益生菌是否以及如何成为帮助保持老年人认知功能的潜在干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

自引率

0.00%

发文量