Association of plasma fatty acid profile with trajectory of multimorbidity and mortality: A community-based longitudinal study

Yang Li, Jiao Wang, Yuyang Miao, Michelle M Dunk, Silvia Maioli, Zhongze Fang, Qiang Zhang, Weili Xu
{"title":"Association of plasma fatty acid profile with trajectory of multimorbidity and mortality: A community-based longitudinal study","authors":"Yang Li, Jiao Wang, Yuyang Miao, Michelle M Dunk, Silvia Maioli, Zhongze Fang, Qiang Zhang, Weili Xu","doi":"10.1093/gerona/glaf031","DOIUrl":null,"url":null,"abstract":"Background Plasma fatty acids have been linked to various chronic diseases and mortality, but the extent to which fatty acids are associated with the trajectory of multimorbidity remains unclear. We investigated the association of fatty acid profile with multimorbidity trajectories and event-free survival. Methods Within the UK Biobank, 138,685 chronic disease-free participants were followed for up to 16 years. 17 plasma fatty acids were measured by nuclear magnetic resonance. A comprehensive healthy fatty acid score (HFAS) was constructed using LASSO regression. Incidence of chronic diseases and death were ascertained through linkages to medical and death records. Event-free survival was defined as survival without chronic diseases or death. Data were analyzed using a linear mixed-effects model, Cox regression, and Laplace regression. Results High HFAS was associated with lower risk of chronic diseases/death (hazard ratio [HR]: 0.907, 95% confidence interval [CI]: 0.888-0.925) and prolonged event-free survival time by 0.636 (95% CI: 0.500-0.774) years compared to low HFAS. High HFAS was also associated with a slower accumulation trajectory of multimorbidity (β: -0.042, 95% CI: -0.045 to -0.038). There was a significant multiplicative interaction between moderate-to-high HFAS and healthy lifestyle on chronic disease/death (P for interaction = 0.002) and multimorbidity accumulation trajectories (P for interaction<0.001). Conclusions A healthier plasma fatty acid metabolic profile is associated with a slower accumulation of multimorbidity and prolonged event-free survival time. A healthy lifestyle may strengthen the protective association of HFAS with the risk of chronic diseases/death and the accumulation trajectory of multimorbidity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"79 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/gerona/glaf031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background Plasma fatty acids have been linked to various chronic diseases and mortality, but the extent to which fatty acids are associated with the trajectory of multimorbidity remains unclear. We investigated the association of fatty acid profile with multimorbidity trajectories and event-free survival. Methods Within the UK Biobank, 138,685 chronic disease-free participants were followed for up to 16 years. 17 plasma fatty acids were measured by nuclear magnetic resonance. A comprehensive healthy fatty acid score (HFAS) was constructed using LASSO regression. Incidence of chronic diseases and death were ascertained through linkages to medical and death records. Event-free survival was defined as survival without chronic diseases or death. Data were analyzed using a linear mixed-effects model, Cox regression, and Laplace regression. Results High HFAS was associated with lower risk of chronic diseases/death (hazard ratio [HR]: 0.907, 95% confidence interval [CI]: 0.888-0.925) and prolonged event-free survival time by 0.636 (95% CI: 0.500-0.774) years compared to low HFAS. High HFAS was also associated with a slower accumulation trajectory of multimorbidity (β: -0.042, 95% CI: -0.045 to -0.038). There was a significant multiplicative interaction between moderate-to-high HFAS and healthy lifestyle on chronic disease/death (P for interaction = 0.002) and multimorbidity accumulation trajectories (P for interaction<0.001). Conclusions A healthier plasma fatty acid metabolic profile is associated with a slower accumulation of multimorbidity and prolonged event-free survival time. A healthy lifestyle may strengthen the protective association of HFAS with the risk of chronic diseases/death and the accumulation trajectory of multimorbidity.
血浆脂肪酸谱与多病和死亡率轨迹的关联:一项基于社区的纵向研究
血浆脂肪酸与多种慢性疾病和死亡率有关,但脂肪酸与多种疾病轨迹的关联程度尚不清楚。我们研究了脂肪酸谱与多病轨迹和无事件生存的关系。方法在英国生物银行中,138,685名无慢性疾病的参与者被随访了长达16年。采用核磁共振法测定17种血浆脂肪酸。采用LASSO回归构建健康脂肪酸综合评分(HFAS)。通过与医疗和死亡记录的联系,确定了慢性病的发病率和死亡率。无事件生存期定义为无慢性疾病或死亡的生存期。数据分析采用线性混合效应模型、Cox回归和拉普拉斯回归。结果与低HFAS相比,高HFAS与较低的慢性疾病/死亡风险相关(风险比[HR]: 0.907, 95%可信区间[CI]: 0.888-0.925),无事件生存时间延长0.636年(95% CI: 0.500-0.774)。高HFAS还与多病积累轨迹较慢相关(β: -0.042, 95% CI: -0.045至-0.038)。中至高HFAS与健康生活方式对慢性疾病/死亡(相互作用P = 0.002)和多病积累轨迹(相互作用P = 0.001)之间存在显著的乘法相互作用。结论:健康的血浆脂肪酸代谢谱与较慢的多病积累和延长的无事件生存时间相关。健康的生活方式可能会加强HFAS与慢性疾病/死亡风险和多重疾病积累轨迹的保护性关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信