The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献_第3页

Hair copper concentrations and cognitive performance in Mexican adults aged 50 and older. 50岁及以上墨西哥成年人头发铜浓度与认知能力的关系

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-04-06 DOI: 10.1093/gerona/glag093

Halle Cathey,David Hernández-Bonilla,Marlene Cortez-Lugo,Silvia Mejía-Arango,Rebeca Wong

{"title":"Hair copper concentrations and cognitive performance in Mexican adults aged 50 and older.","authors":"Halle Cathey,David Hernández-Bonilla,Marlene Cortez-Lugo,Silvia Mejía-Arango,Rebeca Wong","doi":"10.1093/gerona/glag093","DOIUrl":"https://doi.org/10.1093/gerona/glag093","url":null,"abstract":"BACKGROUNDPrevious epidemiological studies have examined the relationship between metal exposures and cognitive function in older adults. However, results regarding copper suggest that both deficient and excessive concentrations can be detrimental to cognitive function.METHODSThis cross-sectional study analyzed the association between hair copper concentrations and cognitive function in 2,371 Mexican adults aged 50 and older from the 2018 Mexican Health and Aging Study. An adapted version of the Cross-Cultural Cognitive Examination, referred to as the cognitive battery, was used to assess cognitive function. Hair copper concentrations were determined by inductively coupled plasma mass spectrometry and divided into approximately normally distributed (0.05 to 20.95 µg/g, 91% of the cohort) and high-concentration (>21.11 µg/g, 9% of the cohort) groups.RESULTSLinear regression revealed a positive association between raw cognitive scores and normally distributed copper concentrations (βstd = 0.04; 95% CI [0.01, 0.07]) after adjusting for sociodemographic, health, and environmental factors. Post hoc analysis revealed that socioeconomic status moderates the association between copper and cognitive performance.CONCLUSIONSThe findings suggest that normally distributed copper concentrations were associated with better cognitive performance, and this effect is specific to the medium socioeconomic level after controlling for covariates. Further studies are needed to confirm the beneficial relationship between copper and cognition and to explore which aspects of socioeconomic status may moderate the effects of copper and other metal exposures.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative Impact of Multidomain Lifestyle Interventions on Deficit Accumulation Frailty Over 24 Months in the U.S. POINTER Trial. 在美国POINTER试验中，多领域生活方式干预对24个月赤字积累虚弱的相对影响。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-04-06 DOI: 10.1093/gerona/glag094

Mark A Espeland,KayLoni Olson,Christy C Tangney,Darren R Gitelman,MaryJo Cleveland,Amber A Thro,Yitbarek N Demesie,Heather M Snyder,Rachel A Whitmer,Pankaja Desai,Rifat Alam,Lucia Crivelli,Thomas M Holland,Olivia Preissle,Rema Raman,Michele K York,Laura D Baker,

{"title":"Relative Impact of Multidomain Lifestyle Interventions on Deficit Accumulation Frailty Over 24 Months in the U.S. POINTER Trial.","authors":"Mark A Espeland,KayLoni Olson,Christy C Tangney,Darren R Gitelman,MaryJo Cleveland,Amber A Thro,Yitbarek N Demesie,Heather M Snyder,Rachel A Whitmer,Pankaja Desai,Rifat Alam,Lucia Crivelli,Thomas M Holland,Olivia Preissle,Rema Raman,Michele K York,Laura D Baker, ","doi":"10.1093/gerona/glag094","DOIUrl":"https://doi.org/10.1093/gerona/glag094","url":null,"abstract":"BACKGROUNDMultidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with increased mortality and chronic disease risk but the degree to which multidomain lifestyle changes impact frailty is not clear.METHODSThe U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) was a 2-year randomized clinical trial to compare two multidomain lifestyle interventions designed to increase exercise, improve diet, and promote social and cognitive stimulating activities and health monitoring. The Structured intervention incorporated greater structure, intensity, and accountability than the Self-Guided intervention. A modified FI (mFI) was developed from data collected at baseline, 12, and 24 months.RESULTSThe trial enrolled 2,111 adults (ages 60-79 years) who were at increased risk for accelerated cognitive decline. At 24 months, the mean (standard error) changes from baseline of a 31-component mFI were -0.009 (0.002) for Self-Guided and -0.024 (0.002) for Structured participants, a difference averaging -0.014 [-0.019, -0.008] (p < 0.0001). Group differences were similar across subgroups based on age, sex, body mass index, diabetes, and baseline mFI. Changes in mFI did not account for the relative cognitive benefits provided by the Structured intervention compared to the Self-Guided intervention.CONCLUSIONSMultidomain lifestyle interventions may decrease frailty and slow aging processes with greater structure and intensity resulting in greater benefits.CLINICALTRIALS.GOV IDENTIFIERClinicalTrials.gov Identifier: NCT03688126.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty Phenotype in Adults with Sickle Cell Disease. 成人镰状细胞病的脆弱表型。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-04-02 DOI: 10.1093/gerona/glag091

Charity I Oyedeji,Rania E Mohamed,Richard Faldowski,Teagan Callaway,Tamara Poole,Francyess Denis Oliva,Veronica Mathis,Arvind Subramaniam,Heather Whitson,Bryce B Reeve,Carl Pieper,Marilyn J Telen,Allison Ashley-Koch,Harvey J Cohen,Katherine Hall,John J Strouse

{"title":"Frailty Phenotype in Adults with Sickle Cell Disease.","authors":"Charity I Oyedeji,Rania E Mohamed,Richard Faldowski,Teagan Callaway,Tamara Poole,Francyess Denis Oliva,Veronica Mathis,Arvind Subramaniam,Heather Whitson,Bryce B Reeve,Carl Pieper,Marilyn J Telen,Allison Ashley-Koch,Harvey J Cohen,Katherine Hall,John J Strouse","doi":"10.1093/gerona/glag091","DOIUrl":"https://doi.org/10.1093/gerona/glag091","url":null,"abstract":"BACKGROUNDPeople with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty is characterized by decreased physiologic reserve and increased vulnerability to stressors that can lead to disability and death. The purpose of this study was to evaluate frailty phenotype in adults with SCD and identify factors associated with frailty.METHODSFrailty was defined by meeting ≥3 of the following criteria: slowness, weakness, weight loss, low physical activity, and exhaustion. Participants meeting 1-2 criteria were prefrail and 'robust' if no criteria were present.RESULTSWe analyzed frailty in 137 adults (age ≥18) with SCD in a single-center cross-sectional study (mean age 45; range 19-82). Three (2%) participants were frail, 47% prefrail, and 51% robust. Compared to robust, frail/prefrail participants were more likely to have emergency department visits in the past year (66% vs 46%; p < 0.02), hypertension (42% vs 19%; p < 0.003), diabetes (16% vs 4%; p < 0.02), more SCD complications (2.8 vs 2.1; p < 0.02), and significantly worse socioeconomic status, cognitive function, depression, physical function, and disability in activities of daily living.CONCLUSIONSThe prevalence of prefrailty in this sample of young and predominantly middle-aged adults with SCD was similar to older adults in the general population, further supporting that accelerated aging occurs in this population and emphasizing the need for early identification and initiation of interventions to prevent and attenuate frailty in SCD. In future studies we will evaluate SCD-specific cutpoints for frailty components that predict clinically meaningful outcomes.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice. 限时喂养可改善老年小鼠的代谢灵活性，促进衰老，减轻脂肪组织中的纤维炎症。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-30 DOI: 10.1093/gerona/glag085

Duraipandy Natarajan,Madison Milan,Zeke Reyff,Sharon Negri,Shoba Ekambaram,Rohan R Varshney,Michael C Rudolph,Stefano Tarantini,Priya Balasubramanian

{"title":"Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice.","authors":"Duraipandy Natarajan,Madison Milan,Zeke Reyff,Sharon Negri,Shoba Ekambaram,Rohan R Varshney,Michael C Rudolph,Stefano Tarantini,Priya Balasubramanian","doi":"10.1093/gerona/glag085","DOIUrl":"https://doi.org/10.1093/gerona/glag085","url":null,"abstract":"Adipose dysfunction contributes to age-related systemic decline primarily through its adverse effects on energy metabolism, insulin sensitivity, circulating adipokines, and inflammation. Time-restricted feeding (TRF) has emerged as a promising approach to correct adipose and metabolic dysfunction. However, most of these studies were carried out in young animals. Whether TRF could exert similar beneficial effects in the adipose tissue during aging remains unknown. To address this, 18-month-old C57BL/6 mice were placed on either a TRF diet (food intake restricted to a 6-hour time window every day in the dark phase) or an unrestricted diet for 6 months. Young animals on an unrestricted diet acted as additional controls to compare the effects of aging. Here, we demonstrate that a 6-month TRF regimen induces a biphasic pattern in whole-body energy metabolism characterized by a selective increase in energy expenditure and oxygen consumption during the active dark phase, aligning with the feeding schedule. TRF increased uncoupling protein 1 (UCP1) expression in the white adipose tissue (WAT) and reverses age-associated whitening of brown adipose tissue (BAT) in aged mice. In addition, TRF selectively enhances mitochondrial metabolism in WAT depots. Furthermore, TRF reduces macrophage infiltration, induces a favorable shift in macrophage polarization (lower M1/M2 ratio), and decreases fibrosis in adipose tissue. Overall, our findings indicate that TRF promotes a metabolically beneficial adipose phenotype characterized by beiging and reduced fibro-inflammation during aging. These results underscore the potential of TRF as a dietary intervention to mitigate adipose dysfunction and promote metabolic health in the aging population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Predictors of Resilience following Total Knee Arthroplasty: the PRIME-KNEE Study. 全膝关节置换术后恢复力的临床预测因素：PRIME-KNEE研究。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-30 DOI: 10.1093/gerona/glag086

Cathleen S Colón-Emeric,Sarah Peskoe,Marissa C Ashner,Virginia B Kraus,Janet L Huebner,Katherine S Hall,Patrick Smith,Jody A Feld,Leah C Acker,Heather E Whitson

{"title":"Clinical Predictors of Resilience following Total Knee Arthroplasty: the PRIME-KNEE Study.","authors":"Cathleen S Colón-Emeric,Sarah Peskoe,Marissa C Ashner,Virginia B Kraus,Janet L Huebner,Katherine S Hall,Patrick Smith,Jody A Feld,Leah C Acker,Heather E Whitson","doi":"10.1093/gerona/glag086","DOIUrl":"https://doi.org/10.1093/gerona/glag086","url":null,"abstract":"BACKGROUNDWe aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasible measures predicting recovery.METHODSProspective cohort study in a single academic medical center. Adults ≥60 years (n = 203) scheduled for elective TKA had preoperative assessments of physical reserve (3-minute walk test, grip strength), psychological reserve (PHQ-9, Resilience Scale), social support (emotional support scale, financial resource sufficiency, education level), and cognitive reserve (3MS, Trail Making Test Part B, Digit Symbol Substitution Test, 15-item recall). Provocative tests with experimental stressors included dual task gait speed, and functional near infrared spectroscopy (fNIRS). Outcomes were the PROMIS pain scales, the Lower Extremity Gain Scale, and average daily step counts measured at postoperative day 1-7 and months 1, 2, 4 and 6. Latent class trajectory analysis defined common recovery patterns for each outcome.RESULTSFor each outcome, 3-4 recovery trajectory groups were defined. Overall, 7% of participants were in the highest recovery group in all 4 outcomes and 20% in the lowest for all outcomes. Pre-operative depression score, cognitive tests, emotional support scale, 3-minute walk distance, and grip strength were significantly different across resilience groups in multiple outcomes. Provocative tests were not predictive of recovery.CONCLUSIONSRecovery trajectories after TKA are predicted by physical, cognitive, and psychological reserve measures. Results inform future resilience research and may allow for shared decision-making and targeted preoperative optimization.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composition of Gut Microbiota and Renal Transcriptome Fluctuate with Age: Midlife Represents a Key Transitional Point. 肠道微生物群和肾脏转录组的组成随年龄波动：中年是一个关键的过渡点。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-28 DOI: 10.1093/gerona/glag084

Lu Zeng,Lei Chen,Limin Wei,Jie Li,Shanshan Liang,Jiang Hongli,Fanfan Gao

{"title":"Composition of Gut Microbiota and Renal Transcriptome Fluctuate with Age: Midlife Represents a Key Transitional Point.","authors":"Lu Zeng,Lei Chen,Limin Wei,Jie Li,Shanshan Liang,Jiang Hongli,Fanfan Gao","doi":"10.1093/gerona/glag084","DOIUrl":"https://doi.org/10.1093/gerona/glag084","url":null,"abstract":"Human aging is associated with declining renal function, potentially worsened by gut microbiota-derived uremic toxins. Although the gut-kidney axis is implicated in disease, its dynamic role in physiological aging remains unclear. Through integrated 16S rDNA and transcriptomic analyses in young (3-month), middle (12-month), and old-aged (24-month) mice, we identified age-dependent shifts in gut microbiota and renal gene expression. The shifts are non-linear, with midlife (12 months) representing a key transitional point. The gut microbiota shifts from a commensal metabolic partner in youth to a driver of a pro-inflammatory microenvironment in old age. Concurrently, the kidney shows enhanced inflammatory, pro-fibrotic, and pro-coagulant transcriptional signatures. These changes are synchronized, revealing a stage-specific gut-kidney interplay: an adaptive peak in midlife precedes a coordinated functional shift toward a pro-aging microenvironment in late life. Our findings introduce the concepts of \"stage-specific aging\" and aging changes in both gut microbiota and kidney transcriptome are non-linear, midlife is an important stage for gut-kidney aging transit.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia. 在没有痴呆的老年人中，睡眠结构和自我报告的睡眠质量与阿尔茨海默病的生物标志物有关。

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-23 DOI: 10.1093/gerona/glag081

Sofia Liu,Jing Huang,Russell Calderon,Adam P Spira,Miranda V Mcphillips,Nalaka Goonertne,Jessica Gill,Junxin Li

{"title":"Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia.","authors":"Sofia Liu,Jing Huang,Russell Calderon,Adam P Spira,Miranda V Mcphillips,Nalaka Goonertne,Jessica Gill,Junxin Li","doi":"10.1093/gerona/glag081","DOIUrl":"https://doi.org/10.1093/gerona/glag081","url":null,"abstract":"BACKGROUNDSleep disruption is common in older adults and is a significant risk factor for developing Alzheimer's disease (AD). This study examines the association between self-reported sleep quality, actigraphy- and electroencephalogram (EEG)-measured sleep parameters, and plasma amyloid-tau-neurodegeneration (ATN) biomarkers in older adults without dementia.METHODSWe analyzed baseline data from a randomized controlled trial of 103 sedentary community-dwelling older adults with insomnia symptoms but without dementia. Participants completed the Pittsburgh Sleep Quality Index (PSQI) and wrist actigraphy, provided blood samples for plasma biomarkers assays (amyloid-beta [Aβ] 42, Aβ40, Aβ42/40 ratio, total tau, and neurofilament light [NfL]), and a subsample (n = 56) underwent two-night ambulatory EEG. Multiple regression models tested associations between sleep measures and plasma ATN biomarkers.RESULTSParticipants averaged 70.0 ± 6.0 years old, and 80.6% were female. Adjusted analyses showed greater rapid eye movement (REM) sleep percentage was associated with lower Aβ40 (β = -0.018; 95% confidence interval [CI] = -0.027, -0.010) and higher Aβ42/40 ratio (β = 0.016; 95% CI = 0.007, 0.025). Higher PSQI scores were nominally associated with higher Aβ42 (β = 0.017, 95% CI = 0.004, 0.031) and NfL (β = 0.034, 95% CI = 0.007, 0.062), but these associations did not sustain false discovery rate correction.CONCLUSIONSGreater REM sleep was associated with a more favorable plasma amyloid profile, whereas associations between subjective sleep quality and plasma biomarkers were nominal and require confirmation in larger studies. These findings suggest that REM sleep architecture measured using ambulatory EEG may be particularly sensitive to amyloid-related changes prior to dementia.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"25 8-9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptom-based indicators of autonomic dysfunction and their bidirectional associations with Parkinson’s disease incidence and adverse outcomes 自主神经功能障碍的症状指标及其与帕金森病发病率和不良结局的双向关联

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-21 DOI: 10.1093/gerona/glag077

Tianmi Yang, Qianqian Wei, Dejiang Pang, Yangfan Cheng, Jingxuan Huang, Junyu Lin, Yi Xiao, Qirui Jiang, Shichan Wang, Jiyong Liu, Sirui Zhang, Yuanzheng Ma, Chunyu Li, Huifang Shang

{"title":"Symptom-based indicators of autonomic dysfunction and their bidirectional associations with Parkinson’s disease incidence and adverse outcomes","authors":"Tianmi Yang, Qianqian Wei, Dejiang Pang, Yangfan Cheng, Jingxuan Huang, Junyu Lin, Yi Xiao, Qirui Jiang, Shichan Wang, Jiyong Liu, Sirui Zhang, Yuanzheng Ma, Chunyu Li, Huifang Shang","doi":"10.1093/gerona/glag077","DOIUrl":"https://doi.org/10.1093/gerona/glag077","url":null,"abstract":"Background Symptom-based indicators suggestive of autonomic dysfunction are common but under-recognized in Parkinson’s disease (PD), with potential implications as a biomarker of aging for early detection and prognosis. We aimed to examine the associations between autonomic dysfunction and PD in a large, population-based cohort. Methods We analysed 374,657 UK Biobank participants free of PD at baseline. Autonomic symptoms—including orthostatic hypotension, constipation, urinary and sexual dysfunction, hyperhidrosis, and other autonomic disorders—was identified via hospital records. Incident PD and subsequent outcomes, including dementia and all-cause mortality, were tracked through June 2023. Cox models estimated hazard ratios for PD and adverse outcomes, and conditional logistic regression assessed the temporal trajectory of autonomic dysfunction relative to PD diagnosis. Results Over a median 14.1-year follow-up, 2,568 participants developed PD. Orthostatic hypotension (HR, 2.91; 95% CI, 1.39 to 6.13), constipation (HR, 1.63; 95% CI, 1.19 to 2.24), urinary dysfunction (HR, 1.45; 95% CI, 1.04 to 2.02), and sexual dysfunction (HR, 3.56; 95% CI, 1.60 to 7.95) independently predicted PD risk. Pre- and post-diagnostic autonomic dysfunction were associated with higher risk of PD dementia and mortality. Autonomic dysfunction was detectable over 10 years before PD diagnosis (OR, 4.46; 95% CI, 3.76 to 5.29), with the strongest association observed within 5 years after PD onset (OR, 8.59; 95% CI, 7.58 to 9.74). Conclusions Symptom-based indicators suggestive of autonomic dysfunction serve as early clinical signals and robust prognostic markers in PD, highlighting their potential utility for early risk stratification and long-term patient management in large population-based settings.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"49 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice 慢性雷帕霉素治疗以性别依赖的方式减轻UM-HET3小鼠的年龄相关运动缺陷

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-21 DOI: 10.1093/gerona/glag070

Rashmi Singh, Vanessa Elia Calderon, Holstein Deborah, Vivian Diaz, Paul Anthony Martinez, Veronica Galvan, Martin Javors, Elizabeth Fernandez, James Lechleiter, Randy Strong

{"title":"Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice","authors":"Rashmi Singh, Vanessa Elia Calderon, Holstein Deborah, Vivian Diaz, Paul Anthony Martinez, Veronica Galvan, Martin Javors, Elizabeth Fernandez, James Lechleiter, Randy Strong","doi":"10.1093/gerona/glag070","DOIUrl":"https://doi.org/10.1093/gerona/glag070","url":null,"abstract":"Interventions Testing Program identified rapamycin as a robust lifespan-extending agent at multiple testing sites and in both sexes, with particularly strong effects in females, making it a leading candidate in aging research. We used genetically heterogeneous UM-HET3 mice of both sexes to determine whether rapamycin can prevent or delay age-sensitive traits. Mice were supplemented with microencapsulated rapamycin at 14 ppm starting at 12 months of age. Chronic rapamycin supplementation prevented the age-related decline in motor function, with females benefiting more than males. We further determined that rapamycin attenuated the age-related increase in protein carbonyls, principally in the insoluble protein fraction of brain regions that subserve motor function. We also found increased protein expression of glial fibrillary acidic protein (GFAP) across several brain regions, surprisingly, rapamycin treatment further increased GFAP levels in the striatum of both sexes, however this increase is not supporting evidence for a decrease in oxidative stress. Age-related increase in ER stress has been reported to be associated with increased protein carbonyls. We observed that rapamycin reduced the expression of C/EBP homologous protein (CHOP), a marker of ER stress-mediated apoptosis, in the striatum region of female mice. Our data show a novel beneficial effect of rapamycin on age-related motor deficits that is not sex-specific and that these changes are associated with reduction in protein carbonyls in brain regions linked to motor function. Furthermore, our results are consistent with the idea that rapamycin’s beneficial effects are mediated, at least in part, by reducing oxidative stress and ER stress-mediated apoptosis.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Perspectives and Emerging Directions in Research and Practice: Highlights from the 15th Annual International Workshop on Aging and HIV 研究与实践的当前观点和新兴方向：第15届老龄化与艾滋病毒国际研讨会的亮点

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2026-03-20 DOI: 10.1093/gerona/glag082

Jun Y Byun, Raymond Jones, Evelyn Iriarte, Casey D Xavier Hall, Kristen D Krause, Crystal X Wang, Savita Pahwa, Jennifer O Lam, Julian Falutz, Mary Clare Masters, Michael Corley, Catia Marzolini, Meredith Greene, Jaime Vera, Eugenia L Siegler, Joseph B Margolick, Ronald J Ellis, Scott Letendre, David J Moore

{"title":"Current Perspectives and Emerging Directions in Research and Practice: Highlights from the 15th Annual International Workshop on Aging and HIV","authors":"Jun Y Byun, Raymond Jones, Evelyn Iriarte, Casey D Xavier Hall, Kristen D Krause, Crystal X Wang, Savita Pahwa, Jennifer O Lam, Julian Falutz, Mary Clare Masters, Michael Corley, Catia Marzolini, Meredith Greene, Jaime Vera, Eugenia L Siegler, Joseph B Margolick, Ronald J Ellis, Scott Letendre, David J Moore","doi":"10.1093/gerona/glag082","DOIUrl":"https://doi.org/10.1093/gerona/glag082","url":null,"abstract":"The 15th Annual International Workshop on Aging and HIV (October 24-25, 2024) centered on integrating aging-related science into HIV research and care and aimed to advance interdisciplinary exchange and identify actionable priorities for research and practice. This manuscript summarizes keynote presentations on geroscience-informed aging mechanisms; clinical manifestations of aging with HIV, including frailty, neurocognitive impairment, and perinatally acquired HIV; polypharmacy; scalable geriatric-HIV care models and implementation; and career development. It identifies priorities for advancing the field, including geroscience-informed trials, frailty and cognitive screening, deprescribing, scalable geriatric-HIV care models, and research addressing aging challenges in perinatally acquired HIV.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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