Sultan Qaboos University Medical Journal最新文献

18^th Asian Federation of Sports Medicine Congress cum 8^th ISN international Sports Medicine & Sports Science Conference: Sabah International Convention Centre, Kota Kinabalu, Sabah, Malaysia, 26-28 April 2024. 第 18 届亚洲运动医学联合会大会暨第 8 届 ISN 国际运动医学与运动科学大会：2024 年 4 月 26-28 日，马来西亚沙巴州哥打基纳巴卢沙巴国际会议中心。

Sultan Qaboos University Medical Journal Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.18295/squmj.8.2024.049

引用次数: 0

Blastic Plasmacytoid Dendritic Cell Neoplasm. 疱性类浆细胞树突状细胞肿瘤

Sultan Qaboos University Medical Journal Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.18295/squmj.6.2024.036

Dmitry V Kravchenko, Dmitry A Zinovkin, Denis A Davydov, Pavel G Kisialeu, Pavel A Kopschaj, Oleg Savchenko, Mariya Savchenko, Maryna V Barauniova, Anna S Portyanko, Md Zahidul Islam Pranjol

引用次数: 0

Re: Efficacy and Safety of Vildagliptin and Remogliflozin as Add-on Therapy to Metformin in Patients of Type 2 Diabetes Mellitus. 关于维达列汀和雷莫格列净作为二甲双胍附加疗法对 2 型糖尿病患者的疗效和安全性。

Sultan Qaboos University Medical Journal Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.18295/squmj.8.2024.050

Hunain Raza, Muhammad E Bhutta, Muhammad H Siddique

引用次数: 0

A Case of Mirizzi Syndrome with Pancreatic Divisum 一例米利兹综合征并发胰腺憩室的病例

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.047

Divya Muthuvel, Anita Soundarapandian

引用次数: 0

Short-term Weight Loss Outcomes of 104 Mini Gastric Bypass or One Anastomosis Gastric Bypass Operations 104 例迷你胃旁路手术或单次吻合胃旁路手术的短期减肥效果

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.045

Nabaz H Ismael, N. Shabila

{"title":"Short-term Weight Loss Outcomes of 104 Mini Gastric Bypass or One Anastomosis Gastric Bypass Operations","authors":"Nabaz H Ismael, N. Shabila","doi":"10.18295/squmj.7.2024.045","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.045","url":null,"abstract":"Objectives: This study aimed to examine the short-term effects of Mini gastric bypass (MGB) or one anastomosis gastric bypass (OAGB) procedures on weight loss in individuals with obesity. Methods: This retrospective study was conducted in Iraq from January 2019 to May 2020. 104 patients with obesity underwent MGB or OAGB surgery in a single center in Iraq. Preoperative body mass index (BMI), age, height, and preoperative weight were recorded as baseline measures. Weight-related changes were evaluated during a follow-up phase of 48 weeks. Results: The mean baseline parameters of the subjects before surgery included 1.64 meters for height, 122.9 kg for weight, and 45.6 kg/m² for BMI. During the 48-week follow-up period, there was a substantial reduction in mean weight, which dropped from 122.9 kg at baseline to 75.5 kg at week 48. The weight change (in percentage) gradually increased from -11.8% at week 12 to -37.9% at week 48, without statistically significant association with demographic factors or chronic diseases. From week 12 to week 48, the percentage of excess weight loss (%EWL) increased substantially from 26.8% to 86.1%. The results of the subgroup analysis indicated that the %EWL was considerably higher among those aged 30 or older at week 36 and singles at week 48. Conclusion: The results of this study illustrate the efficacy of MGB or OAGB procedures in significantly reducing weight in the short term. The %EWL increased with the follow up time and it was significantly associated with age and marital status.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Autoimmune Profiles of Omani Patients with True Versus False Positive Autoimmune Encephalitis Antibodies Panels 自身免疫性脑炎抗体面板真假阳性的阿曼患者的临床和自身免疫特征

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.046

Ahmed Al-Qassabi, Haifa Al-Abri, Mahmood Al Kindi, Abdullah Al-Asmi, Jalila Alshekaili, Said Al Farsi, Rawan Al Hinai, Ikram Al Lawati, A. Gujjar

{"title":"Clinical and Autoimmune Profiles of Omani Patients with True Versus False Positive Autoimmune Encephalitis Antibodies Panels","authors":"Ahmed Al-Qassabi, Haifa Al-Abri, Mahmood Al Kindi, Abdullah Al-Asmi, Jalila Alshekaili, Said Al Farsi, Rawan Al Hinai, Ikram Al Lawati, A. Gujjar","doi":"10.18295/squmj.7.2024.046","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.046","url":null,"abstract":"The incidence of autoimmune encephalitis (AE) is rising due to increased awareness of the condition and detection of new autoantibodies. Coinciding with this rise are false positive autoantibodies without clinical correlates. Objective: To explore the clinical profiles of Omani patients who are truly positive for AE autoantibodies and compare them with those with false-positive autoantibodies. Methods: We reviewed the medical records of all patients who tested positive for AE antibody from May 2016 to December 2022. Cases were verified by three neurologists based on the existing criteria for AE. Results: The participants comprised N = 67 patients, 19 (28%) of whom fulfilled the criteria for AE. True-positive AE patients were younger with mean age of 35.3 ± 4.7 years (p = 0.010). They were also more likely to present with subacute memory disturbances (6/19; 32%; p = 0.030), seizures (12; 63%; p = 0.028), abnormal electroencephalogram (EEG) findings (10; 65%; p = 0.040), and abnormal signals in limbic region on magnetic resonance imaging (MRI) (5; 26%; p = 0.010). Subacute memory disturbance was a significant predictor for true positivity (OR = 17.807, 95%CI = 1.608–197.202; p = 0.019). Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis was the most frequent type of AE (8; 42.1%), followed by anti-glutamic acid decarboxylase 65 (GAD65) (4; 21.1%). Conclusion: Of the 67 cases with positive AE autoantibody panel, 48 (72%) were false-positive. The presence of subacute memory impairment was a significant predictor of AE. Anti-NMDAR encephalitis was the most frequent AE encountered in our cohort.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bloodstream Infection in Children Managed at a Tertiary Hospital in Oman 阿曼一家三级医院收治的儿童血流感染病例

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.044

Nadiya Al Saeghi, Marwah Al Thuhli, Hajer Al Hamrashi, Naema Al Shibli, Adil Al Wahaibi, Badriya Al Adawi, Laila S. Al Yazidi

{"title":"Bloodstream Infection in Children Managed at a Tertiary Hospital in Oman","authors":"Nadiya Al Saeghi, Marwah Al Thuhli, Hajer Al Hamrashi, Naema Al Shibli, Adil Al Wahaibi, Badriya Al Adawi, Laila S. Al Yazidi","doi":"10.18295/squmj.7.2024.044","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.044","url":null,"abstract":"Objectives: Little is known about bloodstream infection (BSI) among children in Oman. This study was done to assess the local epidemiology and outcome of BSI among Omani children. Methods: A retrospective study of laboratory-confirmed BSI was conducted among children (0 -12 years) managed at Sultan Qaboos University Hospital, Oman, over a 5-year period (2014-2018). Patients’ demographic, clinical, and laboratory data were extracted from the hospital’s electronic records and were used to assess BSI rates and outcome. Results: A total of 1253 positive blood cultures were identified of which 592 (47.2%) were regarded as contaminants. Overall, 404 (32.2%) significant episodes of BSI were identified in 272 patients of whom 346 (85.6%) were ≤ 5 years of age and 366 (90.6%) had comorbidities. The 5-years incidence of BSI was 13 per 1000 admissions. Three hundred and thirty-three (82.4%) episodes were healthcare-related infections. Enterobacterales (152; 37.6%) were the most common organisms identified followed by coagulase-negative staphylococci (63; 15.5%). About 40% of Gram-negative organisms were resistant to 3rd generation cephalosporins. The crude mortality rate at 30 days was 9.2%. Pediatric Intensive Care Units admission (COR = 2.24, 95% CI: 0.98-4.78) and the presence of Graft-Versus-Host Disease (COR = 7.99, 95% CI: 1.52-37.76) were associated with increased death within 30 days. The multivariate logistic regression analysis showed that Pseudomonas aeruginosa (AOR = 18.46, 95% CI: 3.96-97.84) was the only independent predictor of increasing 30-day mortality in this cohort. Conclusions: This study found a high rate of hospital-related BSI in children in Oman. This highlights the need to optimize infection control strategies and the care of central vein access devices.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immuno-Informatics Insight into Relationship Between Cholesterol and Cytokines in Cutaneous Leishmaniasis 免疫信息学揭示皮肤利什曼病中胆固醇与细胞因子之间的关系

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.043

Evan H. Sulaiman, L. J. Mohammad, Allaa H. Thanoon, Isaac Karimi

{"title":"Immuno-Informatics Insight into Relationship Between Cholesterol and Cytokines in Cutaneous Leishmaniasis","authors":"Evan H. Sulaiman, L. J. Mohammad, Allaa H. Thanoon, Isaac Karimi","doi":"10.18295/squmj.7.2024.043","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.043","url":null,"abstract":"Objectives: The role of serum cholesterol and its interactions with cytokines in the pathophysiology of human cutaneous leishmaniasis (CL) is not known. This study was aimed to evaluate the correlation between serum total cholesterol (TC), very-low-density lipoprotein-cholesterol (VLDL-C), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides (TG), and cytokines including interleukin-10 (IL10), interleukin-12 (IL12), tumor necrosis factor-alpha (TNF-α), in CL. Moreover, we analyzed the cholesterol-cytokine network to shed light on the pathogenesis of CL. Methods: A case-control study including CL patients (n = 50) and control subjects (n = 25) ranging between 20-30 years old was conducted from December 2022 to March 2023. The serum samples were analyzed via commercial kits to detect the levels of TC, IL-10, IL-12, TNF-α, VLDL-C, LDL-C, HDL-C and TG. Computational efforts to dissect cholesterol-protein interaction networks was also employed using STITCH. Results: TC, HDL-C, and LDL-C levels were markedly lower (p =0.0001) in CL patients compared to those of control subjects, whereas IL10, IL12, TNF-α, VLDL-C and TG levels were higher in CL patients. Serum cholesterol did not exhibit a correlation with cytokines, however a significant correlation (r = 0.57; p = 0.026) was observed between IL12 and TNF-α. Within the cholesterol-protein network, cholesterol potentially interacted with IL10, connecting cholesterol to modules with immunological significance, including TARAF1, TARAF2, and TNFRSF1B, as well as IL10, IL10RA, and IL12RB1. Conclusion: This study showed alteration of lipid and lipoprotein in CL, and it introduced two immunological modules in CL which appreciates attention to the altered cholesterol-cytokine interaction network in CL.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Acute Carbon Monoxide Toxicity Mimicking Stroke and Successfully Managed with Hyperbaric Oxygen Therapy 一氧化碳急性中毒模拟中风的罕见病例，通过高压氧疗法成功治愈

Sultan Qaboos University Medical Journal Pub Date : 2024-07-25 DOI: 10.18295/squmj.7.2024.048

Yasser K Al Lawati, Darapanarayan Hazra, Awatif KA Al-Alawi, Suad Al Abri

{"title":"A Rare Case of Acute Carbon Monoxide Toxicity Mimicking Stroke and Successfully Managed with Hyperbaric Oxygen Therapy","authors":"Yasser K Al Lawati, Darapanarayan Hazra, Awatif KA Al-Alawi, Suad Al Abri","doi":"10.18295/squmj.7.2024.048","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.048","url":null,"abstract":"Acute carbon monoxide (CO) poisoning significantly impacts neurological function, stemming from incomplete combustion of carbon-containing materials, posing a substantial risk. Symptoms range from mild headaches to severe neurological complications, complicating diagnosis. Primary treatment involves supplemental oxygen via a nonrebreather mask. Hyperbaric oxygen therapy (HBOT), though debated, initiated within six hours, may enhance carboxyhemoglobin (CO-Hb) elimination and tissue oxygenation, even with decreased CO-Hb levels. Our report outlines the case of an elderly woman who arrived at the emergency department with symptoms initially suggestive of a cerebrovascular event. However, further history and examination revealed indications of acute CO poisoning, likely due to exposure to a charcoal-burning heater. Despite stable vital signs, her CO-Hb and lactates levels were high. Treatment with normobaric oxygen therapy resulted in some improvement, but significant neurological recovery was achieved with HBOT. This case represents the first documented instance of successful HBOT treatment for acute CO toxicity in Oman.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral Graves’ Orbitopathy in a patient with Marine-Lenhart Syndrome 一名马林-伦哈特综合征患者的单侧巴塞杜氏眼病

Sultan Qaboos University Medical Journal Pub Date : 2024-06-13 DOI: 10.18295/squmj.6.2024.038

Abdulla Alfutaisi, Alaa Osman, Zainab S Al Siyabi, Osama S Al Senani, Fatima Bahowairath, Ahmed Al Farqani, Sara K Al Rasbi

引用次数: 0