Spinal cordPub Date : 2026-04-23DOI: 10.1038/s41393-026-01202-4
Maria Ribeiro-Cunha, Margarida Rodrigues, Amiram Catz, Maria Teresa Roberto, Sandra I Vieira
{"title":"Translation, cross-cultural adaptation, and psychometric validation of the Spinal Cord independence measure version IV for European Portuguese.","authors":"Maria Ribeiro-Cunha, Margarida Rodrigues, Amiram Catz, Maria Teresa Roberto, Sandra I Vieira","doi":"10.1038/s41393-026-01202-4","DOIUrl":"https://doi.org/10.1038/s41393-026-01202-4","url":null,"abstract":"<p><strong>Study design: </strong>Longitudinal prospective cohort study.</p><p><strong>Objectives: </strong>This study aimed to translate, culturally adapt, and validate the Spinal Cord Independence Measure Version IV (SCIM-IV) for European Portuguese (EU-PT).</p><p><strong>Setting: </strong>Spinal Cord Injury (SCI) unit of a rehabilitation center in Portugal.</p><p><strong>Methods: </strong>The translation followed Beaton's guidelines and included cognitive debriefing by rehabilitation professionals. Psychometric validation complied with COSMIN standards, including internal consistency (Cronbach's α, item-total correlations), construct and structural validity, and responsiveness. Construct validity was tested via correlations with the motor domain of the Functional Independence Measure (FIM) and the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor scores. Confirmatory factor analysis was used to assess structural validity.</p><p><strong>Results: </strong>Sixty-six adults (81.8% male; median age 62.5 years) were assessed at admission and discharge during the subacute phase of SCI. The EU-PT version demonstrated strong semantic and conceptual equivalence. Cognitive debriefing improved the clarity and comprehension of the items. Internal consistency was high for the total scale (α = 0.86-0.91), although it was lower in the 'Respiration and Sphincter Management' subscale. Strong construct validity was supported by correlations with the motor FIM (r = 0.84-0.95) and motor scores (r = 0.63-0.77). Structural validity was suboptimal, particularly in the 'Respiration and Sphincter' domain. The scale was highly responsive (effect size=1.35) and correlated with functional gains (r = 0.77).</p><p><strong>Conclusions: </strong>The EU-PT SCIM-IV version exhibited strong linguistic and psychometric properties. This enables standardized assessment in EU-PT-speaking contexts and supports international collaboration in SCI rehabilitation research and training.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-16DOI: 10.1038/s41393-026-01200-6
Beyza Öztürk, Burak Tayyip Dede, Bülent Alyanak, Mustafa Hüseyin Temel, Mustafa Turgut Yıldızgören, Burcu Hazer, Fatih Bağcıer
{"title":"Digital awareness in spinal cord injury: content and sentiment analysis of the 100 most viewed YouTube videos","authors":"Beyza Öztürk, Burak Tayyip Dede, Bülent Alyanak, Mustafa Hüseyin Temel, Mustafa Turgut Yıldızgören, Burcu Hazer, Fatih Bağcıer","doi":"10.1038/s41393-026-01200-6","DOIUrl":"10.1038/s41393-026-01200-6","url":null,"abstract":"Cross-sectional, observational, and descriptive study. To analyze globally accessible videos and user comments retrieved via the YouTube Data API using the keyword “spinal cord injury.” Publicly available YouTube videos and comments. A total of 588 videos uploaded to YouTube over the past 15 years were screened. After exclusion of non-English content, disabled comments, duplicates, and irrelevant material, the 100 most-viewed videos were included. Video-level metadata and 15,619 user comments were extracted. Using deductive qualitative content analysis, two independent reviewers categorized videos into seven domains: general information, personal experience, daily living activities, treatment trials, exercise demonstrations, rehabilitation center presentations, and others. For text preprocessing and analysis, Python libraries (NLTK, TextBlob, WordCloud) were applied. Sentiment analysis was conducted using the Valence Aware Dictionary and Sentiment Reasoner (VADER). Descriptive statistics and sentiment trends were evaluated using IBM SPSS Statistics, Version 29.0. Most YouTube videos on spinal cord injury focused on general information and personal experiences. A significant rise in video numbers and engagement occurred between 2010 and 2020, followed by a decline after 2021. Positive sentiments predominated but declined over time, while neutral comments increased. Negative sentiments remained consistently low throughout all periods. User engagement with YouTube content on spinal cord injury is influenced by social and global factors, with content largely centered on narratives and general information. Future research should broaden to multiple platforms and incorporate demographic and geographic factors to guide effective digital health communication strategies.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"416-422"},"PeriodicalIF":2.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-15DOI: 10.1038/s41393-026-01199-w
Julio C. Furlan, Di Wang, Dilnur Kurban
{"title":"Effects of concomitant traumatic brain injury on the epidemiology, access to treatment services and outcomes after traumatic spinal cord injury: A retrospective cohort study","authors":"Julio C. Furlan, Di Wang, Dilnur Kurban","doi":"10.1038/s41393-026-01199-w","DOIUrl":"10.1038/s41393-026-01199-w","url":null,"abstract":"Retrospective cohort study. To assess the impact of concomitant traumatic brain injury (TBI) on demographic data, injury characteristics, management choices, access to optimal care, and clinical, neurological and functional outcomes after acute traumatic spinal cord injury (tSCI). 18 acute care centers and 12 rehabilitation facilities across Canada. Data for the study was selected from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) from 2004 to 2020 in Canada. The tSCI-alone group was compared with the tSCI+TBI group regarding injury epidemiology, management, and outcomes post-tSCI. There were 966 individuals with tSCI+TBI and 3520 individuals with tSCI alone. The latter included older and more predominantly White individuals who typically sustained a less severe tSCI, less often at cervical levels due to falls. While need for surgical spinal cord decompression and spine stabilization was more common in the tSCI-alone group (p = 0.0087), mechanical ventilation was more often required in the tSCI+TBI group (p < 0.0001). In-hospital mortality rate, length of stay in the acute care and rehabilitation centers were greater in the tSCI+TBI group (p < 0.0001). However, both groups had similar changes in the motor scores from admission to discharge from the hospital (p = 0.6096). While both groups had similar frequencies of pain (p = 0.9848), spasticity was more frequent in the tSCI+TBI group (p < 0.0001). Our results underscore significant differences between the tSCI+TBI group and the SCI-alone group regarding the injury epidemiology, management and outcomes. Those results suggest that concomitant TBI should be considered a major potential confounder in future SCI research studies.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"438-446"},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-15DOI: 10.1038/s41393-026-01198-x
Nele Bertels, Yvonne Janssen-Potten, Charlotte van Laake-Geelen, Kathleen Borgions, Kristine Oostra, Annemie Spooren
{"title":"Answer to correspondence on ‘Arm-hand training strategies and therapy dose dimensions during the subacute rehabilitation of people with cervical spinal cord injury: a longitudinal observational study’","authors":"Nele Bertels, Yvonne Janssen-Potten, Charlotte van Laake-Geelen, Kathleen Borgions, Kristine Oostra, Annemie Spooren","doi":"10.1038/s41393-026-01198-x","DOIUrl":"10.1038/s41393-026-01198-x","url":null,"abstract":"","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"486-487"},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-11DOI: 10.1038/s41393-026-01201-5
Ema Vidakovic, Elisabeth Bamberg, Björn Zörner, Kathleen Ostheim, Beatrice Minder, Sue Bertschy, Juergen Pannek, Petra Stute, Marija Glisic
{"title":"The role of sex hormones in neurological and functional recovery following spinal cord injury in females: a systematic review of the literature","authors":"Ema Vidakovic, Elisabeth Bamberg, Björn Zörner, Kathleen Ostheim, Beatrice Minder, Sue Bertschy, Juergen Pannek, Petra Stute, Marija Glisic","doi":"10.1038/s41393-026-01201-5","DOIUrl":"10.1038/s41393-026-01201-5","url":null,"abstract":"Systematic review. To synthesize human and animal evidence on the potential neuroprotective effects of sex hormones in women with spinal cord injury (SCI) and in female animal models, with the aim of comparing findings across experimental and clinical studies and identifying gaps in clinical research. EMBASE, Medline, Cochrane CENTRAL, and Web of Science were searched from inception to August 22, 2025, without language restrictions. Two reviewers independently performed study screening, data extraction, and risk of bias assessment. Of 2832 screened records, 26 studies were included (23 preclinical and 3 clinical). Human evidence was scarce and primarily addressed functional recovery after acute SCI, as well as cardiovascular risk factors and bone outcomes in small cohorts of pre- and postmenopausal women with chronic SCI. Preclinical studies consistently demonstrated broad neuroprotective effects of estradiol across multiple outcomes. Inhibition of estrogen synthesis with letrozole was associated with impaired motor recovery, while the presence of intact ovaries was linked to improved sensory outcomes, supporting a protective role of endogenous estrogens. Evidence for progesterone and dehydroepiandrosterone (DHEA) was mixed, although DHEA showed promising effects in two of three studies, including improved motor and sensory recovery and tissue preservation. This review highlights the therapeutic potential of sex hormones in SCI recovery while also revealing substantial gaps in human research. Future studies should investigate endogenous hormone profiles and hormone-based interventions during the acute and subacute phases of SCI to guide therapeutic development and bridge the gap between animal models and clinical practice.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"403-415"},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-11DOI: 10.1038/s41393-026-01196-z
Marta Ríos-León, Ramiro Palazón-García, Miguel Hernández-Bautista, Isabel Escobar-Sánchez, Raquel Menchero, Antonio Segura-Fragoso, Julian Taylor
{"title":"Translation, cross-cultural adaptation and validation of the Spanish version of the Spinal Cord Injury Pain Instrument (SCIPI)","authors":"Marta Ríos-León, Ramiro Palazón-García, Miguel Hernández-Bautista, Isabel Escobar-Sánchez, Raquel Menchero, Antonio Segura-Fragoso, Julian Taylor","doi":"10.1038/s41393-026-01196-z","DOIUrl":"10.1038/s41393-026-01196-z","url":null,"abstract":"Single-center observational study. To perform the translation, cross-cultural adaptation, and analysis of the measurement properties of the Spanish version of the Spinal Cord Injury Pain Instrument (SCIPI) for the screening of neuropathic pain (NP) in spinal cord injury (SCI). Hospital, Spain. Participants with SCI and pain were included for the pre-final version (n = 10) and the final version (n = 136). Translation and cross-cultural adaptation of the SCIPI were performed by native speakers in both languages. The statistical analysis included internal consistency, validity, test-retest reliability, and diagnostic accuracy. All the items of the pre-final version of the SCIPI were understood. Moderate test-retest reliability (intraclass correlation coefficient (ICC) = 0.78, 95% confidence interval (CI), 0.69 to 0.84, p < 0.001) and CR coefficient of internal consistency of 0.484 were found. Strong correlations between the SCIPI and the Douleur Neuropathique 4 (DN4) were revealed (rho = 0.619, p < 0.001). The best cutoff value was 2 points, with an outstanding discriminant ability according to the area under the curve (AUC) value (AUC = 0.937) associated with high sensitivity (91.13%) and specificity (91.67%). The Spanish version of the SCIPI may be a reliable and valid tool, with an excellent discriminant ability, for the screening of NP in people with SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"431-437"},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-09DOI: 10.1038/s41393-026-01197-y
Elsa Alvarez-Madrid, April Herrity, Carla Rich, Kyle Brothers, Susan Harkema, Charles Hubscher, Beatrice Ugiliweneza
{"title":"Motivations and expectations for spinal cord epidural stimulation study participation: perspectives from individuals with spinal cord injury and caregivers","authors":"Elsa Alvarez-Madrid, April Herrity, Carla Rich, Kyle Brothers, Susan Harkema, Charles Hubscher, Beatrice Ugiliweneza","doi":"10.1038/s41393-026-01197-y","DOIUrl":"10.1038/s41393-026-01197-y","url":null,"abstract":"Qualitative, semi structured interviews. Spinal cord epidural stimulation (scES) has shown promise for improving autonomic and motor function in individuals with spinal cord injury (SCI). Participation in translational studies often requires relocation, uprooting the individual and caregivers from their community. Recognizing this burden, this study aimed to explore the motivations and expectations driving the decision to participate in a scES study. Kentucky Spinal Cord Injury Research Center, University of Louisville, USA. 23 interviews were conducted at enrollment in a randomized trial evaluating scES efficacy. Respondents were 18 individuals with SCI (40 ± 10 years old, 12 ± 10 years since injury, 44% males, all cervical, ASIA Impairment Scale: 39% A, 39% B, 22% C) and 5 caregivers. Interviews were audio recorded, transcribed, and analyzed with a thematic approach. Four main themes emerged: gaining independence, improving function, benevolence, and other. Participants and caregivers hoped that improved function would lead to more independence—described as “a little more freedom,” “experience the world,” and to “not rely on someone.” Any change was expressed as improving the quality of life. Many managed their expectations by recognizing the impact of individual characteristics on outcomes. Even if no improvement occurred, participation felt meaningful—motivated by benevolence and a desire to advance SCI research and help others. People with SCI and their caregivers participate in scES research with cautious optimism to gain freedom and improve quality of life through improved function. They also aim to help others through advancing science. This work was funded by Department of Defense (W81XWH-19-1-0734). The parent study was funded by Christopher and Dana Reeve Foundation, Leona M. & Harry B. Helmsley Charitable Trust, and Medtronic Plc for spinal cord epidural stimulation implants.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"423-430"},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-04DOI: 10.1038/s41393-026-01183-4
Lindsay Tetreault, Tanzil Rujeedawa, Lance A. Burn, Carl Zipser, Chad Cook, Konstantinos Margetis, Allan R. Martin, David B. Anderson, Justin M. Lantz, Julia Tabrah, Jamie RF Wilson, Ricardo Rodrigues-Pinto, Ratko Yurac, Lianne Wood, Ligia Onofrei, Rohil V. Chauhan, Tore K. Solberg, James Harrop, Sybil Stacpoole, Jamie Milligan, Caroline Treanor, Julio C. Furlan, Noam Y. Harel, Michael W. Y. Lee, Mike Hutton, Brian K. Kwon, Mark Kotter, Michael G. Fehlings, Benjamin M. Davies
{"title":"A protocol for developing screening criteria for degenerative cervical myelopathy: AO Spine Myelopathy.org RECODE-DCM","authors":"Lindsay Tetreault, Tanzil Rujeedawa, Lance A. Burn, Carl Zipser, Chad Cook, Konstantinos Margetis, Allan R. Martin, David B. Anderson, Justin M. Lantz, Julia Tabrah, Jamie RF Wilson, Ricardo Rodrigues-Pinto, Ratko Yurac, Lianne Wood, Ligia Onofrei, Rohil V. Chauhan, Tore K. Solberg, James Harrop, Sybil Stacpoole, Jamie Milligan, Caroline Treanor, Julio C. Furlan, Noam Y. Harel, Michael W. Y. Lee, Mike Hutton, Brian K. Kwon, Mark Kotter, Michael G. Fehlings, Benjamin M. Davies","doi":"10.1038/s41393-026-01183-4","DOIUrl":"10.1038/s41393-026-01183-4","url":null,"abstract":"Protocol Degenerative cervical myelopathy (DCM) is caused by degenerative changes of the spinal column that lead to progressive spinal cord compression. Early identification of DCM is paramount to ensure appropriate specialist referral, timely intervention, and optimal treatment outcomes. Unfortunately, diagnosis of DCM is often delayed and may be missed entirely. A lack of screening or referral criteria has been identified as a major contributor of diagnostic delay. The objective of this study is to outline the methodology that will be used to develop screening criteria for DCM. We propose a three-step approach for establishing screening criteria for DCM using data-driven and expert-based methods that includes a combination of patient-reported symptoms and clinical signs obtained from physical examination. Our approach includes: (i) an initial scoping review of inclusion criteria used in DCM research studies; (ii) criteria generation through systematic reviews of the literature as well as surveys of individuals with lived experience and international multidisciplinary experts in DCM; and (iii) criteria reduction via a consensus process. Our framework intends to foster the development of valid, reliable and sustainable screening criteria that could improve awareness of DCM, influence practice decisions and reduce delays to diagnosis .","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"453-459"},"PeriodicalIF":2.2,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Passive immunotherapy targeting pathogenic tau restores neuronal structure and function following spinal cord injury","authors":"Amirreza Vahedi, Golnoosh Rahimi, Mohadeseh Rahbar, Yalda Adibi Motlagh, Pegah Siahmansouri, Farzaneh Sorouri, Farzaneh Esmaily, Seyed Massood Nabavi, Sahar Kiani, Koorosh Shahpasand","doi":"10.1038/s41393-025-01149-y","DOIUrl":"10.1038/s41393-025-01149-y","url":null,"abstract":"Animal study. To determine whether eliminating cis pT231-tau with a specific monoclonal antibody can restore neuronal structure and function after spinal cord injury (SCI). Royan Institute, Tehran, Iran. Adult Wistar rats underwent SCI induction using the NYU impactor device. Animals received treatment with cis pT231-tau monoclonal antibody or placebo. Outcomes were assessed via immunostaining, immunoblotting, and the Basso, Beattie, and Bresnahan (BBB) behavioral test to evaluate motor function recovery. Treatment with cis pT231-tau monoclonal antibody reduced inflammatory markers, enhanced myelin sheath formation, increased NF200 protein expression, and decreased GFAP levels compared with placebo. Behavioral testing indicated improved motor function in treated animals. Eliminating cis pT231-tau using a specific monoclonal antibody mitigates neuronal damage and promotes structural and functional recovery following SCI, highlighting its therapeutic potential.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"447-452"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal cordPub Date : 2026-04-01DOI: 10.1038/s41393-026-01192-3
James S. Krause, Clara E. Dismuke-Greer, Devyn E. Smith, Nicole D. Dipiro
{"title":"Relationship of prescription and nonprescription opioid use, opioid misuse, and alcohol use with suicidal ideation among people with spinal cord injury","authors":"James S. Krause, Clara E. Dismuke-Greer, Devyn E. Smith, Nicole D. Dipiro","doi":"10.1038/s41393-026-01192-3","DOIUrl":"10.1038/s41393-026-01192-3","url":null,"abstract":"Cross-sectional study. To identify the relationship of prescription opioid use, self-reported misuse of opioids, and binge drinking days with suicidal ideation (SI) in a cohort of participants with spinal cord injury (SCI). Medical university in the southeastern United States. This was a cross-sectional analysis of self-report data from 1253 study participants with SCI, all of whom were enrolled in a longitudinal study of health outcomes. SI was assessed and dichotomized using item 9 on the Patient Health Questionnaire-9. Occasional use of 3 or more prescription opioids was associated with greater odds of SI (OR = 3.53, CI = 1.50–8.31), as was self-reported misuse of prescription opioids (OR = 3.51, CI = 1.83–6.72). Days of binge drinking was unrelated to SI. Odds of SI were higher for those with depression (OR = 5.98, CI = 3.60–9.92) and those who reported 15 or more painful days in a month (OR = 2.15, CI = 1.24–3.73). Compared with the most severe SCI (high cervical, non-ambulatory), participants who were ambulatory (OR = 0.36, CI = 0.15-0.86) or were non-cervical/non-ambulatory (OR = 0.32, CI = 0.14-0.75) reported lower odds of SI. Prescription opioid use needs to be closely monitored by healthcare professionals for those who use multiple opioids and who self-report misusing opioids, as there is a relationship with SI, even when considering multiple covariates pain and depression.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"64 5","pages":"460-465"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}